scholarly journals Intensity of arterial structure acquired by Silent MRA estimates cerebral blood flow

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhen-An Hwang ◽  
Chia-Wei Li ◽  
Chien-Yuan Eddy Lin ◽  
Jyh-Horng Chen ◽  
Chia-Yuen Chen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Cerebrovascular Disease ◽  
Phase Distribution ◽  
Cerebral Arteries ◽  
Coefficient Of Determination ◽  
Arterial Structure ◽  
Signal Intensities

Abstract Background Cerebral blood flow (CBF) and the morphology of the cerebral arteries are important for characterizing cerebrovascular disease. Silent magnetic resonance angiography (Silent MRA) is a MRA technique focusing on arterial structural delineation. This study was conducted to investigate the correlation between Silent MRA and CBF quantification, which has not yet been reported. Methods Both the Silent MRA and time-of-flight magnetic resonance angiography scans were applied in seventeen healthy participants to acquire the arterial structure and to find arterial intensities. Phase-contrast MRA (PC-MRA) was then used to perform the quantitative CBF measurement of 13 cerebral arteries. Due to different dataset baseline signal level of Silent MRA, the signal intensities of the selected 13 cerebral arteries were normalized to the selected ROIs of bilateral internal carotid arteries. The normalized signal intensities were used to determine the relationship between Silent MRA and CBF. Results The image intensity distribution of arterial regions generated by Silent MRA showed similar laminar shape as the phase distribution by PC-MRA (correlation coefficient > 0.62). Moreover, in both the results of individual and group-leveled analysis, the intensity value of arterial regions by Silent MRA showed positively correlation with the CBF by PC-MRA. The coefficient of determination (R2) of individual trends ranged from 0.242 to 0.956, and the R2 of group-leveled result was 0.550. Conclusions This study demonstrates that Silent MRA provides valuable CBF information despite arterial structure, rendering it a potential tool for screening for cerebrovascular disease.

scholarly journals Inter- and Intra-Rater Reliability of Individual Cerebral Blood Flow Measured by Quantitative Vessel-Flow Phase-Contrast MRI

2020 ◽  
Vol 9 (10) ◽  
pp. 3099
Author(s):  
Kwang-Hwa Chang ◽  
Yuan-Hao Lee ◽  
Chia-Yuen Chen ◽  
Ming-Fang Lin ◽  
Ying Chin Lin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Correlation Coefficient ◽  
Cerebral Artery ◽  
Phase Contrast ◽  
Cerebral Arteries ◽  
Intraclass Correlation ◽  
Vessel Flow

Vessel flow quantification by two-dimensional (2D) phase-contrast magnetic resonance imaging (PC-MRI) using a three-dimensional (3D) magnetic resonance angiography (MRA) model to measure cerebral blood flow has unclear analytical reliability. The present study aimed to determine the inter- and intra-rater reliability of quantitative vessel-flow PC-MRI and potential factors influencing its consistency. We prospectively recruited 30 Asian participants (aged 20–90 years; 16 women; 22 healthy and 8 stroke patients) for performing 1.5-T MR equipped with a head coil. Each participant was first scanned for time-of-flight magnetic resonance angiography (TOF-MRA) images for localization of intracranial arteries. The 2D PC-MRI for each cerebral artery (total 13 arteries in fixed order) was performed twice by two well-trained operators in optimal position. Using the same 3D MRA as a map and facilitated with the non-invasive optimal vessel analysis (NOVA) system, each scan was taken on a plane perpendicular to the target artery. Two consecutive full 13-artery scans were performed at least 15 min apart after participants were removed from the scanner table and then repositioned. A total of four PC flow images obtained from each target artery were transmitted to a workstation facilitated with the NOVA system. Flow data were calculated semi-automatically by the NOVA system after a few simple steps. Two-way mixed-effect models and standard errors of measurements were used. In 13 cerebral arteries, repeatability, using the intra-rater estimate expressed as the average-measures intraclass correlation coefficient, ranged from 0.641 to 0.954, and reproducibility, using the inter-rater estimate, ranged from 0.672 to 0.977. Except in the middle cerebral artery and the distal segment of the anterior cerebral artery, repeatability and reproducibility were excellent (intraclass correlation coefficient exceeded 0.8). The use of quantitative vessel-flow PC-MRI is a precise means to measure blood flow in most target cerebral arteries. This was evidenced by inter-rater and intra-rater correlations that were good/excellent, indicating good reproducibility and repeatability.

Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant

2018 ◽  
Vol 49 (03) ◽  
pp. 213-216 ◽  
Author(s):  
Wibke Janzarik ◽  
Peter Franck ◽  
Markus Hufnagel ◽  
Christopher Beck ◽  
Rudolf Korinthenberg ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Bacterial Meningitis ◽  
Effective Treatment ◽  
Pneumococcal Meningitis ◽  
Severe Disease ◽  
Treatment Resistant ◽  
Intracranial Arteries

AbstractDespite the availability of modern antibiotics, pneumococcal meningitis in both children and adults remains a severe disease—one known to frequently cause grave complications and residual disability. Although the appearance of arterial vasospasms in bacterial meningitis systematically has been investigated and reported on for adult patients, such research is lacking when it comes to infants. We report on a 4-week-old infant who, 6 days after onset of pneumococcal meningitis, suffered severe neurological deterioration with treatment-resistant seizures and coma. Generalized cortical and subcortical edema developed in conjunction with diminished cerebral blood flow, as depicted in magnetic resonance angiography and serial Doppler-sonographic examinations. The ischemia resulted in extensive cystic encephalomalacia. We propose that the degree of variation in cerebral blood flow in the acute phase was the result of an extensive arterial vasculopathy involving vasospasms. Awareness of this complication and prospective serial Doppler-sonographic examinations may improve our understanding of the connection between brain edema and vasculopathy. At present, however, no effective treatment appears available.

