scholarly journals Successful outcome of disseminated Candida tropicalis osteomyelitis on remission induction for childhood Philadelphia chromosome–positive acute lymphoblastic leukaemia-case report

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Lichun Xie ◽  
Qingling Long ◽  
Guichi Zhou ◽  
Sixi Liu ◽  
Fei-Qiu Wen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Acute Lymphoblastic Leukaemia ◽  
Candida Tropicalis ◽  
Lymphoblastic Leukaemia ◽  
Philadelphia Chromosome ◽  
Remission Induction ◽  
Resonance Imaging ◽  
Successful Management ◽  
All Treatment

Abstract Background Invasive fungal infection (IFI) is one of the most challenging complications in children undergoing acute lymphoblastic leukaemia (ALL) treatment, but acute fungal osteomyelitis (OM) is rarely encountered. Case presentation Here, we describe a case of Candida tropicalis osteomyelitis in a 10-year-old patient with Philadelphia chromosome (Ph)-positive ALL. He was on remission induction therapy at the time of neutropenia, and an abscess developed in his right arm. The blood and bone cultures were positive for C. tropicalis. Antibiotics and antifungals were administered. Magnetic resonance imaging of the arm revealed an intraosseous abscess, suggestive of OM. Surgical irrigation and debridement of the bone were performed immediately. The patient was effectively treated with antifungal therapy and ALL treatment. He has fully recovered into complete clinical remission but with visible sequelae on magnetic resonance imaging (MRI). He took oral posaconazole for consolidation until disappearance of the lesion shadows on MRI and received subsequent cycles of chemotherapy in parallel. Conclusions In the successful management of Ph-positive ALL, dasatinib, a second-generation Abl-tyrosine kinase inhibitor, is crucial. The recommended treatment for Candida osteomyelitis in Ph-positive ALL patients is a fungicidal agent combined with surgery and modification chemotherapy with dasatinib. The use of combined modalities of treatment seems to be crucial in the successful management of Ph-positive ALL.

scholarly journals Successful Outcome of Disseminated Candida Tropicalis Osteomyelitis on Remission Induction for Childhood Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia - Case Report

2020 ◽  
Author(s):  
Lichun Xie ◽  
Qingling Long ◽  
Guichi Zhou ◽  
Si-xi Liu ◽  
Feiqiu Wen
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Magnetic Resonance ◽  
Candida Tropicalis ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Successful Outcome ◽  
Remission Induction ◽  
Successful Management ◽  
All Treatment

Abstract Background: Invasive fungal infection (IFI) is one of the most challenging complications in children with acute lymphoblastic leukemia (ALL) treatment, but acute fungal osteomyelitis (OM) is rarely encountered. Case presentation: Here, we describe a case of Candida tropicalis osteomyelitis in a 10-year-old patient with Philadelphia chromosome (Ph)–positive ALL. He was on remission induction therapy at the time of neutropenia, and abscess developed in the right arm. The blood and bone cultures were positive for Candida tropicalis. Antibiotics and anti-fungal were given. A magnetic resonance of the arm revealed in intraosseous abscess, suggestive of OM. Surgical irrigation and debridement of the bone were performed immediately. The patient was effectively treated with antifungal therapy and ALL treatment. Now he full recovered into complete clinical remission but with sequelae visible by Magnetic Resonance Imaging (MRI). He took oral posaconazole for consolidation until disappearance of the lesion shadows on MRI and received subsequent cycles of chemotherapy in parallel. Conclusions: In the successful management of Ph-positive ALL, dasatinib the second-generation Abl–tyrosine kinase inhibitor is crucial. The recommended treatment for candida osteomyelitis in Ph-positive ALL patients are fungicidal agent combined with surgery and modification chemotherapy with dasatinib. Using combined modalities of treatment seem to be crucial in the successful management of Ph-positive ALL.

Giant Right Ventricular Fibroma: Prenatal Diagnosis and Partial Resection in Early Infancy

2021 ◽  
pp. 215013512199269
Author(s):  
Ignacio Juaneda ◽  
Nora Bueno ◽  
Jose Ochoa ◽  
Juan Díaz ◽  
Alejandro Peirone
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Prenatal Diagnosis ◽  
Magnetic Resonance ◽  
Right Ventricular ◽  
Early Infancy ◽  
Resonance Imaging ◽  
Successful Management ◽  
Cardiac Fibroma ◽  
Hemodynamic Deterioration

Congenital cardiac fibromas are very rare and prenatal diagnosis has been reported in just a few cases. We describe a four-month-old infant presenting a symptomatic giant right ventricular fibroma discovered during prenatal scanning at 33 weeks of gestation, which was confirmed after delivery on echocardiogram and cardiac magnetic resonance imaging. Due to progressive hemodynamic deterioration, partial surgical resection was performed and the patient recovered uneventfully. We report the successful management during early infancy of a giant cardiac fibroma prenatally diagnosed.

scholarly journals Successful outcome of disseminated candida tropicalis osteomyelitis on remission induction for childhood Philadelphia chromosome–positive acute lymphoblastic leukemia

2020 ◽  
Author(s):  
Lichun Xie ◽  
Qingling Long ◽  
Guichi Zhou ◽  
Si-xi Liu ◽  
Feiqiu Wen
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Candida Tropicalis ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Successful Outcome ◽  
Remission Induction ◽  
Recommended Treatment ◽  
Fungal Osteomyelitis ◽  
The Right ◽  
All Treatment

Abstract Invasive fungal infection (IFI) is one of the most challenging complications in children with acute lymphoblastic leukemia (ALL) treatment, but acute fungal osteomyelitis (OM) is rarely encountered. Here, we describe a case of Candida tropicalis osteomyelitis in a 10-year-old patient with Philadelphia chromosome (Ph)–positive ALL. He was on remission induction therapy at the time of neutropenia, and abscess developed in the right arm. The blood and bone cultures were positive for Candida tropicalis. Antibiotics and anti-fungal were started. A magnetic resonance of the arm reveal in intraosseous abscess, suggestive of OM. Surgical irrigation and debridement of the bone were performed immediately. The patient was effectively treated with antifungal therapy and ALL treatment. Now he is full recovery, having complete clinical remission but with sequelae visible by MRI. He is taking oral posaconazole for consolidation until disappearance of the lesion shadows on MRI and having subsequent cycles of chemotherapy in parallel. The recommended treatment for candida osteomyelitis in Ph-positive ALL patients is fungicidal agent combined with surgery and modification chemotherapy with dasatinib. Using combined modalities of treatment seem to be crucial in the successful management of Ph-positive ALL.

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