Posttraumatic stress disorder and the risk of erectile dysfunction: a nationwide cohort study in Taiwan

Abstract Background This study aimed to investigate the association between posttraumatic stress disorder and the risk of developing erectile dysfunction. Methods In this population-based retrospective cohort study, we used Taiwan’s National Health Insurance Research Database to analyze patients who were newly diagnosed with posttraumatic stress disorder (PTSD) between 2000 and 2013, with a 1:3 ratio by age and index year matched with patients in a non-PTSD comparison group, for the risk of erectile dysfunction. Results In total, 5 out of 1079 patients in the PTSD group developed erectile dysfunction, and 3 out of 3237 patients in the non-PTSD group (47.58 vs. 9.03 per 100,000 per person-year) developed erectile dysfunction. The Kaplan–Meier analysis showed that the PTSD cohort had a significantly higher risk of erectile dysfunction (log-rank, p < 0.001). The Cox regression analysis revealed that the study subjects were more likely to develop an injury (hazard ratio: 12.898, 95% confidence intervals = 2.453–67.811, p = 0.003) after adjusting for age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications used by the patients with PTSD were not associated with the risk of erectile dysfunction. Conclusions Patients who suffered from PTSD had a higher risk of developing erectile dysfunction.

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Post-Traumatic Stress Disorder and the Risk of Erectile Dysfunction: A Nationwide Cohort Study in Taiwan

10.21203/rs.3.rs-370664/v1 ◽

2021 ◽

Author(s):

Sheng-Chiang Wang ◽

Wu-Chien Chien ◽

Chi-Hsiang Chung ◽

Nian-Sheng Tzeng ◽

Yia-Ping Liu

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Erectile Dysfunction ◽

Posttraumatic Stress ◽

Stress Disorder ◽

Cox Regression ◽

Geographic Region ◽

Research Database ◽

Post Traumatic Stress ◽

Cox Regression Analysis

Abstract BACKGROUND: This study aimed to investigate the association between posttraumatic stress disorder and the risk of developing erectile dysfunction.METHODS: In this population-based, retrospective cohort study, we used Taiwan’s National Health Insurance Research Database to analyze the patients who were newly diagnosed with posttraumatic stress disorder (PTSD) between 2000 and 2013, with a 1:3 ratio by age, and index year matched in the non-PTSD comparison group, for the risk of erectile dysfunction. RESULTS: In total, five out of 1,079 patients with PTSD developed erectile dysfunction, and three out of 3,237 patients in the non-PTSD group (47.58 vs 9.03 per 100,000 per person-year) developed erectile dysfunction. The Kaplan-Meier analysis showed that the PTSD cohort had a significantly higher risk of erectile dysfunction (log-rank, p<0.001). The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 12.898, 95% CI=2.453- 67.811, p=0.003) after adjusting for age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the patients with PTSD were not associated with the risk of erectile dysfunction.CONCLUSIONS: Patients who suffered PTSD had a higher risk of developing erectile dysfunction.

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Cognitive enhancers associated with decreased risk of injury in patients with dementia: a nationwide cohort study in Taiwan

Journal of Investigative Medicine ◽

10.1136/jim-2017-000595 ◽

2017 ◽

Vol 66 (3) ◽

pp. 684-692 ◽

Cited By ~ 8

Author(s):

Pei-Chun Chao ◽

Wu-Chien Chien ◽

Chi-Hsiang Chung ◽

Ching-Wen Chu ◽

Chin-Bin Yeh ◽

...

Keyword(s):

Cohort Study ◽

Cox Regression ◽

Geographic Region ◽

Cox Proportional Hazards ◽

Psychotropic Medications ◽

Control Group ◽

Research Database ◽

Cognitive Enhancers ◽

Cox Regression Analysis ◽

Risk Of Injury

This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144 008 enrolled patients ≥age of 50, with 36 002 study subjects who suffered from dementia and 108 006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000–2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification. When adjusting for the confounding factors, a Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up. Of the study subjects, 6701 (18.61%) suffered injury when compared with 20 919 (19.37%) in the control group. The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 2.294, 95% CI=2.229 to 2.361, P<0.001) after adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the subjects with dementia were associated with the risk of injury (adjusted HR=0.217, 95% CI: 0.206 to 0.228, P<0.001). Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, were associated with the risk of injury in the study subjects after being adjusted for all comorbidities and medications (adjusted HR=0.712(95% CI=0.512 to 0.925, P<0.01)). In conclusion, patients who suffered dementia had a higher risk of developing injury, and the cognitive enhancers were associated with the decreased risk of injury.

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New Opioid and Benzodiazepine Co-Prescribing and Mortality Among Veteran Affairs Patients with Posttraumatic Stress Disorder: A Retrospective Cohort Study

SSRN Electronic Journal ◽

10.2139/ssrn.3235664 ◽

2018 ◽

Author(s):

Eric J. Hawkins ◽

Simon Goldberg ◽

Carol A. Malte ◽

Andrew J. Saxon

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Posttraumatic Stress ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Stress Disorder ◽

Veteran Affairs

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Differential predictors of birth-related posttraumatic stress disorder symptoms in mothers and fathers – a longitudinal cohort study

Journal of Affective Disorders ◽

10.1016/j.jad.2021.05.058 ◽

2021 ◽

Author(s):

Victoria Kress ◽

Tilmann von Soest ◽

Marie Kopp ◽

Pauline Wimberger ◽

Susan Garthus-Niegel

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Posttraumatic Stress ◽

Stress Disorder ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort ◽

Mothers And Fathers ◽

Posttraumatic Stress Disorder Symptoms

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Impact of peritraumatic distress on posttraumatic stress disorder symptoms at 6 months after acute coronary syndrome: a prospective cohort study

European Journal of Psychotraumatology ◽

10.1080/20008198.2020.1854511 ◽

2021 ◽

Vol 12 (1) ◽

pp. 1854511

Author(s):

Tomomi Narisawa ◽

Daisuke Nishi ◽

Ryo Okubo ◽

Hiroko Noguchi ◽

Kei Hamazaki ◽

...

