Long term treatment with omalizumab in adolescent with refractory solar urticaria

Abstract Background Solar urticaria represents an uncomfortable form of chronic inducible urticaria. First and second-line treatments are ineffective in some patients, leading to an impairment in their quality of life. Omalizumab represents a safe therapeutic option in case of refractory solar urticaria. Case presentation We update a case of a 21-year-old Caucasian girl affected by solar urticaria from the age of 14. Poor disease control was achieved with standard or high-dose of H1-antihistamines. Several omalizumab courses, including a 1-year-long course, were practiced resulting in clinical remission and significant improvement in patient’s quality of life. Conclusion Our experience confirms the effectiveness and safety of omalizumab for the management of refractory solar urticaria. Future studies are awaited in order to monitor long term effects and chronic doses of this treatment, particularly in patients who need concomitant therapy with antihistamines.

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PECULIARITIES OF HOSPITALIZED MORBIDITY AND QUALITY OF LIFE OF CHILDREN WITH CRANIOCEREBRAL TRAUMA IN RUSSIA

Physical and rehabilitation medicine, medical rehabilitation ◽

10.36425/2658-6843-2019-2-14-18 ◽

2019 ◽

pp. 14-18

Keyword(s):

Quality Of Life ◽

Brain Injuries ◽

Craniocerebral Trauma ◽

Risk Groups ◽

Term Treatment ◽

Long Term Effects ◽

Long Term Treatment ◽

High Incidence

Craniocerebral trauma (TBI) in children acquires special significance, causing a high incidence of morbidity, mortality, hospitalization and leading to the emergence of severe neurological and psychiatric disorders requiring long-term treatment and rehabilitation. In this paper, we examine the features of hospitalization of children with CCI and study the quality of life of children with mild to moderate trauma to identify the risk groups of patients who are threatened by the occurrence of various long-term effects of trauma. The results obtained in the course of the study are aimed at improving medical care in order to improve the outcomes of traumatic brain injuries.

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PECULIARITIES OF HOSPITALIZED MORBIDITY AND QUALITY OF LIFE OF CHILDREN WITH CRANIOCEREBRAL TRAUMA IN RUSSIA

Physical and rehabilitation medicine, medical rehabilitation ◽

10.36425/2658-6843-19181 ◽

2019 ◽

Vol 1 (2) ◽

pp. 14-18 ◽

Cited By ~ 1

Author(s):

S A Valiullina ◽

E A Sharova

Keyword(s):

Quality Of Life ◽

Brain Injuries ◽

Craniocerebral Trauma ◽

Risk Groups ◽

Term Treatment ◽

Long Term Effects ◽

Long Term Treatment ◽

High Incidence

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Prophylaxis in people with haemophilia

Thrombosis and Haemostasis ◽

10.1160/th08-07-0483 ◽

2009 ◽

Vol 101 (04) ◽

pp. 674-681 ◽

Cited By ~ 36

Author(s):

Massimo Franchini ◽

Annarita Tagliaferri ◽

Antonio Coppola

Keyword(s):

Quality Of Life ◽

Cost Benefit ◽

Primary Prophylaxis ◽

Secondary Prophylaxis ◽

Severe Haemophilia ◽

Duration Of Treatment ◽

First Choice ◽

Long Term Treatment

SummaryA four-decade clinical experience and recent evidence from randomised controlled studies definitively recognised primary prophylaxis, i.e. the regular infusion of factor concentrates started after the first haemarthrosis and/or before the age of two years, as the first-choice treatment in children with severe haemophilia. The available data clearly show that preventing bleeding since an early age enables to avoid or reduce the clinical impact of muscle-skeletal impairment from haemophilic arthropathy and the related consequences in psycho-social development and quality of life of these patients. In this respect, the aim of secondary prophylaxis, defined as regular long-term treatment started after the age of two years or after two or more joint bleeds, is to avoid (or delay) the progression of arthropathy. The clinical benefits of secondary prophylaxis have been less extensively studied, especially in adolescents and adults; also in the latter better outcomes and quality of life for earlier treatment have been reported. This review summarises evidence from literature and current clinical strategies for prophylactic treatment in patients with severe haemophilia, also focusing on challenges and open issues (optimal regimen and implementation, duration of treatment, long-term adherence and outcomes, cost-benefit ratios) in this setting.

