Effect of single follow-up home visit on readmission in a group of frail elderly patients – a Danish randomized clinical trial

Abstract Background Unplanned hospital admissions are costly and prevention of these has been a focus for research for decades. With this study we aimed to determine whether discharge planning including a single follow-up home visit reduces readmission rate. The intervention is not representing a new method but contributes to the evidence concerning intensity of the intervention in this patient group. Methods This study was a centrally randomized single-center controlled trial comparing intervention to usual care with investigator-blinded outcome assessment. Patients above the age of 65 were discharged from a single Danish hospital during 2013–2014 serving a rural and low socioeconomic area. For intervention patients study and department nurses reviewed discharge planning the day before discharge. On the day of discharge, study nurses accompanied the patient to their home, where they met with the municipal nurse. Together with the patient they reviewed cognitive skills, medicine, nutrition, mobility, functional status, and future appointments in the health care sector and intervened if appropriate. Readmission at any hospital in Denmark within 8, 30, and 180 days after discharge is reported. Secondary outcomes were time to first readmission, number of readmissions, length of stay, and readmission with Ambulatory Care Sensitive Conditions, visits to general practitioners, municipal services, and mortality. Results One thousand forty-nine patients aged > 65 years discharged from medical, geriatric, emergency, surgical or orthopedic departments met inclusion criteria characteristic of frailty, e.g. low functional status, need of more personal help and multiple medications. Among 945 eligible patients, 544 were randomized. Seven patients died before discharge. 56% in the intervention group and 54% in the control group were readmitted (p = 0.71) and 23% from the intervention group and 22% from the control group died within 180 days. There were no significant differences between intervention and control groups concerning other secondary outcomes. Conclusions There was no effect of a single follow-up home visit on readmission in a group of frail elderly patients discharged from hospital. Trial registration https://clinicaltrials.gov (identifier NCT02318680), retrospectively registered December 11, 2014.

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The impact of medication reviews conducted in primary care on hospital admissions and mortality - a randomized controlled trial

10.21203/rs.2.11674/v1 ◽

2019 ◽

Author(s):

Veronica Milos Nymberg ◽

Cecilia Lenander ◽

Beata Borgström Bolmsjö

Keyword(s):

Primary Care ◽

Elderly Patients ◽

Usual Care ◽

Frail Elderly ◽

Hospital Admissions ◽

Intervention Group ◽

Control Group ◽

Randomized Controlled ◽

Medication Reviews ◽

The Impact

Abstract Background Drug-related problems among the elderly population are common and increasing. Multi-professional medication reviews (MR) have arisen as a method to optimize drug therapy for frail elderly patients. Research has not yet been able to show conclusive evidence of the effect of MRs on mortality or hospital admissions. Aim The aim of this study was to assess the impact of MRs’ on hospital admissions and mortality after six and 12 months in a frail population of 369 patients in primary care in a randomized controlled study. Methods Patients were blindly randomized to an intervention group (receiving MRs) and a control group (receiving usual care). Descriptive data on mortality and hospital admissions at six and 12 months were collected. Survival analysis was performed for time to death and time to the first hospital admission within 12 months. Results Of the total number of 369 included patients, 182 were randomized to the intervention group and 187 to the control group. Most of the patients (75%) were females and lived in nursing homes. At six months, 50 patients of the baseline population (27%) in the control group had been admitted to hospital at least once, compared to 40 patients (21%) in the intervention group. At 12 months, the percentage had increased to 70 (37%) in the control group compared to 53 (29%) in the intervention group. Compared to usual care, we found that MRs reduced the risk of hospital admissions within 12 months by 36% (HR = 0.64, 95% CI 0.45-0.90), but found no difference on mortality (HR = 1.12, 95% CI 0.78-1.61) between the groups. Conclusion We suggest that MRs should be recommended in the care of frail elderly patients with expected benefits on hospital admissions.

