scholarly journals Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Christina N. Byrne-Hoffman ◽  
Wentao Deng ◽  
Owen McGrath ◽  
Peng Wang ◽  
Yon Rojanasakul ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Interleukin 12 ◽  
B16 Melanoma Cells

scholarly journals Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2697
Author(s):  
Thouria Bourhim ◽  
Myra O. Villareal ◽  
Chemseddoha Gadhi ◽  
Hiroko Isoda
Keyword(s):  
Signaling Pathways ◽  
Press Cake ◽  
Global Gene Expression ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Dependent Manner ◽  
Melanin Biosynthesis ◽  
B16 Melanoma Cells ◽  
Pigmentary Disorders ◽  
Argan Oil

The beneficial effect on health of argan oil is recognized worldwide. We have previously reported that the cake that remains after argan oil extraction (argan press-cake or APC) inhibits melanogenesis in B16 melanoma cells in a time-dependent manner without cytotoxicity. In this study, the global gene expression profile of B16 melanoma cells treated with APC extract was determined in order to gain an understanding of the possible mechanisms of action of APC. The results suggest that APC extract inhibits melanin biosynthesis by down-regulating microphthalmia-associated transcription factor (Mitf) and its downstream signaling pathway through JNK signaling activation, and the inhibition of Wnt/β-catenin and cAMP/PKA signaling pathways. APC extract also prevented the transport of melanosomes by down-regulating Rab27a expression. These results suggest that APC may be an important natural skin whitening product and pharmacological agent used for clinical treatment of pigmentary disorders.

scholarly journals Effect of Phlorotannins Isolated From Eisenia bicyclis on Melanogenesis in Mouse B16 Melanoma Cells

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110192
Author(s):  
Yuki Ohno ◽  
Shiori Kondo ◽  
Kiho Tajima ◽  
Toshiyuki Shibata ◽  
Tomohiro Itoh
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Physiological Effects ◽  
Related Protein ◽  
Eisenia Bicyclis ◽  
Melanin Production ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
Anti Cancer ◽  
Tyrosinase Related Protein

Phlorotannins isolated from brown algae, such as Eisena bicyclis, have positive physiological effects, including anti-cancer, anti-inflammatory, and anti-Alzheimer’s disease. Although phlorotannins have been shown to inhibit tyrosinase, an enzyme essential for melanogenesis, their effect on melanogenesis remains unexplored. Thus, we isolated phlorotannins from E. bicyclis and examined their effects on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis in murine B16 melanoma cells. Both fucofuroeckol-A (FF-A) and phlorofucofuroeckol-A (PFF-A) suppressed α-MSH-induced melanogenesis. Neither inhibited human tyrosinase (TYR) activity, but both inhibited tyrosinase-related protein-2 activity. FF-A downregulated the expression of microphthalmia-associated transcription factor and TYR, which subsequently suppressed melanin production. These results suggest that phlorotannins could be beneficial as melanin control drugs for hyperpigmentation disorders.

Saponified Evening Primrose Oil Reduces Melanogenesis in B16 Melanoma Cells and Reduces UV-Induced Skin Pigmentation in Humans

Lipids ◽  
2010 ◽  
Vol 45 (5) ◽  
pp. 401-407 ◽  
Author(s):  
Jeung-Hyun Koo ◽  
Ikjae Lee ◽  
Seok-Kweon Yun ◽  
Han-Uk Kim ◽  
Byung-Hyun Park ◽  
...  
Keyword(s):  
Skin Pigmentation ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Evening Primrose Oil ◽  
Evening Primrose ◽  
B16 Melanoma Cells

Combined Treatment of Adriamycin and Dipyridamole Inhibits Lung Metastasis of B16 Melanoma Cells in Mice

1990 ◽  
Vol 22 (4) ◽  
pp. 213-218 ◽  
Author(s):  
Y. Sakaguchi ◽  
Y. Emi ◽  
Y. Maehara ◽  
S. Kohnoe ◽  
K. Sugimachi
Keyword(s):  
Lung Metastasis ◽  
Combined Treatment ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

Characterization of morphological changes of B16 melanoma cells under natural killer cell attack

2019 ◽  
Vol 67 ◽  
pp. 366-371
Author(s):  
Ji Sung Kim ◽  
Boyeong Kim ◽  
Hong Kyung Lee ◽  
Hyung Sook Kim ◽  
Eun Jae Park ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Morphological Changes ◽  
Killer Cell ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

Exercise effects on lung tumor metastases and in vitro alveolar macrophage antitumor cytotoxicity

1998 ◽  
Vol 274 (5) ◽  
pp. R1454-R1459 ◽  
Author(s):  
J. M. Davis ◽  
M. L. Kohut ◽  
D. A. Jackson ◽  
L. H. Colbert ◽  
E. P. Mayer ◽  
...  
Keyword(s):  
Alveolar Macrophage ◽  
Prolonged Exercise ◽  
Lung Tumor ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Intravenous Injections ◽  
B16 Melanoma Cells ◽  
Strong Trend ◽  
Tumor Metastases

This study examined the effects of moderate and prolonged exercise on 1) lung tumor metastases and 2) alveolar macrophage antitumor response in vitro. C57Bl/6 mice were assigned to either Ex-30 (30-min run), Ex-F (run to fatigue), Ex-F-24 h (run to fatigue 24 h before tumor injection), or Con (rested in lanes above the treadmill). Mice received intravenous injections of syngeneic B16 melanoma cells 30 min postexercise. Lungs were removed 7 or 10 days later, and tumor foci were counted. Ex-F had fewer tumors than either Ex-30 or Con, whereas Ex-F-24 h also showed a strong trend toward fewer tumors. The initial localization of tumor cells in the lungs after injection was not different among groups. For the in vitro experiment, mice were killed immediately after exercise or 8 h later. Alveolar macrophages were removed and cultured in vitro with B16 melanoma cells. The growth of the tumors cultured with macrophages from Ex-F was lower than Con after exercise and, to a lesser extent, 8 h later. In Ex-30, this effect was only found immediately after exercise. The data suggest that prolonged exercise has a protective effect on lung tumor metastases and enhances alveolar macrophage antitumor cytotoxicity.

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