scholarly journals A pelvic cavity malignant solitary fibrous tumor with dedifferentiation and multifocal cytokeratin expression

2020 ◽  
Author(s):  
Yan He ◽  
Guan Huang ◽  
Wensong Lin ◽  
Zhaohui Zheng ◽  
Haiyan Zhao
Keyword(s):  
Laparoscopic Surgery ◽  
Solitary Fibrous Tumor ◽  
Malignant Tumors ◽  
Benign Lesion ◽  
Pelvic Mass ◽  
Clinical Image ◽  
Pelvic Cavity ◽  
Cytokeratin Expression ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor

Abstract Background: Solitary fibrous tumor is an uncommon mesenchymal neoplasm that originates from fibroblasts and occurs predominantly in the visceral pleura. Pelvic cavity small sized malignant solitary fibrous tumor is very rare; it is easily misjudged by surgeons as a benign lesion and resected by laparoscopic surgery. When accompanied by dedifferentiation, malignant solitary fibrous tumor is difficult to diagnose by pathologists. Here, we describe a challenging case.Case presentation: A 47-year-old man was accidentally found to have a pelvic mass for three months, with pain and distension for seven days. The mass was adhered and compressed to the ureter and bladder. The right side of the pelvic cavity had a palpable and substantial mass, with no obvious associated pain. With an assumed diagnosis of a benign tumor, the patient underwent laparoscopic surgery to resect the tumor. Histologically, spindle cell areas and dedifferentiated areas were observed. Immunohistochemical analysis of dedifferentiated regions revealed cytokeratin showed multifocal expression. Vimentin and CD34 were abnormal negative. This case was diagnosed as a MSFT with dedifferentiation. The patient was well after the operation, but, unfortunately, he had a recurrence one year later.Conclusion: Pelvic cavity malignant solitary fibrous tumor is a rare tumor that is in frequently dedifferentiated and exhibiting cytokeratin expression. The diagnosis of this type of tumor can be confusing, and it should be distinguished from Synovial Sarcoma, Liposarcoma, and other malignant tumors. The expression of cytokeratin and the absence of vimentin and CD34 are pitfalls to diagnosis. In this case, there was still a high degree of malignancy despite the small size of the tumor. Clinical-image-pathological multidisciplinary analysis has a great effect on diagnosis and therapy of diseases. This case is a cautionary tale for surgeons and pathologists.

scholarly journals Solitary Fibrous Tumor of the Chest Wall in an Infant- A Rare Case Report

2015 ◽  
Vol 4 (1) ◽  
pp. 28-31
Author(s):  
SM Sabbir Enayet ◽  
Kaniz Hasina
Keyword(s):  
Chest Wall ◽  
Solitary Fibrous Tumor ◽  
Malignant Tumors ◽  
Therapeutic Option ◽  
Surgical Excision ◽  
Mesenchymal Neoplasm ◽  
Accurate Preoperative Diagnosis ◽  
Rare Case Report ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor

Solitary fibrous tumor is an uncommon mesenchymal neoplasm that very rarely appears in extra serosal soft tissue. Though pleural solitary fibrous tumor is more common, up to one third of the reported cases were at extra pleural sites. Although pleural and extrapleural solitary fibrous tumors are regarded as indolent tumors, there is some evidence that extrapleural subgroup could be a subset of more aggressive malignant tumors. Accurate preoperative diagnosis of extrapleural solitary fibrous tumor is very difficult and usually is a diagnosis of exclusion. Surgical excision is mandatory and is the best therapeutic option. In this article we report a case of solitary fibrous tumor of the chest wall in a 2 months old boy.J. Paediatr. Surg. Bangladesh 4(1): 28-31, 2013 (January)

SOLITARY FIBROUS TUMOR OF PROSTATE – A CASE REPORT

2021 ◽  
pp. 17-18
Author(s):  
Shaila Shaila ◽  
Aparna. C ◽  
Sowmiya. J ◽  
Geetha Sree. A
Keyword(s):  
Case Report ◽  
Benign Prostatic Hyperplasia ◽  
Solitary Fibrous Tumor ◽  
Prostatic Hyperplasia ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor ◽  
Cut Surface ◽  
Made In

Solitary Fibrous Tumor (SFT) of prostate is an unusual mesenchymal neoplasm. We report SFT in a 62 year-old man which was clinically misdiagnosed as benign prostatic hyperplasia (BPH). The specimen of surgically resected two prostate mass, we received were solid grey-white nodular on cut surface. Based on histopathological ndings and IHC assessment, a diagnosis of SFT was made. In addition, we review the literature and discuss the challenging issues of misdiagnosis. The case is presented in view of its rarity.

scholarly journals Dedifferentiated Solitary Fibrous Tumor: A Concise Review

2018 ◽  
Vol 142 (6) ◽  
pp. 761-766 ◽  
Author(s):  
Nicholas J. Olson ◽  
Konstantinos Linos
Keyword(s):  
Solitary Fibrous Tumor ◽  
Correct Diagnosis ◽  
The Body ◽  
Molecular Alterations ◽  
Concise Review ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor ◽  
Aggressive Clinical Course ◽  
Age Range ◽  
Ancillary Studies