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The impact of medication reviews conducted in primary care on hospital admissions and mortality - an observational follow up of a randomized controlled trial

10.21203/rs.2.11674/v2 ◽

2020 ◽

Author(s):

Veronica Milos Nymberg ◽

Cecilia Lenander ◽

Beata Borgström Bolmsjö

Keyword(s):

Primary Care ◽

Elderly Patients ◽

Usual Care ◽

Frail Elderly ◽

Hospital Admissions ◽

Intervention Group ◽

Control Group ◽

Randomized Controlled ◽

Medication Reviews ◽

The Impact

Abstract Background Drug-related problems among the elderly population are common and increasing. Multi-professional medication reviews (MRs) have arisen as a method to optimize drug therapy for frail elderly patients. Research has not yet been able to show conclusive evidence of the effect of MRs on mortality or hospital admissions. Aim The aim of this study was to assess the impact of MRs’ on hospital admissions and mortality after six and 12 months in a frail population of 369 patients in primary care in a randomized controlled study. Methods Patients were blindly randomized to an intervention group (receiving MRs) and a control group (receiving usual care). Descriptive data on mortality and hospital admissions at six and 12 months were collected. Survival analysis was performed for time to death and time to the first hospital admission within 12 months. Results Of the total number of 369 included patients, 182 were randomized to the intervention group and 187 to the control group. Most of the patients (75%) were females and lived in nursing homes. At six months, 50 patients of the baseline population (27%) in the control group had been admitted to hospital at least once, compared to 40 patients (21%) in the intervention group. At 12 months, the percentage had increased to 70 (37%) in the control group compared to 53 (29%) in the intervention group. Compared to usual care, we found that MRs reduced the risk of hospital admissions within 12 months by 42% (HR = 0.58, 95% CI 0.37-0.92), but found no difference on mortality (HR = 1.12, 95% CI 0.78-1.61) between the groups. Conclusion We suggest that MRs should be recommended in the care of frail elderly patients with expected benefits on delayed hospital admissions.

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Motivational Interviewing to Support Oral AntiCoagulation adherence in patients with non-valvular Atrial Fibrillation (MISOAC-AF): a randomised clinical trial

European Heart Journal ◽

10.1093/ehjci/ehaa946.0641 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

A Tzikas ◽

A Samaras ◽

A Kartas ◽

D Vasdeki ◽

G Fotos ◽

...

Keyword(s):

Atrial Fibrillation ◽

Medication Adherence ◽

Medical Care ◽

Oral Anticoagulation ◽

Intervention Group ◽

Control Group ◽

Motivational Intervention ◽

Clinical Events ◽

Secondary Outcomes

Abstract Background Oral anticoagulation (OAC) is paramount to effective thromboprophylaxis; yet adherence to OAC remains largely suboptimal in patients with atrial fibrillation (AF). Purpose We aimed to assess the impact of an educational, motivational intervention on the adherence to OAC in patients with non-valvular AF. Methods Hospitalised patients with non-valvular AF who received OAC were randomly assigned to usual medical care or a proactive intervention, comprising motivational interviewing and tailored counseling on medication adherence. The primary study outcome was adherence to OAC at 1-year, evaluated as Proportion of Days Covered (PDC) by OAC regimens and assessed through nationwide prescription registers. Secondary outcomes included the rate of persistence to OAC, gaps in treatment, proportion of VKA-takers with labile INR (defined as time to therapeutic range<70%) and clinical events. Results A total of 1009 patients were randomised, 500 in the intervention group and 509 in the control group. At 1-year follow-up, 77.2% (386/500) of patients in the intervention group had good adherence (PDC>80%), compared with 55% (280/509) in the control group (adjusted odds ratio 2.84, 95% confidence interval 2.14–3.75; p<0.001). Mean PDC±SD was 0.85±0.26 and 0.75±0.31, respectively (p<0.001). Patients that received the intervention were more likely to persist in their OAC therapy at 1 year, while usual medical care was associated with more major (≥3 months) treatment gaps [Figure]. Among 212 VKA-takers, patients in the intervention group were less likely to have labile INR compared with those in the control group [21/120 (17.1%) vs 34/92 (37.1%), OR 0.33 95% CI 1.15–0.72, p=0.005]. Clinical events over a median follow-up period of 2 years occurred at a numerically lower, yet non-significant, rate in the intervention group [Table]. Conclusions In patients receiving OAC therapy for non-valvular AF, a motivational intervention significantly improved patterns of medication adherence, without significantly affecting clinical outcomes. Primary and secondary outcomes Funding Acknowledgement Type of funding source: None

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Effects of a home-based physical training and activity promotion program in community-dwelling older persons with cognitive impairment after discharge from rehabilitation: A randomized controlled trial

The Journals of Gerontology Series A ◽

10.1093/gerona/glac005 ◽

2022 ◽

Author(s):

Phoebe Ullrich ◽

Christian Werner ◽

Anton Schönstein ◽

Martin Bongartz ◽

Tobias Eckert ◽

...

