Colon cancer metastasis mimicking a hilar cholangiocarcinoma: a case report and literature review

Abstract Background An accurate diagnosis of the primary cancer or metastatic tumor is quite important because misdiagnosis may lead to the selection of incorrect adjuvant therapy and worse long-term outcomes after surgery. Here, we present a rare case with an unusual metastatic pattern mimicking a hilar cholangiocarcinoma originated from colon cancer Case presentation A 69-year-old man was referred to our hospital because of an upper bile duct stenosis. He had the past history of the sigmoidectomy for the primary colon cancer and the partial hepatectomy with radiofrequency ablation (RFA) for synchronous liver metastases 4 years ago. After 2 years from the initial operation, he had experienced the local recurrence of post-RFA lesion and had undergone a partial hepatectomy. According to the radiological findings of the bile duct stenosis, we diagnosed a hilar cholangiocarcinoma (Bismuth type II), and then he underwent the extended right hepatectomy with extrahepatic bile duct resection. Histological findings including the immune-histochemical examinations (CK7−, CK20+, CDX2+ and SATB2+) uncovered the metastatic tumor into extrahepatic bile duct originated from the primary colon cancer. Conclusion We experienced an extremely rare case with a colon cancer metastasis mimicking a hilar cholangiocarcinoma. In this case with a past history of colon cancer, an immunohistochemical staining led us to distinguish the primary hilar cholangiocarcinoma and the mimicking tumor.

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Proteomics analysis of colon cancer progression

Clinical Proteomics ◽

10.1186/s12014-019-9264-y ◽

2019 ◽

Vol 16 (1) ◽

Cited By ~ 5

Author(s):

Saira Saleem ◽

Sahrish Tariq ◽

Iffat Aleem ◽

Sadr-ul Shaheed ◽

Muhammad Tahseen ◽

...

Keyword(s):

Colon Cancer ◽

Cancer Progression ◽

Metastatic Tumor ◽

Global Changes ◽

Ionization Mass ◽

Colon Cancer Progression ◽

Primary Colon Cancer ◽

Primary Colon ◽

Cytoskeleton Disruption ◽

Disease Stages

Abstract Background The aim of this pilot study was to identify proteins associated with advancement of colon cancer (CC). Methods A quantitative proteomics approach was used to determine the global changes in the proteome of primary colon cancer from patients with non-cancer normal colon (NC), non-adenomatous colon polyp (NAP), non-metastatic tumor (CC NM) and metastatic tumor (CC M) tissues, to identify up- and down-regulated proteins. Total protein was extracted from each biopsy, trypsin-digested, iTRAQ-labeled and the resulting peptides separated using strong cation exchange (SCX) and reverse-phase (RP) chromatography on-line to electrospray ionization mass spectrometry (ESI-MS). Results Database searching of the MS/MS data resulted in the identification of 2777 proteins which were clustered into groups associated with disease progression. Proteins which were changed in all disease stages including benign, and hence indicative of the earliest molecular perturbations, were strongly associated with spliceosomal activity, cell cycle division, and stromal and cytoskeleton disruption reflecting increased proliferation and expansion into the surrounding healthy tissue. Those proteins changed in cancer stages but not in benign, were linked to inflammation/immune response, loss of cell adhesion, mitochondrial function and autophagy, demonstrating early evidence of cells within the nutrient-poor solid mass either undergoing cell death or adjusting for survival. Caveolin-1, which decreased and Matrix metalloproteinase-9, which increased through the three disease stages compared to normal tissue, was selected to validate the proteomics results, but significant patient-to-patient variation obfuscated interpretation so corroborated the contradictory observations made by others. Conclusion Nevertheless, the study has provided significant insights into CC stage progression for further investigation.

