scholarly journals Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Haidara Kherbek ◽  
Jana Skef ◽  
Nadim Zahlouk ◽  
Rafik Abdulal ◽  
...  
Keyword(s):  
Case Report ◽  
Triple Negative ◽  
Molecular Subtype ◽  
Excisional Biopsy ◽  
Molecular Characteristics ◽  
Breast Cancers ◽  
Apocrine Carcinoma ◽  
Palpable Mass ◽  
First Case ◽  
Eosinophilic Cytoplasm

Abstract Background Apocrine carcinoma is a rare tumor that constitutes < 4% of all breast malignancies, characterized by the proliferation of large atypical cells with strictly defined borders, abundant eosinophilic cytoplasm, large nuclei, and prominent nucleoli in more than 90% of tumor cells. Triple-negative apocrine carcinoma is a rare molecular subtype that constitutes less than 1% of triple-negative breast cancers and is characterized by negative expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor, with positive expression of androgen receptor. Case presentation We report a case of a 45-year-old Syrian female who presented to our hospital due to a painless palpable mass in her left breast. Following physical and radiological examinations, an excisional biopsy was performed. Microscopic examination of the specimen followed by immunohistochemical staining revealed the diagnosis of a triple-negative apocrine carcinoma. Conclusion Triple-negative apocrine carcinoma is an extremely rare neoplasm that must be considered in the differential diagnoses of breast lesions through detailed clinical, histological, and immunohistochemical correlations. In our manuscript, we aimed to present the first case report of a Syrian female who was diagnosed with a triple-negative apocrine carcinoma, aiming to highlight the importance of detailed clinical, histological and immunohistochemical correlations with a detailed review of diagnostic criteria, molecular characteristics, and treatment recommendations.

scholarly journals Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

2020 ◽  
Vol 2020 (11) ◽  
Author(s):  
Breanne Gillie ◽  
Michael Kmeid ◽  
Armand Asarian ◽  
Philip Xiao
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Triple Negative ◽  
Treatment Guideline ◽  
Excisional Biopsy ◽  
Breast Cancers ◽  
Palpable Mass ◽  
Adenoid Cystic ◽  
Screening Mammograms ◽  
Low Incidence ◽  
Rare Malignancy

Abstract Adenoid cystic carcinoma (ACC) of the breast is a rare malignancy, accounting for 0.1–1% of breast cancers. Histologically breast ACC is similar to ACC’s found in salivary tissue and is a triple-negative breast cancer with an uncharacteristically favorable prognosis and low incidence of metastasis. Most cases present as a painful, palpable mass; however, asymptomatic cases found on screening mammograms have also been noted. Core needle biopsy or excisional biopsy is necessary for definitive diagnosis of breast ACC. Immunohistochemistry of these cancers can differentiate breast ACC from masses with similar histology, such as invasive cribriform carcinoma and collagenous spherulosis. There is no well-established treatment guideline for ACC; however, it has been noted that reoccurrence and metastasis are noted more in cases of local resection than mastectomy.

Three-Millimeter Apocrine Adenoma in a Man: A Case Report and Review of the Literature

2003 ◽  
Vol 127 (11) ◽  
pp. 1498-1500
Author(s):  
Melissa A. Pasquale-Styles ◽  
Clara Milikowski
Keyword(s):  
Case Report ◽  
Microscopic Examination ◽  
Rare Case ◽  
Excisional Biopsy ◽  
Left Breast ◽  
Review Of The Literature ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
Hypoechoic Nodule

Abstract We describe a rare case of apocrine adenoma of the breast in a 45-year-old man. The patient presented with a tender lump in his left breast that had been present for 6 months. A mammogram identified a 3-mm nodular density in the breast, which was described as a hypoechoic nodule on ultrasound. Microscopic examination of tissue from an excisional biopsy revealed a 3-mm group of benign glands with abundant granular, eosinophilic cytoplasm and apical luminal blebbing, consistent with an apocrine adenoma. After reviewing other reported apocrine adenomas in the literature, we determined that our case was the smallest detected apocrine adenoma to be reported to date.

scholarly journals TRIPLE NEGATIVE APOCRINE CARCINOMA OF BREAST: A CASE REPORT

2016 ◽  
Vol 5 (68) ◽  
pp. 4937-4938
Author(s):  
Devadhason Darwin Britto ◽  
Arun Prasanth ◽  
Alankrith Ramesh Kashyap ◽  
Floret Soundrapandian ◽  
Vidya Thiagu
Keyword(s):  
Case Report ◽  
Triple Negative ◽  
Apocrine Carcinoma

