scholarly journals Disc hemorrhage following peripapillary retinoschisis in glaucoma: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Won June Lee ◽  
Mincheol Seong
Keyword(s):  
Open Angle Glaucoma ◽  
Ophthalmic Solution ◽  
Fundus Photography ◽  
Fiber Layer ◽  
Disc Hemorrhage ◽  
Swept Source ◽  
Case Presentation ◽  
Future Studies ◽  
The Relationship ◽  
Layer Defect

Abstract Background Disc hemorrhage (DH) is an important factor often associated with the development and especially progression of glaucoma. In contrast, some studies have reported peripapillary retinoschisis in glaucoma, but it is not recognized as a pathognomonic finding, and opinions on the clinical significance of retinoschisis are not consistent. Here,we present the case of DH following peripapillary retinoschisis in the same area within the same glaucomatous eye. Case presentation A 70-year-old man with high intraocular pressure (IOP) was referred to the glaucoma clinic. At the time of the baseline study, the IOP was 30mmHg, and peripapillary retinoschisis was discovered at 7 o’clock on the periphery of the optic nerve with swept-source optical coherence tomography. Accompanying retinal nerve fiber layer defect were manifest in the inferotemporal part with red-free fundus photography. Under the impression of open-angle glaucoma, we prescribe latanoprost ophthalmic solution. Eight months later, the IOP was 17mmHg, and the peripapillary retinoschisis had disappeared. DH was observed in the inferotemporal area in the same direction as that of the previous peripapillary retinoschisis. Conclusions The case presented here are the first to report on the relationship between peripapillary retinoschisis and DH. Hopefully future studies will reveal the actual connection between peripapillary retinoschisis and DH.

scholarly journals Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Christoph Nützi ◽  
Andreas Schötzau ◽  
Matthias C. Grieshaber
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Light Sensitivity ◽  
Fundus Photography ◽  
Retinal Sensitivity ◽  
Open Angle ◽  
Central Visual Field ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Custom Made

Purpose. To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). Methods. Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM−) of ARAM on red-free fundus photography and with the corresponding RNFL by optical coherence tomography (OCT). Results. In the eyes of POAG patients, ARAM+ had overall a significantly lower retinal sensitivity (ARAM+: 7.34 dB, ARAM−: 11.9 dB; p<0.001) and lower RNFL thickness in the inferior peripapillary quadrants compared to ARAM− (RNFL superior: ARAM+ 74.2 μm, ARAM− 77.5 μm; RNFL temporal: ARAM+ 46.8 μm, ARAM− 53.0 μm, p<0.001; and RNFL inferior: ARAM+ 63.2 μm, ARAM− 73.1 μm, p<0.001). Within the same eye, ARAM+ showed a lower retinal sensitivity compared to ARAM− ([ARAM− (11.13 dB)] − [ARAM+ (9.56 dB) = 1.57 dB; p=0.25). The proportion of ARAM+ per eye correlated strongly with reduced retinal light sensitivity (p=0.02), corresponding lower peripapillary RNFL thickness (p=0.02), and lower RNFL temporal quadrant thickness (p<0.01), but not with greater age (p=0.45). Conclusion. ARAM was more frequently identified in the eyes with a lower retinal sensitivity and peripapillary RNFL thickness and may be a clinical sign in the macula for an advanced stage of POAG.

The Associations of Optic Disc Hemorrhage with Retinal Nerve Fiber Layer Defect and Peripapillary Atrophy in Normal-tension Glaucoma

Ophthalmology ◽  
1997 ◽  
Vol 104 (11) ◽  
pp. 1926-1933 ◽  
Author(s):  
Kazuhisa Sugiyama ◽  
Goji Tomita ◽  
Yoshiaki Kitazawa ◽  
Eiji Onda ◽  
Hisashi Shinohara ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Optic Disc ◽  
Retinal Nerve Fiber Layer ◽  
Normal Tension Glaucoma ◽  
Fiber Layer ◽  
Disc Hemorrhage ◽  
Nerve Fiber Layer ◽  
Peripapillary Atrophy ◽  
Layer Defect ◽  
Nerve Fiber Layer Defect

scholarly journals Risk factors associated with progressive nerve fiber layer thinning in open-angle glaucoma with mean intraocular pressure below 15 mmHg

