scholarly journals The use of autologous platelet-rich fibrin matrix combined with meniscal repair in the treatment of parameniscal cyst: clinical results and cyst recurrence after 2-year of follow up

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Daniele Screpis ◽  
Gianluca Piovan ◽  
Simone Natali ◽  
Stefano Pasqualotto ◽  
Stefano Magnanelli ◽  
...  
Keyword(s):  
Meniscal Repair ◽  
Clinical Results ◽  
Open Approach ◽  
Knee Score ◽  
Platelet Rich Fibrin ◽  
Fibrin Matrix ◽  
Lysholm Knee Score ◽  
Autologous Platelet ◽  
Parameniscal Cyst

Abstract Purpose Parameniscal cysts are associate with horizontal meniscal tears. Arthroscopic meniscal repair and the excision of the cyst by mini-open approach represent a valid treatment. However, the recurrence of cyst is still a current issue. Therefore, biological factors may be considered to promote the biological repair and avoid recurrence. The aim of the present study was to report the clinical results and the rate of recurrence of the cyst after minimum 2-year of follow up in a cohort of patients treated by meniscal repair and autologous platelet-rich fibrin matrix augment. Methods Patients with lateral parameniscal cyst undergoing arthroscopic meniscal repair and autologous platelet-rich fibrin matrix augment between 2016 and 2019 were retrospectively reviewed in March 2021. Inclusion criteria were absence of prior surgery on the affected knee with minimum 2-year of follow-up. Exclusion criteria were concomitant ligament lesions, rheumatic diseases and knee osteoarthritis. After reviewing the database, each selected patient was contacted and asked to participate in the study; at the follow-up evaluation all patient signed an informed consent. Tegner-Lysholm knee score, IKDC and NRS were collected before surgery and at follow-up. Results This study included 15 patients (8 male) with mean age of 32.8 years old. No recurrence of the cysts was observed. The Tegner-Lysholm knee score and IKDC subjective scores increased respectively from 41.3 ± 5.4 and 37.6 ± 5.1 at baseline to 92.3 ± 4.6 and 89.4 ± 2.6 at the final follow up. Concerning pain relief, the Numeric Pain Rating Scale (NRS) displayed a significant improvement reaching at the follow up a score of 1,3 ± 1.1 in comparison to 6.8 ± 0.9 at the baseline. Conclusion Surgical management of symptomatic lateral parameniscal cyst with cyst excision, autologous PRP membrane application and meniscus repair demonstrated excellent subjective clinical outcome with any cyst reoccurrence. Level of evidence III, retrospective cohort study.

Meniscal Ramp Lesion Repair Using the FasT-Fix Technique: Evaluating Healing and Patient Outcomes with Second-Look Arthroscopy

2017 ◽  
Vol 31 (08) ◽  
pp. 710-715 ◽  
Author(s):  
Zhong Chen ◽  
Wei-Ping Li ◽  
Rui Yang ◽  
Bin Song ◽  
Chuan Jiang ◽  
...  
Keyword(s):  
Acl Reconstruction ◽  
Cruciate Ligament ◽  
Meniscal Repair ◽  
Acl Injury ◽  
Knee Score ◽  
Second Look ◽  
Ramp Lesion ◽  
Lysholm Knee Score ◽  
Objective Score

AbstractAlthough the suture-hook technique remains popular for meniscal ramp lesions, which frequently occur after anterior cruciate ligament (ACL) injury, it is unclear whether the all-inside FasT-Fix technique (Smith & Nephew, Andover, MA) is appropriate for the repair of ramp lesions. This study evaluated results of arthroscopic FasT-Fix meniscal ramp lesion repair using second-look arthroscopy. From August 2010 to December 2014, 46 knees diagnosed with combined ACL injury and ramp lesion underwent ACL reconstruction with meniscal repair using the FasT-Fix technique. We classified ramp lesions into three types according to tear pattern: meniscotibial ligament tear, meniscocapsular tear, and combined meniscotibial/meniscocapsular tear. Second-look arthroscopy was performed postoperatively. The healing capacity of the ramp lesion was evaluated retrospectively. At the final follow-up (mean = 32 months), the Lysholm knee score and the International Knee Documentation Committee (IKDC) objective score were compared with preoperative scores. All patients (n = 46) underwent a second-look arthroscopy, with 45 (97.8%) exhibiting complete or partial healing after the FasT-Fix technique was used in conjunction with ACL reconstruction. The Lysholm knee score and IKDC objective score were significantly better than preoperative scores at final follow-up. The FasT-Fix technique for meniscal ramp lesion repair—when performed with concomitant ACL reconstruction—exhibits excellent healing results.

