scholarly journals Ovarian seromucinous tumors: clinicopathological features of 10 cases with a detailed review of the literature

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Romana Idrees ◽  
Nasir Ud Din ◽  
Sabeehudin Siddique ◽  
Saira Fatima ◽  
Jamshid Abdul-Ghafar ◽  
...  
Keyword(s):  
Who Classification ◽  
Borderline Tumor ◽  
Review Of Literature ◽  
Stromal Invasion ◽  
Detailed Review ◽  
Mean Size ◽  
Ovarian Involvement ◽  
Female Genital

Abstract Background The 2014 WHO Classification of ovarian neoplasms introduced a new entity of seromucinous tumors associated with endometriosis. These tumors encompassed a spectrum from benign to malignant and included seromucinous cystadenoma/ cystadenofibroma, seromucinous borderline tumor/atypical proliferative seromucinous tumor and seromucinous carcinoma. However, the 2020 WHO Classification of Female Genital Tumours removed seromucinous carcinomas as a distinct entity and recategorized them as Endometrioid carcinomas with mucinous differentiation. Here we describe clinico-morphologic features of seromucinous tumors recategorizing cases originally diagnosed as seromucinous carcinoma in light of 2020 WHO classification and present detailed review of literature. Methods Slides of seromucinous tumors were reviewed. Special emphasis was given to evaluation of stromal invasion. Follow-up was obtained. Results Ten cases were diagnosed. Mean age was 40 years. Four cases were bilateral. Mean size was 19 cm. Grossly; luminal papillary projections were seen in 6 cases. Tumors demonstrated a papillary architecture with papillae lined by stratified seromucinous epithelium showing nuclear atypia. Stromal invasion was seen in 4 cases. Six cases were reported as borderline seromucinous tumors and 4 cases originally diagnosed as seromucinous carcinoma were recategorized as endometrioid carcinoma with mucinous differentiation on review. Endometriosis was seen in 4 cases. CK7, PAX8 and ER were positive in 7/7 cases. Two cases showed extra-ovarian involvement. Follow up was available in 7 cases. Six patients were alive and well at follow up ranging from 8 to 46 months. Six patients received chemotherapy postoperatively. One patient with carcinoma died of disease 18 months postoperatively. Conclusion In our series, 4 cases were originally diagnosed as seromucinous carcinomas. However, these were recategorized in light of the 2020 WHO Classification of Female Genital tumors as endometrioid carcinomas with mucinous differentiation. Six cases were diagnosed as seromucinous borderline tumors. Thus, majority of cases were borderline in agreement with published literature.

scholarly journals Unclassifiable Isolated Monoclonal Lymphocytosis: Comprehensive Description of a Retrospective Cohort

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1495
Author(s):  
Degaud ◽  
Baseggio ◽  
Grange ◽  
Manzoni ◽  
Huet ◽  
...  
Keyword(s):  
Who Classification ◽  
High Throughput Sequencing ◽  
Variable Region ◽  
Lymphocytic Leukemia ◽  
World Health ◽  
Trisomy 12 ◽  
Royal Marsden Hospital ◽  
Health Organization

According to the World Health Organization (WHO) classification, the nosology of B-cell neoplasms integrates clinical, morphological, phenotypic, and genetic data. In this retrospective analysis, we identified 18 patients with isolated neoplastic lymphocytosis that could not be accurately classified within the WHO classification. Most of them were asymptomatic at the time of diagnosis and the evolution was relatively indolent, as only five patients required treatment after a median follow-up of 48 months. The neoplastic B-cells expressed CD5 in most cases, but the Royal Marsden Hospital score was strictly below 3. Trisomy 12 was the most frequent cytogenetic abnormality. High-throughput sequencing highlighted mutations found in both chronic lymphocytic leukemia (CLL) and marginal zone lymphoma (MZL). Similarly, the immunoglobulin heavy chain variable region repertoire was distinct from those reported in CLL or MZL. However, as treatment choice is dependent on the correct classification of the lymphoproliferative disorder, a histological diagnosis should be performed in case patients need to be treated.