Keyword(s):

Physical Training ◽

Controlled Trial ◽

Intervention Group ◽

Physical Capacity ◽

Control Group ◽

Promotion Program ◽

Home Based ◽

Activity Promotion ◽

Secondary Outcomes

Abstract Background Older people with cognitive impairment (CI) are at high risk for mobility limitations and adverse outcomes after discharge from geriatric rehabilitation settings. Study aim was to estimate the effects of a specifically designed home-based physical training and activity promotion program on physical capacity, different aspects of physical activity (PA), and psychosocial status. Methods Patients with mild-to-moderate CI (Mini-Mental State Examination [MMSE]: 17-26 points) discharged home after rehabilitation were included in this randomized, double-blind, placebo-controlled trial with a 12-week intervention and 12-week follow-up period. The intervention group performed a CI-specific, autonomous, home-based strength, balance and walking training supported by tailored motivational strategies to foster training adherence and promote PA. The control group participated in an unspecific motor placebo activity. Primary outcomes were physical capacity (Short Physical Performance Battery [SPPB]) and PA (sensor-based activity time). Results Among 118 randomized participants (82.3±6.0 years) with CI (MMSE: 23.3±2.4) and high levels of multi-morbidity, those participants undergoing home-based training demonstrated superior outcomes to the control group in SPPB (mean difference between groups 1.9 points; 95%-CI: 1.0-2.8; p<.001), with persistent benefits over the follow-up (1.3 points; 95%-CI: 0.4-2.2; p<.001). There were no differences in PA across any time points. Among secondary outcomes, fear of falling and activity avoidance behavior were reduced in the intervention group at all time points, life-space mobility improved short-term. Conclusions Study results demonstrate clinically important benefits of an individually tailored autonomous physical training and activity promotion program on physical capacity and secondary outcomes in different domains in a vulnerable, multi-morbid population.

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Follow-up Intervention: Its Effect on Compliance Behavior to a Diabetes Regimen

The Diabetes Educator ◽

10.1177/014572179001600408 ◽

1990 ◽

Vol 16 (4) ◽

pp. 291-295 ◽

Cited By ~ 73

Author(s):

Angela L. Estey ◽

Meng H. Tan ◽

Karen Mann

Keyword(s):

Home Visit ◽

Diabetes Management ◽

Glycosylated Hemoglobin ◽

Intervention Group ◽

Dependent Diabetes Mellitus ◽

Control Group ◽

Standard Protocol ◽

Weight Changes ◽

Telephone Calls

This study tested the hypothesis that follow-up intervention (by telephone calls and home visit) affects compliance in patients with non-insulin-dependent diabetes mellitus (NIDDM). Sixty NIDDM patients were randomly assigned to two groups—a control group, which received the standard protocol (3-day educational program and a review session 1 month after the program); and an intervention group, which received the standard protocol as well as a series offour telephone calls and one home visit by a registered nurse over a 3-month period. Compliance to prescribed regimens was determined by analyzing three sets of data: changes in pre- to poststudy glycosylated hemoglobin (HbA1c) values; changes in pre- to poststudy weight; and frequency with which self-monitoring of blood glucose (SMBG) was practiced. Results showed that SMBG practice was significantly better for the intervention group. No significant differences were seen in poststudy HbA 1c values and weight changes between the two groups. Follow-up inter vention by telephone calls and home visit can enhance patient compliance to certain aspects of the prescribed diabetes management plan.

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Early rehabilitation after hospital admission for road trauma using an in-reach multidisciplinary team: a randomised controlled trial

Clinical Rehabilitation ◽

10.1177/0269215517694462 ◽

2017 ◽

Vol 31 (9) ◽

pp. 1189-1200 ◽

Cited By ~ 4

Author(s):

Jane Wu ◽

Steven G Faux ◽

John Estell ◽

Stephen Wilson ◽

Ian Harris ◽

...

