scholarly journals Secretory carcinoma of the breast with multiple distant metastases in the brain and unfavorable prognosis: a case report and literature review

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hongping Tang ◽  
Lihua Zhong ◽  
Hongbing Jiang ◽  
Yan Zhang ◽  
Guannan Liang ◽  
...  
Keyword(s):  
Case Report ◽  
Neoadjuvant Chemotherapy ◽  
Distant Metastases ◽  
Left Breast ◽  
Unfavorable Outcome ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast ◽  
Favorable Prognosis ◽  
Mri Scans ◽  
The Brain

Abstract Background Secretory carcinoma of the breast is one of the rarest entities, accounting for less than 0.15 % of all infiltrating breast carcinomas. It has characteristic histopathological and molecular features and, in general, a more favorable prognosis. In this case report, we describe a local, advanced secretory carcinoma of the breast with aggressive course and an unfavorable outcome. Case presentation A hard, painless, and palpably bossed mass approximately 12.0 cm in diameter occupied most of the left breast of a 39-year-old woman with fixation to the overlying skin. Breast ultrasonography and magnetic resonance imaging (MRI) scans gave the same grading as BI-RADS IV. A needle biopsy was performed, and the pathological diagnosis was secretory carcinoma. Neoadjuvant chemotherapy (NAC) was then performed, after which ultrasonography and MRI scans revealed chemo-resistance of the tumor to NAC. Left breast mastectomy and axillary lymphadenectomy were subsequently performed. Tumor cells were triple-negative and positive for S-100 and periodic acid-Schiff (PAS) staining. Fluorescence in-situ hybridization (FISH) analysis indicated a fusion arrangement of the ETV6-NTRK3 gene. The patient developed multiple distant metastases in the brain and died of these metastases 19 months after initial diagnosis. Conclusions Secretory carcinomas of the breast have been described as a low-grade histologic subtype with a favorable prognosis. This case showed chemo-resistance to neoadjuvant chemotherapy, multiple distant metastases, and a final unfavorable outcome. Further research is needed to better understand the behavior and treatment of this rare tumor.

scholarly journals Secretory Carcinoma of the Breast With Multiple Distant Metastases in Brain and Unfavorable Prognosis: a Case Report and Literature Review

2021 ◽  
Author(s):  
Hongping Tang ◽  
Lihua Zhong ◽  
Hongbing Jiang ◽  
Gui’e Xie
Keyword(s):  
Case Report ◽  
Neoadjuvant Chemotherapy ◽  
Distant Metastases ◽  
Left Breast ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mri Scan ◽  
Carcinoma Of The Breast ◽  
Favorable Prognosis ◽  
Axillary Lymphadenectomy

Abstract Background: Secretory carcinoma of the breast is one of the rarest entities accounting for less than 0.15% of all infiltrating breast carcinomas. It has characteristic histopathological and molecular features and more favorable prognosis. In this case report, we describe a local advanced secretory carcinoma of the breast with chemo-resisted for neoadjuvant chemotherapy and unfavorable prognosis.Case Presentation: A hard, painless and palpably bossed mass about 12 cm in diameter occupied most of the left breast of a 39-year-old woman and fixation to the overlying skin. Breast ultrasonography and magnetic resonance imaging (MRI) scan gave the same grading as BI-RADS IV. A needle biopsy was performed and pathological diagnosis was secretory carcinoma. Neoadjuvant chemotherapy (NAC) was then performed, after which ultrasonography and MRI scan revealed the tumor was partial response for EC therapy while progressive disease after the DC therapy. The tumor showed chemo-resisted for neoadjuvant chemotherapy. Left breast mastectomy and axillary lymphadenectomy were subsequently performed. Tumor cells were triple-negative and positive for S-100 and periodic acid-Schiff (PAS) staining. Fluorescence in-situ hybridization (FISH) analysis indicated the fusion arrangement of ETV6-NTRK3 gene. The patient underwent multiple distant metastases in brain, and died of these metastases 19 months after initial diagnosis.Conclusion: Secretory carcinomas of breast have been described as a low-grade histologic subtype with a favorable prognosis. This case showed chemo-resisted for neoadjuvant chemotherapy, multiple distant metastases, and final an unfavorable prognosis. Further research is needed to better understanding of its behavior and treatment of this rare tumor.