Solitary fibrous tumor (SFT) is a unique mesenchymal neoplasm that was originally believed to be of submesothelial origin. Eventually, SFT expanded to include what was previously called hemangiopericytoma in other regions of the body that had similar immunohistochemical and morphologic features. Although most are benign, many studies have tried to identify histologic features that predict which tumors will behave in an aggressive manner. Recently, dedifferentiation has been described in rare cases of SFT and does appear to correlate with a more aggressive clinical course. Dedifferentiated SFT occurs in a similar age range and location as conventional SFT and can resemble multiple different malignant entities. Utilization of ancillary studies and thorough tissue sampling is important to reach the correct diagnosis. The morphologic features, immunohistochemistry, molecular alterations, and prognosis will be discussed.

scholarly journals Solitary extrapleural fibrous tumor with hepatic bilobar metastases: multimodal approach treatment

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maitane I. Orue-Echebarria ◽  
Laura Garciafília ◽  
Luis Rodriguez-Bachiller ◽  
Benjamín Díaz-Zorita ◽  
Enrique Velasco ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Solitary Fibrous Tumor ◽  
Future Liver Remnant ◽  
Distant Metastases ◽  
R0 Resection ◽  
Two Stage ◽  
Liver Remnant ◽  
Therapeutic Decisions ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor is an unusual fibroblastic mesenchymal neoplasm typically described in the pleura. It may appear anywhere with a varied anatomic distribution and essentially it can develop from any soft tissue or visceral location. Its course is usually indolent and it rarely causes distant metastases, so it has a prolonged survival rate. It sometimes presents itself as a disseminate disease being the liver the most frequently involved location. In these occasions, the management should be discussed in a multidisciplinary tumor committee formed by surgeons, oncologists and radiologists. Surgery remains the gold standard for treatment. Case representation We present the case of a woman with a tumor in the left abdominal wall and bilobar massive liver metastases, both locations histologically diagnosed as solitary fibrous tumor. She receives biological treatment for a severe case of Crohn´s disease. Evaluated in a multidisciplinary committee, surgery was recommended for both the primary lesion and the liver metastases. The hepatobiliary surgeons considered a two-stage hepatectomy with portal vein embolization (PVE) as the best strategy. After the first procedure consisting in cleaning the left hepatic lobe followed by PVE the future liver remnant volume (FLRV) was considered inadequate, so the patient was also treated with right transarterial radioembolizacion with yttrium 90 (TARE-Y90) intending a double goal: to treat the tumor and to increased the FLRV. Furthermore, a severe flare of Crohn´s disease forced us to intensify the patient’s treatment with the addition of biological agents (infliximab and adalimumab) until complete remission of the symptoms. The second stage of the liver surgery had to be postponed for more than 6 months and could finally be carried out without complications, achieving an R0 resection. The postoperative course was uneventful and the follow up has showed no recurrence to date. Conclusion Solitary fibrous tumours with extensive liver metastases are infrequent but when they appear modern surgical strategies like two stage hepatectomy are the treatment of choice and must be carried out by specialised units. The therapeutic decisions should be guided by a multidisciplinary committee.

scholarly journals Solitary Fibrous Tumor of the Postcricoid Region: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Brian Cervenka ◽  
Brenda Villegas ◽  
Uttam Sinha
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Management Strategies ◽  
The Body ◽  
Surgical Approaches ◽  
Current Management ◽  
First Case ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor

Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm that can present essentially anywhere in the body. Presentations in the hypopharynx are extremely rare with only two previous cases reported. We report the first case of postcricoid SFT occurring in a 58-year-old male requiring a microsuspension laryngoscopy excision following an unsuccessful transoral robotic attempt. The excision was uneventful, and the patient is currently without recurrence. Current management strategies of the hypopharyngeal SFT, the unique differential diagnosis, and challenges in surgical approaches in the postcricoid region are discussed.

scholarly journals Solitary fibrous tumor of the pleura: 3 case reports

2015 ◽  
Vol 61 (3) ◽  
pp. 207-208 ◽  
Author(s):  
Elias Amorim
Keyword(s):  
Solitary Fibrous Tumor ◽  
Case Reports ◽  
Benign Lesion ◽  
Complete Resection ◽  
The Other ◽  
Posterolateral Thoracotomy ◽  
Pertinent Literature ◽  
Complete Surgical Resection ◽  
Fibrous Tumor

Summary Introduction: solitary fibrous tumor of the pleura (SFTP) is a rare tumor arising from mesenchymatous cells in submesothelial pleural tissue which, unlike mesothelioma, is not related to asbestos or smoking. Methods: report of four patients who underwent surgical treatment for giant SFTP and review of the pertinent literature. Results: of the four patients operated, two presented symptoms including cough, chest pain and feeling of compression, whereas the other two subjects were asymptomatic. All patients underwent complete surgical resection by wide posterolateral thoracotomy, and surgical specimens removed with minimum bleeding. None of the cases required complementary lobectomy or segmentectomy. All tumors were histologically benign. Conclusion: complete resection of the lesion is the treatment of choice in all SFTP cases. Prognosis of the benign lesion is excellent, although close follow-up is necessary. In the rarer, more aggressive forms, treatment may be complemented by adjunctive chemotherapy or radiotherapy, the benefits of which have yet to be confirmed.

