Post-Traumatic Stress Disorder and the Risk of Erectile Dysfunction: A Nationwide Cohort Study in Taiwan

Abstract BACKGROUND: This study aimed to investigate the association between posttraumatic stress disorder and the risk of developing erectile dysfunction.METHODS: In this population-based, retrospective cohort study, we used Taiwan’s National Health Insurance Research Database to analyze the patients who were newly diagnosed with posttraumatic stress disorder (PTSD) between 2000 and 2013, with a 1:3 ratio by age, and index year matched in the non-PTSD comparison group, for the risk of erectile dysfunction. RESULTS: In total, five out of 1,079 patients with PTSD developed erectile dysfunction, and three out of 3,237 patients in the non-PTSD group (47.58 vs 9.03 per 100,000 per person-year) developed erectile dysfunction. The Kaplan-Meier analysis showed that the PTSD cohort had a significantly higher risk of erectile dysfunction (log-rank, p<0.001). The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 12.898, 95% CI=2.453- 67.811, p=0.003) after adjusting for age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the patients with PTSD were not associated with the risk of erectile dysfunction.CONCLUSIONS: Patients who suffered PTSD had a higher risk of developing erectile dysfunction.

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Posttraumatic stress disorder and the risk of erectile dysfunction: a nationwide cohort study in Taiwan

Annals of General Psychiatry ◽

10.1186/s12991-021-00368-w ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Sheng-Chiang Wang ◽

Wu-Chien Chien ◽

Chi-Hsiang Chung ◽

Nian-Sheng Tzeng ◽

Yia-Ping Liu

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Erectile Dysfunction ◽

Posttraumatic Stress ◽

Stress Disorder ◽

Cox Regression ◽

Geographic Region ◽

Research Database ◽

Cox Regression Analysis ◽

Ptsd Group

Abstract Background This study aimed to investigate the association between posttraumatic stress disorder and the risk of developing erectile dysfunction. Methods In this population-based retrospective cohort study, we used Taiwan’s National Health Insurance Research Database to analyze patients who were newly diagnosed with posttraumatic stress disorder (PTSD) between 2000 and 2013, with a 1:3 ratio by age and index year matched with patients in a non-PTSD comparison group, for the risk of erectile dysfunction. Results In total, 5 out of 1079 patients in the PTSD group developed erectile dysfunction, and 3 out of 3237 patients in the non-PTSD group (47.58 vs. 9.03 per 100,000 per person-year) developed erectile dysfunction. The Kaplan–Meier analysis showed that the PTSD cohort had a significantly higher risk of erectile dysfunction (log-rank, p < 0.001). The Cox regression analysis revealed that the study subjects were more likely to develop an injury (hazard ratio: 12.898, 95% confidence intervals = 2.453–67.811, p = 0.003) after adjusting for age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications used by the patients with PTSD were not associated with the risk of erectile dysfunction. Conclusions Patients who suffered from PTSD had a higher risk of developing erectile dysfunction.

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Cognitive enhancers associated with decreased risk of injury in patients with dementia: a nationwide cohort study in Taiwan

Journal of Investigative Medicine ◽

10.1136/jim-2017-000595 ◽

2017 ◽

Vol 66 (3) ◽

pp. 684-692 ◽

Cited By ~ 8

Author(s):

Pei-Chun Chao ◽

Wu-Chien Chien ◽

Chi-Hsiang Chung ◽

Ching-Wen Chu ◽

Chin-Bin Yeh ◽

...

Keyword(s):

Cohort Study ◽

Cox Regression ◽

Geographic Region ◽

Cox Proportional Hazards ◽

Psychotropic Medications ◽

Control Group ◽

Research Database ◽

Cognitive Enhancers ◽

Cox Regression Analysis ◽

Risk Of Injury

This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144 008 enrolled patients ≥age of 50, with 36 002 study subjects who suffered from dementia and 108 006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000–2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification. When adjusting for the confounding factors, a Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up. Of the study subjects, 6701 (18.61%) suffered injury when compared with 20 919 (19.37%) in the control group. The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 2.294, 95% CI=2.229 to 2.361, P<0.001) after adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the subjects with dementia were associated with the risk of injury (adjusted HR=0.217, 95% CI: 0.206 to 0.228, P<0.001). Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, were associated with the risk of injury in the study subjects after being adjusted for all comorbidities and medications (adjusted HR=0.712(95% CI=0.512 to 0.925, P<0.01)). In conclusion, patients who suffered dementia had a higher risk of developing injury, and the cognitive enhancers were associated with the decreased risk of injury.

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New Opioid and Benzodiazepine Co-Prescribing and Mortality Among Veteran Affairs Patients with Posttraumatic Stress Disorder: A Retrospective Cohort Study

SSRN Electronic Journal ◽

10.2139/ssrn.3235664 ◽

2018 ◽

Author(s):

Eric J. Hawkins ◽

Simon Goldberg ◽

Carol A. Malte ◽

Andrew J. Saxon

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Posttraumatic Stress ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Stress Disorder ◽

Veteran Affairs

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Differential predictors of birth-related posttraumatic stress disorder symptoms in mothers and fathers – a longitudinal cohort study

Journal of Affective Disorders ◽

10.1016/j.jad.2021.05.058 ◽

2021 ◽

Author(s):

Victoria Kress ◽

Tilmann von Soest ◽

Marie Kopp ◽

Pauline Wimberger ◽

Susan Garthus-Niegel

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Posttraumatic Stress ◽

Stress Disorder ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort ◽

Mothers And Fathers ◽

Posttraumatic Stress Disorder Symptoms

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Impact of peritraumatic distress on posttraumatic stress disorder symptoms at 6 months after acute coronary syndrome: a prospective cohort study

European Journal of Psychotraumatology ◽

10.1080/20008198.2020.1854511 ◽

2021 ◽

Vol 12 (1) ◽

pp. 1854511

Author(s):

Tomomi Narisawa ◽

Daisuke Nishi ◽

Ryo Okubo ◽

Hiroko Noguchi ◽

Kei Hamazaki ◽

...

