scholarly journals Attributions of survival and methods of coping of long-term ovarian cancer survivors: a qualitative study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dana Ketcher ◽  
Susan K. Lutgendorf ◽  
Susan Leighton ◽  
Marianne Matzo ◽  
Jeanne Carter ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Survivors ◽  
Coping Strategies ◽  
Cancer Patients ◽  
Qualitative Interviews ◽  
Personal Characteristics ◽  
Term Survival ◽  
Targeted Interventions ◽  
Long Term Survivors

Abstract Background Only 8–23% of advanced epithelial ovarian cancer patients survive for 10 years or longer. Given the need for targeted interventions to improve survival, we interviewed this relatively rare survivor population to gain personalized insights into the reasons for their survival. The aim of this study was to characterize subjective attributions of survival and specific coping mechanisms long-term survivors of ovarian cancer. Methods Twenty-two semi-structured, qualitative interviews assessing survival attributions and coping strategies were conducted from April to November 2014. Data were analyzed in a multistep process using ATLAS.ti.8: codes were identified during review of the transcripts and refined with literature review; the frequency of codes and code co-occurrence was calculated, and codes were grouped into themes. Resulting themes were checked by a national leader of an ovarian cancer advocacy organization and compared against available literature. Results Thematic analysis found that participants credited their long-term survival to a variety of factors including medical, social, religious/spiritual, and lifestyle/personal characteristics. Some participants rejected these same attributions, concluding that the reason for survival was due to luck or unknowable. Several of Carver et al.’s theoretical dimensions of coping were evident in our sample: planning, positive reinterpretation, social support, religion and acceptance whereas three relatively new strategies were uncovered: conserving emotional energy, value-based activity coping, and self-care. Conclusions Long-term survivors’ perspectives were largely consistent with those of newly diagnosed ovarian cancer patients and ovarian cancer survivors of shorter duration. However, the long-term survivors were also willing to reject conventional attributions for survival and recognized the importance of disciplined self-preservational coping strategies.

Does neoadjuvant chemotherapy impair long-term survival for ovarian cancer patients? A nationwide Danish study

2014 ◽  
Vol 132 (2) ◽  
pp. 292-298 ◽  
Author(s):  
Carsten Lindberg Fagö-Olsen ◽  
Bent Ottesen ◽  
Henrik Kehlet ◽  
Sofie L. Antonsen ◽  
Ib J. Christensen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Term Survival ◽  
Long Term Survival ◽  
Danish Study

“I am not a statistic” ovarian cancer survivors’ views of factors that influenced their long-term survival

2019 ◽  
Vol 155 (3) ◽  
pp. 461-467 ◽  
Author(s):  
Aliya Alimujiang ◽  
Lilah Khoja ◽  
Ashley Wiensch ◽  
Malcolm C. Pike ◽  
Penelope M. Webb ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Survivors ◽  
Term Survival ◽  
Long Term Survival

Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis

2021 ◽  
pp. ijgc-2020-002023
Author(s):  
Joanna Baum ◽  
Elena Ioana Braicu ◽  
Oliver Hunsicker ◽  
Ignace Vergote ◽  
Nicole Concin ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Control Group ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Term Survival ◽  
Long Term Survival ◽  
Tumor Involvement ◽  
Upper Abdomen ◽  
Long Term Survivors

IntroductionLong-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian cancer.MethodsLong-term survivors were defined as patients living longer than 8 years after first diagnosis and were recruited within seven high volume centers across Europe from November 1988 to November 2008. The control group included patients with high-grade serous ovarian cancer with less than 5 years' survival identified from the systematic ‘Tumorbank ovarian cancer’ database. A subanalysis of Charité patients only was performed separately for in-depth analysis of tumor dissemination. Propensity score matching with nearest-neighbor caliper width was used to match long-term survivors and the control group regarding age, FIGO stage, and residual tumor.ResultsA total of 276 patients with high-grade serous ovarian cancer were included, divided into 131 long-term survivors and 145 control group patients. After propensity score matching and multivariable adjustment, platinum sensitivity (p=0.002) was an independent favorable prognostic factor whereas recurrence (p<0.001) and ascites (p=0.021) were independent detrimental predictors for long-term survival. Significantly more long-term survivors tested positive for mutation in the BRCA1 gene than the BRCA2 gene (p=0.016). Intraoperatively, these patients had less tumor involvement of the upper abdomen at initial surgery (p=0.024). Complexity of surgery and surgical techniques were similar in both cohorts.ConclusionPlatinum sensitivity constitutes a favorable factor for long-term survival whereas tumor involvement of the upper abdomen, ascites, and recurrence have a negative impact. Based on clinical estimation, long-term survival is associated with combinations of clinical, surgical, and molecular factors.

