S1-induced vasospastic angina—diagnostic utility of Holter ECG: a report of a case

We investigated the diagnostic value and pathophysiological role of circulating microRNA (miR) in vasospastic angina (VA). We enrolled patients who underwent coronary angiography for chest pain to explore the miR’s diagnostic utility. In addition, we investigated the role of miRs in regulating endothelial nitric oxide synthase (eNOS) expression in human coronary artery endothelial cells (hCAECs). Among the 121 patients, 46 were diagnosed with VA (VA group), 26 with insignificant coronary lesions (ICL group), and 49 with atherothrombotic angina (AA group). The VA group showed a significantly higher expression of miR-17-5p, miR-92a-3p, and miR-126-3p than the ICL group. In contrast, miR-221-3p and miR-222-3p were upregulated in the AA group compared to the VA group, and all levels of miR-17-5p, miR-92a-3p, miR-126-3p, miR-145-5p, miR-221-3p, and miR-222-3p differed between the AA group and the ICL group. In the hCAECs, transfection with mimics (pre-miR) of miR-17-5p, miR-92a-3p, and miR-126-3p was associated with eNOS suppression. Additionally, transfection with inhibitors (anti-miR) of miR-92a-3p significantly rescued the eNOS suppression induced by lipopolysaccharide. In conclusion, the circulating miRs not only proved to have diagnostic utility, but also contributed to pathogenesis by eNOS regulation.

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Comment on “The Effects of Age on the Diagnostic Utility of the Rollover Phenomenon”

Journal of Speech and Hearing Disorders ◽

10.1044/jshd.4104.556b ◽

1976 ◽

Vol 41 (4) ◽

pp. 5561-5562 ◽

Cited By ~ 2

Author(s):

James Jerger ◽

Susan Jerger

Keyword(s):

Diagnostic Utility

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The diagnostic utility of pericholecystic high signal by magnetic resonance cholangiography in the patient with acute cholecystitis

Gastroenterology ◽

10.1016/s0016-5085(01)82866-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A577-A577

Author(s):

T SEKI ◽

M FURUKAWA ◽

M OGIHARA ◽

Y MAGAMI ◽

T HORIBE ◽

...

Keyword(s):

Magnetic Resonance ◽

Acute Cholecystitis ◽

Magnetic Resonance Cholangiography ◽

High Signal ◽

Diagnostic Utility

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1798: Expression and Diagnostic Utility of P63 and Alpha-Methyl-Coa-Racemase (P504S) Cocktail in Ambiguous Lesion of the Prostate

The Journal of Urology ◽

10.1016/s0022-5347(18)38990-0 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 475-475

Author(s):

Vincent Molinie ◽

Jean-Marie Herve ◽

Mathilde Sibony ◽

Gaelle Fromont ◽

Annick Vieillefond ◽

...

Keyword(s):

Diagnostic Utility

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Tissue plasminogen activator as a novel diagnostic aid in acute pulmonary embolism

VASA ◽

10.1024/0301-1526/a000392 ◽

2014 ◽

Vol 43 (6) ◽

pp. 450-458 ◽

Cited By ~ 1

Author(s):

Julio Flores ◽

Ángel García-Avello ◽

Esther Alonso ◽

Antonio Ruíz ◽

Olga Navarrete ◽

...

Keyword(s):

Pulmonary Embolism ◽

Negative Predictive Value ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Predictive Value ◽

Acute Pulmonary Embolism ◽

Enzyme Linked Immunosorbent Assay ◽

Diagnostic Utility ◽

Tissue Plasminogen ◽

D Dimer

Background: We evaluated the diagnostic efficacy of tissue plasminogen activator (tPA), using an enzyme-linked immunosorbent assay (ELISA) and compared it with an ELISA D-dimer (VIDAS D-dimer) in acute pulmonary embolism (PE). Patients and methods: We studied 127 consecutive outpatients with clinically suspected PE. The diagnosis of PE was based on a clinical probability pretest for PE and a strict protocol of imaging studies. A plasma sample to measure the levels of tPA and D-dimer was obtained at enrollment. Diagnostic accuracy for tPA and D-dimer was determined by the area under the receiver operating characteristic (ROC) curve. Sensitivity, specificity, predictive values, and the diagnostic utility of tPA with a cutoff of 8.5 ng/mL and D-dimer with a cutoff of 500 ng/mL, were calculated for PE diagnosis. Results: PE was confirmed in 41 patients (32 %). Areas under ROC curves were 0.86 for D-dimer and 0.71 for tPA. The sensitivity/negative predictive value for D-dimer using a cutoff of 500 ng/mL, and tPA using a cutoff of 8.5 ng/mL, were 95 % (95 % CI, 88–100 %)/95 % (95 % CI, 88–100 %) and 95 % (95 % CI, 88–100 %)/94 %), respectively. The diagnostic utility to exclude PE was 28.3 % (95 % CI, 21–37 %) for D-dimer and 24.4 % (95 % CI, 17–33 %) for tPA. Conclusions: The tPA with a cutoff of 8.5 ng/mL has a high sensitivity and negative predictive value for exclusion of PE, similar to those observed for the VIDAS D-dimer with a cutoff of 500 ng/mL, although the diagnostic utility was slightly higher for the D-dimer.

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