scholarly journals Factors affecting development of Clostridium difficile infection in hospitalized pediatric patients in the country Georgia

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Iuri Migriauli ◽  
Vakhtang Meunargia ◽  
Ivane Chkhaidze ◽  
Giorgi Sabakhtarishvili ◽  
Kakha Gujabidze ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Pediatric Patients ◽  
Factors Affecting

scholarly journals The risk of developing a Clostridium difficile infection from the administration of different classes of antibiotics and their combinations to children in an oncological hospital

2020 ◽  
Vol 7 (1) ◽  
pp. 54-58
Author(s):  
Mariya G. Shvydkaya ◽  
◽  
Aleksandr M. Zatevalov ◽  
Dzhamilya T. Dzhandarova ◽  
Sergey D. Mitrokhin ◽  
...  
Keyword(s):  
At Risk ◽  
Clostridium Difficile ◽  
Retrospective Analysis ◽  
Clostridium Difficile Infection ◽  
Pediatric Patients ◽  
Patient Records ◽  
Chemotherapeutic Drugs ◽  
Antimicrobial Drugs ◽  
Different Types

Patients in pediatric oncological hospitals are at risk of developing a Clostridium difficile infection. The purpose of this study was to determine the risk of developing a Clostridium difficile infection in patients who are treated with antibiotics of different classes and combinations by way of a retrospective analysis of 122 patient records. It was shown that the administration of antibacterial chemotherapeutic drugs that belong to the classes of nitrofurans (enterofuryl), sulfonamides (biseptol), cephalosporins, and macrolides/azalides significantly increased the risk of developing a Clostridium difficile infection in pediatric patients. On the contrary, treatment with antibiotics of different classes, such as linezolid, colistin, and metronidazole, significantly reduced the risk of developing a Clostridium difficile infection. The use of penicillins, aminoglycosides, fluoroquinolones, glycopeptides, and carbapenems was not associated with the risk of developing a Clostridium difficile infection in pediatric patients. The administration of one or two antimicrobial drugs of different classes increased the risk of developing a Clostridium difficile infection while a combination of three different types of antimicrobial drugs lowered the rate of this infection in pediatric patients.

Risk Factors for Hospital-acquired Clostridium difficile Infection Among Pediatric Patients With Cancer

2017 ◽  
Vol 39 (3) ◽  
pp. e167-e172 ◽  
Author(s):  
Atsuro Daida ◽  
Hiroki Yoshihara ◽  
Ikuko Inai ◽  
Daisuke Hasegawa ◽  
Yasushi Ishida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Pediatric Patients ◽  
Patients With Cancer ◽  
Hospital Acquired

scholarly journals Acid-Suppressing Agents and Risk for Clostridium difficile Infection in Pediatric Patients

2015 ◽  
Vol 54 (11) ◽  
pp. 1102-1106 ◽  
Author(s):  
Katelyn E. Brown ◽  
Chad A. Knoderer ◽  
Kristen R. Nichols ◽  
Ashley S. Crumby
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Pediatric Patients

Analyzing the outcome of clostridium difficile infection in cancer patients.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19340-e19340
Author(s):  
Kamal Kant Sahu ◽  
Ajay Mishra ◽  
Susan V George ◽  
George Abraham ◽  
Ahmad Daniyal Siddiqui
Keyword(s):  
Clostridium Difficile ◽  
Cancer Patients ◽  
Clostridium Difficile Infection ◽  
P Value ◽  
Nursing Facility ◽  
Factors Affecting ◽  
Patients With Cancer ◽  
History Of ◽  
Study Population ◽  
Qsofa Score

