scholarly journals The effect of duration of dependence and daily dose of tramadol in tramadol dependent patients on cognitive performance

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Hossam Eddin Khalifa Ahmad ◽  
Alaa Eldin Mohamed Darweesh ◽  
Shehab Hassan Mahmoud Hassaan ◽  
Mostafa Nooman ◽  
Islam Shaaban ◽  
...  

Abstract Background Tramadol dependence represents a major medical and legal hazardous phenomenon in the last decade. It is a synthetic opiate analgesic which exerts its therapeutic effect by its action on μ opioid receptors. It has a weak dependence ability. The present study investigated the effect of duration of dependence and daily dose of tramadol on cognitive performance. Cognitive functions were assessed using the following: the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) test, Brief Visuospatial Memory Test–Revised (BVMT-R), Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), the P300 (ERP), and conventional electroencephalogram. Results There was a non-significant negative correlation between the daily dose of tramadol and cognitive performance as regards IQ, Mini-Mental State Examination, MoCA score, P300 reaction time (μs), and deterioration index (r = − 0.08, P = 0.689; r = − 0.02, P = 0.896; r = − 0.11, P = 0.554; r = − 0.11, P = 0.581, r = − 0.17; P = 0.368, respectively). Additionally, the results showed non-significant negative correlation between the duration of dependence and the cognitive performance (r = − 0.19, P = 0.325; r = − 0.15, P = 0.424; r = − 0.30, P = 0.108; r = − 0.02, P = 0.909; r = − 0.02, P = 0.937, respectively). Conclusion Daily dose and duration of tramadol dependence have a negative but non-significant effect on cognitive performance.

1994 ◽  
Vol 79 (1) ◽  
pp. 664-666 ◽  
Author(s):  
Toru Hosokawa ◽  
Yoshiaki Yamada ◽  
Atsushi Isagoda ◽  
Ryuichi Nakamura

Responses to the Hasegawa Dementia Scale—Revised and the Mini-Mental State Examination were examined for 49 stroke patients to investigate the psychometric equivalence between the two tests. Pearson product-moment correlation and Spearman rank-order correlation between the two tests were 0.87 and 0.78. Each test's scores significantly correlated with the Full Scale IQs on the Wechsler Adult Intelligence Scale—Revised: 0.61 for Hasegawa's Dementia Scale and 0.69 for the Mini-Mental State Examination. These values indicate that the two tests are judged comparable measures for screening cognitive impairment in stroke patients.


1993 ◽  
Vol 5 (2) ◽  
pp. 135-146 ◽  
Author(s):  
John O. Brooks ◽  
Jerome A. Yesavage ◽  
Joy Taylor ◽  
Leah Friedman ◽  
Elizabeth Decker Tanke ◽  
...  

The purpose of this paper was to use the Wechsler Adult Intelligence Scale (WAIS) to further define the nature of the underlying factors of the Mini-Mental State Examination (MMSE) as proposed by Tinklenberg et al. (1990). The MMSE was administered to 51 patients once every 6 months for at least one year; the WAIS was administered only at the beginning of the study. Stepwise regression analyses yielded these results: for the Following Commands factor, the best correlate was the Comprehension subtest; for the Language Repetition factor, the best correlate was the Picture Arrangement subtest; and for the Language Expression factor, the best correlates were the Digit Symbol and Object Assembly subtests. These relations help clarify the correlates of decline of AD patients on the MMSE.


1987 ◽  
Vol 150 (3) ◽  
pp. 338-340 ◽  

Cognitive performance in 46 first episode schizophrenics was assessed within 1 week of admission to hospital by Progressive Matrices, Mill Hill Vocabulary Scale, Block Design and Similarities subtests of the Wechsler Adult Intelligence Scale, and Digit Copying Test. Patients' intellectual performance was at a dull normal level, just within one standard deviation from the mean. There was an association between the presence of anxiety and depression and lower scores on psychological tests. Patients assessed by the Present State Examination as belonging to the ‘uncertain psychosis' category performed more poorly.


2019 ◽  
Vol 33 (3) ◽  
pp. 207-218 ◽  
Author(s):  
Shamona Maharaj ◽  
Ty Lees ◽  
Sara Lal

Abstract. Nurses’ inherently stressful occupation leaves them at a higher risk of developing negative mental states (stress, anxiety, and depression). However, research examining the effect of negative mental states on these health professionals’ cognitive performance is sparse. Thus, the present study aimed to assess the link between negative mental states and cognitive performance in nurses ( n = 53). Negative mental state data was obtained using the Depression Anxiety Stress Scale, brain activity was measured using electroencephalography, and finally, cognitive performance was assessed using the Cognistat and the Mini-Mental State Examination. Significant negative correlations ( p < .05) were observed between anxiety and attention, and all three negative mental states and memory performance. Electroencephalographic changes indicated that increases in anxiety were significantly associated ( p < .05) with decreases in gamma reactivity at fronto-central sites. The current study suggests that higher levels of negative mental states are associated with domain-specific cognitive impairments, and variations in gamma reactivity; possibly reflecting less optimal cortical functioning.


1999 ◽  
Vol 14 (1) ◽  
pp. 52-53 ◽  
Author(s):  
H.J. Schewe ◽  
R. Uebelhack ◽  
K. Vohs

SummaryIn a small (n = 15) clinically heterogeneous group of patients with dementia of the Alzheimer-type or vascular dementia, abnormally high frequency of saccadic intrusions during fixation was significantly correlated to the Mini-Mental-State-Examination (MMSE) scores. In addition, the latency of saccades and hypometric saccades also correlated significantly to MMSE-scores. The results point to the possible use of saccadic eye movement as a physiological marker of cognitive performance.


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