Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults

The Alzheimer’s Disease Neuroimaging Initiative showed that Japanese had significantly lower brain Aβ burden than Americans among a cognitively normal population. This cross-sectional study aimed to compare vascular disease burden, Aβ burden, and neurodegeneration between cognitively normal elderly Japanese and Americans. Japanese and American participants were matched for age (± 4-year-old), sex, and Apolipoprotein E (APOE) genotype. Brain vascular disease burden and brain Aβ burden were measured using white matter lesions (WMLs) and 11C-labeled Pittsburgh Compound B (PiB) retention, respectively. Neurodegeneration was measured using hippocampal volumes and cortical thickness. A total of 95 Japanese and 95 Americans were recruited (50.5% men, mean age = 82). Compared to Americans, Japanese participants had larger WMLs, and a similar global Aβ standardized uptake value ratio (SUVR), cortical thickness and hippocampal volumes. Japanese had significantly lower regional Aβ SUVR in the anterior ventral striatum, posterior cingulate cortex, and precuneus. Cognitively normal elderly Japanese and Americans had different profiles regarding vascular disease and Aβ burden. This suggests that multiple risk factors are likely to be involved in the development of dementia. Additionally, Japanese might have a lower risk of dementia due to lower Aβ burden than Americans. Longitudinal follow-up of these cohorts is warranted to ascertain the predictive accuracy of these findings.

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0292 Sleep Spindle Characteristics and Their Association with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in Cognitively Normal Older Adults

SLEEP ◽

10.1093/sleep/zsy061.291 ◽

2018 ◽

Vol 41 (suppl_1) ◽

pp. A112-A113

Author(s):

A W Varga ◽

K Kam ◽

A Parekh ◽

R A Sharma ◽

B Castillo ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Cerebrospinal Fluid ◽

Sleep Spindle ◽

Cognitively Normal ◽

Cerebrospinal Fluid Biomarkers

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Effects of APOE genotype, age and sex on cerebrospinal fluid biomarkers measured with NeuroToolKit in the Longitudinal Swedish Biofinder Cohort

Alzheimer s & Dementia ◽

10.1002/alz.055153 ◽

2021 ◽

Vol 17 (S5) ◽

Author(s):

Claudia Cicognola ◽

Shorena Janelidze ◽

Sebastian Palmqvist ◽

Ivonne Suridjan ◽

Gwendlyn Kollmorgen ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Apoe Genotype ◽

Cerebrospinal Fluid Biomarkers ◽

Age And Sex

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Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study

BMC Neurology ◽

10.1186/s12883-021-02487-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xin-Yu Yang ◽

Xiao-He Hou ◽

Yan-Lin Bi ◽

Hao Hu ◽

Xi-Peng Cao ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Severe Anaemia ◽

Linear Regression Models ◽

Cognitively Normal ◽

Cerebrospinal Fluid Biomarkers ◽

Close Relationship ◽

History Of ◽

Β Amyloid ◽

Alzheimer’S Pathology ◽

T Tau

Abstract Background Anaemia has been reported to be associated with cognitive decline and Alzheimer’s disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study aimed to investigate the associations between anaemia and CSF AD biomarkers. Methods Participants were included from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) study. The associations of anaemia and its severity with CSF AD biomarkers including β-amyloid 1–42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau) were analysed by multiple linear regression models. Adjusted for age, gender, educational levels, APOE ε4 alleles, comorbidities (history of coronary heart disease, history of stroke, hypertension, diabetes mellitus, dyslipidaemia) and glomerular filtration rate. Results A total of 646 cognitively normal older adults, consisting of 117 anaemia patients and 529 non-anaemia individuals, were included in this study. Anaemia patients had lower levels of CSF Aβ42 than individuals without anaemia (p = 0.035). Besides, participants with more severe anaemia had lower CSF Aβ42 levels (p = 0.045). No significant association of anaemia with CSF t-tau and p-tau levels was found. Conclusion Cross-sectionally, anaemia was associated with lower CSF Aβ42 levels. These findings consolidated the causal close relationship between anaemia and AD.

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