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Long-term Impact of Adenotonsillectomy on the Quality of Life of Children with Sleep-disordered breathing

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1709195 ◽

2020 ◽

Author(s):

Juliana Alves Sousa Caixeta ◽

Jessica Caixeta Silva Sampaio ◽

Vanessa Vaz Costa ◽

Isadora Milhomem Bruno da Silveira ◽

Carolina Ribeiro Fernandes de Oliveira ◽

...

Keyword(s):

Quality Of Life ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Sleep Disordered Breathing ◽

Long Term Effects ◽

Obstructive Sleep ◽

Long Term Impact ◽

Disordered Breathing

Abstract Introduction Adenotonsillectomy is the first-line treatment for obstructive sleep apnea secondary to adenotonsillar hypertrophy in children. The physical benefits of this surgery are well known as well as its impact on the quality of life (QoL), mainly according to short-term evaluations. However, the long-term effects of this surgery are still unclear. Objective To evaluate the long-term impact of adenotonsillectomy on the QoL of children with sleep-disordered breathing (SDB). Method This was a prospective non-controlled study. Children between 3 and 13 years of age with symptoms of SDB for whom adenotonsillectomy had been indicated were included. Children with comorbities were excluded. Quality of life was evaluated using the obstructive sleep apnea questionnaire (OSA-18), which was completed prior to, 10 days, 6 months, 12 months and, at least, 18 months after the procedure. For statistical analysis, p-values lower than 0.05 were defined as statistically significant. Results A total of 31 patients were enrolled in the study. The average age was 5.2 years, and 16 patients were male. The OSA-18 scores improved after the procedure in all domains, and this result was maintained until the last evaluation, done 22 ± 3 months after the procedure. Improvement in each domain was not superior to achieved in other domains. No correlation was found between tonsil or adenoid size and OSA-18 scores. Conclusion This is the largest prospective study that evaluated the long-term effects of the surgery on the QoL of children with SDB using the OSA-18. Our results show adenotonsillectomy has a positive impact in children's QoL.

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Yoga therapy to reduce fatigue in cancer: effects of reminder e-mails and long-term efficacy

Supportive Care in Cancer ◽

10.1007/s00520-021-06345-z ◽

2021 ◽

Author(s):

Teresa Zetzl ◽

Andre Pittig ◽

Agnes Renner ◽

Birgitt van Oorschot ◽

Elisabeth Jentschke

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Mediation Model ◽

Long Term Effects ◽

Long Term Outcomes ◽

Cognitive Fatigue ◽

Yoga Therapy ◽

Life Data

Abstract Objective To examine the efficacy of reminder e-mails to continue yoga therapy on practice frequency and fatigue in cancer patients and long-term effects of yoga on fatigue, depression, and quality of life. Methodology One hundred two cancer patients who completed an 8-week yoga therapy were randomly allocated to two groups: reminder (N = 51) vs. no-reminder group (N = 51). After completing yoga therapy, the reminder group received weekly e-mails for 24 weeks, which reminded them of practicing yoga, whereas the no-reminder group did not. Primary outcomes were fatigue and practice frequency, and long-term outcomes were fatigue, depression, and quality of life. Data were assessed using questionnaires after yoga therapy (T1) and 6 months after completing yoga therapy (T2). Result A significantly stronger reduction of general (p = 0.038, d = 0.42) and emotional fatigue (p = 0.004, d = 0.59) and a higher increase of practice frequency (p = 0.015, d = 0.52) between T1 and T2 were found for the reminder group compared to the no-reminder group. In the mediation model, practice frequency as a mediator partially explained the changes in emotional fatigue (indirect effect B = − 0.10). Long-term effects of yoga therapy regarding fatigue, depression, and quality of life were found (F > 7.46, p < 0.001, d > 0.54). Conclusion Weekly reminder e-mails after yoga therapy can positively affect general and emotional fatigue and help cancer patients with fatigue establish a regular yoga practice at home. However, higher practice frequency did not lead to higher physical or cognitive fatigue improvement, suggesting other factors that mediate efficacy on physical or cognitive fatigue, such as mindfulness or side effects of therapy.

