scholarly journals The prognostic role of heart rate recovery after exercise and metabolic syndrome in IgA nephropathy

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Balázs Sági ◽  
István Késői ◽  
Tibor Vas ◽  
Botond Csiky ◽  
Judit Nagy ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Iga Nephropathy ◽  
Heart Rate Recovery ◽  
Stress Test ◽  
Prognostic Role ◽  
Cox Regression Analysis ◽  
Ckd Stage ◽  
Significant Difference

Abstract Background Cardiovascular (CV) morbidity and mortality are higher in chronic kidney disease (CKD) than in the general population. Reduced heart rate recovery (HRR) is an independent risk factor for CV disease. The aim of the study was to determine the prognostic role of HRR in a homogenous group of CKD patients. Methods One hundred and twenty-five IgA nephropathy patients (82 male, 43 female, age 54.7 ± 13 years) with CKD stage 1–4 were investigated and followed for average 70 months. We performed a graded exercise treadmill stress test. HRR was derived from the difference of the peak heart rate and the heart rate at 1 min after exercise. Patients were divided into two groups by the mean HRR value (22.9 beats/min). The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularisation (CV) and end-stage renal disease, renal replacement therapy (renal). Results Patients with reduced HRR (< 23 bpm) had significantly more end point events (22/62 patients vs. 9/53 patients, p = 0.013) compared to the higher HRR (≥23 bpm). Of the secondary the endpoints (CV or renal separately) rate of the renal endpoint was significantly higher in the lower HRR group (p = 0.029), while there was no significant difference in the CV endpoint between the two HRR groups (p = 0.285). Independent predictors of survival were eGFR and diabetes mellitus by using Cox regression analysis. Kaplan-Meier curves showed significant differences in metabolic syndrome and non-metabolic syndrome when examined at the combined endpoints (cardiovascular and renal) or at each endpoint separately. The primary endpoint rate was increased significantly with the increased number of metabolic syndrome component (Met.sy. comp. 0 vs. Met. sy. comp. 2+, primary endpoints, p = 0.012). Conclusion Our results showed that reduced HRR measured by treadmill exercise test has a predictive value for the prognosis of IgA nephropathy. The presence of metabolic syndrome may worsen the prognosis of IgA nephropathy.

THE PROGNOSTIC ROLE OF HEART RATE RECOVERY AFTER EXERCISE IN IGA NEPHROPATHY

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e187-e188
Author(s):  
B. Sági ◽  
I. Késoi ◽  
T. Vas ◽  
B. Csiky ◽  
T. Kovács ◽  
...  
Keyword(s):  
Heart Rate ◽  
Iga Nephropathy ◽  
Heart Rate Recovery ◽  
Prognostic Role

scholarly journals PROGNOSTIC ROLE OF ATRIAL FIBRILLATION AND HEART RATE CONTROL IN CHRONIC HEART FAILURE PATIENTS

2013 ◽  
Vol 61 (10) ◽  
pp. E735
Author(s):  
Savina Nodari ◽  
Marco Triggiani ◽  
Laura Lupi ◽  
Alessandra Manerba ◽  
Giuseppe Milesi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Heart Rate ◽  
Chronic Heart Failure ◽  
Rate Control ◽  
Heart Rate Control ◽  
Prognostic Role ◽  
Heart Failure Patients

Impaired heart rate recovery may predict radial artery spasm in patients undergoing coronary angiography via radial access

2021 ◽  
Author(s):  
İsmail Gürbak ◽  
Arda Güler ◽  
Cafer Panç ◽  
Ahmet Güner ◽  
Mehmet Ertürk
Keyword(s):  
Heart Rate ◽  
Coronary Angiography ◽  
Radial Artery ◽  
Autonomic Dysfunction ◽  
Heart Rate Recovery ◽  
Stress Test ◽  
Female Gender ◽  
Current Data ◽  
Autonomic Nervous System Dysfunction ◽  
Procedural Time