Obsidian ASG® Autologous Platelet-Rich Fibrin Matrix and Colorectal Anastomotic Healing: A Preliminary Study

2021 ◽  
Vol 39 ◽  
Author(s):  
Andreas Shamiyeh ◽  
◽  
Bettina Klugsberger ◽  
Carina Aigner ◽  
Wolfgang Schimetta ◽  
...  
Keyword(s):  
Anastomotic Leakage ◽  
Anastomotic Leak ◽  
Colorectal Resection ◽  
Rectal Resection ◽  
Leak Rate ◽  
Anastomotic Healing ◽  
Platelet Rich Fibrin ◽  
Anastomotic Leak Rate ◽  
Fibrin Matrix ◽  
Autologous Platelet

Introduction: Anastomotic leakage (AL) following colorectal resection is a devastating complication affecting morbidity, mortality, and quality of life of patients in the long term. Different tissue sealants and biologic glues were tested showing conflicting results regarding their influence on anastomotic healing and leak prevention. Application of autologous platelet-rich fibrin (Vivostat A/S, Alleroed, Denmark), which acts as a source of angiogenic growth factors and cytokines, showed promising results in an in-vivo porcine model. Herein, we present the first human study of stapled colorectal anastomoses supplemented with an autologous-derived platelet-rich fibrin matrix (Obsidian ASG®, Rivolution GmbH, Rosenheim, Germany and Vivostat A/S, Alleroed, Denmark). Materials and Methods: A retrospective analysis of prospectively accumulated data was performed in two colorectal centers (Linz, Vienna) on patients undergoing left-sided colorectal or coloanal stapled anastomosis between October 2018 and December 2019. The Obsidian ASG® Matrix was applied to the rectal stump, and after closure with the circular stapling device, at the circumference of anastomosis in every single case. Anastomoses were supplemented with intra- and extra-anastomotic application (IAA—intra-anastomotic application developed by Rivolution GmbH, Rosenheim, Germany) of Obsidian ASG® Matrix. The primary endpoints were incidence of perioperative complications and anastomotic leak rate. Results: Two-hundred-sixty-one (138 female) patients underwent left-sided colonic (n=177) or rectal resection (n=84). In 253 (96.9%) cases, a laparoscopic or robotic-assisted approach was used. There were no complications attributable to the intraoperative application of the Obsidian ASG® Matrix. All intraoperative leak tests were negative. Overall, anastomotic leak rate accounted for 2.3% (6/261). AL following colonic and rectal resection was seen in 2.3% (4/177) and 2.4% (2/84), respectively. Complication and leak rate was similar in the two participating centers. Postoperative fever and elevated CRP levels were significantly correlated to AL. There was no significant risk factor for AL on multivariate analysis. Conclusion: Application of an autologous-derived platelet-rich fibrin matrix (Obsidian ASG®) at anastomotic site following colorectal resection is safe and associated with a low rate of anastomotic leakage.

scholarly journals Autologous platelet-rich fibrin matrix in non-healing trophic ulcers in patients with Hansen's disease

2017 ◽  
Vol 10 (1) ◽  
pp. 3 ◽  
Author(s):  
Umashankar Nagaraju ◽  
PriyaK Sundar ◽  
Priyanka Agarwal ◽  
BelliappaP Raju ◽  
Mahesh Kumar
Keyword(s):  
Hansen's Disease ◽  
Platelet Rich Fibrin ◽  
Fibrin Matrix ◽  
Hansen’S Disease ◽  
Autologous Platelet

scholarly journals Is radiofrequency use in arthroscopic treatment of isolated medial meniscus horizontal cleavage tears more effective than mechanical debridement in young adults?

2020 ◽  
pp. 76-76
Author(s):  
Özgür Korkmaz ◽  
Uğur Kasman ◽  
Sıtkı Çeçen
Keyword(s):  
Clinical Outcomes ◽  
Medial Meniscus ◽  
Knee Score ◽  
Arthroscopic Partial Meniscectomy ◽  
Vas Score ◽  
Bipolar Radiofrequency ◽  
Lysholm Knee Score ◽  
The Mean ◽  
Early Clinical Outcomes

Introduction/Objective. Arthroscopic mechanical hand tools, motorized shavers, and bipolar radiofrequency are used in arthroscopic partial meniscectomy. The aim of this study is to evaluate efficacy of radiofrequency on early clinical outcomes in patients who underwent arthroscopic partial meniscectomy with horizontal cleavage tear and without additional intraarticular knee pathology. Methods. A total of 37 patients complied with the study criteria. Patients were divided into two groups according to usage of bipolar radiofrequency. Patients were evaluated by using visual analog scale (VAS) and Tegner Lysholm knee scores at the end of the first year follow-up. Results. Twenty-two patients comprised the shaver-using group. Preoperative mean VAS score was 7.9 ? 0.8, and the Tegner Lysholm knee score was 49.6 ? 9.6. Fifteen patients comprised the bipolar radiofrequency-using group. Preoperative VAS score was 7.8 ? 0.9, and the Tegner Lysholm knee score was 52.2 ? 10.7. The mean VAS score was 1.2 ? 0.9, and the mean Tegner Lysholm knee score was 89.5 ? 8.1 in shaver used group at last follow-up. At the last postoperative follow-up, the mean VAS score was 1.1 ? 1, and the Tegner Lysholm knee score was 88.8 ? 7.3 in the bipolar radiofrequency-using group. No statistically significant differences between the VAS and Tegner Lysholm knee scores of the preoperative and postoperative controls of the two groups were observed (p?0.05). Conclusion. Radiofrequency use has no effect on early clinical outcomes in the arthroscopic treatment of isolated medial meniscus posterior horn horizontal cleavage tears; we do not recommend its use