Thyroid-Like Follicular Carcinoma of the Kidney With Oncocytic Cells: A Case Report and Review of Metastatic and Non-metastatic Tumors

2020 ◽  
Vol 28 (8) ◽  
pp. 913-917
Author(s):  
Vinita Agrawal ◽  
Zafar Neyaz ◽  
Rakesh Kapoor
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Cell ◽  
Follicular Carcinoma ◽  
Clinicopathological Features ◽  
Renal Tumors ◽  
Review Of Literature ◽  
Metastatic Tumors ◽  
Histological Appearance

Thyroid-like follicular carcinoma of kidney (TLFCK) is a morphological subtype of renal cell carcinoma, which is included as an emerging/provisional entity in the classification of renal tumors, with only about 40 cases reported in literature. It has a distinct histological appearance and immunohistochemical profile as compared with other renal cell cancers. However, these tumors, while appearing distinctive, have not been characterized fully either morphologically or by ancillary techniques. The reported cases show variable demographical and clinical features. Most are indolent, while some present with metastasis. The histological, immunohistochemical, and ultrastructural features of a case of TLFCK with clusters of oncocytic cells and pseudosarcomatous stroma are presented. Follow-up of 5 years was uneventful. A review of literature to analyze features in metastatic as compared with non-metastatic TLFCK is discussed. We report a patient of TLFCK and compare the clinicopathological features of metastatic and non-metastatic tumors.

scholarly journals Crossed testicular ectopia

1995 ◽  
Vol 113 (4) ◽  
pp. 935-940 ◽  
Author(s):  
Edward Esteves ◽  
Jaques Pinus ◽  
Renato Frota de Albuquerque Maranhão ◽  
Simone de Campos Vieira Abib ◽  
José Pinus
Keyword(s):  
Inguinal Hernia ◽  
Inguinal Canal ◽  
Review Of Literature ◽  
Rare Anomaly ◽  
The Right ◽  
Testicular Ectopia ◽  
Crossed Ectopia

Crossed testicular ectopia (CTE) is a rare anomaly, characterized by migration of one testis towards the opposite inguinal canal. Presented here is a case of crossed ectopia of the right testis, treated by extraperitoneal transposition of the gonad and right orchiopexy. Embriology and surgical findings suggest that CTE is a common consequence of many unclear ethiologic factors, specially mechanical ones, and can be associated with Muller duct persistence. Review of literature suggests a classification of CTE into 3 types: I - associated with inguinal hernia alone; II - associated with persistent mullerian remnants; III - associated with other anomalies without mullerian remnants. Treatment includes transeptal orchiopexy or extraperitoneal transposition of the testis, research for mullerian remnants and other anomalies, and long term postoperative follow-up, due to the risk of becoming malignant.

scholarly journals Clinicopathological and immunohistochemical study of 29 cases of solid-pseudopapillary neoplasms of the pancreas in patients under 20 years of age along with detailed review of literature

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Nasir Ud Din ◽  
Shabina Rahim ◽  
Jamshid Abdul-Ghafar ◽  
Arsalan Ahmed ◽  
Zubair Ahmad
Keyword(s):  
Progesterone Receptor ◽  
Malignant Tumors ◽  
Age Groups ◽  
Low Grade ◽  
Beta Catenin ◽  
Review Of Literature ◽  
Detailed Review ◽  
Prognostic Features ◽  
Solid Pseudopapillary Neoplasms

Abstract Background Pancreatic Solid Pseudopapillary Neoplasms (SPNs) are rare low-grade malignant tumors with a marked preponderance for young females. Objective was to describe the morphology, differential diagnosis, and prognosis of SPNs in patients under 20 years of age and present a detailed review of literature. Methods A total of 29 cases in patients under 20 years of age reported as SPN during the period January 2014 to December 2019, were included in the study. These included 19 resection specimens, 4 incision biopsies and 6 cases received as blocks for second opinion. Hematoxylin and eosin (H&E) slides as well as immunohistochemistry (IHC) slides of all cases were retrieved and reviewed by the authors. TFE3 and Progesterone Receptor were performed retrospectively. Results Twenty-eight of the 29 patients were females. Ages of patients ranged from 12 to 19 years. Nineteen cases were resections. Tail was the commonest location. Mean tumor size was 9.5 cm. In 89.5% cases, tumor was confined to the pancreas. In 2 cases, distant metastasis was present. In 2 cases, extension beyond pancreas was seen. Solid and pseudopapillary areas were seen in all cases while other features were variable. Beta catenin and Cyclin D1 were positive in most cases while TFE3 was positive in 57% cases. Progesterone Receptor (PR) was positive in all 13 cases in which it was performed. Follow up was available in 14 patients. Follow up period ranged from 3 to 70 months. Twelve were alive and well without recurrence or metastasis while 2 were alive with recurrence and metastasis to liver and omentum respectively. Conclusions Although many studies on SPNs have been published, surgeons, oncologists and even pathologists in this part of the world are often not aware of these rare tumors leading to inaccuracies and delays in diagnosis. In addition, this paper focusses on the interesting observation that the majority of SPNs diagnosed in our department during study period occurred in patients under 20 years of age (29 versus 21 in patients over 20). However, clinico-epidemiological, morphologic and prognostic features were similar in both age groups. Possibility of SPNs should always be considered in case of pancreatic neoplasms occurring in patients under 20 years of age as well. We believe that this is a very interesting and helpful study for the clinicians as well as the pathologists.