Triple‐negative apocrine carcinoma: A rare pathologic subtype with a better prognosis than other triple‐negative breast cancers

2020 ◽  
Vol 122 (6) ◽  
pp. 1232-1239
Author(s):  
Cletus A. Arciero ◽  
Albert H. Diehl ◽  
Yuan Liu ◽  
Qin Sun ◽  
Theresa Gillespie ◽  
...  
Keyword(s):  
Triple Negative ◽  
Breast Cancers ◽  
Apocrine Carcinoma

scholarly journals Conspicuity and imaging features of breast cancers on digital breast tomosynthesis according to molecular profile

2021 ◽  
Author(s):  
Léa Manse ◽  
Martine Boisserie-Lacroix ◽  
Véronique Brouste ◽  
Marie-Pierre Depetiteville ◽  
Benoît Mesurolle ◽  
...  
Keyword(s):  
Molecular Subtype ◽  
Digital Breast Tomosynthesis ◽  
Wilcoxon Test ◽  
Molecular Profile ◽  
Molecular Characteristics ◽  
Imaging Features ◽  
Breast Cancers ◽  
Breast Tomosynthesis ◽  
Exact Test ◽  
Institutional Review

Abstract Objective To describe BI-RADS features and evaluate conspicuity of breast cancer on digital breast tomosynthesis (DBT) according to their molecular profile. Materials and method Institutional review board was obtained for this retrospective study. Consecutive patients with histologically proven breast cancers who underwent digital breast tomosynthesis (DBT) with 2D synthetic mammography (SM) and digital mammography (DM) at the time of diagnosis were included. Morphological features and conspicuity of cancers on DM, SM and DBT were evaluated in consensus by two breast radiologists. Imaging features were compared across molecular subtypes (luminal, triple negative (TN) and HER2+) using Fisher’s exact test and between DBT and SM and DM using McNemar’s test. Conspicuity was compared between DBT and SM and DM using Wilcoxon matched pairs test and between each molecular subtype using the Wilcoxon test. Results One hundred and eleven consecutive patients were included. On DBT, TN cancers more frequently presented as masses with microlobulated margins (P = 0.04) while HER2 + cancers were more often associated with microcalcifications (P = 0.02). Greater conspicuity on DBT in comparison to DM was observed for cancers with low Ki67 (P = .015), less aggressive tumours (P = .005), positive ER (P = 0.005), positive PR (P = .005) or negative HER2 (P = .024), and for luminal molecular profiles (P = 0.012) while no difference was observed between the two techniques for TN (P = .73) and HER+ (P = .79) tumours. Conclusion DBT reveals specific features of breast cancers according to their molecular characteristics. In comparison with DM, DBT improves conspicuity of luminal subtype cancers and tumours demonstrating less aggressive features on pathology.

scholarly journals Immune-related biomarkers in triple-negative breast cancer

Breast Cancer ◽  
2021 ◽  
Author(s):  
Juan Zhang ◽  
Qi Tian ◽  
Mi Zhang ◽  
Hui Wang ◽  
Lei Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Combined Treatment ◽  
Tumor Infiltrating Lymphocytes ◽  
Molecular Characteristics ◽  
Immune Gene ◽  
Breast Cancers ◽  
Related Factors ◽  
Molecular Features

AbstractBreast cancer is a commonly diagnosed female cancer in the world. Triple-negative breast cancer (TNBC) is the most dangerous and biologically aggressive subtype in breast cancer which has a high mortality, high rates of relapse and poor prognosis, representing approximately 15–20% of breast cancers. TNBC has unique and special biological molecular characteristics and higher immunogenicity than other breast cancer types. On the basis of molecular features, TNBC is divided into different subtypes and gets various treatments. Especially, immunotherapy becomes a promising and effective treatment to TNBC. However, not all of the TNBC patients are sensitive to immunotherapy, the need of selecting the patients suitable for immunotherapy is imperative. In this review, we discussed recent discoveries about the immune-related factors of TNBC, including tumor-infiltrating lymphocytes (TILs), programmed death-ligand protein-1 (PD-L1), immune gene signatures, some other emerging biomarkers for immunotherapy effectivity and promising biomarkers for immunotherapy resistance. In addition, we summarized the features of these biomarkers contributing to predict the prognosis and effect of immunotherapy. We hope we can provide some helps or evidences to clinical immunotherapy and combined treatment for TNBC patients.

