scholarly journals Assessing the validity and reliability of the Turkish versions of craving beliefs and beliefs about substance use questionnaire in patients with heroin use disorder: demonstrating valid tools to assess cognition-emotion interplay

Author(s):  
Melike Küçükkarapınar ◽  
Hale Yapici Eser ◽  
Vahap Ozan Kotan ◽  
Merve Yalcinay-Inan ◽  
Rifat Tarhan ◽  
...  
2014 ◽  
Vol 55 (5) ◽  
pp. 1244-1251 ◽  
Author(s):  
Liliana Dell’Osso ◽  
Fabio Rugani ◽  
Angelo Giovanni Icro Maremmani ◽  
Sara Bertoni ◽  
Pier Paolo Pani ◽  
...  

2014 ◽  
Vol 20 (3) ◽  
pp. 6 ◽  
Author(s):  
Lisa Dannatt ◽  
Karen Jacqueline Cloete ◽  
Martin Kidd ◽  
Lize Weich

<p><strong>Background</strong>. There is a lack of studies addressing the frequency and correlates of comorbidities among heroin users admitted for treatment in South Africa (SA). Objective. To assess the frequency and correlates of psychiatric comorbidity among patients with heroin use disorder admitted to the Opioid Detoxification Unit at Stikland Hospital in the Western Cape, SA.</p><p><strong>Method.</strong> Participants (<em>N</em>=141) were assessed for psychiatric illness (Mini International Neuropsychiatric Interview), comorbid substance use disorders (World Health Organization’s Alcohol Smoking Substance Involvement Screening Tool), and legal and social problems (Maudsley Addiction Profile). Demographic, personal, psychiatric and substance-use history, in addition to mental state examination on admission, were collected from the case notes.</p><p><strong>Results.</strong> The largest group of patients (<em>n</em>=56, 40%) had not been abstinent from heroin use since drug debut, and most had been arrested for drug-related activities (<em>n</em>=117, 83%) and had family conflicts related to use <em>(n</em>=135, 96%). Nicotine was the most common comorbid substance of dependence (<em>n</em>=137, 97%) and methamphetamine was the most common comorbid substance abused (<em>n</em>=73, 52%). The most common comorbid psychiatric illness was previous substance-induced psychosis (<em>n</em>=42, 30%) and current major depressive disorder (<em>n</em>=37, 26%). Current major depressive disorder was significantly associated with females (p=0.03), intravenous drug use (<em>p</em>=0.03), alcohol use (<em>p</em>=0.02), and a higher number of previous rehabilitation attempts (<em>p</em>=0.008).</p><p><strong>Conclusion.</strong> Patients with heroin use disorders present with high rates of psychiatric comorbidities, which underscores the need for substance treatment services with the capacity to diagnose and manage these comorbidities.</p>


2020 ◽  
Vol 19 (3) ◽  
pp. 161-173
Author(s):  
Icro Maremmani ◽  
Maria T. Avella ◽  
Martina Novi ◽  
Silvia Bacciardi ◽  
Angelo G.I. Maremmani

2018 ◽  
Vol 09 (06) ◽  
Author(s):  
Hung-Chi Wu ◽  
Meng-Chang Tsai ◽  
Jui-Kang Tsai ◽  
Cheng-Fang Yen ◽  
Weilun Chung

2021 ◽  
Vol 12 ◽  
Author(s):  
Haixiong Liu ◽  
Wenjin Xu ◽  
Jiying Feng ◽  
Hong Ma ◽  
Jianbin Zhang ◽  
...  

Heroin use disorder is a chronic and relapsing disease that induces persistent changes in the brain. The diagnoses of heroin use disorders are mainly based on subjective reports and no valid biomarkers available. Recent researches have revealed that circulating miRNAs are useful non-invasive biomarkers for diagnosing brain diseases such as Alzheimer's disease, multiple sclerosis, schizophrenia, and bipolar disorder. However, studies on circulating miRNAs for the diagnosis of heroin use disorders are rarely reported. In this study, we investigated the differential expression of plasma miRNAs in 57 heroin-dependent patients. Based on literature research and microarray analysis, two candidate miRNAs, miR-320a and let-7b-5p, were selected and analyzed by quantitative real-time RT-PCR. The results showed miR-320a and let-7b were significantly upregulated in plasma of the heroin-dependent patients compared to that in healthy controls. The area under curves (AUCs) of receiver operating characteristic (ROC) curves of miR-320a and let-7b-5p were 0.748 and 0.758, respectively. The sensitivities of miR-320a and let-7b-5p were 71.9 and 70.2%, while the specificities of miR-320a and let-7b-5p were 76.1 and 78.3%, respectively. The combination of these two miRNAs predicted heron dependence with an AUC of 0.782 (95% CI 0.687–0.876), with 73.7% sensitivity and 82.6% specificity. Our findings suggest a potential use for circulating miRNAs as biomarkers for the diagnosis of heroin abuse.


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