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Eradication of minimal residual disease in the perioperative period in primary colon cancer

Colorectal Cancer ◽

10.2217/crc.15.20 ◽

2015 ◽

Vol 4 (4) ◽

pp. 157-166 ◽

Cited By ~ 5

Author(s):

Paul H Sugarbaker ◽

Paolo Sammartino ◽

Antonios-Apostolos Tentes

Keyword(s):

Colon Cancer ◽

Minimal Residual Disease ◽

Residual Disease ◽

Perioperative Period ◽

Primary Colon Cancer ◽

Primary Colon ◽

Minimal Residual

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Colorectal Metastasis from Ovarian Neoplasm Mimicking Primary Colon Cancer

Case Reports in Gastroenterology ◽

10.1159/000510934 ◽

2021 ◽

pp. 41-46

Author(s):

Anum Aqsa ◽

Sami Droubi ◽

Shivantha Amarnath ◽

Fady Haddad ◽

Liliane Deeb

Keyword(s):

Colon Cancer ◽

Previous History ◽

Ovarian Neoplasm ◽

Direct Visualization ◽

Female Status ◽

Internal Malignancy ◽

Primary Colon Cancer ◽

Primary Colon ◽

History Of ◽

Secondary Metastasis

Metastasis to the colon from another primary internal malignancy is an untypical and a seldom reported entity. Direct visualization during colonoscopy is considered the gold standard of diagnosis. Pathologic diagnosis with immunohistochemical staining is essential to differentiate primary colorectal malignancy from secondary metastasis to the colon. We, hereby, present a case of a 53-year-old female status-post resection of left-sided papillary serous ovarian neoplasm who presented 2 years later with a single rectosigmoid intraluminal ulcerative mass imitating a primary colon cancer. Biopsies of the mass were consistent with metastasis from her primary ovarian carcinoma. We believe this case is unique because of the rarity of ovarian cancer metastasizing to the colon intraluminally rather than through direct locoregional invasion. Furthermore, it highlights the importance of considering secondary metastasis in patients with previous history of another primary internal malignancy.

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Diffuse Peritoneal Metastases From Primary Colon Cancer Demonstrated by Tc-99m-Labeled Red Blood Cell Scintigraphy

Clinical Nuclear Medicine ◽

10.1097/01.rlu.0000156383.57786.92 ◽

2005 ◽

Vol 30 (4) ◽

pp. 286-288

Author(s):

Venanzio Valenza ◽

Daniela Di Giuda ◽

Germano Perotti ◽

Arnaldo Carbone

Keyword(s):

Colon Cancer ◽

Blood Cell ◽

Red Blood Cell ◽

Peritoneal Metastases ◽

Primary Colon Cancer ◽

Primary Colon

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Primary Colon Cancer Without Gross Mucosal Tumor: Unusual Presentation of a Common Malignancy

Southern Medical Journal ◽

10.1097/00007611-199812000-00017 ◽

1998 ◽

Vol 91 (12) ◽

pp. 1173-1176 ◽

Cited By ~ 3

Author(s):

ALAN P. WIMMER ◽

JOHN P. BOUFFARD ◽

PATRICK R. STORMS ◽

JOHN A. PILCHER ◽

CHANG Y. LIANG ◽

...

Keyword(s):

Colon Cancer ◽

Unusual Presentation ◽

Primary Colon Cancer ◽

Primary Colon ◽

Common Malignancy

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Colonic metastasis after stomach cancer surgery that mimicked primary colon cancer : Case report

Progress of Digestive Endoscopy ◽

10.11641/pde.66.2_86 ◽

2005 ◽

Vol 66 (2) ◽

pp. 86-87

Author(s):

Keizo Yoneda ◽

Keiji Suzuki ◽

Kenji Katumata ◽

Tatehiko Wada ◽

Fumiaki Katou ◽

...