scholarly journals Case Report: A New Tool for Anterior Chest Wall Reconstruction After Sternal Resection for Primary Or Secondary Tumors

2021 ◽  
Vol 8 ◽  
Author(s):  
Duilio Divisi ◽  
Davide Tosi ◽  
Gino Zaccagna ◽  
Andrea De Vico ◽  
Cristina Diotti ◽  
...  
Keyword(s):  
Case Report ◽  
Chest Wall ◽  
Ewing's Sarcoma ◽  
Anterior Chest Wall ◽  
Chest Wall Reconstruction ◽  
Titanium Mesh ◽  
Palpable Mass ◽  
Secondary Tumors ◽  
Innovative Method ◽  
First Case

Sternal resection and anterior chest wall reconstruction techniques for malignant processes are not always standardized. We report an innovative method of sternal osteosynthesis in two patients, 65-year-old and 41-year-old women, with Ewing's sarcoma, and infiltrating thymoma, respectively. The first case manifested itself as a voluminous palpable mass while the second case was characterized for a paramediastinal mass widely extended to the anterior chest wall. Reconstruction with titanium mesh allowed the quick restoration of parietal stability, facilitating respiratory dynamic and recovery of patients.

scholarly journals Familial leiomyoma: a case report

2021 ◽  
Vol 7 (2) ◽  
pp. 300
Author(s):  
Swetha Gutha ◽  
Shalini Sampath
Keyword(s):  
Case Report ◽  
Carbon Dioxide Laser ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Benign Tumors ◽  
Management Options ◽  
Eosinophilic Cytoplasm ◽  
Similar Disease ◽  
Cutaneous Leiomyomas

<p class="abstract">Cutaneous leiomyomas are benign tumors that can be exquisitely painful. Comprise three distinct types such as piloleimyoma, angioleiomyoma, and genital leiomyoma. Piloleiomyomas, derived from arrector pili muscle, are solitary or multiple firm papulonodules located mostly on the extremities and trunk; genital leiomyomas, derived from dartoic, vulvar, or mammary smooth muscle, are solitary or papulonodules located on the scrotum, vulva, or nipple; and angioleiomyomas, include solid, cavernous, or venous subtypes, are derived from the tunica media of small arteries and veins and typically present on the extremities. Excisional biopsy is required for diagnosing all cutaneous leiomyomas Histology shows interlacing fibers of spindle cells with moderate amounts of eosinophilic cytoplasm and a blunt-ended, elongated nucleus with perinuclear halos. Surgical excision is curative for cutaneous leiomyomas, with other management options including medical or destructive therapy. A 36-year-old male patient presented with a 13 years history of painful, multiple lesions over the back. Based on the histopathological examination, imaging, and past medical records, a diagnosis of familial leiomyoma was made. His brother had similar disease. The patient was started on tab gabapentin 300mg at night. Patient advised for carbon dioxide laser excision. The present case report has been reported for its interesting clinical presentations and rarity.</p>

Extramedullary Hematopoiesis Presenting as Bilateral Glomus Tympanicum—First Case Report in a Pediatric Patient and With Bilateral Presentation

2017 ◽  
Vol 21 (3) ◽  
pp. 332-334
Author(s):  
Leonard N Chen ◽  
Alexandra Espinel ◽  
Brian Reilly ◽  
Dragos C Luca
Keyword(s):  
Case Report ◽  
Pediatric Patient ◽  
Excisional Biopsy ◽  
Extramedullary Hematopoiesis ◽  
African American Female ◽  
Resonance Imaging ◽  
Bilateral Presentation ◽  
First Case ◽  
Familial Form ◽  
Glomus Tympanicum

To the best of our knowledge, this is the first case report of middle ear extramedullary hematopoiesis (EMH) in a pediatric patient as well as the first bilateral presentation reported in both children and adults. We report a 13-year-old African-American female with sickle cell disease who developed bilateral hearing loss, with magnetic resonance imaging findings consistent with bilateral glomus tympanicum (GT). Upon excisional biopsy, however, EMH was diagnosed histologically. Besides its novelty, this case highlights the importance of considering EMH in the differential diagnosis of GT including cases with bilateral presentation that may be otherwise highly suggestive of the familial form of GT.

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