scholarly journals An anastomosing hemangioma mimicking a renal cell carcinoma in a kidney transplant recipient: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Chang Seong Kim ◽  
Soo Jin Na Choi ◽  
Sung-Sun Kim ◽  
Sang Heon Suh ◽  
Eun Hui Bae ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Transplantation ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Kidney Transplant ◽  
Renal Cell ◽  
Incidental Finding ◽  
End Stage Kidney Disease ◽  
End Stage ◽  
Anastomosing Hemangioma

Abstract Background Although anastomosing hemangiomas are very rare and benign vascular neoplasms, these tumors are more common among patients with end-stage kidney disease. Incidental finding of these tumors in the kidney or adrenal gland has been reported. Herein, we describe a case in which an anastomosing hemangioma was misdiagnosed as a renal cell carcinoma before kidney transplant. Case presentation A 35-year-old woman with lupus nephritis was admitted to our emergency department for suspected uremic symptoms of nausea and general weakness. She had received hemodialysis due to end-stage kidney disease, and a living-donor kidney transplantation from her father was planned. On pre-operative contrast-enhanced computed tomography and magnetic resonance imaging, a 1.7 cm renal cell carcinoma was observed in the right kidney. On staining after radical nephrectomy, irregularly shaped vascular spaces of various sizes were observed, with these spaces having an anastomosing pattern. As the findings of the anastomosing hemangioma are similar to those of a renal cell carcinoma on imaging, histology examination was necessary to confirm the diagnosis of anastomosing hemangioma and to prevent delay in listing for kidney transplantation. Good kidney function was achieved after transplantation, with no tumor recurrence. Conclusion Our case underlines the importance for prompt surgical resection of an enhancing renal mass to confirm diagnosis in patients scheduled for kidney transplantation to avoid any delay.

576 RENAL CELL CARCINOMA IN END-STAGE RENAL DISEASE: ACCORDING TO THE KIDNEY TRANSPLANT AND DIALYSIS

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Hyung Ho Lee ◽  
Ho Song Yu ◽  
Woo Jin Bang ◽  
Woong Kyu Han ◽  
Sung Jun Hong
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Disease ◽  
Cell Carcinoma ◽  
Kidney Transplant ◽  
End Stage Renal Disease ◽  
Renal Cell ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Psychological Concerns of Children Undergoing Kidney Transplantation During the Pandemic: Single-centre Experience

2021 ◽  
Vol 5 (1) ◽  
pp. e001174
Author(s):  
Alicia Paessler ◽  
Sheila Boyle ◽  
Stephen Marks ◽  
Nicos Kessaris ◽  
Jelena Stojanovic
Keyword(s):  
Kidney Transplantation ◽  
Kidney Disease ◽  
Kidney Transplant ◽  
Children And Families ◽  
Single Centre ◽  
End Stage Kidney Disease ◽  
Single Centre Experience ◽  
End Stage ◽  
Additional Safety

Many paediatric kidney transplant programmes were closed during the COVID-19 pandemic, and due to the vulnerable nature of patients with end-stage kidney disease (ESKD), there were new concerns once these programmes reopened. We surveyed children and families who received a kidney transplant during the pandemic. We found that half of the participants felt scared and/or anxious about receiving a kidney transplant during the pandemic, and 2/8 participants were worried about catching COVID-19 during their recovery. While detailed counselling and additional safety precautions contributed to a good experience, patients and parents still demonstrated fear towards transplantation.

Renal cell carcinoma in kidney transplant recipients at Guy’s and King’s College Hospital (UK) between 1987-2018.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e16066-e16066
Author(s):  
Sabeeh-Ur-Rehman Butt ◽  
Barbara Chow ◽  
Sapna Shah ◽  
Iain MacDougall ◽  
Catriona Shaw ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Kidney Transplant ◽  
Renal Cell ◽  
High Risk Population ◽  
Solid Cancer ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Increased Risk

e16066 Background: The increased incidence of cancer after renal transplantation is well recognised. Differences in cancer risk depend on the type of cancer but overall the incidence of solid cancer in kidney transplant recipient is at least twofold. Long term immunosuppression, oncogenic viruses and changes in immune surveillance are contributing factors. The incidence of renal cell carcinoma (RCC) is approximately six-fold greater than in the general population. Screening for RCC in the post-transplantation setting is not routine. Methods: Retrospective case series of kidney transplant recipients who underwent transplantation between 1987 and 2018 at Guy’s Hospital (London, UK). Collected data on patients who developed RCC post-transplant included: baseline demographics, renal disease, transplant survival, tumour characteristics, cancer treatment and survival. Results: 2968 patients underwent kidney transplantation between 1987 and 2018 at our Centre. 52 patients (1.8%) developed RCC. 40 (74%) were male with a median age of 51 years. 37% (71%) were white and 12 (23%) were black. The causes of end stage kidney disease included IgA nephropathy, hypertension and polycystic kidney disease. Median time to RCC diagnosis after transplant was 9 years (range 0-27). 86% of patients presented with stage 1/2 tumours, with the majority (72%) occurring in native kidneys. Most underwent radical nephrectomy although 5 patients were managed with radiofrequency-ablation (RFA) or surveillance (donor kidneys). Of 6 patients with metastatic disease, 5 received pazopanib and 1 everolimus. 4 patients continued systemic therapy for over 3 months and all derived clinical benefit with a median drug exposure of 19 months .15 patients required further kidney transplant or dialysis. Overall only 2 patients died from RCC. Conclusions: This retrospective study is the largest single-centre UK study to our knowledge. Kidney transplant recipients experience a marked increased risk of developing RCC. Most diagnosed RCCs are small and disease-specific mortality is low. With a third of tumours arising in donor organs, questions around optimum loco-regional approach and screening of high-risk population remain unanswered.

