MAPK Activation in Cerebellar Basket Cell Terminals after Harmaline Treatment

2005 ◽  
Vol 1048 (1) ◽  
pp. 411-417 ◽  
Author(s):  
JELENA MILAŠIN ◽  
ANNALISA BUFFO ◽  
DANIELA CARULLI ◽  
PAVLE ANDJUS ◽  
PIERGIORGIO STRATA
Keyword(s):  
Basket Cell ◽  
Mapk Activation

Constitutively Active 1 RAS in S. Pombe Causes Persistent Cdc42 Signalling But Only Transient MAPK Activation

2018 ◽  
Author(s):  
Emma J. Kelsall ◽  
Ábel Vértesy ◽  
Kees Straatman ◽  
Mishal Tariq ◽  
Raquel Gadea ◽  
...  
Keyword(s):  
Mapk Activation ◽  
Constitutively Active

Integrin-Mediated Differentiation of a Pancreatic Carcinoma Cell Line Is Independent of FAK or MAPK Activation Levels

Pancreas ◽  
2001 ◽  
Vol 23 (3) ◽  
pp. 236-245 ◽  
Author(s):  
Volker Stagge ◽  
Thomas Seufferlein ◽  
Daniel Dürschmied ◽  
Andre Menke ◽  
Guido Adler ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Mapk Activation ◽  
Pancreatic Carcinoma Cell Line

scholarly journals PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

2003 ◽  
Vol 162 (2) ◽  
pp. 281-291 ◽  
Author(s):  
Jill K. Slack-Davis ◽  
Scott T. Eblen ◽  
Maja Zecevic ◽  
Scott A. Boerner ◽  
Adel Tarcsafalvi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signal Transduction Pathway ◽  
Mapk Signaling ◽  
Growth Factor Signaling ◽  
Transduction Pathway ◽  
Mapk Activation ◽  
Src Signaling ◽  
Biological Responses ◽  
P21 Activated Kinase ◽  
A Site

Activation of the Ras–MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that phosphorylation of S298 of MAPK kinase 1 (MEK1) by p21-activated kinase (PAK) is a site of convergence for integrin and growth factor signaling. We find that adhesion to fibronectin induces PAK1-dependent phosphorylation of MEK1 on S298 and that this phosphorylation is necessary for efficient activation of MEK1 and subsequent MAPK activation. The rapid and efficient activation of MEK and phosphorylation on S298 induced by cell adhesion to fibronectin is influenced by FAK and Src signaling and is paralleled by localization of phospho-S298 MEK1 and phospho-MAPK staining in peripheral membrane–proximal adhesion structures. We propose that FAK/Src-dependent, PAK1-mediated phosphorylation of MEK1 on S298 is central to the organization and localization of active Raf–MEK1–MAPK signaling complexes, and that formation of such complexes contributes to the adhesion dependence of growth factor signaling to MAPK.

scholarly journals cFLIP-L Inhibits p38 MAPK Activation

2003 ◽  
Vol 278 (29) ◽  
pp. 26831-26837 ◽  
Author(s):  
Annette Grambihler ◽  
Hajime Higuchi ◽  
Steven F. Bronk ◽  
Gregory J. Gores
Keyword(s):  
P38 Mapk ◽  
Mapk Activation
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