scholarly journals Invasive papillary carcinoma of the breast: a rare case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Pratibha Issar ◽  
M. Ravindranath ◽  
Manish Dewangan
Keyword(s):  
Papillary Carcinoma ◽  
Rare Case ◽  
Radical Mastectomy ◽  
Myoepithelial Cells ◽  
Left Breast ◽  
Good Prognosis ◽  
Menopausal Women ◽  
Malignant Breast ◽  
Post Menopausal ◽  
Invasive Papillary Carcinoma

Abstract Background Invasive Papillary Carcinomas (IPC) are rare and account for approximately 0.5% of all invasive breast carcinomas. Most of them are seen in post-menopausal women and have a good prognosis. These tumors lack the myoepithelial cell layer (MCL) within the papillae or at the periphery of the tumor with areas showing stromal invasion or invasion into lymphovascular spaces. Immunohistochemistry (IHC) for myoepithelial cells and basement membrane is essential for the diagnosis of invasive cancer. Case presentation We present a rare case of IPC in a 74-year-old woman who presented with complaints of gradually increasing painless retroaerolar mass in the left breast of two months duration. The mass was irregular, having an oblong as well an adjacent high density mass lesion on mammography. Ultrasound (US), and Magnetic Resonance Imaging (MRI) helped in the diagnosis of the possibility of a malignant breast lesion. Left-sided modified radical mastectomy was performed and the specimen was histopathologically diagnosed as Invasive Papillary carcinoma. Immunohistochemistry confirmed the diagnosis. Conclusions Invasive Papillary Carcinomas of the breast are rare cancers in post-menopausal women. We have highlighted the role of Mammography, US, and MRI in early diagnosis so that timely management is possible.

scholarly journals Breast Epithelial-myoepithelial Carcinoma With HER2 Gene Amplification: a Rare Case and Review of Literature

2021 ◽  
Author(s):  
Min Hu ◽  
Junqiu Yue ◽  
Fang Guo ◽  
Su Jin ◽  
Mingwei Wang ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Rare Case ◽  
Present Report ◽  
Radical Mastectomy ◽  
Myoepithelial Cells ◽  
Left Breast ◽  
Myoepithelial Carcinoma ◽  
Her2 Gene ◽  
Breast Epithelial ◽  
Epithelial Myoepithelial Carcinoma

Abstract Background: Epithelial-myoepithelial carcinoma is a very rare carcinoma that both luminal and myoepithelial components are malignant. What’s more, HER2 gene amplification has not been detected in the literature up to now. Herein, we report a rare case of breast epithelial-myoepithelial carcinoma with HER2 gene amplification.Case presentation: An 80-year-old woman presented with a mass in the upper outside region of her left breast. The core needle biopsy of the left breast mass revealed invasive breast carcinoma, and then modified radical mastectomy of left breast was performed. Macroscopically, the tumor was measured 6cm in diameter, and it was a solid and lobulated mass with areas of cystic and hemorrhagic lesions. Microscopically, the histological findings of tumor were consisted of 3 components. One component showed biphasic proliferation of both eosinophilic luminal epithelial and pale abluminal myoepithelial cells, arranging predominantly in dilated tubular architecture, which accounted for most of the lesion. Papillary architecture and eosinophilic secretions could be seen in some dilated ducts. The second component was proliferation of myoepithelial cells with pale cytoplasm around the glandular epithelium forming casing-like structures. The third component was few solid-appearing areas which was displayed a predominance of monophasic proliferation of myoepithelial cells. Both cell types exhibited enlarged and markedly atypical nuclei, with obvious nucleoli and prominent mitoses (up to 10-15/10 high power fields). Foci of infiltration were identified at the periphery of the lobules and the surrounding adipose tissue. Areas of central necrosis and stromal hyalinization could be seen. A diagnosis of EMC was made by morphology and immunohistochemistry. It's worth noting that HER2 gene amplification has not been detected in malignant adenomyoepitheIioma in the literature up to now; While in our present report, HER2 was 2+ membranous immunoreactivity, and then HER2 gene amplification was detected by fluorescence in situ hybridization. Conclusion: Accurate diagnosis of malignant adenomyoepitheIioma is challenging but of great importance, and the management of malignant adenomyoepitheIioma would be made according to histologic features.