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“I just wear it and I become normal”: a qualitative study of Tanzanian women’s experiences with long-term vaginal pessary use for stress urinary incontinence

BMJ Open ◽

10.1136/bmjopen-2020-040009 ◽

2021 ◽

Vol 11 (1) ◽

pp. e040009

Author(s):

Karina Holm Nissen ◽

Benjamin C Shayo ◽

Vibeke Rasch ◽

Gileard G Masenga ◽

Ditte Søndergaard Linde

Keyword(s):

Quality Of Life ◽

Urinary Incontinence ◽

Stress Urinary Incontinence ◽

Women’S Experiences ◽

Women's Experiences ◽

Vaginal Pessary ◽

Cost Effective Treatment ◽

Long Term Treatment

IntroductionPrevious research has shown that vaginal pessaries are a cost-effective treatment for women worldwide suffering from stress urinary incontinence. However, little is known about African women’s experiences with vaginal pessary use. The aim of this study was to understand the experiences of vaginal pessary use among Tanzanian women who had received long-term pessary treatment for stress urinary incontinence.Methods15 semi-structured, individual interviews were conducted over a 2-month period in 2019 with Tanzanian women living in the Kilimanjaro Region who suffered from stress urinary incontinence and who had been using a pessary for at least 18 months. The interview transcripts were analysed using qualitative content analysis.ResultsThe primary motivation for seeking treatment were discomfort from symptoms, social consequences and low quality of life. Perceived benefits from pessary use included improved quality of life with reacquired abilities to perform daily activities, participate in social gatherings, feeling symptom relief and improved sexual relations. Further, some women saw pessary treatment as superior to other locally available treatment options. Perceived barriers for pessary use included shame, husband’s disapproval, limited access to treatment and lack of knowledge among the women as well as healthcare personnel.ConclusionVaginal pessaries are well-perceived as a long-term treatment method among Tanzanian women suffering from stress urinary incontinence. This method may have potential to be implemented large scale in Tanzania if combined with basic health education.

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Long-Term Effects of Doxazosin, Finasteride and Combination Therapy on Quality of Life in Men with Benign Prostatic Hyperplasia

The Journal of Urology ◽

10.1016/j.juro.2013.01.061 ◽

2013 ◽

Vol 190 (1) ◽

pp. 187-193 ◽

Cited By ~ 16

Author(s):

Chyng-Wen Fwu ◽

Paul W. Eggers ◽

Steven A. Kaplan ◽

Ziya Kirkali ◽

Jeannette Y. Lee ◽

...

Keyword(s):

Quality Of Life ◽

Benign Prostatic Hyperplasia ◽

Combination Therapy ◽

Prostatic Hyperplasia ◽

Long Term Effects

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Paclitaxel-Based High-Dose Chemotherapy with Autologous Stem Cell Rescue for Relapsed Germ Cell Tumor: Clinical Outcome and Quality of Life in Long-Term Survivors

Clinical Genitourinary Cancer ◽

10.1016/j.clgc.2012.09.007 ◽

2013 ◽

Vol 11 (2) ◽

pp. 121-127 ◽

Cited By ~ 6

Author(s):

Sumanta K. Pal ◽

Jonathan Yamzon ◽

Virginia Sun ◽

Courtney Carmichael ◽

Junmi Saikia ◽

...

Keyword(s):

Quality Of Life ◽

Stem Cell ◽

Clinical Outcome ◽

High Dose Chemotherapy ◽

Cell Tumor ◽

High Dose ◽

Stem Cell Rescue ◽

Long Term Survivors

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The crystal arthropathies

InnovAiT Education and inspiration for general practice ◽

10.1177/1755738013499319 ◽

2013 ◽

Vol 6 (11) ◽

pp. 681-687 ◽

Cited By ~ 1

Author(s):

Robert A Jones ◽

Brian Quilty

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Inflammatory Arthritis ◽

Term Treatment ◽

Routine Practice ◽

Treatment Goals ◽

Crystal Arthropathies ◽

Long Term Treatment

Unlike many other forms of inflammatory arthritis, the crystal arthropathies are routinely diagnosed and managed in primary care. Gout, in particular, is relatively commonplace and rates of other types of crystal-related arthritis are predicted to increase. These are, therefore, conditions that GPs and trainees will regularly encounter during routine practice. While the clinical features and pathophysiology of gout and pseudo-gout are well described, the long-term treatment goals and options of management are often less well understood, and opportunities to assess for associated co-morbidities can easily be missed. GPs can be central in optimising management by promptly and appropriately addressing acute symptoms, preventing recurrent attacks, minimising disability and work absences, reducing cardiovascular risk factors, improving general health and enhancing quality of life.

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