scholarly journals Report on Three Cases of Advance Ovarian Cancer Upon Bangladeshi Population: Successful Management with Bevacizumab Based Chemotherapy

2017 ◽  
Vol 8 (2) ◽  
pp. 157-161
Author(s):  
Md Ehteshamul Hoque ◽  
Shanaz Karim ◽  
Md Mahmudur Rahman Siddiqui ◽  
Tanvir Ahmed
Keyword(s):  
Ovarian Cancer ◽  
Successful Management ◽  
Short Term ◽  
Term Survival ◽  
Medical College ◽  
Bangladeshi Population ◽  
Long Term Survivors ◽  
Annual Mortality ◽  
Short Term Survival

Ovarian cancer is an alarming health problem in Bangladesh. The annual mortality rate per 100,000 people from ovarian cancer in Bangladesh has increased by 40.3% since 1990, an average of 1.8% a year. Globcan predicts a change in the reported incidence of ovarian cancer from 2912 in year 2012 to 3132 in 2015. Recurrent high-grade ovarian cancer is usually associated with short term survival. There are few guidelines to surgically and medically treat long term survivors with ovarian cancer. We are reporting three cases on advance ovarian cancer patients; all are married, age ranging from 40-60 years, primarily treated with chemotherapy. After that, they were experienced with FDA approved (Nov 14, 2014) monoclonal antibody Bevacizumab (AVASTIN), additionally with chemotherapy.Anwer Khan Modern Medical College Journal Vol. 8, No. 2: Jul 2017, P 157-161

Secondary malignancies in long-term ovarian cancer survivors: results of the ‘Carolin meets HANNA’ study

2021 ◽  
pp. ijgc-2020-002155
Author(s):  
Hannah Woopen ◽  
Carolin Rolf ◽  
Elena Ioana Braicu ◽  
Nina Buttmann-Schweiger ◽  
Benjamin Barnes ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Cancer Survival ◽  
Secondary Malignancy ◽  
Secondary Cancer ◽  
Secondary Malignancies ◽  
Primary Ovarian Cancer ◽  
Long Term Survivors

ObjectiveTo evaluate the rate of secondary malignancies in long-term survivors with ovarian cancer.MethodsLong-term survivors with ovarian cancer (survival ≥8 years after initial diagnosis) with multiple malignancies were identified within the Tumorbank Ovarian Cancer and our study ‘Carolin meets HANNA – Holistic Analyses of Long-term Survivors with Ovarian Cancer’.ResultsOf a total of 225 long-term survivors with ovarian cancer, 36 patients (16%) had at least one more cancer diagnosis before, concomitant with, or after, ovarian cancer. Median age was 52.5 years (range 37–79). A total of 60% were diagnosed with stage III/IV and most tumors were high-grade (88.6%), as well as of serous histology (63.9%). Median overall survival was 10 years (range 8–19). Secondary cancer after ovarian cancer was found in 17 long-term survivors (7.6%). Breast cancer was the most frequent secondary malignancy. Median duration between diagnosis of primary ovarian cancer and secondary cancer diagnosis was 78.5 months (range 12–220). BRCA was tested in 11 patients with seven patients being BRCA1 and one patient BRCA2 positive. Secondary cancers were detected by screening in 35.3% and self-detected in 29.4% of patients (breast self-examination).ConclusionA secondary malignancy was diagnosed in 7.6% of long-term survivors. Routine follow-up and cancer screening should be performed in long-term ovarian cancer survivors.

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