Allergy-related diseases in childhood and risk for abdominal pain-related functional gastrointestinal disorders at 16 years—a birth cohort study

Abstract Background Studies on allergy-related diseases in relation to abdominal pain-related functional gastrointestinal disorders (AP-FGIDs) in children are few and results are contradictory. We examined the associations between childhood allergy-related diseases and adolescent AP-FGIDs in general and irritable bowel syndrome (IBS) in particular. Method Prospective population-based birth cohort study of 4089 children born in Sweden 1994-1996. We analysed data from 2949 children with complete follow-up at 16 years (y) and no diagnosis of inflammatory bowel disease or coeliac disease at 12y or 16y. Asthma, rhinitis, eczema, and food hypersensitivity (FH) were assessed through questionnaires at 1–2y, 4y, 8y, 12y, and 16y. AP-FGIDs and IBS were assessed through questionnaires at 16y and defined according to the Rome III criteria. Associations between childhood allergy-related diseases and any AP-FGID and IBS and 16y respectively were examined using binomial generalized linear models with a log link function and described as relative risk with 95% confidence intervals. Results The prevalence of any AP-FGID and IBS at 16y were 12.0% and 6.0% respectively. Eczema at 1–2y, 4y, and 8y, and FH at 12y and 16y were associated with an increased risk for any AP-FGID at 16y. Asthma and FH at 12y and 16y were associated with an increased risk for IBS at 16y. The relative risk for IBS at 16y increased with increasing number of concurrent allergy-related diseases at 16y, but linear trend for relative risk was only borderline statistically significant (P for trend = 0.05). Conclusions This prospective population-based study demonstrated positive associations between childhood allergy-related diseases and adolescent AP-FGIDs, including IBS, implicating shared pathophysiology among these disorders.

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Mo2017 - Recurrent Abdominal Pain and Painful Functional Gastrointestinal Disorders from Birth to Adolescence- A Prospective Swedish Birth Cohort Study

Gastroenterology ◽

10.1016/s0016-5085(18)32978-0 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-881

Author(s):

Jessica Sjölund ◽

Agneta Uusijärvi ◽

Navkiran Jossan ◽

Inger Kull ◽

Anna Bergström ◽

...

Keyword(s):

Cohort Study ◽

Abdominal Pain ◽

Birth Cohort ◽

Functional Gastrointestinal Disorders ◽

Recurrent Abdominal Pain ◽

Birth Cohort Study ◽

Gastrointestinal Disorders

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Sensitization to dust mite is associated with an increased risk of high FeNO levels and future onset of asthma: a population-based birth cohort study

10.26226/morressier.5acdc661d462b8029238e18e ◽

2018 ◽

Author(s):

Tatsuki Fukuie

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Population Based ◽

Birth Cohort Study ◽

Increased Risk ◽

Dust Mite

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Diabetes in pregnancy in associations with perinatal and postneonatal mortality in First Nations and non-Indigenous populations in Quebec, Canada: population-based linked birth cohort study

BMJ Open ◽

10.1136/bmjopen-2018-025084 ◽

2019 ◽

Vol 9 (4) ◽

pp. e025084 ◽

Cited By ~ 7

Author(s):