Keyword(s):

Posttraumatic Stress Disorder ◽

Acute Coronary Syndrome ◽

Cohort Study ◽

Posttraumatic Stress ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Stress Disorder ◽

Coronary Syndrome ◽

Posttraumatic Stress Disorder Symptoms ◽

Peritraumatic Distress

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Posttraumatic stress disorder in partners following severe postpartum haemorrhage: A prospective cohort study

Women and Birth ◽

10.1016/j.wombi.2019.06.016 ◽

2020 ◽

Vol 33 (4) ◽

pp. 360-366 ◽

Cited By ~ 1

Author(s):

Minouk E. van Steijn ◽

Karel W.F. Scheepstra ◽

Tjitske R. Zaat ◽

Joris A.M. van der Post ◽

Miranda Olff ◽

...

Keyword(s):

Posttraumatic Stress Disorder ◽

Cohort Study ◽

Posttraumatic Stress ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Postpartum Haemorrhage ◽

Stress Disorder

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Standard EMDR Protocol for Alcohol and Substance Dependence Comorbid With Posttraumatic Stress Disorder: Four Cases With 12-Month Follow-Up

Journal of EMDR Practice and Research ◽

10.1891/1933-3196.10.1.33 ◽

2016 ◽

Vol 10 (1) ◽

pp. 33-46 ◽

Cited By ~ 9

Author(s):

Claire Kullack ◽

Jonathan Laugharne

Keyword(s):

Posttraumatic Stress Disorder ◽

Substance Use ◽

Alcohol Dependence ◽

Posttraumatic Stress ◽

Substance Use Disorders ◽

Substance Dependence ◽

Stress Disorder ◽

Case Series ◽

Post Traumatic Stress

This report begins with a summary of the literature regarding the theoretical models behind the comorbid relationship between posttraumatic stress disorder and substance use disorders and the various modified addiction protocols formulated to assist in treating these disorders. This case series outlines the effect that the standard eye movement desensitization and reprocessing (EMDR) protocol had on alcohol and substance dependence for 4 patients who attended our Post Traumatic Stress Clinic in Fremantle, Western Australia, primarily for treatment for posttraumatic stress disorder. Patients were assessed for substance use disorders using the Mini International Neuropsychiatric Interview Plus prior to, immediately after, and 12 months after completing EMDR therapy. Results indicate that the standard EMDR protocol was successful in reducing alcohol and substance use. Prior to treatment, 3 patients met criteria for alcohol dependence and 1 met criteria for substance dependence. At 12-month follow-up, 3 out of 4 clients did not meet the diagnostic criteria for current alcohol dependence or current substance dependence. The implications of these findings are discussed with reference to theories of comorbid posttraumatic stress disorder and substance use disorder and the modified EMDR protocols developed for patients with substance dependence.

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Do Children With Constipation Have Increased Risk of Asthma? Real-World Data From a Nationwide Population-Based Cohort Study

Frontiers in Pediatrics ◽

10.3389/fped.2021.714406 ◽

2021 ◽

Vol 9 ◽

Author(s):

Yen-Chu Huang ◽

Meng-Che Wu ◽

Yu-Hsun Wang ◽

James Cheng-Chung Wei

Keyword(s):

Cohort Study ◽

Cox Regression ◽

Population Based ◽

Hazard Ratio ◽

Adjusted Hazard Ratio ◽

Research Database ◽

Real World Data ◽

Childhood Disorders ◽

Cox Regression Analysis ◽

Increased Risk

Background: Asthma is one of the most burdensome childhood disorders. Growing evidence disclose intestinal dysbiosis may contribute to asthma via the gut-lung axis. Constipation can lead to alteration of the gut microbiota. The clinical impact of constipation on asthma has not been researched. Therefore, we aim to assess whether pediatric constipation influence the risk of developing asthma by a nationwide population-based cohort study.Methods: We analyzed 10,363 constipated patients and 10,363 individuals without constipation between 1999 and 2013 from Taiwan's National Health Insurance Research Database. Analysis of propensity score was utilized to match age, sex, comorbidities, and medications at a ratio of 1:1. In addition, multiple Cox regression analysis was performed to evaluate the adjusted hazard ratio of asthma. Furthermore, sensitivity tests and a stratified analysis were performed.Results: After adjustment for age, sex, comorbidities, and medications, constipated patients had a 2.36-fold greater risk of asthma compared to those without constipation [adjusted hazard ratio (aHR): 2.36, 95% C.I. 2.04–2.73, p < 0.001]. Furthermore, the severity of constipation is associated with an increased risk of asthma; the adjusted hazard ratio was 2.25, 2.85, and 3.44 within < 3, 3–12, and ≥12 times of laxatives prescription within 1 year, respectively (p < 0.001).Conclusion: Constipation was correlated with a significantly increased risk of asthma. Pediatricians should be aware of the possibility of asthma in constipated patients. Further research is warranted to investigate the possible pathological mechanisms of this association.

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