scholarly journals Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Isabel Ellerbrock ◽  
Angelica Sandström ◽  
Jeanette Tour ◽  
Silvia Fanton ◽  
Diana Kadetoff ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Gene Interaction ◽  
Pain Modulation ◽  
Anterior Cingulate ◽  
Healthy Controls ◽  
Inhibitory Effects ◽  
Affective Characteristics ◽  
Endogenous Pain Modulation ◽  
Rostral Anterior Cingulate Cortex ◽  
Cerebral Processing

AbstractThe neurotransmitter serotonin, involved in the regulation of pain and emotion, is critically regulated by the 5‐HT1A autoreceptor and the serotonin transporter (5-HTT). Polymorphisms of these genes affect mood and endogenous pain modulation, both demonstrated to be altered in fibromyalgia subjects (FMS). Here, we tested the effects of genetic variants of the 5‐HT1A receptor (CC/G-carriers) and 5-HTT (high/intermediate/low expression) on mood, pain sensitivity, cerebral processing of evoked pain (functional MRI) and concentrations of GABA and glutamate (MR spectroscopy) in rostral anterior cingulate cortex (rACC) and thalamus in FMS and healthy controls (HC). Interactions between serotonin-relevant genes were found in affective characteristics, with genetically inferred high serotonergic signalling (5-HT1A CC/5-HTThigh genotypes) being more favourable across groups. Additionally, 5‐HT1A CC homozygotes displayed higher pain thresholds than G-carriers in HC but not in FMS. Cerebral processing of evoked pressure pain differed between groups in thalamus with HC showing more deactivation than FMS, but was not influenced by serotonin-relevant genotypes. In thalamus, we observed a 5‐HT1A-by-5-HTT and group-by-5-HTT interaction in GABA concentrations, with the 5-HTT high expressing genotype differing between groups and 5‐HT1A genotypes. No significant effects were seen for glutamate or in rACC. To our knowledge, this is the first report of this serotonergic gene-to-gene interaction associated with mood, both among FMS (depression) and across groups (anxiety). Additionally, our findings provide evidence of an association between the serotonergic system and thalamic GABA concentrations, with individuals possessing genetically inferred high serotonergic signalling exhibiting the highest GABA concentrations, possibly enhancing GABAergic inhibitory effects via 5-HT.

scholarly journals Training volume is associated with pain sensitivity, but not with endogenous pain modulation, in competitive swimmers

2019 ◽  
Vol 37 ◽  
pp. 150-156 ◽  
Author(s):  
Kevin Kuppens ◽  
Stef Feijen ◽  
Nathalie Roussel ◽  
Jo Nijs ◽  
Patrick Cras ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Pain Modulation ◽  
Training Volume ◽  
Endogenous Pain Modulation ◽  
Competitive Swimmers

S1814 Aberrant Connectivity of Brain Centers During Somatic Pain and Activation of Endogenous Pain Modulation in IBS Compared to Healthy Controls

2008 ◽  
Vol 134 (4) ◽  
pp. A-275
Author(s):  
Steven Graham ◽  
Clive H. Wilder-Smith ◽  
Guanghui Song ◽  
Khay Guan Yeoh ◽  
Khek Yu Ho
Keyword(s):  
Pain Modulation ◽  
Healthy Controls ◽  
Somatic Pain ◽  
Endogenous Pain Modulation

scholarly journals Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls—antagonistic effects between opioid and serotonin-related genes

Pain ◽  
2017 ◽  
Vol 158 (7) ◽  
pp. 1194-1203 ◽  
Author(s):  
Jeanette Tour ◽  
Monika Löfgren ◽  
Kaisa Mannerkorpi ◽  
Björn Gerdle ◽  
Anette Larsson ◽  
...  
Keyword(s):  
Pain Modulation ◽  
Gene Interactions ◽  
Healthy Controls ◽  
Antagonistic Effects ◽  
Endogenous Pain Modulation

scholarly journals Alterations in the Excitatory and Inhibitory Coupling in Migraine: A Magnetic Resonance Study