Keyword(s):

Length Of Stay ◽

Usual Care ◽

Intervention Group ◽

Psychological Status ◽

Randomised Control Trial ◽

Control Group ◽

Rehabilitation Team ◽

Secondary Outcomes ◽

The Impact

Objective: To investigate the impact of an in-reach rehabilitation team for patients admitted after road trauma. Design: Randomised control trial of usual care versus early involvement of in-reach rehabilitation team. Telephone follow-up was conducted by a blind assessor at three months for those with minor/moderate injuries and six months for serious/severe injuries. Setting: Four participating trauma services in New South Wales, Australia. Subjects: A total of 214 patients admitted during 2012-2015 with a length of stay of at least five days. Intervention: Provision of rehabilitation services in parallel with ward based therapy using an in-reach team for the intervention group. The control group could still access the ward based therapy (usual care). Main measures: The primary outcome was acute length of stay. Secondary outcomes included percentage requiring inpatient rehabilitation, function (Functional Independence Measure and Timed Up and Go Test), psychological status (Depression Anxiety and Stress Score 21), pain (Orebro Musculoskeletal Pain Questionnaire) and quality of life (Short Form-12 v2). Results: Median length of stay in acute care was 13 days (IQR 8-21). The intervention group, compared to the control group, received more physiotherapy and occupational therapy sessions (median number of sessions 16.0 versus 11.5, P=0.003). However, acute length of stay did not differ between the intervention and control groups (median 15 vs 12 days, P=0.37). There were no significant differences observed in the secondary outcomes at hospital discharge and follow-up. Conclusion: No additional benefit was found from the routine use of acute rehabilitation teams for trauma patients over and above usual care.

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P573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial

European Heart Journal ◽

10.1093/eurheartj/ehz747.0184 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

X H Huo ◽

H M K Krumholz ◽

X B Bai ◽

E S S Spatz ◽

Q D Ding ◽

...

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Coronary Heart Disease ◽

Text Messaging ◽

Hba1c Level ◽

Primary Outcome ◽

Intervention Group ◽

Control Group ◽

Secondary Outcomes

Abstract Background Mobile health interventions hold the prospect to support risk factor and lifestyle modification and are readily scalable in healthcare systems. Purpose We aim to assess whether text messaging program can improve glycemic control in high-risk patients with coronary heart disease (CHD) and diabetes mellitus (DM). Methods The study was a multi-centre randomised clinical trial conducted at 34 clinics in China. 502 individuals with both CHD and DM were recruited and randomly assigned to either the text messaging intervention (n=251) or control group (n=251). The control group received 2 thank-you messages per month in addition to usual care. The intervention group received 6 messages per week for 6 months. Messages provided educational and motivational information related to glucose monitoring, BP control, physical activity and lifestyle recommendations. The primary outcome was change in glycemic hemoglobin (HbA1C) from baseline to 6 months. Results Follow-up rate was 99%. At 6 months, HbA1C was significantly lower in intervention group compared to control group (mean HbA1C 6.7% vs. 7.2%, P<0.001), with a mean change of −0.2% and 0.1% from baseline, respectively (mean absolute change −0.3% [95% CI −0.5 to 0.1]; P=0.003). Significantly more participants in intervention group achieved a HbA1c<7% (69.3% vs. 52.6%; P=0.004), and change in FBG was larger in intervention group (−0.5 vs. 0.1 mmol/L; P=0.011). No differences in SBP, LDL-C, BMI and physical activity were observed. Almost all patients reported messages to be easy to understand (97.1%) and useful (94.1%). Table 1. Primary and Secondary Outcomes Analyses at 6 Month Follow-up Parameter Intervention (N=251) Control (N=251) Mean Difference in Change P value for Baseline 6 Months Mean Change Baseline 6 Months Mean Change (95% CI) Difference in Change Primary Outcome HbA1C level, %, mean (SD) 6.9 (1.4) 6.7 (1.3) −0.2 (1.0) 7.1 (1.4) 7.2 (1.5) 0.1 (1.1) −0.3 (−0.5, −0.1) 0.003 Secondary Outcomes HbA1C level<7%, No. (%) 155 (62.0%) 174 (69.3%) – 139 (56.1%) 132 (52.6%) – 1.2 (1.1, 1.3)a 0.004 FBG, mmol/L, mean (SD) 8.1 (2.7) 7.5 (2.7) −0.5 (2.5) 8.5 (3.0) 8.6 (3.3) 0.1 (3.1) −0.6 (−1.1, −0.2) 0.011 SBP, mmHg, mean (SD) 135.9 (18.4) 134.7 (18.7) −1.4 (17.1) 135.9 (18.1) 132.2 (17.7) −3.5 (17.8) 2.4 (−0.8,5.5) 0.144 LDL-C, mmol/L, mean (SD) 2.6 (0.8) 2.5 (0.7) −0.1 (0.7) 2.6 (0.8) 2.5 (0.8) −0.1 (0.7) 0 (−0.1, 0.1) 0.828 BMI, mean (SD) 26.4 (3.2) 26.3 (3.5) −0.1 (2.1) 26.3 (3.2) 26.0 (3.4) −0.4 (2.5) 0.3 (−0.1, 0.7) 0.213 Physical activity (MET min/wk), 1386 1386 177 1386 1386 322 −70.7 0.784 median (IQR) (693–3066) (918–3612) (2840) (693–3066) (693–3002) (2635) (−574.9, 433.5) Conclusion Use of a simple, culturally sensitive mobile text-messaging program could be an effective and scalable way to improve disease self-management among patients with CHD and DM. Acknowledgement/Funding Research Special Fund for Public Welfare Industry of Health (201502009) from the National Health and Family Planning Commission of China

