The impact of chlorhexidine bathing on hospital-acquired bloodstream infections: a systematic review and meta-analysis

Abstract Staphylococcus aureus is a common cause of severe bloodstream infection. We performed a systematic review to assess whether consultation with infectious disease specialists decreased all-cause mortality or rate of complications of S aureus bloodstream infections. The review also assessed parameters associated with the quality of management of the infection. We searched for eligible studies in PubMed, Embase, Scopus, and clinical trials.gov as well as the references of included studies. We identified 22 observational studies and 1 study protocol for a randomized trial. A meta-analysis was not performed because of the high risk of bias in the included studies. The outcomes are reported in a narrative review. Most included studies reported survival benefit, in the adjusted analysis. Recommended management strategies were carried out significantly more often among patients seen by an infectious disease specialist. Trials, such as cluster-randomized controlled trials, can more validly assess the studies at low risk of bias.

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Effect of 2% Chlorhexidine Bathing on the Incidence of Hospital-Acquired Infection and Multidrug-Resistant Organisms in Adult Intensive Care Unit Patients: Systematic Review and Meta-Analysis

Journal of Korean Academy of Nursing ◽

10.4040/jkan.21046 ◽

2021 ◽

Vol 51 ◽

Author(s):

Jisu Seo ◽

Rhayun Song

Keyword(s):

Systematic Review ◽

Intensive Care Unit ◽

Intensive Care ◽

Meta Analysis ◽

Multidrug Resistant ◽

Hospital Acquired Infection ◽

Adult Intensive Care Unit ◽

Chlorhexidine Bathing ◽

Multidrug Resistant Organisms ◽

Hospital Acquired

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Does Copper treating of commonly touched surfaces reduce healthcare acquired infections? A Systematic Review and meta-analysis

10.1101/2020.05.21.20109447 ◽

2020 ◽

Author(s):

Loai Albarqouni ◽

Oyuka Byambasuren ◽

Justin Clark ◽

Anna Mae Scott ◽

David Looke ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Clinical Importance ◽

Potential Effect ◽

Current Evidence ◽

Healthcare Facilities ◽

Healthcare Acquired Infections ◽

Effect Of Copper ◽

Hospital Acquired ◽

The Impact

AbstractBackgroundHealthcare acquired infections (HAIs) cause substantial morbidity and mortality. Copper appears to have strong viricidal properties under laboratory conditions.AimWe conducted a systematic review to examine the potential effect of copper treating of commonly touched surfaces in healthcare facilities.MethodsWe included controlled trials comparing the effect of copper-treated surfaces (furniture or bed linens) in hospital rooms versus standard rooms on hospital acquired infections (HAIs). Two reviewers independently screened retrieved articles, extracted data, and assessed the risk of bias of included studies. The primary outcome was the occurrence of healthcare acquired infections.FindingsWe screened 638 records; 7 studies comprising 12362 patients were included. All of included studies were judged to be at high risk in ≥2 of the 7 domains of bias. All 7 included studies reported the effect of copper-treated surfaces HAIs. Overall, we found low quality evidence of a potential clinical importance that copper-treated hard surfaces and/or bed linens and clothes reduced healthcare acquired infections by 27% (RR 0.73; 95% CI 0.57 to 0.94).ConclusionGiven the clinical and economic costs of healthcare acquired infections, the potentially protective effect of copper-treated surfaces appears important. The current evidence is insufficient to make a strong positive recommendation. However, it would appear worthwhile and urgent to conduct larger-scale publicly funded clinical trials of the impact of copper coating.

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