scholarly journals Drug information update. Lithium and chronic kidney disease: Debates and dilemmas

2017 ◽  
Vol 41 (4) ◽  
pp. 216-220 ◽  
Author(s):  
Sumeet Gupta ◽  
Udayan Khastgir
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Research Evidence ◽  
Evidence Base ◽  
Current Evidence ◽  
Treatment Resistant ◽  
The Past ◽  
Current Evidence Base ◽  
Information Update ◽  
Resistant Depression

SummaryLithium is an established treatment for bipolar disorder and an augmenting agent for treatment-resistant depression. Despite awareness of renal adverse effects, including chronic kidney disease, for the past five decades, there has been a lack of research evidence. This has led to debates around the existence and magnitude of the risk. This article discusses the current evidence base regarding the link between lithium and chronic kidney disease, monitoring of renal functions and its clinical implications.

Optimal Treatment of Unresectable Nonmelanoma Skin Cancers

2014 ◽  
Vol 12 (5S) ◽  
pp. 789-792
Author(s):  
Thomas Olencki
Keyword(s):  
Therapeutic Strategy ◽  
Clinical Evidence ◽  
Evidence Base ◽  
Current Evidence ◽  
Annual Conference ◽  
Merkel Cell ◽  
The Past ◽  
Skin Cancers ◽  
Current Evidence Base ◽  
Nonmelanoma Skin Cancers

Unlike in other types of cancer, in metastatic nonmelanoma, there are few dedicated oncologists to care for patients with unresectable skin cancers and little reliable clinical evidence to craft a therapeutic strategy. In his presentation at the NCCN 19th Annual Conference, Dr. Thomas Olencki offered a glimpse of some of the therapeutic regimens tried in the past for these rare skin cancers and briefly reviewed some of the more promising agents for advanced squamous cell, basal cell, and Merkel cell carcinomas, although the current evidence base is limited.

scholarly journals Employment Supports for Adults With Disabilities in Low- and Middle-Income Countries: A Campbell Systematic Review

2017 ◽  
Vol 29 (3) ◽  
pp. 243-255 ◽  
Author(s):  
Janice Tripney ◽  
Nina Hogrebe ◽  
Elena Schmidt ◽  
Carol Vigurs ◽  
Ruth Stewart
Keyword(s):  
Systematic Review ◽  
Research Evidence ◽  
Evidence Base ◽  
Current Evidence ◽  
Market Outcomes ◽  
High Quality Research ◽  
Middle Income ◽  
Employment Supports ◽  
Wide Range ◽  
Current Evidence Base

Objective: To identify, appraise, and synthesize studies of interventions to improve labor market outcomes of adults in developing countries with physical and/or sensory disabilities. Method: Systematic review methods, following Campbell Collaboration guidelines, were utilized. A comprehensive search was used to identify relevant studies published between 1990 and 2013, which were graded for study quality and a narrative approach used to synthesize the research evidence. Results: Fourteen studies covering a wide range of interventions met the inclusion criteria. Although individual studies reported improvements in outcomes, heterogeneity was high and studies were generally of poor methodological quality. Conclusions: There is a lack of high-quality research evidence to inform decision-making in this area. Stakeholders should be cautious when interpreting the results of the current evidence base.

scholarly journals TAVI for Pure Native Aortic Regurgitation: Are We There Yet?

2019 ◽  
Vol 14 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Eduardo A Arias ◽  
Amit Bhan ◽  
Zhan Y Lim ◽  
Michael Mullen
Keyword(s):  
Aortic Stenosis ◽  
Aortic Regurgitation ◽  
Evidence Base ◽  
Current Evidence ◽  
Native Valve ◽  
Off Label ◽  
The Past ◽  
Transcatheter Aortic Valve ◽  
Current Evidence Base ◽  
Valve Implantation

Treatment of degenerative aortic stenosis has been transformed by transcatheter aortic valve implantation (TAVI) over the past 10–15 years. The success of various technologies has led operators to attempt to broaden the indications, and many patients with native valve aortic regurgitation have been treated ‘off label’ with similar techniques. However, the alterations in the structure of the valve complex in pure native aortic regurgitation are distinct to those in degenerative aortic stenosis, and there are unique challenges to be overcome by percutaneous valves. Nevertheless some promise has been shown with both non-dedicated and dedicated devices. In this article, the authors explore some of these challenges and review the current evidence base for TAVI for aortic regurgitation.

scholarly journals From ‘It Rarely Happens’ to ‘It’s Worse for Men’

2020 ◽  
Vol 2 (3) ◽  
pp. 25-34
Author(s):  
Heleen Touquet ◽  
Sarah Chynoweth ◽  
Sarah Martin ◽  
Chen Reis ◽  
Henri Myrttinen ◽  
...  
Keyword(s):  
Sexual Violence ◽  
Evidence Base ◽  
Current Evidence ◽  
Extensive Experience ◽  
Humanitarian Settings ◽  
The Past ◽  
Current Evidence Base ◽  
Women And Girls ◽  
Common Misconceptions

