scholarly journals A prospective observational study of drug therapy problems in medical ward of a referral hospital in northeast Ethiopia

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Yaschilal Muche Belayneh ◽  
Gedefaye Amberbir ◽  
Asrat Agalu
Keyword(s):  
Drug Therapy ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Medical Ward ◽  
Referral Hospital ◽  
Northeast Ethiopia ◽  
Drug Therapy Problems

scholarly journals A Prospective Observational Study of Drug Therapy Problems in Pediatric Ward of a Referral Hospital, Northeastern Ethiopia

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Gizachew Kassahun Bizuneh ◽  
Betelhem Anteneh Adamu ◽  
Getenet Tadege Bizuayehu ◽  
Solomon Debebe Adane
Keyword(s):  
Risk Factors ◽  
Drug Therapy ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Dose Calculation ◽  
Referral Hospital ◽  
Pediatric Ward ◽  
Drug Therapy Problem ◽  
Drug Therapy Problems ◽  
Dessie Referral Hospital

Background. A drug therapy problem is any undesirable event experienced by a patient during drug therapy that interferes with achieving the desired goals of therapy. It has been pointed out that hospitalized pediatric patients are particularly prone to drug-related problems. Identifying drug therapy problems enables risk quantification and determination of the potential impact of prevention strategies. The purpose of this study was to assess the drug therapy problems in a pediatric ward of Dessie Referral Hospital, northeast of Ethiopia, and to identify associated factors for drug therapy problems. Methods. A prospective observational study design was carried out to assess drug therapy problems in a pediatric ward of Dessie Referral Hospital from February 1, 2018, to May 30, 2018. Ethical approval was obtained, and informed consent was signed by each study participant’s parent before the commencement of the study. All patients admitted to the ward during the study period were included in the study. Data was collected by trained pharmacy staffs through medical record reviews of patients using a prepared standard checklist and semistructured questionnaire. The collected data were cleared and checked every day for completeness and consistency before processing. Data were entered, and descriptive statistical analysis was done using SPSS Version 20 Software. A P value of less than 0.05 was considered significant. Results. The participants’ mean age was 2.32 years with the standard deviation (SD) of 0.76 years. Among 81 patients, 71 (87.7%) of them had at least one drug therapy problem per patient which indicates that the prevalence of the drug therapy problem was substantially high. Needs additional drug was the most predominantly encountered drug therapy problem accounted (30 (25.2%)). On the other hand, ineffective drug was the least (3 (2.5%)) drug therapy problem. Antibiotics (47 (39.5%)) followed by fluid and electrolyte (25 (21%)) were classes of drugs mostly involved in the drug therapy problem. The main risk factors reported to the occurrence of the drug therapy problems were prescribing and dose calculation errors. Conclusion. The present study revealed that majority of the patients had at least one DTP per patient; this indicates that prevalence of DTP was very high in the study area. Needs additional drug therapy followed by noncompliance was the major cause of the occurrence of DTP. Antibiotics were the main class of drugs involved in the drug therapy problem, and among the risk factors assessed, prescribing and dose calculation errors showed statistical significance.

scholarly journals Drug-related problems among patients with infectious disease admitted to medical wards of Wollega University Referral Hospital: Prospective observational study

2021 ◽  
Vol 9 ◽  
pp. 205031212198962
Author(s):  
Firomsa Bekele ◽  
Ginenus Fekadu ◽  
Kumera Bekele ◽  
Dinka Dugassa ◽  
Jiregna Sori
Keyword(s):  
Infectious Disease ◽  
Drug Therapy ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Referral Hospital ◽  
Clinical Pharmacy Service ◽  
Drug Related Problems ◽  
Disease Etiology ◽  
Co Morbidity ◽  
Medical Wards

