scholarly journals MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hao Jia ◽  
Le Kang ◽  
Zhen Ma ◽  
Shuyang Lu ◽  
Ben Huang ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Potential Role ◽  
Surgical Intervention ◽  
Vascular Events ◽  
Aortic Valves ◽  
Key Points ◽  
Bicuspid Aortic Valves

AbstractThe incidence of bicuspid aortic valves (BAV) is high in the whole population, BAV-related thoracic aortic aneurysm (TAA) is accompanied by many adverse vascular events. So far, there are two key points in dealing with BAV-related TAA. First is fully understanding on its pathogenesis. Second is optimizing surgical intervention time. This review aims to illustrate the potential role of miRNAs in both aspects, that is, how miRNAs are involved in the occurrence and progression of BAV-related TAA, and the feasibilities of miRNAs as biomarkers.

THORACIC AORTIC ANEURYSM GROWTH IN PATIENTS WITH BICUSPID AORTIC VALVES: ROLE OF AORTIC STIFFNESS AND PULSATILE HEMODYNAMICS

2018 ◽  
Vol 34 (10) ◽  
pp. S120
Author(s):  
J. Rooprai ◽  
M. Boodhwani ◽  
L. Beauchesne ◽  
K. Chan ◽  
C. Dennie ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Stiffness ◽  
Thoracic Aortic Aneurysm ◽  
Aortic Valves ◽  
Bicuspid Aortic Valves ◽  
Aneurysm Growth

Potential role of multiple mutations altering thoracic aortic aneurysm formation

2015 ◽  
Vol 24 ◽  
pp. S403-S404
Author(s):  
E. Robertson ◽  
Y. Lu ◽  
M. Kekic ◽  
B. Hambly ◽  
R. Jeremy
Keyword(s):  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Potential Role ◽  
Aneurysm Formation

Epigenetic Profiling Identifies Novel Genes for Ascending Aortic Aneurysm Formation with Bicuspid Aortic Valves

2015 ◽  
Vol 18 (4) ◽  
pp. 134 ◽  
Author(s):  
Asad A Shah
Keyword(s):  
Gene Expression ◽  
Aortic Aneurysm ◽  
Methylation Status ◽  
Aortic Aneurysms ◽  
Aortic Valves ◽  
Ascending Aortic Aneurysm ◽  
Novel Genes ◽  
Aneurysm Formation ◽  
Aortic Replacement ◽  
Bicuspid Aortic Valves

<p><strong>Background:  </strong>Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized.  We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patients.</p><p><strong>Methods:  </strong>Ascending aortic aneurysm tissue samples were collected at the time of aortic replacement in subjects with bicuspid and trileaflet aortic valves.  Genome-wide DNA methylation status was determined on DNA from tissue using the Illumina 450K methylation chip, and gene expression was profiled on the same samples using Illumina Whole-Genome DASL arrays.  Gene methylation and expression were compared between bicuspid and trileaflet individuals using an unadjusted Wilcoxon rank sum test.  </p><p><strong>Results:  </strong>Twenty-seven probes in 9 genes showed significant differential methylation and expression (P&lt;5.5x10<sup>-4</sup>).  The top gene was protein tyrosine phosphatase, non-receptor type 22 (<em>PTPN22</em>), which was hypermethylated (delta beta range: +15.4 to +16.0%) and underexpressed (log 2 gene expression intensity: bicuspid 5.1 vs. trileaflet 7.9, P=2x10<sup>-5</sup>) in bicuspid patients, as compared to tricuspid patients.  Numerous genes involved in cardiovascular development were also differentially methylated, but not differentially expressed, including <em>ACTA2</em> (4 probes, delta beta range:  -10.0 to -22.9%), which when mutated causes the syndrome of familial thoracic aortic aneurysms and dissections</p><p><strong>Conclusions:  </strong>Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending aortic aneurysms in patients with bicuspid aortic valves, modulated through epigenetic mechanisms.  The top gene was <em>PTPN22</em>, which is involved in T-cell receptor signaling and associated with various immune disorders.  These differences highlight novel potential mechanisms of aneurysm development in the bicuspid population.</p>

scholarly journals Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2019 Update and Clinical Implications

Aorta ◽  
2019 ◽  
Vol 07 (04) ◽  
pp. 099-107 ◽  
Author(s):  
Thais Faggion Vinholo ◽  
Adam J. Brownstein ◽  
Bulat A. Ziganshin ◽  
Mohammad A. Zafar ◽  
Helena Kuivaniemi ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Natural History ◽  
Molecular Genetics ◽  
Thoracic Aortic Aneurysm ◽  
Surgical Intervention ◽  
Pathogenic Mutation ◽  
Clinical Implications ◽  
Aortic Aneurysm And Dissection

AbstractThoracic aortic aneurysm is a typically silent disease characterized by a lethal natural history. Since the discovery of the familial nature of thoracic aortic aneurysm and dissection (TAAD) almost 2 decades ago, our understanding of the genetics of this disorder has undergone a transformative amplification. To date, at least 37 TAAD-causing genes have been identified and an estimated 30% of the patients with familial nonsyndromic TAAD harbor a pathogenic mutation in one of these genes. In this review, we present our yearly update summarizing the genes associated with TAAD and the ensuing clinical implications for surgical intervention. Molecular genetics will continue to bolster this burgeoning catalog of culprit genes, enabling the provision of personalized aortic care.

scholarly journals DIFFERENTIAL EXPRESSION OF NOX2 AND NOX4 IN THORACIC AORTIC ANEURYSM TISSUE FROM PATIENTS WITH BICUSPID OR TRICUSPID AORTIC VALVES

2016 ◽  
Vol 67 (13) ◽  
pp. 2295
Author(s):  
Aiham Jbeli ◽  
Michael Hagler ◽  
Carolyn Roos ◽  
Thoralf Sundt ◽  
Jordan Miller
Keyword(s):  
Aortic Aneurysm ◽  
Differential Expression ◽  
Thoracic Aortic Aneurysm ◽  
Aortic Valves
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