scholarly journals Primary Squamous Cell Carcinoma of the Endometrium : A Rare Case in the Philippines

2020 ◽  
pp. 1-4
Author(s):  
Doris R Benavides
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Case ◽  
Myometrial Invasion ◽  
The Philippines ◽  
Menopausal Woman ◽  
Primary Squamous Cell Carcinoma ◽  
Menopausal Women ◽  
Post Menopausal

Introduction: Primary Squamous Cell Carcinoma of the Endometrium (PSCCE) is an extremely rare case accounting for only 0.1% of all endometrial cancer cases. It usually occurs in post-menopausal women. Case: We reported a case in the Philippines, a 64-year-old, multiparous, post-menopausal woman who presented with post-menopausal bleeding. Procedure: Endometrial curettage showed squamous cell carcinoma. She then underwent Exploratory Laparotomy, Radical Hysterectomy with Bilateral Salpingo-oophorectomy, with Bilateral Pelvic Lymph Node Dissectionand Peritoneal Fluid Cytology. Results: Histopathology of the uterus showed squamous cell carcinoma, keratinizing, with full thickness myometrial invasion. Postoperative diagnosis was primary squamous cell carcinoma, keratinizing, endometrium, stage IIIA. Patient was advised to undergo chemotherapy and radiotherapy. Conclusion: The etiology of PSCCE is still unclear and usually presents with vaginal bleeding in post-menopausal women. To diagnose, histology should meet three criteria asdefined by Fluhmann. The prognosis is poor and related to stage at diagnosis.

scholarly journals Papillary carcinoma of the male breast in a comparatively young patient: A case report of a rare entity

2020 ◽  
Vol 8 (5) ◽  
pp. 369-374
Author(s):  
Dr. Dolly Prashant ◽  
◽  
Dr. Viplav Prashant ◽  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Young Patient ◽  
Papillary Carcinoma ◽  
Left Breast ◽  
Male Breast ◽  
Rare Entity ◽  
Papillary Lesions ◽  
Invasive Papillary Carcinoma ◽  
Breast Malignancies

Breast carcinoma in men is rare and intra-cystic papillary carcinoma of male breast is an extremelyrare entity. Papillary lesions of male breast comprise of the spectrum of lesions ranging from benignintraductal papilloma to intraductal papillary carcinoma and invasive papillary carcinoma. It occursmost commonly in the seventh decade of life and accounts for <1% of all breast malignancies. Thepresent case report is of a comparatively younger, 37 years old male who presented with a mass onlower quadrant (retro-areolar region) of the left breast.

scholarly journals Pure Mucinous Breast Carcinoma with Micropapillary Pattern in a 32-Year-Old Female

2021 ◽  
pp. 338-341
Author(s):  
Nahid Sadeghi ◽  
Razieh Shahnazari ◽  
Fariba Asadi
Keyword(s):  
Varicose Veins ◽  
Brain Magnetic Resonance Imaging ◽  
Radical Mastectomy ◽  
Mucinous Carcinoma ◽  
Needle Aspiration ◽  
Left Breast ◽  
Good Prognosis ◽  
Case Presentation ◽  
The Face ◽  
Micropapillary Pattern