scholarly journals Secretory carcinoma of the breast: A case report

2019 ◽  
Vol 56 ◽  
pp. 74-77
Author(s):  
Kamil Pohlodek ◽  
Iveta Mečiarová ◽  
Petr Grossmann ◽  
Petr Martínek ◽  
Zdeněk Kinkor
Keyword(s):  
Case Report ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals Secretory Carcinoma in a 79- Year-Old Woman: An Exceptionally Rare Type of Breast Carcinoma

Rare Tumors ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 188-190 ◽  
Author(s):  
Nelson Montalvo ◽  
Veronica Posso ◽  
Ligia Redrobán
Keyword(s):  
Breast Carcinoma ◽  
Distant Metastases ◽  
The Elderly ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Secretory Carcinoma ◽  
Rare Type ◽  
Favorable Prognosis ◽  
Palpable Breast ◽  
Disease Free

Secretory breast carcinoma is an exceptionally rare mammary gland neoplasia described mainly in adult females and children of both sexes, and very rarely in the elderly. It has particular histopathological and immunohistochemical features and a favorable prognosis. We report the case of a 79-year-old Hispanic woman with a palpable breast mass. Currently, the patient is disease free after a followup period of 6 years without local recurrence or axillary lymph-nodes nor distant metastases.

scholarly journals Secretory carcinoma of the breast: A case report and literature review

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Yi-Chen Lai ◽  
I-Kai Wu ◽  
Hong-Jen Chiou ◽  
Chih-Yi Hsu
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals Histological surprise, mammary analogue secretory carcinoma of parotid gland

2021 ◽  
Vol 8 (12) ◽  
pp. 3731
Author(s):  
Iram T. Pasha ◽  
Akhila K. ◽  
Ravikumar V. ◽  
Sandeep Kumar
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast ◽  
Mammary Analogue Secretory Carcinoma ◽  
Male Preponderance ◽  
Slow Growing

A recent described entity, mammary analogue secretary carcinoma (MASC) in 2010 by Skalova et al whose morphological and immunohistochemical features are similar in secretory carcinoma of the breast and salivary gland. This is a low-grade carcinoma which presents as a firm, slow-growing, circumscribed lesion with male preponderance. We present a case report of MASC.

scholarly journals Myoepithelial Carcinoma of the Breast Treated with Surgery and Chemotherapy

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Yumi Endo ◽  
Hiroshi Sugiura ◽  
Hiroko Yamashita ◽  
Satoru Takahashi ◽  
Nobuyasu Yoshimoto ◽  
...  
Keyword(s):  
Adjuvant Radiotherapy ◽  
Distant Metastases ◽  
Breast Conserving Surgery ◽  
Left Breast ◽  
Biological Behavior ◽  
Myoepithelial Carcinoma ◽  
Rare Tumor ◽  
Carcinoma Of The Breast ◽  
Node Metastasis ◽  
Parasternal Lymph Node

Myoepithelial carcinoma (malignant myoepithelioma) of the breast is a rare tumor, for which only a limited number of reports have been published. Most of the reports emphasized diagnosis and pathology but not biological behavior and treatment. We report a 61-year-old patient with breast myoepithelial carcinoma who developed locoregional and distant metastases and received many chemotherapy regimens. She presented with an elastic hard mass of the left breast. Breast conserving surgery was performed as part of both diagnosis and treatment. From the results of histological and immunohistochemical examinations, this case was considered to be a myoepithelial carcinoma. Fifteen months after the completion of adjuvant radiotherapy, distant metastasis of the left parasternal lymph node metastasis developed. She was treated by further excision and received a total of four regimens of chemotherapy including a combination of doxorubicin and cyclophosphamide. She received chemotherapy for 20 months after the diagnosis of metastasis.

