Cognitive impairment in bipolar affective disorder: implications for the bipolar diathesis

2002 ◽  
Vol 180 (4) ◽  
pp. 293-295 ◽  
Author(s):  
I. Nicol Ferrier ◽  
Jill M. Thompson
Keyword(s):  
Cognitive Impairment ◽  
Affective Disorder ◽  
Bipolar Affective Disorder

CHARACTERISTICS OF COGNITIVE IMPAIRMENT IN PATIENTS WITH DEPRESSIVE DISORDERS

2020 ◽  
Vol 86 (1) ◽  
pp. 41-49
Author(s):  
S. A. Yaroslavtsev
Keyword(s):  
Differential Diagnosis ◽  
Cognitive Impairment ◽  
Depressive Disorder ◽  
Affective Disorder ◽  
Depressive Disorders ◽  
Bipolar Affective Disorder ◽  
Cognitive Dysfunctions ◽  
Visual Spatial ◽  
Linguistic Functions ◽  
Depressive Reaction

362 patients with cognitive impairment in depressive disorders were examined: 123 patients with recurrent depressive disorder (RDD), 141 patients with bipolar affective disorder (BAD) and 98 people with prolonged depressive reaction (PDR). It was found that cognitive dysfunctions were less pronounced in patients with PDR, than in patients with RDD and BAR (p<0,035). Cognitive dysfunctions in depressive disorders was underlined by the presence of disorders in the mental sphere, in the sphere of attention, executive, visual-spatial and linguistic functions. The differential features of cognitive impairment in patients with RDD, BAR and PDR are highlighted and it should be taken during conducting differential diagnosis of cognitive impairment in depressive disorders. Keywords: patients with cognitive impairment, depressive disorders, cognitive dysfunctions, recurrent depressive disorder, bipolar depressive disorder, prolonged depressive reaction.

Cognitive impairment in the euthymic phase of affective disorder

1998 ◽  
Vol 28 (5) ◽  
pp. 1027-1038 ◽  
Author(s):  
LARS VEDEL KESSING
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Cognitive Outcome ◽  
Case Register ◽  
Single Episode ◽  
Icd 10 ◽  
And Gender ◽  
Bipolar Patients

Background. A review of studies of cognition in the euthymic phase of unipolar and bipolar affective disorder reveals diverging results.Methods. The study was designed as a controlled cohort study, with the Danish psychiatric case register of admissions used to identify patients and the Danish civil register to identify controls. Patients who were hospitalized between 19 and 25 years ago with an affective diagnosis and who at interviews fulfilled criteria for a primary affective unipolar or bipolar disorder, according to ICD-10, were compared with age- and gender-matched controls. Interviews and assessment of the cognitive function were made in the euthymic phase of the disorder. In all, 118 unipolar patients, 28 bipolar patients and 58 controls were included. Analyses were adjusted for differences in the level of education and for subclinical depressive and anxiety symptoms.Results. Patients with recurrent episodes were significantly more impaired than patients with a single episode and more impaired than controls. Also, within patients the number of prior episodes seemed to be associated with cognitive outcome. There was no difference in the severity of the dysfunction between unipolar and bipolar patients.Conclusions. Cognitive impairment in out-patients with unipolar and bipolar disorder appears to be associated with the number of affective episodes.

scholarly journals Cognitive functions in a mixed episode of bipolar affective disorder

2019 ◽  
Keyword(s):  
Cognitive Impairment ◽  
Affective Disorder ◽  
Cognitive Functions ◽  
Visual Memory ◽  
Verbal Learning ◽  
Bipolar Affective Disorder ◽  
Main Body ◽  
Mixed Episode ◽  
Wide Range ◽  
Depressive Episodes

Summary. According to various meta-analyzes, most patients with bipolar affective disorder have neurocognitive dysfunction even in remission. In recent studies, moderate to severe impairments have been found in attention, verbal learning and memory, and executive function. Whereas premorbid intelligence remains unchanged. The main body of research is devoted to the study of cognitive impairment in the first episode of bipolar affective disorder, in manic, depressive episodes, and euthymia. At the same time, the features of cognitive dysfunction in mixed forms of bipolar affective disorder remain poorly understood. The aim of the study was to study the characteristics of cognitive functions in patients with a mixed episode of bipolar affective disorder. Materials and methods. With the help of a battery of tests (a test for remembering ten unrelated words; a Ray-Osterritz test; a verbal speed test; a digital character substitution test; a symbol linking test), the cognitive features of 25 patients with a mixed episode, 16 patients with a manic episode, and 15 patients with a depressive episode of bipolar affective disorder. Results and conclusions. Deviations in cognitive function were found in all patients regardless of the type of affective symptomatology. In the form of a wide range of psychopathological phenomena which manifested themselves to a greater extent in patients with a mixed episode of bipolar affective disorder. The peculiarities of the phenomenological structure of cognitive impairment in patients with mixed phase of bipolar affective disorder are manifested in the form of a more pronounced deterioration of verbal memory, information processing speed; more pronounced violations of spatial representations, deterioration of visual memory, verbal associative performance and executive functions; a decrease in attention and a violation of its distribution. The findings suggest that the leading role in the formation of these disorders is played by the presence of depressive symptoms in the clinical structure of affective disorders.

