scholarly journals Correction to: Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Chi-Ming Chan ◽  
Duen-Yi Huang ◽  
Ponarulselvam Sekar ◽  
Shu-Hao Hsu ◽  
Wan-Wan Lin
Keyword(s):  
Reactive Oxygen Species ◽  
Retinal Pigment Epithelial ◽  
Mitochondrial Dynamics ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Oxygen Species ◽  
Protective Effects ◽  
Sodium Iodate ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells

scholarly journals Antiviral Bioactivity of Resveratrol Against Zika Virus Infection in Human Retinal Pigment Epithelial Cells

2021 ◽  
Author(s):  
Constanza Andrea Russo ◽  
Maria Florencia Torti ◽  
Agostina Belén Márquez ◽  
Claudia Soledad Sepúlveda ◽  
Agustina Alaimo ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Zika Virus ◽  
Retinal Pigment Epithelial ◽  
Mitochondrial Dynamics ◽  
Retinal Pigment ◽  
Antiviral Agent ◽  
Retinal Pigment Epithelial Cells ◽  
Protective Effects ◽  
Pigment Epithelial ◽  
Pigment Epithelial Cells

Abstract Resveratrol (RES) is a polyphenol with increasing interest for its inhibitory effects on a wide variety of viruses. Zika virus (ZIKV) is an arbovirus of the Flaviviridae family for which there is no approved treatment or vaccine, and which has become a major global health threat. Within the broad spectrum of ophthalmological manifestations after infection, retinal pigment epithelial cells (RPE) type is one of the most permissive and susceptible to the virus. This work explored the protective effects of RES on ZIKV-infected human RPE cells. RES treatment resulted in a significant reduction of infectious viral titer in infected male ARPE-19 and female hTERT-RPE1 cells. This protection was positively influenced by the action of RES on mitochondrial dynamics, restoring the ZIKV induced fragmentation of mitochondrial network to conditions similar to those of uninfected control cultures. Also, docking studies showed that RES has a high affinity for two enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis and viral polymerase. In conclusion, our findings indicated that RES could be considered as an antiviral agent to treat ZIKV-induced ocular abnormalities.

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