e19340 Background: Clostridium difficile infection (CDI) is a considerable health burden, and now identified as the leading cause of acquired diarrhea in patients receiving antibiotics. Cancer patients are more prone to acquire CDI, owing to their frequent exposure to risk factors. This study aims to investigate the factors affecting the outcome of Clostridium Difficile Infection in patients with cancer at our community center. Methods: This is a retrospective study that included a total of 59 cancer patients who were hospitalized for clostridium difficile infection. Results: The median age of the study population was 79 years with 39 males and 20 females. The patients were suffering from cancer located at the following sites: Prostate (25), lung (19), colon (7), bladder (4), breast (3) and renal (1). There were 52 cases of 1st and 7 cases of recurrent CDI admissions. 40 patients detected to have CDI at presentation while 19 patients developed CDI during hospitalization. CDI categories were as follows: Non-severe (29), severe (28), and very severe (3). There were 33 and 20 patients on chemotherapy and radiotherapy respectively. 27 patients had a recent history of cancer care-related procedures or interventions. 29 patients were from either rehab or nursing facility. There were 39 recent hospitalizations with 29 patients receiving antibiotics. Almost half of the patients were on PPI (29) and 12 were on steroids (20.3%) at the time of developing CDI. Patients with a high-risk qSOFA Score of 2 or more (p-value = 0.008) or a high white blood cell count of > 15 X 109/L (p-value = 0.016) were found to have higher in-hospital mortality. Critical care data suggested that 9 patients required intensive care, 7 patients required vasopressor support, and 6 needed mechanical ventilation. Patients were treated with either vancomycin alone (13), or metronidazole alone (25), or combination therapy with vancomycin + metronidazole (21). The median duration of hospital stay was 6 days with 11 fatalities (18.64%). Conclusions: CDI causes significant morbidity in cancer patients. Factors like high qSOFA score and leukocytosis can help to prioritize and intensify the care and in prognosticating the patients.

scholarly journals Risk factors for healthcare-associated Clostridium difficile infection in pediatric hematopoietic stem cell transplant recipients

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S401-S401
Author(s):  
Richard H Drew ◽  
Clara Ni ◽  
Matthew Kelly ◽  
Dustin Wilson ◽  
Christina Sarubbi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Stem Cell ◽  
Clostridium Difficile ◽  
Hematopoietic Stem Cell ◽  
Clostridium Difficile Infection ◽  
Pediatric Patients ◽  
Antibiotic Use ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Healthcare Associated

Abstract Background Limited published literature exists to identify unique risk factors for Clostridium difficile infection (CDI) in pediatric hematopoietic stem cell transplantation (HSCT) recipients. Our objective was to describe the epidemiology of CDI in pediatric patients undergoing HSCT and to identify potential risk factors for CDI. Methods This IRB-waived, single-center retrospective review included Duke University Hospital (DUH) patients 12 months of age or older admitted to pediatrics between March 1, 2012 and August 23, 2016 undergoing initial HSCT during the index hospitalization. The primary endpoint (PCR-confirmed CDI within 100 days post-transplantation) was characterized using descriptive statistics. Transplant type, prior CDI history, days of total parenteral nutrition (TPN), and antibiotic use intensity scores were compared between occurrence groups using Pearson’s chi-square, Wilcoxon rank-sum or Student’s t tests as appropriate. Results 207 subjects (most Caucasian [55%] and male [61%]) were included, and 15 (7.2%) died. CDI occurred in 24 (12%) within a median (interquartile range) of 35 (9, 47) days since HSCT, and most (92%) were hospital-onset. All cases were healthcare-associated and mild-moderate in severity. None of the patients experienced CDI-related complications. CDI-positive and CDI-negative patients were similar with regards to demographics. Higher median (adjusted) days of TPN (80.6 vs. 29, P < 0.0001) and antibiotic use intensity scores (382.8 vs. 191.0, P < 0.0001), respectively, were associated with CDI. No significant differences between these groups were observed with regard to transplant type (P = 0.28) and prior CDI history (P = 0.10). Conclusion CDI occurred in 12% of pediatric patients within 100 days of undergoing initial HSCT. Onset of this mild-moderate, uncomplicated disease occurred within a median of 35 days and commonly during hospitalization. Patients with CDI were more likely to have increased use of TPN and a higher antibiotic use intensity score. Disclosures All authors: No reported disclosures.

Treatment of Clostridium difficile infection in pediatric patients

2015 ◽  
Vol 9 (6) ◽  
pp. 747-755 ◽  
Author(s):  
Susanna Esposito ◽  
Giulia Umbrello ◽  
Luca Castellazzi ◽  
Nicola Principi
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Pediatric Patients
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