scholarly journals Reduction of circulating innate lymphoid cell progenitors results in impaired cytokine production by innate lymphoid cells in patients with lupus nephritis

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Seungwon Ryu ◽  
Eun Young Lee ◽  
Dong Ki Kim ◽  
Yon Su Kim ◽  
Doo Hyun Chung ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Lymphoid Cell ◽  
Cytokine Production ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Innate Lymphoid Cell

scholarly journals The Role of TOX in the Development of Innate Lymphoid Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Corey R. Seehus ◽  
Jonathan Kaye
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
Natural Killer ◽  
Cell Fate ◽  
Lymphoid Cell ◽  
Adaptive Immune System ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Innate Lymphoid Cell

TOX, an evolutionarily conserved member of the HMG-box family of proteins, is essential for the development of various cells of both the innate and adaptive immune system. TOX is required for the development of CD4+T lineage cells in the thymus, including natural killer T and T regulatory cells, as well as development of natural killer cells and fetal lymphoid tissue inducer cells, the latter required for lymph node organogenesis. Recently, we have identified a broader role for TOX in the innate immune system, demonstrating that this nuclear protein is required for generation of bone marrow progenitors that have potential to give rise to all innate lymphoid cells. Innate lymphoid cells, classified according to transcription factor expression and cytokine secretion profiles, derive from common lymphoid progenitors in the bone marrow and require Notch signals for their development. We discuss here the role of TOX in specifying CLP toward an innate lymphoid cell fate and hypothesize a possible role for TOX in regulating Notch gene targets during innate lymphoid cell development.

scholarly journals The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor

2015 ◽  
Vol 16 (6) ◽  
pp. 599-608 ◽  
Author(s):  
Corey R Seehus ◽  
Parinaz Aliahmad ◽  
Brian de la Torre ◽  
Iliyan D Iliev ◽  
Lindsay Spurka ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Innate Lymphoid Cell

scholarly journals Changes in bone marrow innate lymphoid cell subsets in monoclonal gammopathy: target for IMiD therapy

2017 ◽  
Vol 1 (25) ◽  
pp. 2343-2347 ◽  
Author(s):  
Jithendra Kini Bailur ◽  
Sameet Mehta ◽  
Lin Zhang ◽  
Natalia Neparidze ◽  
Terri Parker ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lymphoid Cell ◽  
Monoclonal Gammopathy ◽  
Cell Function ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Innate Lymphoid Cell ◽  
Key Points ◽  
And Function

Key Points Altered number, subset composition, and function of bone marrow innate lymphoid cells are early events in monoclonal gammopathies. Pomalidomide therapy leads to reduction in Ikzf1 and Ikzf3 and enhanced human innate lymphoid cell function in vivo.

scholarly journals Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sandra Bonne-Année ◽  
Mabel C. Bush ◽  
Thomas B. Nutman
Keyword(s):  
Lymphoid Cell ◽  
Cytokine Production ◽  
Ex Vivo ◽  
Low Frequency ◽  
Surface Expression ◽  
Multiparameter Flow Cytometry ◽  
Innate Lymphoid Cell ◽  
Low Frequencies ◽  
Immunoregulatory Cytokines ◽  
Ifn Γ

Abstract Using multiparameter flow cytometry human innate lymphoid cell (ILC) subsets can be detected in the circulation, in relatively low frequencies. Despite the low frequency of ILCs in circulation, ex vivo experiments have demonstrated that these ILCs release extremely large per cell quantities of signature ILC cytokines following activation. To determine how activated ILC cytokine production is regulated, ILC subsets were activated in the presence or absence of the immunoregulatory cytokines IL-10 and TGF-β. An examination of circulating ILC subsets revealed surface expression of IL-10Rα and mRNA expression of both IL-10Rα and TGF-βR1 for all ILC subsets. Stimulated ILC1 production of IFN-γ was decreased by TGF-β and not IL-10. Interestingly, ILC2s stimulated in the presence of IL-10 had a marked reduction in cytokine production of IL-5 and IL-13 while TGF-β had no effect on ILC2 cytokine production. Ex vivo activated ILC1 and ILC2 subsets were also found to be a source of the immunoregulatory cytokine IL-10, raising the potential for ILC-mediated regulation of immune cells. These findings demonstrate the differential effects of immunoregulatory cytokines IL-10 and TGF-β on activated ILC1 and ILC2 populations ex vivo.

scholarly journals Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells

2019 ◽  
Vol 10 ◽  
Author(s):  
Ahmet Eken ◽  
Mehmet Fatih Yetkin ◽  
Alperen Vural ◽  
Fatma Zehra Okus ◽  
Serife Erdem ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Cytokine Production ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

scholarly journals Immune checkpoints on innate lymphoid cells

2017 ◽  
Vol 214 (6) ◽  
pp. 1561-1563 ◽  
Author(s):  
Laura Chiossone ◽  
Eric Vivier
Keyword(s):  
Cytokine Production ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Negative Regulator ◽  
Immune Checkpoints ◽  
Group 2 ◽  
Blocking Antibodies

In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti–PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice.

scholarly journals Interferon-γconstrains cytokine production of group 2 innate lymphoid cells

Immunology ◽  
2015 ◽  
Vol 147 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Fujimi Kudo ◽  
Masashi Ikutani ◽  
Yoichi Seki ◽  
Takeshi Otsubo ◽  
Yuki I. Kawamura ◽  
...  
Keyword(s):  
Cytokine Production ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 2

scholarly journals G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program

2016 ◽  
Vol 213 (7) ◽  
pp. 1153-1162 ◽  
Author(s):  
Frann Antignano ◽  
Mitchell Braam ◽  
Michael R. Hughes ◽  
Alistair L. Chenery ◽  
Kyle Burrows ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
Lymphoid Cells ◽  
Innate Lymphoid Cell ◽  
Genome Wide ◽  
Allergic Lung Inflammation ◽  
Severe Reduction ◽  
Repressive Histone Mark ◽  
Lysine Methyltransferase ◽  
Group 2 ◽  
And Function

Innate lymphoid cells (ILCs) are emerging as important regulators of homeostatic and disease-associated immune processes. Despite recent advances in defining the molecular pathways that control development and function of ILCs, the epigenetic mechanisms that regulate ILC biology are unknown. Here, we identify a role for the lysine methyltransferase G9a in regulating ILC2 development and function. Mice with a hematopoietic cell–specific deletion of G9a (Vav.G9a−/− mice) have a severe reduction in ILC2s in peripheral sites, associated with impaired development of immature ILC2s in the bone marrow. Accordingly, Vav.G9a−/− mice are resistant to the development of allergic lung inflammation. G9a-dependent dimethylation of histone 3 lysine 9 (H3K9me2) is a repressive histone mark that is associated with gene silencing. Genome-wide expression analysis demonstrated that the absence of G9a led to increased expression of ILC3-associated genes in developing ILC2 populations. Further, we found high levels of G9a-dependent H3K9me2 at ILC3-specific genetic loci, demonstrating that G9a-mediated repression of ILC3-associated genes is critical for the optimal development of ILC2s. Together, these results provide the first identification of an epigenetic regulatory mechanism in ILC development and function.

Sign in / Sign up

Export Citation Format

Share Document