Keyword(s):

Colon Cancer ◽

Case Report ◽

Stomach Cancer ◽

Cancer Surgery ◽

Cancer Case ◽

Colonic Metastasis ◽

Primary Colon Cancer ◽

Primary Colon

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Magnetic Resonance Imaging in Primary Sclerosing Cholangitis

Wiedza Medyczna ◽

10.36553/wm.92 ◽

2021 ◽

Vol 3 (2) ◽

pp. 20-24

Author(s):

Aldona Wybraniec-Zaręba ◽

Julia Tuchalska-Czuroń ◽

Gabriela Półtorak-Szymczak ◽

Mariusz Furmanek ◽

Jerzy Walecki ◽

...

Keyword(s):

Bile Duct ◽

Magnetic Resonance ◽

Primary Sclerosing Cholangitis ◽

Sclerosing Cholangitis ◽

Bile Ducts ◽

Extrahepatic Bile Duct ◽

Magnetic Resonance Cholangiopancreatography ◽

Left Liver Lobe ◽

Bile Duct Stenosis ◽

Mri Features

Primary sclerosing cholangitis (PSC) is a chronic liver disease in which there are inflammation and scarring of the bile ducts leading to fibrosis, destruction and narrowing of the bile ducts, resulting in cholestasis. In the long run, PSC can cause liver cirrhosis and failure. In clinical practice, the diagnosis of PSC is generally based on blood tests and imaging studies (currently preferably magnetic resonance cholangiopancreatography). To make a diagnosis of PSC it is necessary to exclude secondary causes of sclerosing cholangitis. The most common MRI features of PSC concerning bile ducts are: bile duct dilatation, beading, extrahepatic bile duct stenosis, wall enhancement and thickening. The most common MRI features of PSC concerning hepatic parenchyma are: rounded shape of the liver caused by hypertrophy of caudate lobe and left liver lobe, atrophy of the right lobe, enlargement of portal and/or portacaval lymph nodes, peripheral parenchymal inflammation, wedge-shaped confluent fibrosis, heterogeneity of the liver parenchyma, periportal oedema, cirrhosis with indirect signs of portal hypertension such as splenomegaly, ascites and collateral vasculature.

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Preoperative Predictors of Lymph Node Metastasis in Colon Cancer

Frontiers in Oncology ◽

10.3389/fonc.2021.667477 ◽

2021 ◽

Vol 11 ◽

Author(s):

Yansong Xu ◽

Yi Chen ◽

Chenyan Long ◽

Huage Zhong ◽

Fangfang Liang ◽

...

Keyword(s):

Colon Cancer ◽

Logistic Regression ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Multivariate Logistic Regression Analysis ◽

Multivariate Logistic Regression ◽

Node Metastasis ◽

Logistic Analysis ◽

Primary Colon Cancer ◽

Primary Colon

BackgroundLymph node metastasis (LNM) is a well-established prognostic factor for colon cancer. Preoperative LNM evaluation is relevant for planning colon cancer treatment. The aim of this study was to construct and evaluate a nomogram for predicting LNM in primary colon cancer according to pathological features.Patients and MethodsSix-hundred patients with clinicopathologically confirmed colon cancer (481 cases in the training set and 119 cases in the validation set) were enrolled in the Affiliated Cancer Hospital of Guangxi Medical University from January 2010 to December 2019. The expression of molecular markers (p53 and β-catenin) was determined by immunohistochemistry. Multivariate logistic regression was used to screen out independent risk factors, and a nomogram was established. The accuracy and discriminability of the nomogram were evaluated by consistency index and calibration curve.ResultsUnivariate logistic analysis revealed that LNM in colon cancer is significantly correlated (P <0.05) with tumor size, grading, stage, preoperative carcinoembryonic antigen (CEA) level, and peripheral nerve infiltration (PNI). Multivariate logistic regression analysis confirmed that CEA, grading, and PNI were independent prognostic factors of LNM (P <0.05). The nomogram for predicting LNM risk showed acceptable consistency and calibration capability in the training and validation sets.ConclusionsPreoperative CEA level, grading, and PNI were independent risk factor for LNM. Based on the present parameters, the constructed prediction model of LNM has potential application value.

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