Background: Mucinous carcinoma (MC) is a rare breast malignancy with a large extracellular mucin secretion. It has a good prognosis in comparison to other breast malignancies.  Case presentation: We report a 32 years old female with multiple hard palpable masses in the left breast with rapid growth in 6 months. She was mentally retarded with lower limb varicose veins associated with mucocutaneous lesions on the face. She underwent ultrasound examination of the breast, thyroid and lower extremity veins. Core needle biopsy and fine needle aspiration from left breast lesions and right thyroid nodules showed MC and follicular lesion with hurtle cell change, respectively. Suspected metastasis in the left rib and calvarium in the subsequent bone scan survey and brain magnetic resonance imaging was reported. She underwent radical mastectomy and right hemi-thyroidectomy. Conclusion: Pure mucinous carcinoma with micropapillary pattern (MUMPC) is a new histology variant of Pure Mucinous Carcinoma (PMC) that shows favorable prognosis with less aggression and occurs in older patients. However, PMC in our patient occurred at a young age with greater aggression.

scholarly journals Invasive papillary ductal carcinoma of the breast: A case report

2020 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Amani S Hadi ◽  
Gamal Abdul Hamid ◽  
Refaat Al-Areqee ◽  
Wafa Abdullah
Keyword(s):  
Papillary Carcinoma ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Residual Tumor ◽  
Excisional Biopsy ◽  
Breast Mass ◽  
Low Grade ◽  
Breast Cancers ◽  
History Of ◽  
Invasive Papillary Carcinoma

The general rate of intrusive papillary carcinoma (IPC) is uncommon, representing for less than 1-2 % of invasive breast cancers. They are most generally observed in postmenposal females and uncommon in males. Invasive papillary carcinomas are low grade tumors originating from large or dilated ducts. They are make out of all around outlined solid nodules of monotones neoplastic cell separated by network of fibrovascular cores, IPC is a remarkable sort of breast cancer and regarded of whether it is in-situ or invasive, it has brilliant prognosis. We presenting two cases of invasive papillary carcinoma in male and female; A case of 55years postmenoposal female who presented with history of left breast mass, which this mass notice after trauma same site for 1 year ago the mass gradually increase in size no tenderness, no signs of inflammation. Excisional biopsy was performed and specimen was histopathology diagnosed as invasive papillary carcinoma, left MRM was performed and histopathology diagnosis confirmed and without residual tumor seen in submitted slides and all submitted lymph nodes were free of tumor infiltration (0/14). IHC show ER and PR negative with HER-2 positive. The second case 70 years male presented with right breast mass and history of post-trauma since one year back with gradual increase in size, right radical mastectomy done and histopathology diagnosed as invasive papillary carcinoma, IHC was done ER and PR positive with HER2- negative.

Evidence of good prognosis of hepatocellular adenoma in post-menopausal women

2016 ◽  
Vol 65 (6) ◽  
pp. 1163-1170 ◽  
Author(s):  
Anne Julia Klompenhouwer ◽  
Dave Sprengers ◽  
François Etienne Johan Antoine Willemssen ◽  
Marcia Patricia Gaspersz ◽  
Jan Nicolaas Maria Ijzermans ◽  
...  
Keyword(s):  
Hepatocellular Adenoma ◽  
Good Prognosis ◽  
Menopausal Women ◽  
Post Menopausal

Synchronous Bilateral Solid Papillary Carcinoma of Breast: A Rare Case Report

2020 ◽  
pp. 1-3
Author(s):  
Ayşe Nur Uğur Kılınç ◽  
Ayşe Nur Uğur Kılınç ◽  
Zeynep Bayramoğlu ◽  
Yaşar Ünlü ◽  
Nergis Aksoy ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Papillary Carcinoma ◽  
Rare Case ◽  
Neuroendocrine Differentiation ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Breast Cancers ◽  
Rare Type ◽  
Solid Papillary Carcinoma

Background: Solid papillary carcinoma is a rare type of carcinoma that accounts for less than 1% of all breast cancers and mostly seen in postmenopausal women. This report presents a rare case of synchronous bilateral solid papillary carcinoma of the breast. Case Report: A 74-year-old female patient had a mass in her right and left breast. Bilateral total mastectomy and sentinel lymph node biopsy were performed. The pathologic diagnosis was synchronous bilateral solid papillary carcinoma. No lymph node metastasis was detected in either of the breasts. Conclusion: To our knowledge, little is known about simultaneous bilateral solid papillary carcinomas. Solid papillary carcinoma should be kept in mind in the differential diagnosis of bilateral breast masses with neuroendocrine differentiation in elderly patients.