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Psychoeducation and motivational interviewing to reduce relapses and increase patients’ involvement in antipsychotic treatment: interventional study

BJPsych Bulletin ◽

10.1192/bjb.2020.28 ◽

2020 ◽

Vol 44 (6) ◽

pp. 265-268

Author(s):

Gabriella Bröms ◽

Lindah Cahling ◽

Anders Berntsson ◽

Lars Öhrmalm

Keyword(s):

Motivational Interviewing ◽

Hospital Admissions ◽

Intervention Group ◽

Control Group ◽

Antipsychotic Treatment ◽

Clinical Implications ◽

Interventional Study ◽

Before And After ◽

Long Acting

Aims and methodTo assess whether the combination of motivational interviewing and psychoeducation affects relapse rate and stimulates involvement of people with psychosis in their treatment. We conducted an interventional study including patients with schizophrenia or schizoaffective disorder treated with oral antipsychotics, without previous experience of long-acting injectable antipsychotics (LAIs). They were randomised to either psychoeducation with motivational interviewing or a control group. Hospital admissions 18 months before and after the intervention, and switches to LAIs 18 months after the intervention, were recorded.ResultsThe two groups each comprised 101 participants. Fourteen from the intervention group and seven from the control group switched to LAIs. Five in the intervention group instigated the switch themselves, compared with zero controls (P = 0.06). Fourteen in the intervention group were readmitted to hospital during follow-up, compared with 23 in the control group (P = 0.14).Clinical implicationsPsychoeducation with motivational interviewing may increase patients' involvement in their treatment and reduce the relapse frequency.

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A Digital Self-Management Program (HOPE) for People Living with Cancer During the COVID-19 Pandemic: Findings from a Feasibility Randomized Controlled Trial (Preprint)

10.2196/preprints.28322 ◽

2021 ◽

Author(s):

Hayley Wright ◽

Faith Martin ◽

Wendy Clyne ◽

Cain Clark ◽

Gabriela Matouskova ◽

...

Keyword(s):

