scholarly journals Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Srikanth Barkeer ◽  
Seema Chugh ◽  
Saswati Karmakar ◽  
Garima Kaushik ◽  
Sanchita Rauth ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
The Self ◽  
Self Renewal ◽  
Pancreatic Cancer Stem Cells

Abstract 214: GLI-1 plays a pivotal role in Hedgehog pathway on self-renewal of pancreatic cancer stem cells.

2013 ◽  
Author(s):  
Yumi Miyazaki ◽  
Qiang Ding ◽  
Makoto Yoshimitsu ◽  
Toru Obara ◽  
Koichirou Tsukasa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Hedgehog Pathway ◽  
Pivotal Role ◽  
Self Renewal ◽  
Gli 1 ◽  
Pancreatic Cancer Stem Cells

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

2017 ◽  
Vol 150 ◽  
pp. 310-322 ◽  
Author(s):  
Jessica Brandi ◽  
Ilaria Dando ◽  
Elisa Dalla Pozza ◽  
Giulia Biondani ◽  
Rosalind Jenkins ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Fatty Acid ◽  
Cancer Stem Cells ◽  
Fatty Acid Synthesis ◽  
Proteomic Analysis ◽  
Functional Role ◽  
Acid Synthesis ◽  
Pancreatic Cancer Stem Cells

scholarly journals Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

2012 ◽  
Vol 10 (1) ◽  
pp. 104
Author(s):  
Enza Lonardo ◽  
Patrick C. Hermann ◽  
Maria-Theresa Mueller ◽  
Stephan Huber ◽  
Anamaria Balic ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Drug Therapy ◽  
Cancer Stem Cells ◽  
Self Renewal ◽  
Activin Signaling ◽  
Pancreatic Cancer Stem Cells

scholarly journals Crucial role of HMGA1 in the self-renewal and drug resistance of ovarian cancer stem cells

2016 ◽  
Vol 48 (8) ◽  
pp. e255-e255 ◽  
Author(s):  
Dae Kyoung Kim ◽  
Eun Jin Seo ◽  
Eun J Choi ◽  
Su In Lee ◽  
Yang Woo Kwon ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Drug Resistance ◽  
Cancer Stem Cells ◽  
Crucial Role ◽  
The Self ◽  
Ovarian Cancer Stem Cells ◽  
Self Renewal

scholarly journals The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sabrina Bimonte ◽  
Antonio Barbieri ◽  
Maddalena Leongito ◽  
Giuseppe Palma ◽  
Vitale del Vecchio ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Drug Resistance ◽  
Cancer Stem Cells ◽  
Biological Activities ◽  
Biological Properties ◽  
Ductal Adenocarcinoma ◽  
Small Noncoding Rnas ◽  
Pancreatic Cancer Stem Cells

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

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