scholarly journals A rare case report of incidental solitary uterine metastasis in primary invasive lobular carcinoma of breast

2016 ◽  
Author(s):  
Vivek Gupta ◽  
Amita Mishra ◽  
Namit Kalra ◽  
Bhawna Narula
Keyword(s):  
Rare Case ◽  
Ductal Carcinoma ◽  
Residual Disease ◽  
Histopathological Examination ◽  
Lobular Carcinoma ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Tram Flap ◽  
Metastatic Pattern ◽  
Her Family

Introduction: Infiltrating Lobular carcinoma (ILC) of the breast is second most common cancer of breast next only to Infiltrating ductal carcinoma (IDC). It has a different metastatic pattern as compared to the IDC. Breast cancer is the most frequent primary site which spreads to gynaecologic organs. Case Presentation: A 40 yrs old Iraqi lady presented as a diagnosed case of lobular carcinoma of left breast. She had already undergone a lumpectomy at Iraq a month back and now had come for completion of treatment. On metastatic workup with PETCT scan, we found a multicentric residual disease in the left breast along with some ipsilateral axillary LN with significant uptake. The concurrent CECT done showed a uterine leiomyomam also. As she was strongly hormone receptor positive, had completed her family and was having mennorhagia probably attributable to uterine fibroids. She was offered hysterectomy with B/L salpingo-oophorectomy. She was keen for breast preservation but in view of her multicentricity of disease on the left breast she was counselled for mastectomy with upfront whole breast reconstruction with TRAM flap. She underwent left modified radical mastectomy with hysterectomy with BSO and TRAM flap reconstruction. The histopathological examination revealed a multicentric, multifocal ILC, grade II with heavy nodal involvement including extracapsular extension. The leiomyoma of uterus also showed tumor deposits from lobular carcinoma breast. Conclusion: We report a very rare case of metastatic pattern of carcinoma of breast. On literature review we found that it is common for the lobular carcinomas of breast to metastasise to gynaecologic organs. Uterine corpus is a very rare site of metastasis for extragenital cancers including breast. All the patients of primary lobular carcinoma of breast should be screened for gynaecologic secondaries in the preoperative workup with high degree of suspicion.

scholarly journals Primary angiosarcoma of the breast: a rare entity

2017 ◽  
Vol 4 (2) ◽  
pp. 800
Author(s):  
Dyan D’Souza ◽  
Ann Sunny ◽  
Rahul Sima ◽  
Anthony P. Rozario
Keyword(s):  
Disease Free Survival ◽  
Radical Mastectomy ◽  
Needle Aspiration ◽  
Lymph Node Involvement ◽  
Left Breast ◽  
Primary Angiosarcoma ◽  
Angiosarcoma Of The Breast ◽  
Malignant Breast ◽  
Needle Aspiration Cytology ◽  
Rare Malignancy

Primary angiosarcoma of the breast is a rare form of breast cancer, accounting for only 0.04% of all malignant breast tumours. We report a 35-year-old woman who presented with a recurrent lump in the left breast for four months. Fine needle aspiration cytology (FNAC) was suspicious of angiosarcoma and this diagnosis was confirmed on core needle biopsy. Modified radical mastectomy was performed as sole treatment. No chemo radiotherapy was given as tumor was grade I, margins were negative and there was no lymph node involvement. She is on regular follow up and no recurrence reported since the surgery. The 5-year disease-free survival for grade I tumours can be as high as 76%, and up to 70% for grade II tumours whereas for grade III tumours it is reportedly about 15%. Primary angiosarcoma of the breast is a rare malignancy with a poor prognosis, even after complete resection. Surgery is the mainstay of treatment with a limited role for chemotherapy and radiotherapy.

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