Solitary Fibrous Tumor Treated with Laparoscopic Surgery: Case Report and Review of the Literature

2014 ◽  
Vol 30 (6) ◽  
pp. 353-356 ◽  
Author(s):  
Eugenio Volpi ◽  
Luca Bernardini ◽  
Michele Moroni ◽  
Franco Fedeli
Keyword(s):  
Case Report ◽  
Laparoscopic Surgery ◽  
Solitary Fibrous Tumor ◽  
Review Of The Literature ◽  
Fibrous Tumor

scholarly journals Extraordinarily long-inactive solitary fibrous tumor transformed to produce big insulin-like growth factor-2, leading to hypoglycemia and rapid liposarcoma growth: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Keizo Kaneko ◽  
Shojiro Sawada ◽  
Chihiro Satake ◽  
Keiichi Kondo ◽  
Tomohito Izumi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Solitary Fibrous Tumor ◽  
Renal Tumor ◽  
Left Kidney ◽  
Arterial Embolization ◽  
Immunoblot Analysis ◽  
Insulin Like Growth Factor ◽  
Mesenchymal Neoplasm ◽  
Computed Tomography Scanning ◽  
Fibrous Tumor

Abstract Background A high-molecular-weight form of insulin-like growth factor-2 (IGF-2), known as “big” IGF-2, is occasionally produced by various tumor types, leading to hypoglycemia. Although solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm, it has been estimated that 4–6% of SFT patients develop hypoglycemia due to circulating big IGF-2. The mean time elapsed from tumor detection until the onset of hypoglycemia is reportedly less than one year (8.5 ± 1.9 months). Case presentation A 68-year-old man was hospitalized for exacerbation of recurring hypoglycemic episodes. He had been diagnosed with an SFT 17 years before the onset of hypoglycemia, and the SFT had already been very large at that time. The tumor, which was non-resectable and refractory to chemotherapies, had slowly increased in size since the initial diagnosis. Half a year before the hypoglycemic episodes manifested, another tumor, adjacent to the left kidney, was newly identified. Fluorodeoxyglucose positron emission tomography-computed tomography scanning, revealed the left peri-renal tumor to show much higher fluorodeoxyglucose uptake than the preexisting SFT, suggesting that it was unlikely to be a metastasis from the SFT. Abundant serum big IGF-2 was detected by western immunoblot analysis, indicating it to be the cause of the hypoglycemia. Since the 17 years between SFT detection and the onset of IGF-2-induced hypoglycemia was an extremely long period as compared with those in previous reports, we initially suspected that the new, peri-renal tumor had produced big IGF-2, but transcatheter arterial embolization of its feeding arteries did not suppress hypoglycemia. Notably, by measuring the tumor volume doubling time, the peri-renal tumor growth was shown to be markedly accelerated in parallel with exacerbation of the hypoglycemia. The patient died of heart failure 21 months after the onset of hypoglycemia. Unexpectedly, autopsy revealed that big IGF-2 had been produced only by the preexisting SFT, not the peri-renal tumor, and that the peri-renal tumor was a dedifferentiated liposarcoma. Conclusions We should keep in mind that even a long-inactive SFT can undergo transformation to produce big IGF-2, which then acts on both insulin and IGF-1 receptors, possibly leading to both hypoglycemia and the development/growth of another tumor, respectively.

scholarly journals A Case of Solitary Fibrous Tumor Presenting as Lower Neck Mass

2021 ◽  
Vol 37 (2) ◽  
pp. 87-90
Author(s):  
Sang Yen Geum ◽  
Jeong Kyu Kim
Keyword(s):  
Solitary Fibrous Tumor ◽  
Malignant Tumors ◽  
Neck Region ◽  
Needle Aspiration ◽  
Neck Mass ◽  
Anatomic Site ◽  
S 100 ◽  
Hypoechoic Mass ◽  
Fibrous Tumor ◽  
Lower Neck

Solitary fibrous tumor (SFT) is rare mesenchymal tumor usually arising from pleura. SFT can be found at all anatomic site in our body but incidence of SFT is much lower in head and neck region especially at lower neck area. We found a case of SFT that presented as a lower neck mass in a 41-year old woman. Ultrasonography showed a 3×1cm sized hypoechoic mass in the intermuscular fat plane of left lower neck, and computed tomography showed a well circumscribed, low-density mass with contrast enhancement. Fine needle aspiration showed no malignant cells with abundant red blood cells, but it was not possible to completely rule out malignant tumors or nodules clinically. Surgery was performed to make a definitive diagnosis and histopathology showed tightly packed, round to fusiform cells with staghorn shaped vessels at microscopic examination. The tumor cell were positive for CD34 but negative for CD31 and S-100 protein.

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