Are preterm birth and intra-uterine growth restriction more common in Western Australian children of immigrant backgrounds? A population based data linkage study

AbstractThe Western Australian Twin Register (WATR) was established in 1997 to study the health of all child multiples born in Western Australia (WA). The Register has until recently consisted of all multiples born in WA between 1980 and 1997. Using unique record linkage capacities available through the WA data linkage system, we have subsequently been able to identify all multiple births born in WA since 1974. New affiliations with the Australian Twin Registry and the WA Institute for Medical Research are further enabled by the use of the WA Genetic Epidemiology Resource — a high-end bioinformatics infrastructure that allows efficient management of health datasets and facilitates collaborative research capabilities. In addition to this infrastructure, funding provided by these institutions has allowed the extension of the WATR to include a greater number of WA multiples, including those born between 1974 and 1979, and from 1998 onwards. These resources are in the process of being enabled for national and international access.

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Intra-uterine Growth Restriction in Developing Countries: Impact on Child Mental Development and Behavior

Handbook of Growth and Growth Monitoring in Health and Disease ◽

10.1007/978-1-4419-1795-9_9 ◽

2011 ◽

pp. 147-158

Author(s):

Susan P. Walker ◽

Susan M. Chang

Keyword(s):

Developing Countries ◽

Mental Development ◽

Growth Restriction ◽

Uterine Growth ◽

Intra Uterine Growth Restriction ◽

And Behavior

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The Potential of Gene Therapy as a Treatment Strategy for Intra-uterine Growth Restriction

Handbook of Growth and Growth Monitoring in Health and Disease ◽

10.1007/978-1-4419-1795-9_142 ◽

2011 ◽

pp. 2379-2392

Author(s):

Mounira Habli ◽

Timothy M. Crombleholme

Keyword(s):

Gene Therapy ◽

Treatment Strategy ◽

Growth Restriction ◽

Uterine Growth ◽

Intra Uterine Growth Restriction

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Frailty Assessed by Administrative Tools and Mortality in Patients With Pneumonia Admitted to the Hospital and ICU: a Population-based Data-linkage Study

10.21203/rs.3.rs-450880/v1 ◽

2021 ◽

Author(s):

Tamas Szakmany ◽

Joe Hollinghurst ◽

Richard Pugh ◽

Ashley Akbari ◽

Rowena Griffiths ◽

...

Keyword(s):

Data Linkage ◽

Social Deprivation ◽

Frailty Index ◽

Significant Risk ◽

Population Based ◽

Linkage Study ◽

Increased Risk ◽

Comorbidity Index ◽

Population Scale

Abstract Background: The ideal method of identifying frailty is uncertain, and data on long-term outcomes is relatively limited. We examined frailty indices derived from population-scale linked data on Intensive Care Unit (ICU) and hospitalised non-ICU patients with pneumonia to elucidate the influence of frailty on mortality.Methods: Longitudinal cohort study between 2010-2018 using population-scale anonymised data linkage of healthcare records for adults admitted to hospital with pneumonia in Wales. Primary outcome was in-patient mortality. Age, hospital frailty risk score (HFRS), electronic frailty index (eFI), Charlson comorbidity index (CCI), and social deprivation index were entered in the multivariate regression models.Results: Of the 107,188 patients, mean (SD) age was 72.6 (16.6) years, 50% were men. The two frailty indices and the comorbidity index had an increased risk of mortality for individuals with an ICU admission. Advancing age, increased frailty and comorbidity affected short- and long-term mortality. For predicting inpatient deaths, the CCI and HFRS based models were similar, however for longer term outcomes the CCI based model was superior. Discussion: Frailty and comorbidity are significant risk factors for patients admitted to hospital with pneumonia. Frailty and comorbidity scores based on administrative data have only moderate ability to predict outcome.

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