scholarly journals Mean blastomere diameter may predict clinical pregnancy in long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Suleyman Guven ◽  
Sebnem Alanya Tosun ◽  
Emine Seda Guvendag Guven
Keyword(s):  
Pregnancy Rate ◽  
Single Embryo Transfer ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Female Age ◽  
Vitro Fertilization ◽  
A Value ◽  
The Mean ◽  
Embryo Grade

Abstract Background The main purpose of this study was to investigate the effect of mean blastomere diameter (MBD) on pregnancy rates in in vitro fertilization (IVF) cases undergoing the long agonist cycle protocol. A total of 84 cases were evaluated within the scope of this observational prospective study. All cases were normoresponders, under 35 years old, with the long agonist protocol applied and single embryo (grade I or II) transfer performed. On the third day after ICSI, each embryo selected for transfer was subjected to measurement of the mean blastomere diameter (MBD) at ×25 magnification. Results The mean female age was 30.14 ± 3.32 years, and the total clinical pregnancy rate was 33.3%. In the group that got pregnant, MBD was found to be statistically significantly higher than in the nonpregnant group. In terms of predicting clinical pregnancy, when the MBD value of 49.73 μm was accepted as the best cutoff value, the sensitivity was calculated as 75% and specificity as 53.6%. Clinical pregnancy rate was 18.9% in cases below this value, whereas clinical pregnancy rate was 44.7% in cases with this value and above. In other words, when the MBD value rose above 49.73 μm from a value below 49.73 μm, the clinical pregnancy rate increased by an average of 2.3 times. Conclusions With MBD measurement, it is possible to select the embryo with the best implantation capability in microinjection cycles with the long luteal agonist protocol.

scholarly journals Male adiposity impairs clinical pregnancy rate by in vitro fertilization without affecting day 3 embryo quality

Obesity ◽  
2013 ◽  
Vol 21 (8) ◽  
pp. 1608-1612 ◽  
Author(s):  
Zaher O. Merhi ◽  
Julia Keltz ◽  
Athena Zapantis ◽  
Joshua Younger ◽  
Dara Berger ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Embryo Quality ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Vitro Fertilization ◽  
Day 3 Embryo

scholarly journals Comparison of pregnancy outcomes using a time-lapse monitoring system for embryo incubation versus a conventional incubator in in vitro fertilization: an age-stratification analysis

2021 ◽  
Author(s):  
Pattraporn Chera-aree ◽  
Isarin Thanaboonyawat ◽  
Benjawan Thokha ◽  
Pitak Laokirkkiat
Keyword(s):  
Pregnancy Rate ◽  
Live Birth ◽  
Birth Rate ◽  
Age Groups ◽  
Implantation Rate ◽  
Live Birth Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Vitro Fertilization

Objective: The aim of this study was to compare the pregnancy outcomes of in vitro fertilization with embryo transfer between embryos cultured in a time-lapse monitoring system (TLS) and those cultured in a conventional incubator (CI).Methods: The medical records of 250 fertilized embryos from 141 patients undergoing infertility treatment with assisted reproductive technology at a tertiary hospital from June 2018 to May 2020 were reviewed. The study population was divided into TLS and CI groups at a 1 to 1 ratio (125 embryos per group). The primary outcome was the live birth rate. Results: The TLS group had a significantly higher clinical pregnancy rate (46.4% vs. 27.2%, p=0.002), implantation rate (27.1% vs. 12.0%, p=0.004), and live birth rate (32% vs. 18.4%, p=0.013) than the CI group. Furthermore, subgroup analyses of the clinical pregnancy rate and live birth rate in the different age groups favored the TLS group. However, this difference only reached statistical significance in the live birth rate in women aged over 40 years and the clinical pregnancy rate in women aged 35–40 years (p=0.048 and p=0.031, respectively). The miscarriage rate, cleavage rate, and blastocyst rate were comparable.Conclusion: TLS application improved the live birth rate, implantation rate, and clinical pregnancy rate, particularly in the advanced age group in this study, while the other reproductive outcomes were comparable. Large randomized controlled trials are needed to further explore the ramifications of these findings, especially in different age groups.

scholarly journals Estimating the causal effect of embryo transfer day on clinical in vitro fertilization outcomes using propensity score matching

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Han-Chih Hsieh ◽  
Chun-I Lee ◽  
En-Yu Lai ◽  
Jia-Ying Su ◽  
Yi-Ting Huang ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Live Birth ◽  
Implantation Rate ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Day 5 Transfer

Abstract Background For women undergoing in vitro fertilization (IVF), the clinical benefit of embryo transfer at the blastocyst stage (Day 5) versus cleavage stage (Day 3) remains controversial. The purpose of this study is to compare the implantation rate, clinical pregnancy rate and odds of live birth of Day 3 and Day 5 embryo transfer, and more importantly, to address the issue that patients were chosen to receive either transfer protocol due to their underlying clinical characteristics, i.e., confounding by indication. Methods We conducted a retrospective cohort study of 9,090 IVF cycles collected by Lee Women’s Hospital in Taichung, Taiwan from 1998 to 2014. We utilized the method of propensity score matching to mimic a randomized controlled trial (RCT) where each patient with Day 5 transfer was matched by another patient with Day 3 transfer with respect to other clinical characteristics. Implantation rate, clinical pregnancy rate, and odds of live birth were compared for women underwent Day 5 transfer and Day 3 transfer to estimate the causal effects. We further investigated the causal effects in subgroups by stratifying age and anti-Mullerian hormone (AMH). Results Our analyses uncovered an evidence of a significant difference in implantation rate (p=0.04) favoring Day 5 transfer, and showed that Day 3 and Day 5 transfers made no difference in both odds of live birth (p=0.27) and clinical pregnancy rate (p=0.11). With the increase of gestational age, the trend toward non-significance of embryo transfer day in our result appeared to be consistent for subgroups stratified by age and AMH, while all analyses stratified by age and AMH were not statistically significant. Conclusions We conclude that for women without strong indications for Day 3 or Day 5 transfer, there is a small significant difference in implantation rate in favor of Day 5 transfer. However, the two protocols have indistinguishable outcomes on odds of live birth and clinical pregnancy rate.

Effect of Female Body Mass Index on Clinical Pregnancy Rate After In Vitro Fertilization

2017 ◽  
Vol 23 (7) ◽  
pp. 7009-7011 ◽  
Author(s):  
Shabrina Narasati ◽  
Oki Riayati ◽  
Budi Wiweko ◽  
Achmad Kemal Harzif ◽  
Gita Pratama ◽  
...  
Keyword(s):  
Body Mass Index ◽  
In Vitro Fertilization ◽  
Pregnancy Rate ◽  
Body Mass ◽  
Female Body ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Vitro Fertilization ◽  
Female Body Mass
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