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jihei Sara Lee ◽  
Gong Je Seong ◽  
Chan Yun Kim ◽  
Sang Yeop Lee ◽  
Hyoung Won Bae
Keyword(s):  
Risk Factors ◽  
Intraocular Pressure ◽  
Nerve Fiber ◽  
Open Angle Glaucoma ◽  
Rapid Progression ◽  
Open Angle ◽  
Fiber Layer ◽  
Disc Hemorrhage ◽  
Factors Associated ◽  
Slow Progression

AbstractThe purpose of this study was to identify risk factors associated with progressive retinal nerve fiber layer(RNFL) thinning of open-angle glaucoma(OAG) in patients whose intraocular pressure(IOP) was maintained low with medical treatment. Based on a retrospective review of medical records, OAG patients with ≥60 months of follow-up and mean IOP below 15 mmHg were recruited. All eyes underwent IOP measurement with Goldmann applanation tonometer(GAT), standard automated perimetry(SAP), and cirrus optical coherence tomography(cirrus OCT) at 6 month or 1 year intervals. RNFL thinning was assessed using the Guided Progression Analysis(GPA) software. Forty-one eyes of 41 patients (mean age 54.9 ± 13.5) were followed up for 77.8 ± 7.8 months. GPA detected 20 eyes (48.8%) with progressive RNFL thinning(−1.5 ± 0.5 um/year), who were subsequently classified as the ‘rapid progression group.’ Those whose rate of change in RNFL thickness was slower than −1.00 µm/year was classified as the ‘slow progression group’ (n = 21, −0.0 ± 0.4 um/year, P < 0.001). Mean IOP after initiating therapy was 13.2 ± 1.1 mmHg in the rapid progression group and 13.1 ± 1.3 mmHg in the slow progression group (P = 0.300; 14.8 ± 10.0% vs. 19.6 ± 12.4% reduction, P = 0.155). Disc hemorrhage was found to more frequently occur in the rapid progression group (P = 0.001). Multivariate logistic regression analysis showed that patients with disc hemorrhage were at a higher risk for progressive RNFL thinning in OAG (OR 37.529 95% CI 2.915–483.140) after adjusting for baseline co-variates (P = 0.005). In conclusion, disc hemorrhage is associated with progressive RNFL thinning in OAG with well-maintained IOP. Factors other than IOP appear to also play a role in OAG progression.

scholarly journals Betaxolol Ophthalmic Solution as Alternative Treatment for Patients with Timolol Allergy: A Case Report

Reports ◽  
2020 ◽  
Vol 3 (3) ◽  
pp. 21
Author(s):  
Olivia Müllertz ◽  
Jette Jacobsen ◽  
Jacob P. Thyssen ◽  
Anna Horwitz ◽  
Miriam Kolko
Keyword(s):  
Allergic Reaction ◽  
Alternative Treatment ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ophthalmic Solution ◽  
Blocking Agent ◽  
Case Presentation ◽  
Atopic Patient ◽  
Β Blocker ◽  
Β Blockers

Background: To establish if an allergy towards all β-blockers, as a group, should be assumed, if an allergic reaction is observed while using one specific β-blocking agent. Case presentation: The non-selective β-blocker timolol caused a severe allergic ocular reaction in a non-atopic patient with advanced primary open-angle glaucoma. Results: A patch test confirmed timolol allergy. No allergic reaction to other anti-glaucomatous topical drugs was observed, and treatment with the selective β-blocker betaxolol was successfully initiated. Conclusion: Allergy to the non-selective β-blocker timolol does not necessarily predict allergy to the selective β-blocker betaxolol, and betaxolol should therefore not be excluded as an alternative treatment.

scholarly journals Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185573 ◽  
Author(s):  
Naoki Miura ◽  
Kazuko Omodaka ◽  
Koudai Kimura ◽  
Akiko Matsumoto ◽  
Tsutomu Kikawa ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Wide Field ◽  
Fiber Layer ◽  
Swept Source ◽  
Inner Limiting Membrane ◽  
En Face ◽  
Swept Source Oct ◽  
Layer Defect ◽  
Nerve Fiber Layer Defect
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