scholarly journals Guillain-Barre syndrome: a typical paraneoplastic syndrome in a kidney transplant recipient with allograft renal cell carcinoma: a case report and review of the literature

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Izabela Zakrocka ◽  
Iwona Baranowicz-Gąszczyk ◽  
Agnieszka Korolczuk ◽  
Wojciech Załuska
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Transplantation ◽  
Cell Carcinoma ◽  
Kidney Transplant ◽  
Renal Cell ◽  
Guillain Barre Syndrome ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Abstract Background Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy affecting the peripheral nervous system. This neurological disorder has been previously reported in bone marrow transplant recipients but is uncommon after kidney transplantation. Viral infections and calcineurin inhibitors are the main triggers of GBS in renal transplant recipients. Case presentation In this report, we present a case of a 47-year-old male patient 12 years after his second kidney transplantation who developed GBS due to papillary renal cell carcinoma. Infectious and drug-related origins of GBS were excluded. Despite intensive treatment, graftectomy was performed, after which neurological symptoms resolved. Conclusions In kidney transplant recipients, paraneoplastic aetiology should be considered in the differential diagnosis of GBS.

scholarly journals Peritoneal Dialysis and Retroperitoneal Laparoscopic Radical Nephrectomy: A Favorable Experience With a Patient Complicated by Renal Cell Carcinoma

2017 ◽  
Vol 10 ◽  
pp. 117954761774636 ◽  
Author(s):  
Reika Imai ◽  
Tetsu Akimoto ◽  
Takaaki Kimura ◽  
Marina Kohara ◽  
Toshihiro Shimizu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Peritoneal Dialysis ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Radical Nephrectomy ◽  
Therapeutic Option ◽  
Laparoscopic Technique ◽  
End Stage Kidney Disease ◽  
Laparoscopic Radical Nephrectomy ◽  
End Stage

Peritoneal dialysis (PD) is an accepted modality for managing end-stage kidney disease. We herein report a 75-year-old female patient on chronic PD who was complicated by renal cell carcinoma. She was successfully treated with retroperitoneal laparoscopic radical nephrectomy followed by a prompt resumption of the procedure. Various surgeries disturbing the abdominal wall integrity often disrupt the regular PD schedule, and using minimally invasive approaches is therefore an attractive therapeutic option. Our experience emphasizes the feasibility and safety of a retroperitoneal approach–based laparoscopic technique based on several empirical examples. However, systemic studies on this topic are obviously lacking, so we strongly recommend the accumulation of more cases similar to our own. Several surgical concerns that need to be dealt with among PD patients are also discussed.

Impaired Vitamin D Signaling Is Associated With Frequent Development of Renal Cell Tumor in End-stage Kidney Disease

2020 ◽  
Vol 40 (11) ◽  
pp. 6525-6530
Author(s):  
JANOS DOCS ◽  
DANIEL BANYAI ◽  
TIBOR FLASKO ◽  
ARPAD SZANTO ◽  
GYULA KOVACS
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Renal Cell ◽  
Cell Tumor ◽  
End Stage Kidney Disease ◽  
Vitamin D Signaling ◽  
End Stage

scholarly journals Modeling Neoplastic Growth in Renal Cell Carcinoma and Polycystic Kidney Disease

2021 ◽  
Vol 22 (8) ◽  
pp. 3918
Author(s):  
Cassandra Millet-Boureima ◽  
Stephanie He ◽  
Thi Bich Uyen Le ◽  
Chiara Gamberi
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Polycystic Kidney Disease ◽  
Renal Cell ◽  
Primary Cilia ◽  
Genetic Model ◽  
Cell Metabolism ◽  
Neoplastic Cell ◽  
Polycystic Kidney

Renal cell carcinoma (RCC) and autosomal dominant polycystic kidney disease (ADPKD) share several characteristics, including neoplastic cell growth, kidney cysts, and limited therapeutics. As well, both exhibit impaired vasculature and compensatory VEGF activation of angiogenesis. The PI3K/AKT/mTOR and Ras/Raf/ERK pathways play important roles in regulating cystic and tumor cell proliferation and growth. Both RCC and ADPKD result in hypoxia, where HIF-α signaling is activated in response to oxygen deprivation. Primary cilia and altered cell metabolism may play a role in disease progression. Non-coding RNAs may regulate RCC carcinogenesis and ADPKD through their varied effects. Drosophila exhibits remarkable conservation of the pathways involved in RCC and ADPKD. Here, we review the progress towards understanding disease mechanisms, partially overlapping cellular and molecular dysfunctions in RCC and ADPKD and reflect on the potential for the agile Drosophila genetic model to accelerate discovery science, address unresolved mechanistic aspects of these diseases, and perform rapid pharmacological screens.

Renal cell carcinoma in patients with end-stage renal disease: relationship between histological type and duration of dialysis

2010 ◽  
Vol 105 (5) ◽  
pp. 620-627 ◽  
Author(s):  
Mohammed A.A.M. Nouh ◽  
Naoto Kuroda ◽  
Motoki Yamashita ◽  
Yushi Hayashida ◽  
Toshifumi Yano ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Disease ◽  
Cell Carcinoma ◽  
End Stage Renal Disease ◽  
Renal Cell ◽  
Histological Type ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Beta Catenin Signaling: Linking Renal Cell Carcinoma and Polycystic Kidney Disease

Cell Cycle ◽  
2006 ◽  
Vol 5 (24) ◽  
pp. 2839-2841 ◽  
Author(s):  
Benedetta Peruzzi ◽  
Donald P. Bottaro
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Polycystic Kidney Disease ◽  
Renal Cell ◽  
Beta Catenin ◽  
Polycystic Kidney
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