scholarly journals Guillain-Barre syndrome: a typical paraneoplastic syndrome in a kidney transplant recipient with allograft renal cell carcinoma: a case report and review of the literature

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Izabela Zakrocka ◽  
Iwona Baranowicz-Gąszczyk ◽  
Agnieszka Korolczuk ◽  
Wojciech Załuska
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Transplantation ◽  
Cell Carcinoma ◽  
Kidney Transplant ◽  
Renal Cell ◽  
Guillain Barre Syndrome ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Abstract Background Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy affecting the peripheral nervous system. This neurological disorder has been previously reported in bone marrow transplant recipients but is uncommon after kidney transplantation. Viral infections and calcineurin inhibitors are the main triggers of GBS in renal transplant recipients. Case presentation In this report, we present a case of a 47-year-old male patient 12 years after his second kidney transplantation who developed GBS due to papillary renal cell carcinoma. Infectious and drug-related origins of GBS were excluded. Despite intensive treatment, graftectomy was performed, after which neurological symptoms resolved. Conclusions In kidney transplant recipients, paraneoplastic aetiology should be considered in the differential diagnosis of GBS.

Guillain–Barré syndrome in a patient with renal cell carcinoma following the first course of pazopanib therapy

2017 ◽  
Vol 23 (11) ◽  
pp. 798-799 ◽  
Author(s):  
Hiroaki Koshikawa ◽  
Tomomi Tsukie ◽  
Akira Kurita ◽  
Mikio Fujikura ◽  
Megumi Suzuki ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Guillain-Barré Syndrome following Treatment with Sunitinib Malate

2014 ◽  
Vol 2014 ◽  
pp. 1-2 ◽  
Author(s):  
Ziad Kanaan ◽  
Zain Kulairi ◽  
Mirela Titianu ◽  
Sandip Saha ◽  
Sarwan Kumar
Keyword(s):  
Renal Cell Carcinoma ◽  
Side Effects ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Kinase Inhibitor ◽  
Guillain Barre Syndrome ◽  
Sunitinib Malate ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Sunitinib malate (Sutent, SU011248) is an oral multitargeted tyrosine kinase inhibitor (TKI) used for the treatment of metastatic renal cell carcinoma and imatinib (Gleevec)—resistant gastrointestinal stromal tumor (GIST) with few reported side effects including asthenia, myelosuppression, diarrhea, and mucositis. Scarce literature exists regarding the rare but often serious toxicities of sunitinib. Autoimmune and neurological side effects have been linked to sunitinib’s inhibition of VEGF receptors with a corresponding increase in VEGF levels, which is associated with development of different neuropathies. We hereby report an interesting case of Guillain-Barré syndrome in a middle-aged patient with metastatic renal cell carcinoma following sunitinib treatment.

Renal cell carcinoma of native kidney in renal transplant recipients

2006 ◽  
Vol 98 (2) ◽  
pp. 298-302 ◽  
Author(s):  
SAID M. MOUDOUNI ◽  
AMINE LAKMICHI ◽  
MOHAMMED TLIGUI ◽  
ARACH RAFII ◽  
KESSILE TCHALA ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Transplant ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Native Kidney

Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients

2010 ◽  
Vol 105 (9) ◽  
pp. 1260-1265 ◽  
Author(s):  
Tobias Klatte ◽  
Christian Seitz ◽  
Matthias Waldert ◽  
Michela de Martino ◽  
Željko Kikic ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Transplant ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals De Novo Renal Cell Carcinoma of Native Kidneys in Renal Transplant Recipients: A Single-center Experience

2017 ◽  
Vol 37 (2) ◽  
pp. 773-780 ◽  
Author(s):  
DEMETRIOS MORIS ◽  
KIRIAKI KAKAVIA ◽  
CHRYSOULA ARGYROU ◽  
NIKOLAOS GARBIS ◽  
JOHN BOKOS ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Transplant ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
De Novo ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Single Center ◽  
Single Center Experience

scholarly journals Guillain-Barre Syndrome Caused by Tislelizumab and Axitinib

2021 ◽  
Author(s):  
Yang Sun ◽  
Yanjun Guo ◽  
Yaqing Wu ◽  
Ningning Luo ◽  
Xinjia He
Keyword(s):  
Renal Cell Carcinoma ◽  
Nervous System ◽  
T Cell ◽  
Adverse Events ◽  
Renal Cell ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Treatment Paradigm ◽  
Triggering Factor ◽  
Guillain Barré

Abstract Immunotherapy combinations have changed the treatment paradigm of advanced renal cell carcinoma (RCC). Notably, immunotherapy induces a new spectrum of immune-related adverse events (irAEs). Guillain–Barré syndrome (GBS) is a rare and potentially fatal nervous system irAE. The activation of T-cell is considered a triggering factor of GBS. We herein reported a case of GBS-like syndrome during treatment of tislelizumab and axitinib in a patient with RCC. To our knowledge, this is the first report of tislelizumab-related GBS.

scholarly journals Clear Cell Papillary Renal Cell Carcinoma in the Bilateral Native Kidneys after 2 Years of Renal Transplantation: Report of a Case and Review of the Literature

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Zhanyong Bing ◽  
John E. Tomaszewski
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Transplantation ◽  
Renal Transplant ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Tumors ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Renal transplantation increases the probability of malignant tumors by about 2–4-fold overall with a much higher rate for renal epithelial malignancy. Renal tumors in renal transplant recipients are commonly conventional clear cell or papillary renal cell carcinoma. Clear cell papillary renal cell carcinoma is a recently described unique renal epithelial neoplasm with scant eosinophilic or moderate amount of clear cytoplasm and pyknotic small nuclei oriented commonly toward the apical surfaces. No such tumor has been reported in renal transplant recipients. In this paper, we describe a clear cell papillary renal cell carcinoma involving bilateral native kidneys in a patient who had received a renal transplant 2 years earlier. Clear cell papillary renal cell carcinoma commonly presents with low pathologic stage and lower Fuhrman grade and is clinically indolent. Additional cases are needed to evaluate the clinical behavior of this type of tumor in renal transplant recipients.

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