scholarly journals Anizocoria – a diagnostic challenge. Case report

2019 ◽  
Author(s):  
Marta Sophie S Stęga ◽  
Wojciech Choiński ◽  
Michał Puliński
Keyword(s):  
Case Report ◽  
Family Doctor ◽  
Unknown Origin ◽  
Final Diagnosis ◽  
Cystic Lesions ◽  
Diagnostic Challenge ◽  
Neoplastic Tissue ◽  
Diagnostic Difficulties ◽  
Mri Scans ◽  
The Brain

ntroduction Anisocoria is a condition characterized by unequal pupils. There are two described types: physiologic and pathologic. Pathologic anisocoria is caused by interruption in reflex arc. Reason of anisocoria can be difficult to define due to variety of possible diseases that may be causing it. Aim Case presentation of anisocoria caused by congenital cystic lesions of the brain. Case Study 12-year-old girl after head trauma was admitted to the Emergency Department due to anisocoria noticed by family doctor. Patient had headache, sleepiness, dizziness and lacrimation. After looking at patients’ childhood photo it was stated, that anisocoria was present before the injury. In physical examination decreased mobility of left eyeball, left-sided ptosis and left-sided decreased reaction to the light (both, direct and consensual) were noted. Head CT scan was performed, which revealed bilateral cystic lesions in basal ganglia, thalamus and in mesencephalon. The biggest lesions were located in left thalamus – 29x15mm. Biopsy of the biggest cyst was performed. No neoplastic tissue was found. Final diagnosis was stated: diencephalic and mesencephalic polycyclic lesions of unknown origin. Surgical approach was departed and conservative treatment was applied (regular head MRI scans) Results and discussion Described case report was an example of diagnostic difficulties which can be caused by anisocoria. In this case pathologic anisocoria was caused by congenital cystic lesions of the brain that were detected in the age of 12. Conclusions Anisocoria can be a sign of many different pathologies, but also can be physiologic. If pathologic anisocoria is suspected, imaging diagnostics should always be performed.

PR49 Secretory carcinoma of the breast – case report

The Breast ◽  
2014 ◽  
Vol 23 ◽  
pp. S18
Author(s):  
C. Alzamora ◽  
C. Meireles ◽  
C. Ferreira ◽  
M. Ferreira ◽  
F. Sousa ◽  
...  
Keyword(s):  
Case Report ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast

scholarly journals Achievement of Three Year Remission with Bevacizumab and Irinotecan in Recurrent Glioblastoma Multiforme: A case Report

2011 ◽  
Vol 5 ◽  
pp. CMO.S6525 ◽  
Author(s):  
Abhirami Vivekanandarajah ◽  
Balakumar Krishnarasa ◽  
Mervat Mourad ◽  
Nelly Aoun ◽  
Marcel Odaimi
Keyword(s):  
Case Report ◽  
Glioblastoma Multiforme ◽  
Adjuvant Chemotherapy ◽  
Recurrent Glioblastoma ◽  
Recurrent Glioblastoma Multiforme ◽  
Mri Scans ◽  
The Brain

A 34-year-old man presented to the hospital with right-sided headache. He was diagnosed with GBM. He underwent resection of the tumor with placement of carmustine impregnated wafers. Then he underwent adjuvant chemotherapy with temozolamide. Before the completion of chemotherapy he had a recurrence. He underwent re-resection with placement of carmustine impregnated wafers. Subsequently he had eighteen cycles of salvage biochemotherapy with bevacizumab and irinotecan. To date, routine MRI scans of the brain have not shown evidence of recurrence. He continues to be in remission three years after treatment with bevacizumab and irinotecan.

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