scholarly journals Relationship between middle cerebral artery signal density on magnetic resonance angiography and cerebral blood flow

Nosotchu ◽  
2016 ◽  
Vol 38 (5) ◽  
pp. 307-312
Author(s):  
Yuichiro Toyama ◽  
Yoshiyuki Wakugawa ◽  
Masahiro Yasaka ◽  
Kotaro Yasumori ◽  
Masaki Saitoh ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Signal Density

PREDICTION OF CEREBRAL HYPERPERFUSION AFTER CAROTID ENDARTERECTOMY USING MIDDLE CEREBRAL ARTERY SIGNAL INTENSITY IN PREOPERATIVE SINGLE-SLAB 3-DIMENSIONAL TIME-OF-FLIGHT MAGNETIC RESONANCE ANGIOGRAPHY

Neurosurgery ◽  
2009 ◽  
Vol 64 (6) ◽  
pp. 1065-1072 ◽  
Author(s):  
Hiroki Kuroda ◽  
Kuniaki Ogasawara ◽  
Ryonoshin Hirooka ◽  
Masakazu Kobayashi ◽  
Shunro Fujiwara ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Middle Cerebral Artery ◽  
Predictive Value ◽  
Signal Intensity ◽  
3 Dimensional ◽  
Cerebral Hyperperfusion ◽  
Patients At Risk

Abstract OBJECTIVE Cerebral hyperperfusion after carotid endarterectomy (CEA) occurs in patients with preoperative impairments in cerebral hemodynamics. Signal intensity of the middle cerebral artery (MCA) on single-slab 3-dimensional time-of-flight magnetic resonance angiography (MRA) can assess hemodynamic impairment in the cerebral hemisphere. The purpose of the present study was to determine whether the signal intensity of the MCA on preoperative MRA could identify patients at risk for cerebral hyperperfusion after CEA. METHODS The signal intensity of the MCA ipsilateral to CEA on preoperative MRA was graded according to the ability to visualize the MCA in 81 patients with ipsilateral internal carotid artery stenosis (≥70%). Cerebral blood flow was also quantified using single-photon emission computed tomography before and immediately after CEA and on the third postoperative day. RESULTS Cerebral hyperperfusion immediately after CEA (cerebral blood flow increase ≥100% compared with preoperative values) was observed in 10 patients. Multivariate analysis revealed that only reduced signal intensity of the MCA was significantly associated with the development of postoperative cerebral hyperperfusion (95% confidence interval, 1.015–1.401; P = 0.0319). When the reduced signal intensity of the MCA on MRA was defined as an impairment in cerebral hemodynamics, MRA grading resulted in 100% sensitivity and 63% specificity, with a 28% positive predictive value and a 100% negative predictive value for the development of post-CEA hyperperfusion. Hyperperfusion syndrome developed on the fourth and sixth postoperative days in 2 of the 10 patients who exhibited hyperperfusion immediately after CEA. CONCLUSION Signal intensity of the MCA, as assessed by this simple MRA method, may identify patients at risk for post-CEA cerebral hyperperfusion.

Measuring Cerebral Blood Flow in Moyamoya Angiopathy by Quantitative Magnetic Resonance Angiography Noninvasive Optimal Vessel Analysis

Neurosurgery ◽  
2017 ◽  
Vol 81 (6) ◽  
pp. 921-927 ◽  
Author(s):  
Nadia Khan ◽  
Robert M Lober ◽  
Lauren Ostergren ◽  
Jacob Petralia ◽  
Teresa Bell-Stephens ◽  
...  
Keyword(s):  
Blood Flow ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Carotid Artery ◽  
Internal Carotid ◽  
Cerebral Arteries ◽  
Posterior Circulation ◽  
Flow Rates ◽  
Revascularization Surgery ◽  
Artery Flow

Abstract BACKGROUND Moyamoya disease causes progressive occlusion of the supraclinoidal internal carotid artery, and middle, anterior, and less frequently the posterior cerebral arteries, carrying the risk of stroke. Blood flow is often partially reconstituted by compensatory moyamoya collaterals and sometimes the posterior circulation. Cerebral revascularization can further augment blood flow. These changes to blood flow within the cerebral vessels, however, are not well characterized. OBJECTIVE To evaluate blood flow changes resulting from the disease process and revascularization surgery using quantitative magnetic resonance angiography with noninvasive optimal vessel analysis (NOVA). METHODS We retrospectively analyzed 190 preoperative and postoperative imaging scans in 66 moyamoya patients after revascularization surgery. Images were analyzed for blood flow using NOVA and compared with preoperative angiographic staging and postoperative blood flow. Blood flow rates within superficial temporal artery grafts were compared based on angiographic evidence of patency. RESULTS Diseased vessels had lower blood flow, correlating with angiographic staging. Flow in posterior cererbal and basilar arteries increased with disease severity, particularly when both the anterior and middle cerebral arteries were occluded. Basilar artery flow and ipsilateral internal carotid artery flow decreased after surgery. Flow rates were different between angiographically robust and poor direct bypass grafts, as well as between robust and patent grafts. CONCLUSION Preoperative changes in cerebral vessel flow as measured by NOVA correlated with angiographic disease progression. NOVA demonstrated that preoperative augmentation of the posterior circulation decreased after surgery. This report is the first to quantify the shift in collateral supply from the posterior circulation to the bypass graft.

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