Intervention Group ◽

Patient Activation ◽

Management Program ◽

Mental Wellbeing ◽

Self Management ◽

Control Group ◽

Wait List Control ◽

Definitive Trial ◽

Secondary Outcomes

BACKGROUND Trial Design We present the results from a feasibility, randomised wait-list control group parallel design study, with a 1:1 allocation ratio. Participants were randomised to an intervention group or a waitlist control group.The intervention was a six-week digital self-management program (HOPE Program) for people with cancer. OBJECTIVE The aim of this study was to test the feasibility of a digitally delivered self-management program for people with cancer. This will inform the design of a definitive RCT. Additionally, preliminary assessment of the impact of the HOPE Program, via secondary outcomes, will be used to assess signals of efficacy in a trial context. METHODS Participants were drawn from an opportunity sample, referred by Macmillan Cancer Support and were invited via email to take part in the study (N=61). Primary outcomes were rates of recruitment, retention, follow up, completion and adherence, sample size and effect size estimation, and assessment of progression criteria for a definitive trial. Secondary outcomes were self-report measures of participants’ positive mental wellbeing, depression, anxiety and patient activation (i.e. confidence to manage their cancer). The intervention and data collection took place online. RESULTS The recruitment rate was 77% (N=47). Forty one participants (n=41) completed the baseline questionnaires and were randomised to either the intervention group (n=21) or waitlist control group (n=20). The retention rate (attending all program sessions) was over 50% (all n=21, 51.2%; intervention group n=10, 47.6%; control group n=11, 55.0%), the follow up rate (completing all questionnaires) was over 80% (all 80.5%, n=33; intervention group 76.2%, n=16; control group 85.0%, n=17), and completion rate (attending 3 sessions and completing all questionnaires) was over 60% (all n=25, 61.0%; intervention group n=13, 61.9%; control group n=12, 60.0%). Engagement data showed that participants viewed between half (n=5.1, 51.0%) and three quarters (n=12.2, 76.3%) of the pages in each session. CONCLUSIONS All progression criteria for a definitive trial were met, as supported by the primary outcome data. On average, participants showed improved postprogram scores on measures of positive mental wellbeing, depression, anxiety and patient activation. A full scale trial of the digital HOPE Program for people with cancer will allow us to fully evaluate the efficacy of the intervention relative to a control group. CLINICALTRIAL This feasibility randomised wait-list control trial was retrospectively registered with the ISRCTN registry (https://www.isrctn.com/ISRCTN79623250) on Nov 4, 2020. The feasibility trial protocol has been registered and published [International Registered Report Identifier (IRRID): DERR1-10.2196/24264. INTERNATIONAL REGISTERED REPORT RR2-10.2196/24264

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Effectiveness of Physical Therapy– and Occupational Therapy–Based Rehabilitation in People Who Have Glioma and Are Undergoing Active Anticancer Treatment: Single-Blind, Randomized Controlled Trial

Physical Therapy ◽

10.1093/ptj/pzz180 ◽

2020 ◽

Vol 100 (3) ◽

pp. 564-574 ◽

Cited By ~ 3

Author(s):

Anders Hansen ◽

Christian Bonde Pedersen ◽

Jens Ole Jarden ◽

Dagmar Beier ◽

Lisbeth Rosenbek Minet ◽

...

Keyword(s):

Physical Therapy ◽

Occupational Therapy ◽

Controlled Trial ◽

Intervention Group ◽

Control Group ◽

Rehabilitation Care ◽

Rehabilitation Intervention ◽

Anticancer Treatment ◽

Secondary Outcomes

Abstract Background It is recommended that people with gliomas engage in rehabilitation, but high-quality evidence to support this recommendation is lacking. Objective This study assesses the effectiveness of a physical therapy– and occupational therapy–based rehabilitation intervention compared with usual rehabilitation care for quality of life (QoL) during active anticancer treatment. Design This study was a randomized controlled trial. Setting The study took place in Odense University Hospital, Denmark. Participants The trial included people with gliomas who were functionally independent. Intervention The participants were randomly assigned to a supervised rehabilitation intervention or usual rehabilitation care during the active anticancer period. The supervised rehabilitation included physical therapy and occupational therapy-based interventions. Measurements The primary outcome was the between-group difference in the overall QoL from baseline to the 6-week follow-up. It was self-rated with the global health status (GHS)/QoL domains from the European Organization for Research and Treatment of Cancer Questionnaire. Eighty-eight participants per group were required to find a 10% between-group difference from baseline to the 6-week follow-up. Secondary outcomes were the health-related QoL domains, symptomatology, and functional performance. Results A total of 64 participants were included (32 in the intervention group and 32 in the control group). At follow-up, the intervention group self-rated a nonsignificantly better score for GHS/QoL than the control group (adjusted mean difference = 8.7% [95% confidence interval = −4.36 to 21.79]). Compared with the control group, the intervention group had consistently better results on self-rated secondary outcomes, including cognitive functioning (β = 16.2) and fatigue (β = −13.4), and objectively measured aerobic power (β = 2.6). Limitations The number of participants and duration of follow-up were inadequate to determine if the intervention was superior to the current usual rehabilitation care. Conclusions The physical therapy– and occupational therapy–based rehabilitation intervention did not affect GHS/QoL. However, the trial found promising significant effects on both objective and self-reported secondary outcomes, making rehabilitation efforts during active anticancer treatment promising.

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