scholarly journals Design of the Weight-loss Endoscopy Trial (WET): a multi-center, randomized, controlled trial comparing weight loss in endoscopically implanted duodenal-jejunal bypass liners vs. intragastric balloons vs. a sham procedure

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Marcus Hollenbach ◽  
Christiane Prettin ◽  
Felix Gundling ◽  
Wolfgang Schepp ◽  
Jochen Seufert ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Intragastric Balloons ◽  
Randomized Controlled ◽  
Sham Procedure ◽  
Jejunal Bypass

A randomized controlled trial of matching of deposit contracts to promote weight loss

2013 ◽  
Author(s):  
Jeffrey T. Kullgren ◽  
Andrea B. Troxel ◽  
George Loewenstein ◽  
Laurie A. Norton ◽  
Dana Gatto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Promote Weight Loss ◽  
Randomized Controlled ◽  
Deposit Contracts

scholarly journals Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women: Randomized Controlled Trial

2012 ◽  
Vol 30 (19) ◽  
pp. 2314-2326 ◽  
Author(s):  
Kristin L. Campbell ◽  
Karen E. Foster-Schubert ◽  
Catherine M. Alfano ◽  
Chia-Chi Wang ◽  
Ching-Yun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Free Testosterone ◽  
Randomized Controlled ◽  
Weight Loss Diet ◽  
Vigorous Intensity ◽  
Free Estradiol

Purpose Estrogens and androgens are elevated in obesity and associated with increased postmenopausal breast cancer risk, but the effect of weight loss on these biomarkers is unknown. We evaluated the individual and combined effects of a reduced-calorie weight loss diet and exercise on serum sex hormones in overweight and obese postmenopausal women. Patients and Methods We conducted a single-blind, 12-month, randomized controlled trial from 2005 to 2009. Participants (age 50 to 75 years; body mass index > 25.0 kg/m2, exercising < 100 minutes/wk) were randomly assigned using a computer-generated sequence to (1) reduced-calorie weight loss diet (“diet”; n = 118), (2) moderate- to vigorous-intensity aerobic exercise (“exercise”; n = 117), (3) combined reduced-calorie weight loss diet and moderate- to vigorous-intensity aerobic exercise (“diet + exercise”; n = 117), or (4) control (n = 87). Outcomes were estrone concentration (primary) and estradiol, free estradiol, total testosterone, free testosterone, androstenedione, and sex hormone–binding globulin (SHBG) concentrations (secondary). Results Mean age and body mass index were 58 years and 30.9 kg/m2, respectively. Compared with controls, estrone decreased 9.6% (P = .001) with diet, 5.5% (P = .01) with exercise, and 11.1% (P < .001) with diet + exercise. Estradiol decreased 16.2% (P < .001) with diet, 4.9% (P = .10) with exercise, and 20.3% (P < .001) with diet + exercise. SHBG increased 22.4% (P < .001) with diet and 25.8% (P < .001) with diet + exercise. Free estradiol decreased 21.4% (P < .001) with diet and 26.0% (P < .001) with diet + exercise. Free testosterone decreased 10.0% (P < .001) with diet and 15.6% (P < .001) with diet + exercise. Greater weight loss produced stronger effects on estrogens and SHBG. Conclusion Weight loss significantly lowered serum estrogens and free testosterone, supporting weight loss for risk reduction through lowering exposure to breast cancer biomarkers.

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