Introduction: Drug-related problems can affect the treatment outcomes of hospitalized patients and outpatients that lead to morbidity and mortality. Despite this, there were scanty of studies among patients with infectious diseases in Ethiopia. As the result, this study was tried to assess the magnitude and determinants of drug therapy problems among infectious disease patients admitted to the medical wards of Wollega University Referral Hospital. Methods: A prospective observational study was conducted from May to August 2019. The prevalence and types of drug- related therapy problems were studied using the Pharmaceutical Care Network Europe Foundation classification system, and adverse drug reaction was assessed by using the Naranjo algorithm. Multivariable logistic regression analysis was used to determine the predictors of drug-related problems, and a significant association was declared if p-value < 0.05. Result: Of the 172 study participants, 106 (61.6%) were males, and the patient’s mean age was 39.1 ± 14.31 years. Over the study period, 123 (71.51%) patients had drug-related problems. Need for additional drug therapy was the widely occurred drug-related problem that accounts for 107 (22.77%), and the most common drug-associated with the drug therapy problem was ceftriaxone (77 (44.77%)). This inappropriate use of ceftriaxone might be due to the preference of physicians to prescribe this broad spectrum antibiotic in which it was prescribed for the majority of the infectious disease etiology. Polypharmacy (adjusted odds ratio (AOR) = 2.505, 95% confidence interval (CI): 1.863–11.131), length of hospital stay ⩾ 7 days (AOR = 4.396, 95% CI: 1.964–7.310), and presence of co-morbidity (AOR = 2.107, 95% CI: 1.185–4.158, p = 0.016) were determinants of drug-related problems. Conclusion: The magnitude of drug-related problems was found to be high. Hence, the clinical pharmacy service should be established to tackle inappropriate indications, ineffective drug therapy, and adverse drug events in the study area.

scholarly journals Magnitude and Determinants of Non Communicable Disease and Its Contributing Factors in Medical Ward of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Observational Study

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
Gudisa Bereda ◽  
◽  
Gemechis Bereda ◽  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Communicable Disease ◽  
Communicable Diseases ◽  
Medical Ward ◽  
Referral Hospital ◽  
Noncommunicable Disease ◽  
Contributing Factors ◽  
Non Communicable Diseases ◽  
Non Communicable Disease

Background: Non-communicable diseases are defined as diseases or conditions, which affect individuals over an extended period of time (years, decades or even an entire lifetime) and for which there are no known causative agents that are transmitted from one affected individual to another. Noncommunicable diseases are a major global problem. Objective: To find out magnitude and determinants of non-communicable disease and its contributing factors in medical ward of Mettu Karl Referral Hospital. Methods: A prospective observational study design was conducted from April 23/2021 to June 24/2021. Data was collected through employing structured questioner, and then the collected data was coded and analyzed by statistical packages for social sciences 25.0-version statistical software. A test of association was done using binary and multiple logistic regressions. P value <0.05 was considered significant. Findings: The overall prevalence of non-communicable disease in medical ward was 288 (68.2%).Hypertension was the commonest type of noncommunicable disease 41.71% followed by diabetes mellitus 41.5%. Regarding body mass index majority 153 (36.3%) of patients were normal (18.5-24.9 kg/m²) and least 57 (13.5%) of the patients were underweight (<18.5kg/m²). Age, every khat chewers, every alcohol drinkers, BMI ≥thirty kg/m², biochemical risk factors (obesity, high blood pressure, high fasting blood sugar, low density lipoprotein, and comorbidity were significantly predictors of non-communicable diseases). Conclusion and Recommendation: Majority of patients had physical activity ten minutes per day, had sedentary lifestyle ten to thirty hours per week, were walking ten to thirty hours/per week, and above half of patients were use salt always/usually. Health care workers should have teach the patients how to prevent non-communicable diseases.

scholarly journals Drug-related problems and its determinant among hospitalized neonates with sepsis at Jimma University Medical Center, Ethiopia: a prospective observational study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mengist Awoke ◽  
Tsegaye Melaku ◽  
Mohammed Beshir
Keyword(s):  
Drug Therapy ◽  
Observational Study ◽  
Neonatal Intensive Care ◽  
Prospective Observational Study ◽  
Medical Center ◽  
Clinical Pharmacy Service ◽  
Drug Related Problems ◽  
Combined Use ◽  
Jimma University ◽  
Neonatal Population