scholarly journals 2020 WHO Classification of Female Genital Tumors

2021 ◽  
Vol 81 (10) ◽  
pp. 1145-1153
Author(s):  
Anne Kathrin Höhn ◽  
Christine E. Brambs ◽  
Grit Gesine Ruth Hiller ◽  
Doris May ◽  
Elisa Schmoeckel ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Who Classification ◽  
Surrogate Marker ◽  
Cervix Uteri ◽  
Grading System ◽  
P16 Expression ◽  
Female Genital

AbstractThe 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.

scholarly journals What’s new in gynecologic pathology 2021: ovary and fallopian tube

2021 ◽  
Vol 55 (5) ◽  
pp. 366-367
Author(s):  
Gulisa Turashvili ◽  
Ricardo Lastra
Keyword(s):  
Fallopian Tube ◽  
Who Classification ◽  
World Health ◽  
Stromal Tumors ◽  
The World ◽  
Fallopian Tube Neoplasms ◽  
Health Organization ◽  
Sex Cord Stromal Tumors ◽  
Female Genital

The 5th edition of the World Health Organization (WHO) Classification of Female Genital Tumors was published in 2020. Although the classification of ovarian and fallopian tube neoplasms is largely unchanged from the prior (4th) edition, this newsletter compiles the most important refinements in these organ sites, including serous and non-serous epithelial tumors, and sex cord-stromal tumors.

Adenoid cystic carcinoma of the female genital tract – Case series with review of literature

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S75-S75
Author(s):  
S Bhele ◽  
G Crisi ◽  
J Hunt
Keyword(s):  
High Risk ◽  
Adenoid Cystic Carcinoma ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Case Series ◽  
Review Of Literature ◽  
Adenoid Cystic ◽  
High Risk Hpv ◽  
Female Genital

Abstract Introduction/Objective Adenoid cystic carcinoma (ACC) of the female genital tract is rare and the published literature is sparse. In the vulva it is considered to arise from Bartholin’s gland whereas, in cervix it arises from the reserve cells. Although morphologically ACC of female genital tract is similar to its counterparts in salivary glands, the clinical behavior is different. Methods/Case Report We describe the clinicopathologic and immunohistochemical features of three cases of adenoid cystic carcinoma of female genital tract with review of literature. The age of our patients ranged from 48 to 75 years with tumors ranging from 1.9 to 3.9 cm. The tumor sites were vulva (2 cases) and cervix (1 case). Two of the 3 patients presented with mass lesions and one patient presented with postmenopausal bleeding. Microscopically, all tumors showed classic morphologic features with cribriform, tubular and solid patterns. On immunohistochemistry, CD117 was consistently reactive in all 3 cases. In addition, the ductal and myoepithelial cell population were highlighted by keratin cocktail and p63 respectively. P16 was diffuse and block-like positive in two cases (one vulvar and cervical ACC). High risk HPV (HPV 33) was detected in one case of vulvar ACC. Two patients underwent surgical excision while one patient was deemed unfit for surgical treatment. All 3 patients received radiation therapy. On follow- up that ranged from 17 to 76 months, one patient is alive without evidence of disease. One patient died of disease with local recurrence and lung metastasis. The other patient died of complications (radiation proctocolitis with colonic perforation). Results (if a Case Study enter NA) NA Conclusion Our cases highlight the aggressive behavior of adenoid cystic carcinoma in the female genital tract and the need for close follow-up. Also high risk HPV has been demonstrated in cervical ACC previously, but our series demonstrates high risk HPV association with vulvar ACC.

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