scholarly journals Solitary extrapleural fibrous tumor with hepatic bilobar metastases: multimodal approach treatment

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maitane I. Orue-Echebarria ◽  
Laura Garciafília ◽  
Luis Rodriguez-Bachiller ◽  
Benjamín Díaz-Zorita ◽  
Enrique Velasco ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Solitary Fibrous Tumor ◽  
Future Liver Remnant ◽  
Distant Metastases ◽  
R0 Resection ◽  
Two Stage ◽  
Liver Remnant ◽  
Therapeutic Decisions ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor is an unusual fibroblastic mesenchymal neoplasm typically described in the pleura. It may appear anywhere with a varied anatomic distribution and essentially it can develop from any soft tissue or visceral location. Its course is usually indolent and it rarely causes distant metastases, so it has a prolonged survival rate. It sometimes presents itself as a disseminate disease being the liver the most frequently involved location. In these occasions, the management should be discussed in a multidisciplinary tumor committee formed by surgeons, oncologists and radiologists. Surgery remains the gold standard for treatment. Case representation We present the case of a woman with a tumor in the left abdominal wall and bilobar massive liver metastases, both locations histologically diagnosed as solitary fibrous tumor. She receives biological treatment for a severe case of Crohn´s disease. Evaluated in a multidisciplinary committee, surgery was recommended for both the primary lesion and the liver metastases. The hepatobiliary surgeons considered a two-stage hepatectomy with portal vein embolization (PVE) as the best strategy. After the first procedure consisting in cleaning the left hepatic lobe followed by PVE the future liver remnant volume (FLRV) was considered inadequate, so the patient was also treated with right transarterial radioembolizacion with yttrium 90 (TARE-Y90) intending a double goal: to treat the tumor and to increased the FLRV. Furthermore, a severe flare of Crohn´s disease forced us to intensify the patient’s treatment with the addition of biological agents (infliximab and adalimumab) until complete remission of the symptoms. The second stage of the liver surgery had to be postponed for more than 6 months and could finally be carried out without complications, achieving an R0 resection. The postoperative course was uneventful and the follow up has showed no recurrence to date. Conclusion Solitary fibrous tumours with extensive liver metastases are infrequent but when they appear modern surgical strategies like two stage hepatectomy are the treatment of choice and must be carried out by specialised units. The therapeutic decisions should be guided by a multidisciplinary committee.

scholarly journals Oncological Outcomes after Liver Venous Deprivation for Colorectal Liver Metastases: A Single Center Experience

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 200
Author(s):  
Salah Khayat ◽  
Gianluca Cassese ◽  
François Quenet ◽  
Christophe Cassinotto ◽  
Eric Assenat ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Metastases ◽  
Portal Vein Embolization ◽  
Colorectal Liver Metastases ◽  
Future Liver Remnant ◽  
Small Sample ◽  
Right Hepatectomy ◽  
Liver Remnant ◽  
Oncological Outcomes ◽  
Extended Right Hepatectomy

Colorectal liver metastases (CRLM) are the major cause of death in patients with colorectal cancer (CRC). The cornerstone treatment of CRLM is surgical resection. Post-operative morbidity and mortality are mainly linked to an inadequate future liver remnant (FLR). Nowadays preoperative portal vein embolization (PVE) is the most widely performed technique to increase the size of the future liver remnant (FLR) before major hepatectomies. One method recently proposed to increase the FLR is liver venous deprivation (LVD), but its oncological impact is still unknown. The aim of this study is to report first short- and long-term oncological outcomes after LVD in patients undergoing right (or extended right) hepatectomy for CRLM. Seventeen consecutive patients undergoing LVD between July 2015 and May 2020 before an (extended) right hepatectomy were retrospectively analyzed from an institutional database. Post-operative and follow-up data were analyzed and reported. Primary outcomes were 1-year and 3-year overall survival (OS) and hepatic recurrence (HR). Postoperative complications occurred in 8 patients (47%). No deaths occurred after surgery. HR occurred in 9 patients (52.9%). 1-year and 3-year OS were 87% (95% confidence interval [CI]: ±16%) and 60.3%, respectively (95% CI: ±23%). Median Disease-Free Survival (DFS) was 6 months (CI 95%: 4.7–7.2). With all the limitations of a retrospective study with a small sample size, LVD showed similar oncological outcomes compared to literature reports for Portal Vein Embolization (PVE).