Abstract Background Neonatal populations are quite susceptible to drug-related problems (DRPs) because of clinical heterogeneity and clinical practice trends. However, studies reporting DRPs in the neonatal population are quite limited. Objective This study aimed to assess the magnitude and types of DRPs and determinant factors among neonates admitted with neonatal sepsis at the Neonatal Intensive Care Unit (NICU) of the Jimma University Medical Center (JUMC), Ethiopia. Methods A hospital-based prospective observational study was conducted involving 201 neonates with sepsis admitted to the NICU from May to August 30, 2018. DRPs were classified using Cipolle’s classification method. Statistical Package for Social Science Version 22 was employed for data analysis. Logistical regression was carried out to determine the determinants of DRPs. A p-value < 0.05 was considered to be statistically significant. Results Of 201 neonates with sepsis included in this study, 125 (62.2%) were males and the median age of the neonate was 5 days. The mean (±standard deviation) number of medications taking during their hospital stay was 2.6 ± 0.7. DRPs were identified in 98 neonates, at a rate of 48.8% (95% CI, 41.7–55.9). Dose too high (42, 35.8%) and need additional drug therapy (40, 34.1%) were the commonly identified DRPs. Taking antibiotics plus other medications (Adjusted Odds Ratio (AOR) =5.2, 95%CI [1.2–22.0], p = 0.02) was a determinant factor for the occurrence of DRPs. Conclusion The burdens of DRPs occurrence were high in hospitalized neonates with sepsis. The most common DRPs identified were dose too high and need additional drug therapy. Combined use of other medicines with antibiotics was a predictor of DRP occurrence. The innovative way to tackle the occurrence of DRPs, such as the incorporation of clinical pharmacy service provider into the neonatal care team, which will prevent, detect and/or minimize the occurrence of DRPs, is highly recommended.

scholarly journals Perioperative Risk Factors for Intraoperative Hypothermia in Adult Patients Undergoing Elective Surgery at a National Referral Hospital in Bhutan: A Prospective Observational Study

2019 ◽  
Author(s):  
Kinley Zangmo ◽  
Sunisa Chatmongkolchart ◽  
Pasuree Sangsupawanich
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Elective Surgery ◽  
Perioperative Risk ◽  
Referral Hospital ◽  
Adult Patients ◽  
Intraoperative Hypothermia ◽  
National Referral Hospital

Objective: Intraoperative hypothermia is commonly encountered in anesthetic practice. It is related to several risk factors and can lead to various adverse events. It is important to detect it early and prevent the complications related to it. This study was done to identify incidence and perioperative risk factors of intraoperative hypothermia at a national referral hospital in Bhutan.Material and Methods: A prospective observational study was conducted in adult patients who underwent elective surgery lasting more than 30 minutes. Patient characteristics, incidence of hypothermia, and any interventions for treatment of hypothermia during the operation were recorded. Intraoperative hypothermia was defined as a core body temperature less than 36 °C measured with an esophageal probe.Results: Data were obtained from 91 patients with a mean (±standard deviation; S.D.) age of 42.3 (17.2) and American Society of Anesthesiologists (ASA) scores of 1 and 2 in 62.6% and 37.4% of the patients, respectively The patients underwent elective surgery with a mean (S.D.) duration of 73.24 (48.1) minutes and a mean (S.D.) duration of anaesthesia of 80.9 (49.2) minutes. The incidence of intraoperative hypothermia was 61.5% (56/91). Preoperative heart rate more than 80 beats per minute [hazard ratio (HR) 0.45, 95% confidence interval (CI), 0.26-0.77] was a protective factor and duration of anesthesia more than 60 minutes (HR 1.82, 95% CI, 0.98–3.38) was a risk factor for intraoperative hypothermia.Conclusion: Patients with a preoperative heart rate less than 80 beats per minute and undergoing duration of anesthesia more than 60 minutes should be assessed from the preoperative period and continuously monitored throughout the intraoperative period.

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