Multiple sclerosis characteristics in A frican A merican patients in the New York State Multiple Sclerosis C onsortium

2003 ◽  
Vol 9 (3) ◽  
pp. 293-298 ◽  
Author(s):  
B Weinstock-Guttman ◽  
L D Jacobs ◽  
C M Brownscheidle ◽  
M Baier ◽  
D F Rea ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
New York ◽  
Clinical Characteristics ◽  
Disease Duration ◽  
New York State ◽  
Genetic Studies ◽  
York State ◽  
Disease Modifying Therapies ◽  
Younger Age ◽  
Group A

The objective of this study was to determine the clinical characteristics of multiple sclerosis (MS) in A frican A merican (A A) patients in the New York State Multiple Sclerosis C onsortium (NYSMSC) patient registry. The NYSMSC is a group of 18 MS centers throughout New York State organized to prospectively assess clinical characteristics of MS patients. AA s comprise 6% (329) of the total NYSMSC registrants (5602). Demographics, disease course, therapy, and socioeconomic status were compared in A A registrants versus nonA frican A mericans (NA A). There was an increased female preponderance and a significantly younger age at diagnosis in the AA group. A A patients were more likely to have greater disability with increased disease duration. No differences were seen in types of MS and use of disease modifying therapies. O ur findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility.

Trend for decreasing Multiple Sclerosis Severity Scores (MSSS) with increasing calendar year of enrollment into the New York State Multiple Sclerosis Consortium

2011 ◽  
Vol 17 (6) ◽  
pp. 725-733 ◽  
Author(s):  
Ilya Kister ◽  
Eric Chamot ◽  
Joshua H Bacon ◽  
Gary Cutter ◽  
Joseph Herbert
Keyword(s):  
Multiple Sclerosis ◽  
New York ◽  
Quantile Regression ◽  
Disease Duration ◽  
New York State ◽  
Multivariable Analysis ◽  
Diagnostic Delay ◽  
York State ◽  
Severity Scores ◽  
History Of

Background: Although the natural history of multiple sclerosis has been charted extensively, it is still not known whether the trajectory of disability accumulation has changed in the era of disease-modifying therapies (DMTs). Objective: The objective of this study was to examine trends in Multiple Sclerosis Severity Score (MSSS) with regard to calendar year of enrollment into the New York State MS Consortium (NYSMSC). Methods: Distributions of MSSS were calculated for each year of enrollment, from 1996 to 2007. Quantile regression was used in a multivariable analysis to model for conditional distribution of MSSS quantiles as functions of potential confounders. Results: The cohort consisted of 6238 patients. Mean age at enrollment was 38 years (SD = 10) and mean disease duration was 10.1 years (SD = 7.3); 57% were on DMTs. The quantile regression model of trends in MSSS between 1996 and 2007 controlled for age, sex, ethnicity, diagnostic delay, and disease duration and demonstrated a robust trend toward lower MSSS with increasing year of enrollment. The model-predicted median MSSS at enrollment in 1996 was 5.04 (95% CI, 4.86–5.21), and in 2007 was 3.78 (95%CI, 3.36–4.20; p < 0.001). The downward trend in MSSS during the enrollment period was confirmed by analysis of Expanded Disability Status Scale (EDSS) distributions, adjusted for disease duration, in successive years of enrollment. Conclusions: The recent enrollees into the NYSMSC had lower MSSSs compared to the earlier enrollees. The apparent slowing in disability accumulation is likely due to a complex combination of factors: advent of DMTs and improvements in MS care, as well as selection, migration, and recall biases.

scholarly journals Fatigue at enrollment predicts EDSS worsening in the New York State Multiple Sclerosis Consortium

2018 ◽  
Vol 26 (1) ◽  
pp. 99-108 ◽  
Author(s):  
Caila B Vaughn ◽  
Katelyn S Kavak ◽  
Michael G Dwyer ◽  
Aisha Bushra ◽  
Muhammad Nadeem ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
New York ◽  
Proportional Hazards ◽  
New York State ◽  
Cox Proportional Hazards ◽  
Common Symptom ◽  
York State ◽  
Study Enrollment ◽  
Severe Fatigue ◽  
Patient Reported