scholarly journals Features of the cognitive sphere in patients with a mixed episode of bipolar affective disorder

2019 ◽  
Vol 25 (3) ◽  
pp. 124-129
Author(s):  
V. S. Pidkorytov ◽  
O. I. Syerikova ◽  
S. O. Ukrainskyi ◽  
O. V. Skrynnyk ◽  
O. S. Serikova
Keyword(s):  
Cognitive Impairment ◽  
Executive Functions ◽  
Affective Disorder ◽  
Verbal Learning ◽  
Bipolar Affective Disorder ◽  
Biologically Active ◽  
Main Body ◽  
Mixed Episode ◽  
Wide Range ◽  
Depressive Episodes

Background. Data of various meta-analyzes confirm that the majority of patients with bipolar affective disorder (BAD) have neurocognitive dysfunction, even during remission. According to the latest research, disturbed domains with moderate to pronounced changes are attention, verbal learning and memory, as well as executive functions, whereas premorbid intelligence may remain unchanged. The main body of research is devoted to the study of cognitive impairment in the first episode of BAD, in manic, depressive episodes and euthymia. At the same time, the features of cognitive dysfunction in mixed forms of biologically active substances remain insufficiently studied. Objective – to study the characteristics of the cognitive sphere in patients with a mixed episode of BAD. Materials and methods. With the help of battery tests (a test to memorize ten unrelated words; Rey-Osterreith Complex Figure Test; Verbal Fluency Test Digit Symbol Substitution Test; Trail making test), the cognitive functions of 25 patients with mixed episodes, 16 patients with manic episodes, and 15 patients with depressive episode of BAD. Results. Cognitive impairments were identified in all patients, regardless of the type of affective symptoms, in the form of a wide range of psychopathological phenomena, which are more pronounced in patients with a mixed episode BAD. The peculiarities of the phenomenological structure of cognitive impairment in patients with mixed phase BAD manifest themselves in the form of: a more pronounced deterioration of verbal memory, speed of information processing; more pronounced violations of spatial representations, impairment of visual memory, verbal associative performance and executive functions; reduction of attention and violations of its distribution. Conclusions. The findings suggest that the presence of depressive symptoms in the structure of mixed affect plays a dominant role in the formation of these disorders.

Cognitive impairment in euthymic patients with bipolar affective disorder

1996 ◽  
Vol 39 (7) ◽  
pp. 580
Author(s):  
W.G. van Gorp ◽  
L.L. Altshuler ◽  
W. Dixon ◽  
D.C. Theberge
Keyword(s):  
Cognitive Impairment ◽  
Affective Disorder ◽  
Bipolar Affective Disorder

Lithium and prevention of cognitive impairment

2011 ◽  
Vol 28 (3) ◽  
pp. 148-150
Author(s):  
Zareena Abidin ◽  
Colm Cooney ◽  
Deirdre Jackson ◽  
Aideen Freyne
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Affective Disorder ◽  
Mmse Score ◽  
Lithium Treatment ◽  
Bipolar Affective Disorder ◽  
Retrospective Chart Review

AbstractObjective: To examine the rate of cognitive decline and occurrence of dementia among patients attending a lithium clinic for those aged 65 years and over.Method: Retrospective chart review of the cognitive function of 29 patients receiving maintenance lithium treatment attending the Dublin South East Old Age Psychiatry service, over a nine-year time period.Results: Twenty-nine patients were included in the study (20 female, nine males), with a mean age of 79 years. Two patients had concurrent dementia. Six patients fulfilled ICD10 criteria for mild cognitive disorder and all of these patients also fulfilled revised consensus criteria for mild cognitive impairment amnestic subtype. Sixteen patients were commenced on lithium as an augmentation treatment for recurrent depressive disorder, 12 patients were on treatment for bipolar affective disorder and one patient on treatment for schizoaffective disorder. Patients had been receiving lithium treatment for an average of 109 months with follow-up by the service for a mean duration of 38 months. The initial mean MMSE score of patients at first presentation to the service was 26.9 (SD = 5.6) compared to a mean MMSE score 25.8 (SD = 5.8) (CI of change in MMSE score at 95% level = −2.1 and 0) at follow-up. The mean MMSE of patients with mild cognitive impairment prior at first contact with the service was 26.8 (SD = 3.2) and at follow-up was 26 (SD = 3.2) which was not statistically significantly different (p=0.40) (CI for change in MMSE at 95% level = −3.2 to 1.5). No patient had developed incident dementia during the follow-up period of the study.Conclusion: The results tentatively suggest that lithium may have a protective effect against cognitive decline and a neuroprotective role in patients with concurrent affective disorder and cognitive impairment. Multi-centre prospective studies of cognitive function in patients attending lithium clinics are needed to examine the neuroprotective properties of lithium.

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