scholarly journals A comparative biomechanical study of repaired tendons wrapped with two biological matrices in Bucks

2016 ◽  
Vol 40 (1) ◽  
pp. 73-78
Author(s):  
N. H. AL-Falahi
Keyword(s):  
Extracellular Matrix ◽  
Tensile Strength ◽  
Matrix Group ◽  
Biological Matrices ◽  
Control Groups ◽  
Platelet Rich Fibrin ◽  
Fibrin Matrix ◽  
Superficial Digital Flexor Tendon ◽  
And Control ◽  
Autologous Platelet

     This study is planned to evaluate the efficacy of two biological matrices represented by autologous platelet rich fibrin matrix, as well as a cross linked decellularized caprine pericardial extracellular matrix on enhancing healing of the experimentally severed superficial digital flexor tendon in a goat model. It was carried out on 48 adult apparently healthy bucks, which were divided randomly into three equal groups. Under the effect of sedative and local ring block anesthesia, superficial digital flexor tendon was severed at the mid metacarpal region of the right forelimb. In the first control group, tenorrhaphy was performed and left without additives. While in the second group the tenorrhaphy site was wrapped with a previously prepared autologous platelet rich fibrin strips, as well as in the third group the tenorrhaphy site was wrapped with a cross linked decellularized pericardial extracellular matrix strip which was prepared from the whole fresh caprine pericardium obtained from the slaughter house. Both matrices were fixed in their position at the tenorrhaphy site by few interrupted stitches. The biomechanical evaluation of the operated tendon indicated an increase in tensile strength with time in all groups, but the comparisons among groups showed a significant (P≤0.05) increase at day 15 in both treated as compared to control animals. On day 45 the pericardial extracellular matrix group showed a significant increase in tensile strength as compared to platelet rich fibrin matrix and control groups, but at day 75 there were no differences among groups, at day 180 the pericardial extracellular matrix group showed a significant increase in the tensile strength as compared to platelet rich fibrin matrix and control groups. In conclusion, both biological matrices led to improvement in the biomechanical properties of the operated tendons with time.

All-Inside Arthroscopic Repair For Longitudinal Meniscal Tears: Clinical and Functional Results

2021 ◽  
Author(s):  
Stefano Grossi ◽  
Edoardo Ipponi ◽  
Eric Bufalino ◽  
Gabriele Gariffo ◽  
Gabriele Filoni ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Meniscal Tear ◽  
Meniscal Repair ◽  
Functional Results ◽  
Repair System ◽  
Knee Score ◽  
Meniscal Tears ◽  
Lysholm Knee Score ◽  
Arthroscopic Meniscectomy ◽  
The Mean

Meniscal injuries are a common challenge in orthopaedic surgery. Depending on their location and the patient’s age and functional needs, they can be treated either conservatively or surgically. A surgical approach can consist of arthroscopic meniscectomy or meniscal suture. The latter is the treatment of choice in case of lesions involving the red-red or red-white areas of the meniscus, especially for young high-demanding patients. We report here our experience with the repair of longitudinal meniscal tears using the all-inside technique with the Fast-Fix™ 360 Meniscal Repair System (Smith & Nephew Endoscopy, Andover, MA). We retrospectively evaluated 20 consecutive cases of longitudinal meniscal tears. In 4 cases, concomitant ACL rupture was diagnosed and treated alongside the meniscal repair. All patients underwent periodic clinical evaluations. At the latest check-up, their functional outcomes were rated according to the Tegner-Lysholm Knee and KOOS scoring scales. The mean Tegner-Lysholm Knee score was 84.85 (44-100) and the mean KOOS score was 88.58. No failure or major complications were observed. Furthermore, a negative statistical association was observed between age at surgery and the post-operative Tegner-Lysholm Knee score (coef. = -1.01189 [-1.942073,-0.0817063], p = 0.035). This relation, independent of gender, meniscus involved, eventual associated ACL reconstruction, and chondral injury, suggests that functional outcomes worsen with increasing patient age. Our results suggest that the arthroscopic all-inside suture is both safe and effective in cases of longitudinal meniscal tear, considering the good post-operative functionality and low rates of local complications and surgical failures.