Background: Fatigue is one of the most common and distressing symptoms among persons with multiple sclerosis (pwMS). Objective: The aim of this study is to evaluate fatigue as a predictor for disease worsening among pwMS. Methods: In this retrospective cohort study of New York State MS Consortium (NYSMSC) registry, MS patients reporting moderate-to-severe fatigue at study enrollment ( n = 2714) were frequency matched to less-fatigued subjects ( n = 2714) on age, baseline Kurtzke Expanded Disability Status Scale (EDSS), disease duration, and MS phenotype. Change from baseline patient-reported outcomes (PROs), as measured by LIFEware™, categorized participants into two groups: those with stable/improved outcomes and those who worsened. In a subgroup of patients with longitudinal data ( n = 1951), sustained EDSS worsening was analyzed using Cox proportional hazards modeling to explore the effect of fatigue. Results: The median survival time from study enrollment to sustained EDSS worsening was 8.7 years (CI: 7.2–10.1). Participants who reported fatigue at baseline were more likely to experience sustained EDSS worsening during follow-up (HR: 1.4, 95% CI: 1.2–1.7). Patients who were fatigued at baseline were also more likely to report worsening psychosocial limitations (all ps ⩽ 0.01). Conclusion: In addition to being a common symptom of MS, severe fatigue was a significant predictor for EDSS worsening in the NYSMSC.

scholarly journals Prevalence and risk factors forStaphylococcus aureuscolonization in individuals entering maximum-security prisons

2013 ◽  
Vol 142 (3) ◽  
pp. 484-493 ◽  
Author(s):  
D. V. MUKHERJEE ◽  
C. T. A. HERZIG ◽  
C. Y. JEON ◽  
C. J. LEE ◽  
Z. L. APA ◽  
...  
Keyword(s):  
Risk Factors ◽  
New York ◽  
Staphylococcus Aureus ◽  
Population Control ◽  
New York State ◽  
York State ◽  
Maximum Security ◽  
Younger Age ◽  
Fair Poor ◽  
Mrsa Colonization

SUMMARYTo assess the prevalence and risk factors for colonization withStaphylococcus aureusin inmates entering two maximum-security prisons in New York State, USA, inmates (N = 830) were interviewed and anterior nares and oropharyngeal samples collected. Isolates were characterized usingspatyping. Overall, 50·5% of women and 58·3% of men were colonized withS. aureusand 10·6% of women and 5·9% of men were colonized with MRSA at either or both body sites. Of MSSA isolates, the major subtypes werespatype 008 and 002. Overall, risk factors forS. aureuscolonization varied by gender and were only found in women and included younger age, fair/poor self-reported general health, and longer length of prior incarceration. Prevalence of MRSA colonization was 8·2%, nearly 10 times greater than in the general population. Control of epidemicS. aureusin prisons should consider the constant introduction of strains by new inmates.

A profile of multiple sclerosis: The New York State Multiple Sclerosis Consortium

1999 ◽  
Vol 5 (5) ◽  
pp. 369-376 ◽  
Author(s):  
L.D. Jacobs ◽  
K.E. Wende ◽  
C.M. Brownscheidle ◽  
B. Apatoff ◽  
P.K. Coyle ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
New York ◽  
New York State ◽  
York State

Multiple sclerosis in the Republic of Tatarstan: epidemiological and clinical characteristics

2020 ◽  
Vol 18 (5) ◽  
pp. 50-57
Author(s):  
F. A. KHABIROV ◽  
◽  
T. I. KHAYBULLIN ◽  
E. V. GRANATOV ◽  
L. A. AVERIANOVA ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Characteristics ◽  
Disease Duration ◽  
Dominant Type ◽  
Adequate Treatment ◽  
Primary Progressive ◽  
Positive Tendency ◽  
Disease Modifying Therapies ◽  
The Republic ◽  
Epidemiological Characteristics

The purpose — to clarify the clinical and epidemiological characteristics of multiple sclerosis (MS) in the Republic of Tatarstan (RT). Material and methods. A retrospective analysis of the register of MS patients in RT from 2015 to 2019 was carried out. The sample size was 2351 patients. The type of MS course, disease duration, clinical characteristics, including EDSS and MSSS scores, used by disease modifying therapies (DMT) were analyzed. Results and conclusions. The prevalence of MS in RT continues to grow and has increased by 29% over a 5-year period (from 46,6 to 60,3 per 100,000 population in 2015 and 2019, respectively). The incidence has relatively stabilized and averages 4,2 cases per 100,000 population per year. The dominant type of MS course in RT is remitting (51,3%), patients with progressive forms account for 48,7%, including those with primary progressive MS (6,9%). In RT, a positive tendency towards a more favorable course of the disease with a decrease in the degree of patients’ disability was traced, mainly due to early diagnosis and timely prescription of adequate treatment with DMT. The problem of timely diagnosis of MS in children and adolescents and in the primary progressive course of MS remains.

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