scholarly journals Future Liver Remnant (FLR) Increase in Patients with Colorectal Liver Metastases Is Highest the First Week After Portal Vein Occlusion

2018 ◽  
Vol 23 (3) ◽  
pp. 556-562 ◽  
Author(s):  
Kristina Hasselgren ◽  
Per Sandström ◽  
Bård Ingvald Røsok ◽  
Ernesto Sparrelid ◽  
Gert Lindell ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Future Liver Remnant ◽  
Liver Remnant ◽  
Portal Vein Occlusion ◽  
Vein Occlusion

SOLITARY FIBROUS TUMOR OF PROSTATE – A CASE REPORT

2021 ◽  
pp. 17-18
Author(s):  
Shaila Shaila ◽  
Aparna. C ◽  
Sowmiya. J ◽  
Geetha Sree. A
Keyword(s):  
Case Report ◽  
Benign Prostatic Hyperplasia ◽  
Solitary Fibrous Tumor ◽  
Prostatic Hyperplasia ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor ◽  
Cut Surface ◽  
Made In

Solitary Fibrous Tumor (SFT) of prostate is an unusual mesenchymal neoplasm. We report SFT in a 62 year-old man which was clinically misdiagnosed as benign prostatic hyperplasia (BPH). The specimen of surgically resected two prostate mass, we received were solid grey-white nodular on cut surface. Based on histopathological ndings and IHC assessment, a diagnosis of SFT was made. In addition, we review the literature and discuss the challenging issues of misdiagnosis. The case is presented in view of its rarity.

scholarly journals Dedifferentiated Solitary Fibrous Tumor: A Concise Review

2018 ◽  
Vol 142 (6) ◽  
pp. 761-766 ◽  
Author(s):  
Nicholas J. Olson ◽  
Konstantinos Linos
Keyword(s):  
Solitary Fibrous Tumor ◽  
Correct Diagnosis ◽  
The Body ◽  
Molecular Alterations ◽  
Concise Review ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor ◽  
Aggressive Clinical Course ◽  
Age Range ◽  
Ancillary Studies

Solitary fibrous tumor (SFT) is a unique mesenchymal neoplasm that was originally believed to be of submesothelial origin. Eventually, SFT expanded to include what was previously called hemangiopericytoma in other regions of the body that had similar immunohistochemical and morphologic features. Although most are benign, many studies have tried to identify histologic features that predict which tumors will behave in an aggressive manner. Recently, dedifferentiation has been described in rare cases of SFT and does appear to correlate with a more aggressive clinical course. Dedifferentiated SFT occurs in a similar age range and location as conventional SFT and can resemble multiple different malignant entities. Utilization of ancillary studies and thorough tissue sampling is important to reach the correct diagnosis. The morphologic features, immunohistochemistry, molecular alterations, and prognosis will be discussed.

NAB2–STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases

2015 ◽  
Vol 32 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Satoko Nakada ◽  
Hiroshi Minato ◽  
Tsutomu Takegami ◽  
Nozomu Kurose ◽  
Hiroko Ikeda ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Fusion Gene ◽  
Distant Metastases ◽  
Gene Analysis ◽  
Fibrous Tumor

Biphasic solitary fibrous tumor of the orbit with distant metastases

2013 ◽  
Vol 33 (6) ◽  
pp. 701-705 ◽  
Author(s):  
Raffaele Parrozzani ◽  
Stefano Fusetti ◽  
Cristina Montesco ◽  
Vittorio Favero ◽  
Edoardo Midena
Keyword(s):  
Solitary Fibrous Tumor ◽  
Distant Metastases ◽  
Fibrous Tumor

scholarly journals Solitary Fibrous Tumor of the Postcricoid Region: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Brian Cervenka ◽  
Brenda Villegas ◽  
Uttam Sinha
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Management Strategies ◽  
The Body ◽  
Surgical Approaches ◽  
Current Management ◽  
First Case ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor

Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm that can present essentially anywhere in the body. Presentations in the hypopharynx are extremely rare with only two previous cases reported. We report the first case of postcricoid SFT occurring in a 58-year-old male requiring a microsuspension laryngoscopy excision following an unsuccessful transoral robotic attempt. The excision was uneventful, and the patient is currently without recurrence. Current management strategies of the hypopharyngeal SFT, the unique differential diagnosis, and challenges in surgical approaches in the postcricoid region are discussed.