Sexual violence against men and boys in conflict and displacement has garnered increasing attention over the past decade and has been recognised in UN Security Resolution 2467. Despite increased evidence and understanding of the issue, myths and misconceptions nevertheless abound. The authors of this article – practitioners and academics with extensive experience in the field – aim to dispel ten of the most common misconceptions that we have encountered, and to highlight the current evidence base regarding sexual violence against men and boys in humanitarian settings. We argue that just as there is no universal experience of sexual violence for women and girls, there is no universal experience for men and boys, or for nonbinary people. In order to address the complexities of these experiences, a survivor-centred, intersectional approach is needed.

scholarly journals Polyphenols and Cognition In Humans: An Overview of Current Evidence from Recent Systematic Reviews and Meta-Analyses

2020 ◽  
pp. 1-15
Author(s):  
Daniel Joseph Lamport ◽  
Claire Michelle Williams
Keyword(s):  
Systematic Reviews ◽  
Evidence Base ◽  
Epidemiological Studies ◽  
Cognitive Outcome ◽  
Current Evidence ◽  
Duration Of Treatment ◽  
Current Evidence Base ◽  
Cognitive Benefits ◽  
Meta Analyses ◽  
The Impact

There is increasing interest in the impact of dietary influences on the brain throughout the lifespan, ranging from improving cognitive development in children through to attenuating ageing related cognitive decline and reducing risk of neurodegenerative diseases. Polyphenols, phytochemicals naturally present in a host of fruits, vegetables, tea, cocoa and other foods, have received particular attention in this regard, and there is now a substantial body of evidence from experimental and epidemiological studies examining whether their consumption is associated with cognitive benefits. The purpose of this overview is to synthesise and evaluate the best available evidence from two sources, namely meta-analyses and systematic reviews, in order to give an accurate reflection of the current evidence base for an association between polyphenols and cognitive benefits. Four meta-analyses and thirteen systematic reviews published between 2017–2020 were included, and were categorised according to whether they reviewed specific polyphenol-rich foods and classes or all polyphenols. A requirement for inclusion was assessment of a behavioural cognitive outcome in humans. A clear and consistent theme emerged that whilst there is support for an association between polyphenol consumption and cognitive benefits, this conclusion is tentative, and by no means definitive. Considerable methodological heterogeneity was repeatedly highlighted as problematic such that the current evidence base does not support reliable conclusions relating to efficacy of specific doses, duration of treatment, or sensitivity in specific populations or certain cognitive domains. The complexity of multiple interactions between a range of direct and indirect mechanisms of action is discussed. Further research is required to strengthen the reliability of the evidence base.

scholarly journals P-26 Challenging the pressure on nhs resources: could 48-hour continuous subcutaneous infusions (CSCIS) help? a systematically-structured review of the current evidence base

2017 ◽  
Vol 7 (Suppl 1) ◽  
pp. A9.3-A10
Author(s):  
James Baker ◽  
Andrew Dickman ◽  
Stephen Mason ◽  
John Ellershaw ◽  
Paul Skipper ◽  
...  
Keyword(s):  
Evidence Base ◽  
Current Evidence ◽  
Current Evidence Base

scholarly journals Rates of violence in patients classified as high risk by structured risk assessment instruments

2014 ◽  
Vol 204 (3) ◽  
pp. 180-187 ◽  
Author(s):  
Jay P. Singh ◽  
Seena Fazel ◽  
Ralitza Gueorguieva ◽  
Alec Buchanan
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Risk Groups ◽  
Evidence Base ◽  
Assessment Tools ◽  
Current Evidence ◽  
Assessment Instruments ◽  
Individual Liberty ◽  
Current Evidence Base ◽  
Study Heterogeneity

BackgroundRates of violence in persons identified as high risk by structured risk assessment instruments (SRAIs) are uncertain and frequently unreported by validation studies.AimsTo analyse the variation in rates of violence in individuals identified as high risk by SRAIs.MethodA systematic search of databases (1995–2011) was conducted for studies on nine widely used assessment tools. Where violence rates in high-risk groups were not published, these were requested from study authors. Rate information was extracted, and binomial logistic regression was used to study heterogeneity.ResultsInformation was collected on 13 045 participants in 57 samples from 47 independent studies. Annualised rates of violence in individuals classified as high risk varied both across and within instruments. Rates were elevated when population rates of violence were higher, when a structured professional judgement instrument was used and when there was a lower proportion of men in a study.ConclusionsAfter controlling for time at risk, the rate of violence in individuals classified as high risk by SRAIs shows substantial variation. In the absence of information on local base rates, assigning predetermined probabilities to future violence risk on the basis of a structured risk assessment is not supported by the current evidence base. This underscores the need for caution when such risk estimates are used to influence decisions related to individual liberty and public safety.

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