Objectives: Radial artery spasm (RAS) is associated with several pathophysiological pathways, including endothelial and autonomic dysfunction, and causes failed coronary interventions. Heart rate recovery (HRR) is a simple measurement of autonomic nervous system dysfunction. We aimed to investigate the relationship between HRR and RAS during coronary angiography (CA) in the present study. Patients and Methods: This study included 167 patients (mean age 54.6 ± 8.2, 131 males) who underwent a treadmill stress test (TST) according to the Bruce protocol before trans-radial CA. HRR in the first minute (HRR1) was calculated as the difference between peak heart rate and heart rate one minute after the TST. Patients were divided into two groups according to the presence of RAS. Results: Among the study population, RAS developed in 26 patients (15.5%). HRR1 and HRR in the third minute (HRR3) were lower in the RAS group. Also, the abnormal HRR1 rate was higher in the RAS group (35.5% vs. 76.9%, p < 0.001). Total procedural time, more than one puncture attempt, more than one catheter use, fluoroscopy time, radiation exposure, contrast volume was higher in the RAS group. Female gender, total procedural time, more than one catheter use, and abnormal HRR1 were independent predictors of RAS. Conclusion: The current data suggest that a significant relationship was found between abnormal HRR1 and RAS. HRR, a simple autonomic dysfunction parameter, can provide additional information regarding the success of radial procedures.

scholarly journals The temporal relationship between heart rate recovery immediately after exercise and the metabolic syndrome: the CARDIA study

2006 ◽  
Vol 27 (13) ◽  
pp. 1592-1596 ◽  
Author(s):  
Mohammad Ali Kizilbash ◽  
Mercedes R. Carnethon ◽  
Cheeling Chan ◽  
David R. Jacobs ◽  
Stephen Sidney ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Temporal Relationship ◽  
Heart Rate Recovery ◽  
The Metabolic Syndrome

scholarly journals Association of Epicardial Adipose Tissue Thickness by Echocardiography and Heart Rate Recovery in Metabolic Syndrome

2013 ◽  
Vol 62 (18) ◽  
pp. C159-C160
Author(s):  
Ferit Böyük ◽  
Bülent Özdemir ◽  
Saim Sağ ◽  
Tunay Şentürk ◽  
Aysel Aydın Kaderli ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Heart Rate Recovery ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness

Time- and age-dependent effects of serotonin on gasping and autoresuscitation in neonatal mice

2013 ◽  
Vol 114 (12) ◽  
pp. 1668-1676 ◽  
Author(s):  
Jianping Chen ◽  
Jennifer Magnusson ◽  
Gerard Karsenty ◽  
Kevin J. Cummings
Keyword(s):  
Heart Rate ◽  
Tryptophan Hydroxylase ◽  
Single Injection ◽  
Heart Rate Recovery ◽  
Wild Type ◽  
Tryptophan Hydroxylase 2 ◽  
Age Dependent ◽  
Long Time ◽  
Time Required

The role of brain stem serotonin (5-hydroxytryptamine, 5-HT) in autoresuscitation in neonatal life is unclear. We hypothesized that a specific loss of 5-HT would compromise gasping and autoresuscitation mainly in the second postnatal week and that acute restoration of 5-HT would reverse the defects. We exposed postnatal day (P)4–5, P8–9, and P11–12 tryptophan-hydroxylase-2 knockout ( TPH2−/−) and wild-type littermates (WT) to 10 episodes of anoxia (97% N2, 3% CO2), measuring survival, gasp latency, gasp frequency ( fB), and the time required to restore eupnea and heart rate. We also tested P8–9 TPH2−/− mice after restoring 5-HT with a single injection of 5-hydroxytryptophan (5-HTP) 1–2 h before testing or with multiple injections beginning 24 h before testing. At P4–5 and P8–9, but not at P11–12, gasp latency and the recovery of eupnea were delayed ∼2- to 3-fold in TPH2−/− pups compared with WT ( P < 0.001). At all ages, TPH2−/− pups displayed reduced gasp fB (∼20–30%; P < 0.001) and delayed heart rate recovery (∼60%; P = 0.002) compared with WT littermates. TPH2−/− survival was reduced compared with WT ( P < 0.001), especially at P8–9 and P11–12 ( P = 0.004). Whereas 1–2 h of 5-HTP treatment improved the gasp latency and fB of P8–9 TPH2−/− pups, improved cardiorespiratory recovery and survival required 24 h of treatment. Our data suggest that 5-HT operates over a long time span (∼24 h) to improve survival during episodic severe hypoxia. Early in development (P4–9), 5-HT is critical for both respiratory and cardiovascular components of autoresuscitation; later (P11–12), it is critical mainly for cardiovascular components. Nevertheless, the effect of 5-HT deficiency on survival is most striking from P8 to P12.

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