The diagnostic and prognostic value of cell division cycle associated gene family in Hepatocellular Carcinoma

Abstract Background: The potential correlation between H2AFY (also known as MacroH2A1) and the clinical characteristics of hepatocellular carcinoma (HCC) patients was analysed through gene expression profiles and clinical data in The Cancer Genome Atlas (TCGA) database, and the diagnostic and prognostic value of H2AFY in HCC was discussed. Methods: The gene expression data of HCC and the corresponding clinical characteristics of HCC patients were downloaded from the TCGA database. The differences in H2AFY in normal liver tissues and HCC were analysed. The relationship between H2AFY and clinical characteristics was analysed by Wilcoxon signed-rank test, logistic regression and Kruskal-Wallis test. The Kaplan-Meier method and the Cox regression method were used to analyse the relationship between overall survival and clinical characteristics of the patients. An ROC curve was used to predict the diagnostic value of H2AFY in HCC. Gene set enrichment analysis (GSEA) was used to analyse the pathway enrichment of H2AFY. Result: Compared with normal liver tissues, H2AFY was significantly highly expressed in HCC. H2AFY was positively correlated with the age, clinical stage, G stage (grade) and T stage (tumor stage) of liver cancer patients. Higher H2AFY expression predicted a poor prognosis in HCC patients. Cox regression analysis suggested that H2AFY was an independent risk factor for the prognosis of HCC patients. The ROC curve suggested that H2AFY had certain diagnostic value in HCC. GSEA suggested that H2AFY was correlated with lipid metabolism and a variety of tumour pathways. Conclusion: Our study showed that H2AFY was significantly overexpressed in HCC. H2AFY may be a potential diagnostic and prognostic marker for HCC, and high expression of H2AFY predicts a poor prognosis in patients with HCC.

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Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma

Journal of Cellular and Molecular Medicine ◽

10.1111/jcmm.17032 ◽

2021 ◽

Author(s):

Xiao‐Han Cui ◽

Qiu‐Ju Peng ◽

Ren‐Zhi Li ◽

Xia‐Jie Lyu ◽

Chun‐Fu Zhu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Division ◽

Prognostic Biomarker ◽

Cell Division Cycle

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Role of BCYRN1 in hepatocellular carcinoma pathogenesis by lncRNA–miRNA–mRNA network analysis and its diagnostic and prognostic value

Epigenomics ◽

10.2217/epi-2018-0218 ◽

2019 ◽

Vol 11 (10) ◽

pp. 1209-1231 ◽

Cited By ~ 2

Author(s):

Xin-Liang Ming ◽

Yan-Lin Feng ◽

Ding-Dong He ◽

Chang-Liang Luo ◽

Jia-Ling Rong ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Data Mining ◽

Microarray Data ◽

Prognostic Value ◽

Prognostic Biomarker ◽

Tumor Node Metastasis ◽

Comprehensive Strategy ◽

Node Metastasis ◽

Diagnostic And Prognostic Value

Aim: This study aimed to excavate the roles of BCYRN1 in hepatocellular carcinoma (HCC). Methods: A comprehensive strategy of microarray data mining, computational biology and experimental verification were adopted to assess the clinical significance of BCYRN1 and identify related pathways. Results: BCYRN1 was upregulated in HCC and its expression was positively associated with both tumor, node, metastasis and worse survival rate in patients with HCC. Through combing plasma BCYRN1 with alpha fetoprotein, the diagnosis of HCC was remarkably improved. BCYRN1 may regulate some cancer-related pathways to promote HCC initiation via an lncRNA–miRNA–mRNA network. Conclusion: Our results propose BCYRN1 as a potential diagnostic and prognostic biomarker and offer a novel perspective to explore the etiopathogenesis of HCC.

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STAT gene family mRNA expression and prognostic value in hepatocellular carcinoma

OncoTargets and Therapy ◽

10.2147/ott.s202122 ◽

2019 ◽

Vol Volume 12 ◽

pp. 7175-7191 ◽

Cited By ~ 5

Author(s):

Zhitao Dong ◽

Yi Chen ◽

Cheng Yang ◽

Meng Zhang ◽

Aixue Chen ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Gene Family ◽

Mrna Expression ◽

Prognostic Value

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Diagnostic and prognostic value of serum golgi protein 73 in hepatocellular carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.e15096 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. e15096-e15096

Author(s):

Min Dong ◽

Zhan-Hong Chen ◽

Xiao-Yun Li ◽

Jing-yun Wen ◽

Xing Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Prognostic Value ◽

Golgi Protein ◽

Diagnostic And Prognostic Value

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Higher expression of cell division cycle-associated protein 5 predicts poorer survival outcomes in hepatocellular carcinoma

Aging ◽

10.18632/aging.103501 ◽

2020 ◽

Vol 12 (14) ◽

pp. 14542-14555

Author(s):

Shengzhong Hou ◽

Xing Chen ◽

Mao Li ◽

Xing Huang ◽

Haotian Liao ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Division ◽

Cell Division Cycle ◽

Survival Outcomes

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Prognostic implications of cell division cycle protein 45 expression in hepatocellular carcinoma

PeerJ ◽

10.7717/peerj.10824 ◽

2021 ◽

Vol 9 ◽

pp. e10824

Author(s):

Chen Yang ◽

shufang Xie ◽

Yi Wu ◽

Guoqing Ru ◽

Xianglei He ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Division ◽

Dna Replication ◽

Chemical Carcinogenesis ◽

Cell Division Cycle ◽

Functional Enrichment ◽

Functional Annotations ◽

Normal Tissues ◽

Prognostic Implications ◽

Tissue Specimens

Background The overall prognosis of hepatocellular carcinoma (HCC) is poor and novel prognostic biomarkers might better monitor the progression of HCC. Cell division cycle protein 45 (CDC45) plays a key role in DNA replication and considered to be involved in tumorigenesis. This study investigated CDC45 expression in tumour tissues and defined its prognostic value in HCC patients. Methods We used immunohistochemistry (IHC) staining to examine the expression of CDC45 in tumour tissue specimens and compare them with adjacent normal tissue specimens using a constructed tissue microarray (TMA) and analyzed how clinical features are related to HCC prognosis. Functional enrichment analyses were used to describe significantly involved hallmark pathways of differentially expressed genes (DEGs, which were screened out according to the high or low expression of CDC45 in tumour tissues). Results Our findings showed that the proteome expression of CDC45 was evidently downregulated in HCC tissues compared with matched normal tissues (P < 0.0001). Although we did not find any differences in terms of vascular invasion, metastasis, lymphatic infiltration, or Edmondson grade between patients with high and low CDC45 expression, low CDC45 expression was significantly correlated with microvascular invasion (P = 0.046). Multivariate analysis indicated that CDC45 expression (P = 0.035) was an independent prognostic factor for the overall survival (OS) rate of HCC patients. Patients with CDC45 expression was positively correlated with OS rates among HCC patients (P < 0.05). Functional annotations indicated that CDC45 is involved in the most significant pathways, including the cell cycle, DNA replication, chemical carcinogenesis and drug metabolism–cytochrome P450 pathways. Discussion Our findings showed that low proteomic level of CDC45 was associated with a poor prognosis in HCC patients, indicating that CDC45 might be a novel prognostic marker.

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