scholarly journals Efficacy of Platelet Rich Fibrin in Myringoplasty

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Nida Riaz ◽  
Ajmal Muhammad ◽  
Muhammad sheharyar Khan
Keyword(s):  
Controlled Trial ◽  
Control Group ◽  
Infection Rates ◽  
Hearing Improvement ◽  
Platelet Rich Fibrin ◽  
Creative Commons ◽  
Randomized Controlled ◽  
Autologous Platelet ◽  
Open Access Article

Objective: To determine the efficacy of usage of topical autologous platelet rich fibrin (PRF) in improving outcomes of myringoplasty regarding graft uptake and hearing improvement. Methods: This study was conducted in the ENT department of Holy Family Hospital, Rawalpindi, over a period of six months from August 2019 to January 2020. It was designed as a prospective single blinded randomized controlled trial. The study involved a total of 50 participants in whom myringoplasty was done through post auricular approach using underlay technique. In 25 patients topical drops of PRF were used. Outcomes were compared after three months with the control group (n=25), who underwent myringoplasty without PRF. Results: After three months follow-up, graft uptake was reported 78% and 52% in cases and controls, respectively (P=0.070). Mean hearing improvement was 18 dB and 6 dB in cases and controls, respectively (P=0.014). Postoperative infection occurred in 8% of the cases, and in 32% controls (P=0.037). Conclusion: Topical use of Platelet-Rich Fibrin during myringoplasty results in improved graft uptake. Hence, resulting in much improved hearing, significant reduction in infection rates and decrease in perforation sizes. doi: https://doi.org/10.12669/pjms.37.1.3059 How to cite this:Riaz N, Ajmal M, Khan MS. Efficacy of Platelet Rich Fibrin in Myringoplasty. Pak J Med Sci. 2021;37(1):212-216. doi: https://doi.org/10.12669/pjms.37.1.3059 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Autologous Platelet-Rich Fibrin Matrix–Augmented Repair for Parameniscal Cysts: Surgical Technique

2021 ◽  
Author(s):  
Daniele Screpis ◽  
Simone Natali ◽  
Gianluca Piovan ◽  
Venanzio Iacono ◽  
Stefano Magnanelli ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Platelet Rich Fibrin ◽  
Fibrin Matrix ◽  
Autologous Platelet

scholarly journals Long-Term Clinical Results of Double Bundle Reconstruction of the Medial Patellofemoral Ligament for Patellar Instability

2018 ◽  
Vol 32 (02) ◽  
pp. 153-159 ◽  
Author(s):  
Lei Zhang ◽  
Zhiyao Li
Keyword(s):  
Patellar Instability ◽  
Medial Patellofemoral Ligament ◽  
Clinical Results ◽  
Double Bundle ◽  
Double Bundle Reconstruction ◽  
Kujala Score ◽  
Lysholm Knee Score ◽  
Lost To Follow Up

Medial patellofemoral ligament (MPFL) reconstruction is a satisfactory technique for patellar instability, and the anatomical double bundle variant is recommended for better clinical results. However, long-term outcomes are still uncharacterized. This study aimed to assess the effectiveness of double bundle reconstruction of the MPFL for patellar instability by means of established scores. A total of 68 patients with chronic patellar instability who underwent surgery from May 2005 to February 2010 were included prospectively. Anatomical double reconstruction of the MPFL with the semitendinosus tendon was conducted. Tegner Activity Scale (TAS), Kujala score, Lysholm knee score, and objective physical examination were assessed during follow-up. Median follow-up time for the patients was 8 (range, 6–10) years. Eight patients were lost to follow-up after 2 years. Preoperative mean TAS was 2.85 ± 0.78, increased to 4.91 ± 0.84 at 6 months and 7.26 ± 0.78 at 2 years postoperatively, and was 7.82 ± 0.89 at last follow-up. At last follow-up, pain free at rest was achieved in all patients; and 8 patients had knee pain in activities of daily living. Mean Kujala score was 57.53 ± 8.59 preoperatively, and increased to 61.22 ± 6.46, 89.51 ± 3.90, and 88.92 ± 3.84 at 6 months, 2 years postoperatively, and at last follow-up, respectively. Lysholm scores were also increased from preoperative values of 43.53 ± 10.20 to 58.22 ± 6.80, 89.37 ± 4.38, and 89.67 ± 4.13 at 6 months, 2 years postoperatively, and at last follow-up, respectively. Range of motion was 121.44 ± 12.69, 129.71 ± 6.39, 130.93 ± 5.67, and 130.78 ± 5.80 at preoperative point, 6 months, 2 years postoperatively, and at last follow-up, respectively. Long-term clinical results of double bundle reconstruction of the MPFL for patellar instability were encouraging.

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