2020 ◽  
Author(s):  
Yiwen Cai ◽  
Yingying Tang ◽  
Jijun Wang ◽  
Qinhui Fu ◽  
Min Hang Gan ◽  
...  
Keyword(s):  
Pain Modulation ◽  
Anterior Cingulate ◽  
Healthy Controls ◽  
Gamma Aminobutyric Acid ◽  
Excitatory Neurotransmitter ◽  
Inhibitory Neurotransmitter ◽  
Subgenual Anterior Cingulate Cortex ◽  
Inhibitory Coupling ◽  
The Right ◽  
Bilateral Thalamus

Abstract Background: There is evidence suggesting that an imbalance between the levels of the excitatory neurotransmitter, glutamate, and inhibitory neurotransmitter, gamma aminobutyric acid (GABA), leads to migraine attacks; however, the pathophysiology and specific diagnostic markers remain unknown. Methods: Twenty-one migraine patients (18 female, 3 male, mean age=40.63 14.23years) and 11 healthy controls (9 female, 2 male, mean age=39.78 15.31 years) were included in this study. We used 1H-MRS at 3 Tesla with voxels-of-interest located in the bilateral thalamus and subgenual anterior cingulate cortex (SG ACC) to quantify the GABA and GLX (glutamate-glutamine complex) concentrations measured via the Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) sequence in migraineurs and healthy controls. Result: Statistical analyses revealed significantly decreased GLX/NAA (N-acetylaspartate) in the right thalamus of migraine patients compared to healthy controls. However, we found no group differences in GABA levels in the SG ACC and bilateral thalamus.Conclusion: The right thalamus may be involved in the pain modulation process of migraineurs through changes in the GLX levels. Decreased GLX levels within the right thalamus might be associated with the disruption of "excitation-inhibition" homeostasis in migraine.Trial registration: ClinicalTrials.gov, NCT02580968. Registered 30 October 2015, https://clinicaltrials.gov/ct2/show/study/NCT02580968

scholarly journals Grey matter abnormalities in Tourette syndrome: an activation likelihood estimation meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fang Wen ◽  
Junjuan Yan ◽  
Liping Yu ◽  
Fang Wang ◽  
Jingran Liu ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Grey Matter ◽  
Meta Analysis ◽  
Likelihood Estimation ◽  
Anterior Cingulate ◽  
Precentral Gyrus ◽  
Healthy Controls ◽  
Activation Likelihood Estimation ◽  
Lentiform Nucleus ◽  
Postcentral Gyrus

Abstract Background Tourette syndrome (TS) is a neurodevelopmental disorder defined by the continual presence of primary motor and vocal tics. Grey matter abnormalities have been identified in numerous studies of TS, but conflicting results have been reported. This study was an unbiased statistical meta-analysis of published neuroimaging studies of TS structures. Methods A voxel quantitative meta-analysis technique called activation likelihood estimation (ALE) was used. The meta-analysis included six neuroimaging studies involving 247 TS patients and 236 healthy controls. A statistical threshold of p < 0.05 was established based on the false discovery rate and a cluster extent threshold of 50 voxels. Results We found that grey matter volumes were significantly increased in the bilateral thalamus, right hypothalamus, right precentral gyrus, left postcentral gyrus, left inferior parietal lobule, right lentiform nucleus, and left insula of TS patients compared to those of healthy controls. In contrast, grey matter volumes were significantly decreased in the bilateral postcentral gyrus, bilateral anterior cingulate, bilateral insula, left posterior cingulate and left postcentral gyrus of TS patients compared to those of healthy controls. Conclusions Our present meta-analysis primarily revealed significant increases in grey matter volumes in the thalamus and lentiform nucleus, and decreased grey matter volumes in the anterior cingulate gyrus, of TS patients compared to those in healthy controls. Most of these identified regions are associated with cortico-striato-thalamo-cortical circuits. Further studies with larger sample sizes are needed to confirm these changes in grey matter volumes in TS patients.

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