A summary of molecular genetic findings in fructose-1,6-bisphosphatase deficiency with a focus on a common long-range deletion and the role of MLPA analysis

The author compares several quantitative and qualitative approaches to forecasting to find appropriate methods to incorporate technological change in long-range forecasts of the world economy. A?number of long-run forecasts (with horizons over 10 years) for the world economy and national economies is reviewed to outline advantages and drawbacks for different ways to account for technological change. Various approaches based on their sensitivity to data quality and robustness to model misspecifications are compared and recommendations are offered on the choice of appropriate technique in long-run forecasts of the world economy in the presence of technological change.

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From the clinic to the research laboratory. The role of the clinician in molecular genetic studies

Archives of Dermatology ◽

10.1001/archderm.129.11.1424 ◽

1993 ◽

Vol 129 (11) ◽

pp. 1424-1429

Author(s):

S. E. Palmer

Keyword(s):

Research Laboratory ◽

Molecular Genetic ◽

Genetic Studies

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Epigenetic factors and molecular markers of the risk of early pregnancy losses

GYNECOLOGY ◽

10.26442/20795696.2019.4.190523 ◽

2019 ◽

Vol 21 (3) ◽

pp. 9-16

Author(s):

Nataly I Frolova ◽

Tatiana E Belokrinitskaya

Keyword(s):

Early Pregnancy ◽

Genetic Factors ◽

Molecular Genetic ◽

Pregnancy Complication ◽

Common Complication ◽

Epigenetic Factors ◽

Genetic Determination ◽

Periconceptional Period ◽

Combined Impact

Background. Miscarriage is a common complication in early pregnancy. Current studies have shown a higher prevalence of miscarriage, ranging from 10 to 20%. The review is devoted to modern concepts of etiology and pathogenesis of early pregnancy losses. Aim. Assess the role of epigenetic factors and molecular-genetic markers in the pathogenesis and prediction of early pregnancy losses Materials and methods. In order to write this review domestic and foreign publications were searched in Russian and international search systems (PubMed, eLibrary, etc.) for the last 10-15 years. Relevant articles from the peer-reviewed literature and clinical practice guidelines were included. Results. Many recent studies have proved the contribution of various epigenetic factors to the pathogenesis of spontaneous miscarriages, and the molecular-genetic determination such kinds of pregnancy complication has been confirmed. Conclusion. The miscarriage in early gestation is driven by combined impact of epigenetic and molecular-genetic factors, as well as the presence of intergenic interactions. It is may lead to deterioration of physiological functions, and maternal pathologenic pathways could be changed as during her periconceptional period as so during the pregnancy.

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Editorial. Considering the role of surgery for low-grade glioma in the molecular genetic era

Journal of Neurosurgery ◽

10.3171/2019.7.jns191747 ◽

2020 ◽

Vol 133 (5) ◽

pp. 1288-1290

Author(s):

Michael A. Vogelbaum

Keyword(s):

Molecular Genetic ◽

Low Grade Glioma ◽

Low Grade

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Faculty Opinions recommendation of Evidence for a role of vertebrate Disp1 in long-range Shh signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1362956.834054 ◽

2009 ◽

Author(s):

James Briscoe

Keyword(s):

Long Range ◽

Shh Signaling

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Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS

Molecules ◽

10.3390/molecules26092431 ◽

2021 ◽

Vol 26 (9) ◽

pp. 2431

Author(s):

Natalia A. Shnayder ◽

Marina M. Petrova ◽

Tatiana E. Popova ◽

Tatiana K. Davidova ◽

Olga P. Bobrova ◽

...

Keyword(s):

Chronic Pain ◽

Molecular Genetic ◽

Pain Syndrome ◽

Medical Problem ◽

Single Nucleotide Variants ◽

Genetic Studies ◽

Pain Syndromes ◽

Nos Inhibitors ◽

Peripheral Pain

Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic pain in adults. Standard approaches to the treatment of them do not solve the problem of pain chronicity. This is the reason for the search for new personalized strategies for the prevention and treatment of chronic pain. The nitric oxide (NO) system can play one of the key roles in the development of peripheral pain and its chronicity. The purpose of the study is to review publications devoted to changes in the NO system in patients with peripheral chronical pain syndromes. We have carried out a search for the articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar databases. The search was carried out using keywords and their combinations. The role of NO and NO synthases (NOS) isoforms in peripheral pain development and chronicity was demonstrated primarily from animal models to humans. The most studied is the neuronal NOS (nNOS). The role of inducible NOS (iNOS) and endothelial NOS (eNOS) is still under investigation. Associative genetic studies have shown that single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes encoding nNOS, iNOS, and eNOS may be associated with acute and chronic peripheral pain. Prospects for the use of NOS inhibitors to modulate the effect of drugs used to treat peripheral pain syndrome are discussed. Associative genetic studies of SNVs NOS1, NOS2, and NOS3 genes are important for understanding genetic predictors of peripheral pain chronicity and development of new personalized pharmacotherapy strategies.

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The distribution of myosin II in Dictyostelium discoideum slug cells.

The Journal of Cell Biology ◽

10.1083/jcb.115.5.1267 ◽

1991 ◽

Vol 115 (5) ◽

pp. 1267-1274 ◽

Cited By ~ 12

Author(s):

S Eliott ◽

P H Vardy ◽

K L Williams

Keyword(s):

Cell Motility ◽

Dictyostelium Discoideum ◽

Immunofluorescence Microscopy ◽

Molecular Genetic ◽

Myosin Ii ◽

Three Dimensional ◽

Homogeneous Distribution ◽

Multicellular Development ◽

Insight Into

While the role of myosin II in muscle contraction has been well characterized, less is known about the role of myosin II in non-muscle cells. Recent molecular genetic experiments on Dictyostelium discoideum show that myosin II is necessary for cytokinesis and multicellular development. Here we use immunofluorescence microscopy with monoclonal and polyclonal antimyosin antibodies to visualize myosin II in cells of the multicellular D. discoideum slug. A subpopulation of peripheral and anterior cells label brightly with antimyosin II antibodies, and many of these cells display a polarized intracellular distribution of myosin II. Other cells in the slug label less brightly and their cytoplasm displays a more homogeneous distribution of myosin II. These results provide insight into cell motility within a three-dimensional tissue and they are discussed in relation to the possible roles of myosin II in multicellular development.

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