Changes in peritoneal myeloid populations and their proinflammatory cytokine expression during infection withListeria monocytogenesare altered in the absence of γ/δ T cells

Abstract Ghrelin (Grln) is a peptide hormone that is predominantly produced in the stomach and stimulates appetite and induces growth hormone (GH) release. We have previously reported that ghrelin is also expressed in T cells and exerts prothymic and anti-inflammatory effects. However, the biologic relevance of T cell–derived ghrelin remains to be determined. Here, we report that acylated-bioactive ghrelin is expressed in human T cells and preferentially segregates within the lipid raft domains upon TCR ligation. The RNA interference (RNAi)–mediated down-regulation of ghrelin in primary human T cells activates IkB, and increases Th1 cytokines and IL-17 secretion. Ghrelin expression declines with increasing age in spleen and T cells and exogenous ghrelin administration in old mice reduces proinflammatory cytokines. These findings demonstrate that ghrelin functions in an autocrine and paracrine capacity to regulate proinflammatory cytokine expression in human and murine T cells and may contribute in regulating “inflamm-aging.”

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Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression

Journal of Leukocyte Biology ◽

10.1189/jlb.0311168 ◽

2011 ◽

Vol 90 (6) ◽

pp. 1043-1054 ◽

Cited By ~ 39

Author(s):

Jerod A. Skyberg ◽

Amy Robison ◽

Sarah Golden ◽

MaryClare F. Rollins ◽

Gayle Callis ◽

...

Keyword(s):

T Cells ◽

Proinflammatory Cytokine ◽

Dextran Sulfate ◽

Dextran Sulfate Sodium ◽

Cytokine Expression ◽

Proinflammatory Cytokine Expression

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Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells

Virus Research ◽

10.1016/j.virusres.2013.11.009 ◽

2014 ◽

Vol 179 ◽

pp. 73-84 ◽

Cited By ~ 10

Author(s):

Jessica A. Pane ◽

Nicole L. Webster ◽

Christel Zufferey ◽

Barbara S. Coulson

Keyword(s):

T Cells ◽

Type 1 Diabetes ◽

B Cells ◽

Antigen Presentation ◽

Mhc Class I ◽

Proinflammatory Cytokine ◽

Cytokine Expression ◽

Class I ◽

Proinflammatory Cytokine Expression

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Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract

International Journal of Inflammation ◽

10.1155/2020/8063289 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Anh Thu Nguyen ◽

Ki-young Kim

Keyword(s):

Proinflammatory Cytokines ◽

Proinflammatory Cytokine ◽

Treatment Options ◽

Mapk Signaling ◽

Cytokine Expression ◽

Proinflammatory Cytokine Expression ◽

Cutibacterium Acnes ◽

Anti Inflammatory ◽

New Treatment ◽

Hacat Keratinocyte

Acne is an inflammatory skin disorder; although some anti-inflammatory medicines for treating acne are available in a market, they have considerable side effects; therefore, new treatment options are needed. In the present study, among the 16 aqueous extracts of plants collected from Jeju Island in Korea which are used to test anti-inflammatory activity, B. davidii showed the strong decline of the proinflammatory cytokine expression against the inflammatory process caused by C. acnes in Human HaCaT keratinocyte cells. B. davidii downregulated the expression of 57% of COX-2, 41% of iNOS, and proinflammatory cytokines 29% of TNF-α, 32% of IL-1β, 21% of IL-6, and 35% of IL-8. Furthermore, B. davidii inhibited NF-κB and MAPK signaling cascades in keratinocytes that activated by toll-like receptor 2 (TLR-2) in response to C. acnes. Given those results, B. davidii is a potential agent to reduce the proinflammatory cytokine expression against C. acnes-induced inflammation and might provide an alternative to the current medications.

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