scholarly journals Factors associated with improved survival following surgical treatment for metastatic prostate cancer in the spine: retrospective analysis of 29 patients in a single center

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Tong Meng ◽  
Rui Chen ◽  
Nanzhe Zhong ◽  
Tianqi Fan ◽  
Bo Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Surgical Treatment ◽  
Retrospective Analysis ◽  
Metastatic Prostate Cancer ◽  
Single Center ◽  
Factors Associated

Surgical treatment as option in treatment of metastatic hormone-sensitive prostate cancer after prior drug treatment

2022 ◽  
pp. 41-45
Author(s):  
Sh. G. Khakimova ◽  
G. G. Khakimova ◽  
G. A. Khakimov ◽  
J. B. Sadullaev
Keyword(s):  
Prostate Cancer ◽  
Surgical Treatment ◽  
Drug Treatment ◽  
Bone Metastases ◽  
Clinical Result ◽  
Metastatic Prostate Cancer ◽  
Clinical Case ◽  
Complex Treatment ◽  
Good Clinical Result ◽  
Hormone Sensitive

Currently, there is no consensus on the place of prostatectomy in the complex treatment of patients with metastatic prostate cancer. A description of a clinical case of complex treatment and observation of a patient with prostate cancer with an unfavorable baseline prognosis and the presence of bone metastases with a good clinical result is presented.

scholarly journals Cytoreductive cryosurgery in patients with bone metastatic prostate cancer: A retrospective analysis

2017 ◽  
Vol 33 (12) ◽  
pp. 609-615 ◽  
Author(s):  
Ming-Xiong Sheng ◽  
Ling-Ling Wan ◽  
Chang-Ming Liu ◽  
Chun-Xiao Liu ◽  
Shu-Shang Chen
Keyword(s):  
Prostate Cancer ◽  
Retrospective Analysis ◽  
Metastatic Prostate Cancer

scholarly journals Circulating tumor cells in patients undergoing androgen deprivation therapy with versus without cryosurgery for metastatic prostate cancer: a retrospective analysis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mingxiong Sheng ◽  
Shanming Guo ◽  
Chunxiao Liu
Keyword(s):  
Prostate Cancer ◽  
Treatment Response ◽  
Retrospective Analysis ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Androgen Deprivation Therapy ◽  
Metastatic Prostate Cancer ◽  
Cox Regression ◽  
Androgen Deprivation ◽  
Post Treatment

Abstract Background The study aimed to assess the value of circulating tumor cells (CTCs) as a prognostic and treatment response marker in patients undergoing androgen deprivation therapy (ADT) plus cryosurgery vs. ADT alone for metastatic prostate cancer (mPCA). Methods This retrospective analysis included 43 patients with mPCA: 23 receiving ADT alone (control) and 20 receiving additional cryosurgery (cryosurgery group). CTCs and progression-free survival (PFS) were compared between the two groups. Cox proportional hazards regression was conducted to identify variables associated with PFS. Results Median PFS was 35 months (IQR, 33‑37) in the cryosurgery group vs. 30 months (IQR, 27‑32) in the control (p < 0.001). CTCs count was significantly lower in the cryosurgery group at both 3 months (z = 2.170, p = 0.030) and 12 months (z = 2.481; p = 0.013). In comparison to the baseline, the number of CTCs at both 3 and 12 months was lower in the cryosurgery group (p = 0.004 and p < 0.001, respectively), but not in the ADT alone group. In multivariate Cox regression, shorter PFS was associated with baseline PSA ≧100 ng/ml (HR 6.584, 95% CI, 5.309‑8.166), biopsy Gleason score ≧ 8 (HR 2.064, 95% CI, 1.608‑2.650), clinic T stage>T2b (HR 5.021, 95% CI, 3.925‑6.421), number of bone metastases>3 (HR 3.421, 95% CI, 2.786‑4.202), positive CTCs at 3 months post-treatment (HR 6.833, 95% CI, 5.176‑9.022), positive CTCs 1 year post-treatment (HR 6.051, 95% CI, 4.347‑8.424). Prostate cryosurgery was associated with longer PFS (HR 0.062, 95% CI, 0.048‑.080). Conclusions CTC was a prognostic and treatment response marker for mPCA. ADT plus cryosurgery could reduce CTCs and prolong PFS vs. ADT alone in mPCA patients with low metastatic volume.

Sign in / Sign up

Export Citation Format

Share Document