scholarly journals Quantitative multiparametric MRI allows safe surgical planning in patients undergoing liver resection for colorectal liver metastases: report of two patients

2021 ◽  
pp. 20200172
Author(s):  
Pulkit Sethi ◽  
Navamayooran Thavanesan ◽  
Fenella KS Welsh ◽  
John Connell ◽  
Elisabeth Pickles ◽  
...  
Keyword(s):  
Liver Failure ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Objective Assessment ◽  
Liver Steatosis ◽  
Future Liver Remnant ◽  
Multiparametric Mri ◽  
Mri Scan ◽  
Liver Remnant ◽  
Liver Health

It is not uncommon for clinicians to encounter varying degrees of hepatic steatosis in patients undergoing resection for colorectal liver metastases (CRLM). Magnetic resonance imaging is currently the preferred investigation for identification and pre-operative planning of these patients. An objective assessment of liver quality and degree of steatosis is paramount for planning a safe resection, which is seldom provided by routine MRI sequences. We studied two patients who underwent an additional pre-operative multiparametric MRI scan (LiverMultiScanTM) as a part of an observational clinical trial (HepaT1ca, NCT03213314) to assess the quality of liver. Outcome was assessed in the form of post-hepatectomy liver failure. Both patients (Patient 1 and 2) had comparable pre-operative characteristics. Both patients were planned for an extended right hepatectomy with an estimated future liver remnant of approximately 30%. Conventional preoperative contrast MRI showed mild liver steatosis in both patients. Patient one developed post-hepatectomy liver failure leading to prolonged hospital stay compared to patient two who had uneventful post-operative course. Retrospective evaluation of multiparametric MRI scan revealed findings consistent with fibro-inflammatory disease and steatosis (cT1 829 ms, PDFF 14%) for patient 1 whereas patient two had normal parameters (cT1 735 ms, PDFF 2.4%). These findings corresponded with the resection specimen histology. Multiparametric MRI can objectively evaluate future liver health and volume which may help refine surgical decision-making and improve patient outcomes

scholarly journals A pelvic cavity malignant solitary fibrous tumor with dedifferentiation and multifocal cytokeratin expression

2020 ◽  
Author(s):  
Yan He ◽  
Guan Huang ◽  
Wensong Lin ◽  
Zhaohui Zheng ◽  
Haiyan Zhao
Keyword(s):  
Laparoscopic Surgery ◽  
Solitary Fibrous Tumor ◽  
Malignant Tumors ◽  
Benign Lesion ◽  
Pelvic Mass ◽  
Clinical Image ◽  
Pelvic Cavity ◽  
Cytokeratin Expression ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor

Abstract Background: Solitary fibrous tumor is an uncommon mesenchymal neoplasm that originates from fibroblasts and occurs predominantly in the visceral pleura. Pelvic cavity small sized malignant solitary fibrous tumor is very rare; it is easily misjudged by surgeons as a benign lesion and resected by laparoscopic surgery. When accompanied by dedifferentiation, malignant solitary fibrous tumor is difficult to diagnose by pathologists. Here, we describe a challenging case.Case presentation: A 47-year-old man was accidentally found to have a pelvic mass for three months, with pain and distension for seven days. The mass was adhered and compressed to the ureter and bladder. The right side of the pelvic cavity had a palpable and substantial mass, with no obvious associated pain. With an assumed diagnosis of a benign tumor, the patient underwent laparoscopic surgery to resect the tumor. Histologically, spindle cell areas and dedifferentiated areas were observed. Immunohistochemical analysis of dedifferentiated regions revealed cytokeratin showed multifocal expression. Vimentin and CD34 were abnormal negative. This case was diagnosed as a MSFT with dedifferentiation. The patient was well after the operation, but, unfortunately, he had a recurrence one year later.Conclusion: Pelvic cavity malignant solitary fibrous tumor is a rare tumor that is in frequently dedifferentiated and exhibiting cytokeratin expression. The diagnosis of this type of tumor can be confusing, and it should be distinguished from Synovial Sarcoma, Liposarcoma, and other malignant tumors. The expression of cytokeratin and the absence of vimentin and CD34 are pitfalls to diagnosis. In this case, there was still a high degree of malignancy despite the small size of the tumor. Clinical-image-pathological multidisciplinary analysis has a great effect on diagnosis and therapy of diseases. This case is a cautionary tale for surgeons and pathologists.

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