scholarly journals Expression of the Wnt ligands gene family and its relationship to prognosis in hepatocellular carcinoma

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jia-Jia Dong ◽  
Li Ying ◽  
Ke-Qing Shi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Family ◽  
Wnt Ligands

scholarly journals Expression of the MAGE gene family in human hepatocellular carcinoma

Cancer ◽  
1999 ◽  
Vol 85 (6) ◽  
pp. 1234-1240 ◽  
Author(s):  
Kouichirou Tahara ◽  
Masaki Mori ◽  
Noriaki Sadanaga ◽  
Yoshihiro Sakamoto ◽  
Seigo Kitano ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Family ◽  
Human Hepatocellular Carcinoma ◽  
Mage Gene

scholarly journals STAT gene family mRNA expression and prognostic value in hepatocellular carcinoma

2019 ◽  
Vol Volume 12 ◽  
pp. 7175-7191 ◽  
Author(s):  
Zhitao Dong ◽  
Yi Chen ◽  
Cheng Yang ◽  
Meng Zhang ◽  
Aixue Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Family ◽  
Mrna Expression ◽  
Prognostic Value

scholarly journals ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuqi Xiang ◽  
Liyu Liu ◽  
Ying Wang ◽  
Bo Li ◽  
Jinwu Peng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Matrix Metalloproteinase ◽  
Gene Family ◽  
Tumor Progression ◽  
Molecular Mechanism ◽  
Cell Invasion ◽  
Expression Level ◽  
Invasion And Metastasis ◽  
Direct Association ◽  
The Relationship

Abstract Background The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) remain to be clarified. Human matrix metalloproteinase 21 (MMP21), the newest member of the MMP gene family, has been suggested to play an important role in embryogenesis and tumor progression. So far, nothing is known about the relationship between ADAM17 and MMP21. Methods In this study, the expression level of ADAM17 and MMP21 in HCC tissues was measured by immunohistochemistry. The Scratch wounding assay and Transwell were used to identify the invasion and metastasis ability. ELISA was used to evaluate the production of MMP21. Coimmunoprecipitation experiments demonstrated a direct association between ADAM17 and MMP21. HPLC was used to confirmed that ADAM17 participated in the maturation of MMP21. Results Our present data indicated that ADAM17 and MMP21 was significantly upregulated in human HCC tissues. Knockdown of ADAM17 in HCC inhibited cell invasion and metastasis. Moreover, ADAM17 regulates the secretion and expression of MMP21. Furthermore we discovered a direct association between ADAM17 and MMP21, and we also found MMP21 prodomain could be cleaved by ADAM17. Conclusion Our data suggest that ADAM17 plays an important role in the development of HCC invasion and metastasis and this function may be implement by MMP21.

scholarly journals The roles of the cell division cycle-associated gene family in hepatocellular carcinoma

2021 ◽  
Vol 12 (2) ◽  
pp. 781-794
Author(s):  
Qiang Tao ◽  
Siliang Chen ◽  
Jia Liu ◽  
Peng Zhao ◽  
Lingmin Jiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Gene Family ◽  
Cell Division Cycle

scholarly journals The diagnostic and prognostic value of cell division cycle associated gene family in Hepatocellular Carcinoma

2020 ◽  
Vol 11 (19) ◽  
pp. 5727-5737
Author(s):  
Bowen Wu ◽  
Yu Huang ◽  
Yingwan Luo ◽  
An Ma ◽  
Zhaoxing Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Division ◽  
Gene Family ◽  
Prognostic Value ◽  
Cell Division Cycle ◽  
Diagnostic And Prognostic Value

scholarly journals ADAM17 promotes the metastasis of hepatocellular carcinoma via upregulation MMP21

2020 ◽  
Author(s):  
Yuqi Xiang ◽  
Liyu Liu ◽  
Ying Wang ◽  
Bo Li ◽  
Jinwu Peng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Matrix Metalloproteinase ◽  
Gene Family ◽  
Tumor Progression ◽  
Molecular Mechanism ◽  
Cell Invasion ◽  
Expression Level ◽  
Invasion And Metastasis ◽  
Direct Association ◽  
The Relationship

Abstract Background The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) remain to be clarified. Human matrix metalloproteinase 21 (MMP21), the newest member of the MMP gene family, has been suggested to play an important role in embryogenesis and tumor progression. So far, nothing is known about the relationship between ADAM17 and MMP21. Methods In this study, the expression level of ADAM17 and MMP21 in HCC tissues was measured by immunohistochemistry. The Scratch wounding assay and Transwell were used to identify the invasion and metastasis ability. ELISA was used to evaluate the production of MMP21. Coimmunoprecipitation experiments demonstrated a direct association between ADAM17 and MMP21. HPLC was used to confirmed that ADAM17 participated in the maturation of MMP21. Results Our present data indicated that ADAM17 and MMP21 was significantly upregulated in human HCC tissues. Knockdown of ADAM17 in HCC inhibited cell invasion and metastasis. Moreover, ADAM17 regulates the secretion and expression of MMP21. Furthermore we discovered a direct association between ADAM17 and MMP21, and we also found MMP21 prodomain could be cleaved by ADAM17. Conclusion Our data suggest that ADAM17 plays an important role in the development of HCC invasion and metastasis and this function may be implement by MMP21.

scholarly journals ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21

2020 ◽  
Author(s):  
Yuqi Xiang ◽  
Liyu Liu ◽  
Ying Wang ◽  
Bo Li ◽  
Jinwu Peng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Matrix Metalloproteinase ◽  
Gene Family ◽  
Tumor Progression ◽  
Molecular Mechanism ◽  
Cell Invasion ◽  
Expression Level ◽  
Invasion And Metastasis ◽  
Direct Association ◽  
The Relationship

Abstract Background: The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) remain to be clarified. Human matrix metalloproteinase 21 (MMP21), the newest member of the MMP gene family, has been suggested to play an important role in embryogenesis and tumor progression. So far, nothing is known about the relationship between ADAM17 and MMP21.Methods: In this study, the expression level of ADAM17 and MMP21 in HCC tissues was measured by immunohistochemistry. The Scratch wounding assay and Transwell were used to identify the invasion and metastasis ability. ELISA was used to evaluate the production of MMP21. Coimmunoprecipitation experiments demonstrated a direct association between ADAM17 and MMP21. HPLC was used to confirmed that ADAM17 participated in the maturation of MMP21.Results: Our present data indicated that ADAM17 and MMP21 was significantly upregulated in human HCC tissues. Knockdown of ADAM17 in HCC inhibited cell invasion and metastasis. Moreover, ADAM17 regulates the secretion and expression of MMP21. Furthermore we discovered a direct association between ADAM17 and MMP21, and we also found MMP21 prodomain could be cleaved by ADAM17.Conclusion: Our data suggest that ADAM17 plays an important role in the development of HCC invasion and metastasis and this function may be implement by MMP21.

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