Keyword(s):

Posttraumatic Stress Disorder ◽

Acute Coronary Syndrome ◽

Cohort Study ◽

Posttraumatic Stress ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Stress Disorder ◽

Coronary Syndrome ◽

Posttraumatic Stress Disorder Symptoms ◽

Peritraumatic Distress

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Posttraumatic stress disorder in partners following severe postpartum haemorrhage: A prospective cohort study

Women and Birth ◽

10.1016/j.wombi.2019.06.016 ◽

2020 ◽

Vol 33 (4) ◽

pp. 360-366 ◽

Cited By ~ 1

Author(s):

Minouk E. van Steijn ◽

Karel W.F. Scheepstra ◽

Tjitske R. Zaat ◽

Joris A.M. van der Post ◽

Miranda Olff ◽

...

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Posttraumatic Stress ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Postpartum Haemorrhage ◽

Stress Disorder

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Posttraumatic Stress Disorder and Autobiographical Memories in Everyday Life

Clinical Psychological Science ◽

10.1177/2167702616688878 ◽

2017 ◽

Vol 5 (2) ◽

pp. 325-340 ◽

Cited By ~ 14

Author(s):

Sabine Schönfeld ◽

Anke Ehlers

Keyword(s):

Posttraumatic Stress Disorder ◽

Autobiographical Memory ◽

Everyday Life ◽

Posttraumatic Stress ◽

Stress Disorder ◽

Trauma Survivors ◽

Autobiographical Memories ◽

Self Reports ◽

Distinct Features ◽

Ptsd Group

Evidence from self-reports and laboratory studies suggests that recall of nontrauma autobiographical memories may be disturbed in posttraumatic stress disorder (PTSD), but investigations in everyday life are sparse. This study investigated unintentional nontrauma and trauma memories in trauma survivors with and without PTSD ( N = 52), who kept an autobiographical memory diary for a week. We investigated whether unintentional nontrauma memories show an overgeneral memory bias and further memory abnormalities in people with PTSD, and whether unintentional trauma memories show distinct features. Compared to the no-PTSD group, the PTSD group recorded fewer nontrauma memories, which were more overgeneral, more often from before the trauma or related to the trauma, were perceived as distant, and led to greater dwelling. Trauma memories were more vivid, recurrent, and present and led to greater suppression and dwelling. Within the PTSD group, the same features distinguished trauma and nontrauma memories. Results are discussed regarding theories of autobiographical memory and PTSD.

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Do Children With Constipation Have Increased Risk of Asthma? Real-World Data From a Nationwide Population-Based Cohort Study

Frontiers in Pediatrics ◽

10.3389/fped.2021.714406 ◽

2021 ◽

Vol 9 ◽

Author(s):

Yen-Chu Huang ◽

Meng-Che Wu ◽

Yu-Hsun Wang ◽

James Cheng-Chung Wei

Keyword(s):

Cohort Study ◽

Cox Regression ◽

Population Based ◽

Hazard Ratio ◽

Adjusted Hazard Ratio ◽

Research Database ◽

Real World Data ◽

Childhood Disorders ◽

Cox Regression Analysis ◽

Increased Risk

Background: Asthma is one of the most burdensome childhood disorders. Growing evidence disclose intestinal dysbiosis may contribute to asthma via the gut-lung axis. Constipation can lead to alteration of the gut microbiota. The clinical impact of constipation on asthma has not been researched. Therefore, we aim to assess whether pediatric constipation influence the risk of developing asthma by a nationwide population-based cohort study.Methods: We analyzed 10,363 constipated patients and 10,363 individuals without constipation between 1999 and 2013 from Taiwan's National Health Insurance Research Database. Analysis of propensity score was utilized to match age, sex, comorbidities, and medications at a ratio of 1:1. In addition, multiple Cox regression analysis was performed to evaluate the adjusted hazard ratio of asthma. Furthermore, sensitivity tests and a stratified analysis were performed.Results: After adjustment for age, sex, comorbidities, and medications, constipated patients had a 2.36-fold greater risk of asthma compared to those without constipation [adjusted hazard ratio (aHR): 2.36, 95% C.I. 2.04–2.73, p < 0.001]. Furthermore, the severity of constipation is associated with an increased risk of asthma; the adjusted hazard ratio was 2.25, 2.85, and 3.44 within < 3, 3–12, and ≥12 times of laxatives prescription within 1 year, respectively (p < 0.001).Conclusion: Constipation was correlated with a significantly increased risk of asthma. Pediatricians should be aware of the possibility of asthma in constipated patients. Further research is warranted to investigate the possible pathological mechanisms of this association.

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