Lu Chen ◽

Wen-Juan Wang ◽

Nathalie Auger ◽

Lin Xiao ◽

Jill Torrie ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

First Nations ◽

Birth Cohort ◽

Perinatal Death ◽

Population Based ◽

Indigenous Populations ◽

Birth Cohort Study ◽

Postneonatal Mortality ◽

Increased Risk

ObjectiveBoth pregestational and gestational diabetes mellitus (PGDM, GDM) occur more frequently in First Nations (North American Indians) pregnant women than their non-Indigenous counterparts in Canada. We assessed whether the impacts of PGDM and GDM on perinatal and postneonatal mortality may differ in First Nations versus non-Indigenous populations.DesignA population-based linked birth cohort study.Setting and participants17 090 First Nations and 217 760 non-Indigenous singleton births in 1996–2010, Quebec, Canada.Main outcome measuresRelative risks (RR) of perinatal and postneonatal death. Perinatal deaths included stillbirths and neonatal (0–27 days of postnatal life) deaths; postneonatal deaths included infant deaths during 28–364 days of life.ResultsPGDM and GDM occurred much more frequently in First Nations (3.9% and 10.7%, respectively) versus non-Indigenous (1.1% and 4.8%, respectively) pregnant women. PGDM was associated with an increased risk of perinatal death to a much greater extent in First Nations (RR=5.08[95% CI 2.99 to 8.62], p<0.001; absolute risk (AR)=21.6 [8.6–34.6] per 1000) than in non-Indigenous populations (RR=1.76[1.17, 2.66], p=0.003; AR=4.2[0.2, 8.1] per 1000). PGDM was associated with an increased risk of postneonatal death in non-Indigenous (RR=3.46[1.71, 6.99], p<0.001; AR=2.4[0.1, 4.8] per 1000) but not First Nations (RR=1.16[0.28, 4.77], p=0.35) infants. Adjusting for maternal and pregnancy characteristics, the associations were similar. GDM was not associated with perinatal or postneonatal death in both groups.ConclusionsThe study is the first to reveal that PGDM may increase the risk of perinatal death to a much greater extent in First Nations versus non-Indigenous populations, but may substantially increase the risk of postneonatal death in non-Indigenous infants only. The underlying causes are unclear and deserve further studies. We speculate that population differences in the quality of glycaemic control in diabetic pregnancies and/or genetic vulnerability to hyperglycaemia’s fetal toxicity may be contributing factors.

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Cardiovascular disease in people born to unmarried mothers in two historical periods: The Helsinki Birth Cohort Study 1934–1944

Scandinavian Journal of Public Health ◽

10.1177/14034948211019792 ◽

2021 ◽

pp. 140349482110197

Author(s):

H. Maiju Mikkonen ◽

Minna K. Salonen ◽

Antti Häkkinen ◽

Clive Osmond ◽

Johan G. Eriksson ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

World War Ii ◽

Birth Cohort ◽

Birth Cohort Study ◽

World War ◽

Unmarried Mothers ◽

Increased Risk ◽

Married Mothers ◽

Historical Periods

Aims:Socio-economic conditions in early life are important contributors to cardiovascular disease – the leading cause of mortality globally – in later life. We studied coronary heart disease (CHD) and stroke in adulthood among people born out of wedlock in two historical periods: before and during World War II in Finland. Methods: We compared offspring born out of wedlock before (1934–1939) and during (1940–1944) World War II with the offspring of married mothers in the Helsinki Birth Cohort Study. The war affected the position of unmarried mothers in society. We followed the study subjects from 1971 to 2014 and identified deaths and hospital admissions from CHD and stroke. Data were analysed using a Cox regression, adjusting for other childhood and adulthood socio-economic circumstances. Results: The rate of out-of-wedlock births was 240/4052 (5.9%) before World War II and 397/9197 (4.3%) during World War II. Among those born before World War II, out-of-wedlock birth was associated with an increased risk of stroke (hazard ratio (HR)=1.44; 95% confidence interval (CI) 1.00–2.07) and CHD (HR=1.37; 95% CI 1.02–1.86). Among those born out of wedlock during World War II, the risks of stroke (HR=0.89; 95% CI 0.58–1.36) and CHD (HR=0.70; 95% CI 0.48=1.03) were similar to those observed for the offspring of married mothers. The p-values for interaction of unmarried×World War II were ( p=0.015) for stroke and ( p=0.003) for CHD. Conclusions: In a society in which marriage is normative, being born out of wedlock is an important predictor of lifelong health disadvantage. However, this may change rapidly when societal circumstances change, such as during a war.

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