scholarly journals Neutrophil-mediated clinical nanodrug for treatment of residual tumor after focused ultrasound ablation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jian Shen ◽  
Junnian Hao ◽  
Yini Chen ◽  
Hairong Liu ◽  
Jianrong Wu ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Therapeutic Potential ◽  
Malignant Tumors ◽  
Residual Tumor ◽  
High Intensity Focused Ultrasound ◽  
Drug Uptake ◽  
Integrated Method ◽  
Hifu Ablation ◽  
Inflammatory Stimuli ◽  
Ultrasound Ablation

Abstract Background The risk of local recurrence after high-intensity focused ultrasound (HIFU) is relatively high, resulting in poor prognosis of malignant tumors. The combination of HIFU with traditional chemotherapy continues to have an unsatisfactory outcome because of off-site drug uptake. Results Herein, we propose a strategy of inflammation-tendency neutrophil-mediated clinical nanodrug targeted therapy for residual tumors after HIFU ablation. We selected neutrophils as carriers and PEGylated liposome doxorubicin (PLD) as a model chemotherapeutic nanodrug to form an innovative cell therapy drug (PLD@NEs). The produced PLD@NEs had a loading capacity of approximately 5 µg of PLD per 106 cells and maintained the natural characteristics of neutrophils. The targeting performance and therapeutic potential of PLD@NEs were evaluated using Hepa1-6 cells and a corresponding tumor-bearing mouse model. After HIFU ablation, PLD@NEs were recruited to the tumor site by inflammation (most in 4 h) and released PLD with inflammatory stimuli, leading to targeted and localized postoperative chemotherapy. Conclusions This effective integrated method fully leverages the advantages of HIFU, chemotherapy and neutrophils to attract more focus on the practice of improving existing clinical therapies. Graphical Abstract

scholarly journals Neutrophil-Mediated Clinical Nanodrug for Treatment of Residual Tumor After Focused Ultrasound Ablation

2021 ◽  
Author(s):  
Jian Shen ◽  
Junnian Hao ◽  
Yini Chen ◽  
Hairong Liu ◽  
Jianrong Wu ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Therapeutic Potential ◽  
Malignant Tumors ◽  
Residual Tumor ◽  
High Intensity Focused Ultrasound ◽  
Drug Uptake ◽  
Targeting Therapy ◽  
Hifu Ablation ◽  
Inflammatory Stimuli ◽  
Ultrasound Ablation

Abstract Background: The risk of local recurrence of high intensity focused ultrasound (HIFU) is relatively high, resulting in poor prognosis of malignant tumors. Combination of HIFU with traditional chemotherapy still remains the unsatisfactory outcome because of off-site drug uptake.Results: Herein, we proposed the strategy of inflammation-tendency neutrophil-mediated clinical nanodrug targeting therapy for residual tumor of HIFU ablation. Neutrophils as a carrier, and PEGylated liposome doxorubicin (PLD) as a nanodrug model of chemotherapy, were selected to form an innovative cell therapy drug (PLD@NEs). The targeting performance and therapeutic potential of PLD@NEs were evaluated using hepa1-6 cells and corresponding tumor-bearing mouse model. After HIFU ablation, PLD@NEs were recruited to the tumor site by inflammation, and released PLD with inflammatory stimuli, leading to targeted and localized postoperative chemotherapy.Conclusion: This effective integration takes full use of the advantages of both HIFU, chemotherapy and neutrophil, attracting more focus on the practice of improving the existing clinical therapeutics.

scholarly journals Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: AnIn VitroStudy Using a Clinical Device

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Lu-Yan Zhao ◽  
Jian-Zhong Zou ◽  
Zong-Gui Chen ◽  
Shan Liu ◽  
Jiao Jiao ◽  
...  
Keyword(s):  
Phase Shift ◽  
Focused Ultrasound ◽  
Continuous Wave ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Inertial Cavitation ◽  
Hifu Ablation ◽  
Duty Cycles ◽  
Ultrasound Ablation ◽  
Phosphate Buffered Saline

Purpose.To investigate whether acoustic cavitation could increase the evaporation of a phase-shift inorganic perfluorohexane (PFH) nanoemulsion and enhance high intensity focused ultrasound (HIFU) ablation.Materials and Methods.PFH was encapsulated by mesoporous silica nanocapsule (MSNC) to form a nanometer-sized droplet (MSNC-PFH). It was added to a tissue-mimicking phantom, whereas phosphate buffered saline (PBS) was added as a control (PBS-control). HIFU (Pac=150 W,t=5/10 s) exposures were performed in both phantoms with various duty cycles (DC). US images, temperature, and cavitation emissions were recorded during HIFU exposure. HIFU-induced lesions were measured and calculated.Results.Compared to PBS-control, MSNC-PFH nanoemulsion could significantly increase the volume of HIFU-induced lesion (P<0.01). Peak temperatures were 78.16 ± 5.64°C at a DC of 100%, 70.17 ± 6.43°C at 10%, 53.17 ± 4.54°C at 5%, and 42.00 ± 5.55°C at 2%, respectively. Inertial cavitation was much stronger in the pulsed-HIFU than that in the continuous-wave HIFU exposure. Compared to 100%-DC exposure, the mean volume of lesion induced by 5 s exposure at 10%-DC was significantly larger, but smaller at 2%-DC.Conclusions.MSNC-PFH nanoemulsion can significantly enhance HIFU ablation. Appropriate pulsed-HIFU exposure could significantly increase the volume of lesion and reduce total US energy required for HIFU ablation.

scholarly journals A method for MRI guidance of intercostal high intensity focused ultrasound ablation in the liver

2010 ◽  
Vol 37 (6Part1) ◽  
pp. 2533-2540 ◽  
Author(s):  
Bruno Quesson ◽  
Mathilde Merle ◽  
Max O. Köhler ◽  
Charles Mougenot ◽  
Sebastien Roujol ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Mri Guidance ◽  
Ultrasound Ablation ◽  
Focused Ultrasound Ablation

scholarly journals High-intensity focused ultrasonic ablation of breast cancer

2018 ◽  
Vol 5 (3) ◽  
pp. 67-76
Author(s):  
L. I. Moskvicheva
Keyword(s):  
Breast Cancer ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Malignant Tumors ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Therapy ◽  
Technical Success ◽  
Short Term ◽  
Technical Safety ◽  
Complete Tumor

Breast cancer is the most frequent and socially signifi cant malignant tumor disease of the female popula on of the Russian Federa on. At present, for the treatment of this pathology, the methods of the organ-preserving surgical manual allowing to achieve the maximum cosme c eff ect along with the observance of the principles of cancer safety are ge  ng more and more developed,. In recent decades, researchers from diff erent countries demonstrate the feasibility and technical safety of various mini-invasive methods of thermal abla on of early stages of breast cancer, characterized by rela ve simplicity of implementa on, excellent cosme c results, short-term rehabilita on of pa ents. These include hyperthermic techniques (radiofrequency, microwave, laser abla on) and hypothermic method (cryoabla on). Each technique has unique characteris cs of impact on the tumor and is performed under the control of ultrasound, computer tomography or magne c resonance imaging. The technical success of these abla on techniques is achieved in 93–98% of cases. Complete tumor necrosis a er radiofrequency abla on is observed in 76–100% of pa ents with breast cancer, laser abla on – in 13–76%, microwave abla on – in 0–8%, cryoabla on – in 36–83%. The frequency of development of specifi c complica ons of local thermal destruc on is 4–13%. To date, there is only one method of noninvasive extracorporeal thermal abla on of tumors of diff erent localiza on – high-intensity focused ultrasound therapy, the eff ec veness and safety of which as a method of local destruc on of benign and malignant tumors of the breast demonstrated by many authors. Like all methods of thermal abla on, high-intensity focused ultrasound therapy has its limita ons, complica ons and disadvantages. This ar cle presents a literary review that highlights the possibili es of this method of local destruc on in pa ents with malignant tumors of the breast.

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