Sustained regression of a primary choroidal melanoma under the influence of a therapeutic melanoma vaccine.

1994 ◽  
Vol 12 (2) ◽  
pp. 396-401 ◽  
Author(s):  
M S Mitchell ◽  
P E Liggett ◽  
R L Green ◽  
J Kan-Mitchell ◽  
A L Murphree ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Cutaneous Melanoma ◽  
Specific Immunotherapy ◽  
Choroidal Melanoma ◽  
Ct Scanning ◽  
Melanoma Vaccine ◽  
Computed Tomographic ◽  
Active Specific Immunotherapy ◽  
First Case ◽  
The Right

PURPOSE To determine whether active specific immunotherapy with lysates of cutaneous melanoma cells, administered with immunologic adjuvant DETOX (Ribi ImmunoChem Research, Inc, Hamilton, MT), is effective in shrinking a primary choroidal melanoma, in an elderly patient already blind in the nontumorous eye. An 81-year-old man was referred with a primary choroidal melanoma of the left eye, with virtual blindness of the right eye due to macular degeneration. He was begun on active specific immunotherapy with an experimental melanoma vaccine (melanoma theraccine) and DETOX on weeks 1, 2, 3, 4, and 6, respected after a hiatus of 2 weeks. After a response was noted, monthly injections were given. RESULTS The patient had a significant shrinkage of his choroidal melanoma from a height of 4.2 mm to 2.4 mm within 2 months. This was sustained by continual treatment for 21 months until September 1991. After the patient failed to return for 9 months while recuperating from a stroke, the lesion regrew to a height of 3.7 mm and developed an additional lobe. On resumption of monthly treatments, the lesion shrank to 3.4 mm within 3 months, lost the additional lobe, and has since remained stable. No metastases have been found over a period of nearly 4 years on quarterly computed tomographic (CT) scanning of the chest and abdomen, and magnetic resonance imaging of the head. CONCLUSION Active specific immunotherapy with cutaneous melanoma lysates has caused a clinically useful protracted regression of a primary choroidal melanoma in an elderly patient in whom surgery and radiation therapy were contraindicated. This may represent the first case of a primary choroidal melanoma, and perhaps the only primary tumor, successfully treated with systemic immunotherapy alone. A formal trial of active specific immunotherapy for primary choroidal melanoma in selected patients may be warranted.

Increased effectiveness of interferon alfa-2b following active specific immunotherapy for melanoma.

1994 ◽  
Vol 12 (2) ◽  
pp. 402-411 ◽  
Author(s):  
M S Mitchell ◽  
J Jakowatz ◽  
W Harel ◽  
G Dean ◽  
L Stevenson ◽  
...  
Keyword(s):  
T Cell ◽  
Median Survival ◽  
Specific Immunotherapy ◽  
Objective Response ◽  
Interferon Alfa ◽  
Survival Duration ◽  
Melanoma Vaccine ◽  
Median Survival Duration ◽  
Computed Tomographic ◽  
Active Specific Immunotherapy

PURPOSE To determine whether interferon alfa-2b (IFN-alfa; intron-A, Schering Corp, Kenilworth, NJ) can induce a remission in patients previously treated with active specific immunotherapy (therapeutic melanoma vaccine) without response. PATIENTS AND METHODS Eighteen patients with disseminated melanoma who had failed to respond to at least five injections of Melacine therapeutic melanoma vaccine (Ribi ImmunoChem Research, Inc, Hamilton, MT) were then treated IFN-alfa after a 4-week interval. IFN-alfa 5 or 6 x 10(6) U/m2 was self-administered three times a week subcutaneously by melanoma patients for at least 2 months. Computed tomographic (CT) scans of the chest, abdomen, and pelvis and magnetic resonance imaging of the brain were performed within 4 weeks before treatment as a baseline, and then at 2-month intervals during treatment to evaluate response. All 18 patients were HLA-typed before treatment. The frequency of cytolytic T-cell precursors (pCTL) in the blood had been measured weekly in 13 of the patients during treatment with Melacine. RESULTS Eight of 18 patients (44.4%) had a major objective clinical response induced by IFN-alfa, including site-specific complete remissions in five. Responses lasted a median of 11 months. The median survival duration of the responders has not been reached, and exceeds 32 months. The group as a whole had a median survival duration of 10.1 months, and nonresponders lived 7.3 months. Cytolytic T-cell precursors had been increased by immunization in all five responding patients tested, but also in five of eight nonresponders. There was no association of response to IFN-alfa with specific HLA phenotypes, in contrast to our previous results with melanoma theraccine alone. CONCLUSION These data suggest an additive effect of active specific immunotherapy and IFN-alfa on the objective response rate, perhaps through upregulation of HLA molecules and tumor-associated antigens on the tumor cell by IFN-alfa, after immunization of the patient by Melacine. This treatment may have improved survival over that expected in metastatic melanoma.

scholarly journals First case of nasal transitional carcinoma in a goat infected with Enzootic Nasal Tumor Virus in Belgium

2020 ◽  
Vol 89 (4) ◽  
pp. 226-230
Author(s):  
A. Delaude ◽  
E. Raes ◽  
C. Leroux ◽  
K. Chiers ◽  
L. Sonck
Keyword(s):  
Nasal Passage ◽  
Neoplastic Tissue ◽  
Computed Tomographic ◽  
First Case ◽  
Enzootic Nasal Tumor Virus ◽  
Tumor Virus ◽  
Nasal Tumor ◽  
Retrobulbar Space ◽  
Polymerase Chain ◽  
The Right

An eleven-year-old, female goat was presented for evaluation of breathing difficulties and epistaxis. Radiographs and computed tomographic (CT) examination of the head revealed the presence of a space-occupying lesion involving the right nasal passage and invading the cranial vault and retrobulbar space. Histologic examination and detection of viral genome from the nasal mass led to the diagnosis of nasal transitional carcinoma with concomitant infection with Enzootic Nasal Tumor Virus (ENTV-2). In this case report, the presence of a nasal transitional carcinoma is described in a goat; a very rare tumor which, to the authors’ knowledge, has not been previously reported in goats. Reverse transcription polymerase chain reaction (RT-PCR) detected the genome of ENTV-2 within the neoplastic tissue, suggesting an infectious etiology.

scholarly journals First case of nasal transitional carcinoma in a goat infected with Enzootic Nasal Tumor Virus in Belgium

2020 ◽  
Vol 89 (4) ◽  
pp. 226-230
Author(s):  
A. Delaude ◽  
E. Raes ◽  
C. Leroux ◽  
K. Chiers ◽  
L. Sonck
Keyword(s):  
Nasal Passage ◽  
Neoplastic Tissue ◽  
Computed Tomographic ◽  
First Case ◽  
Enzootic Nasal Tumor Virus ◽  
Tumor Virus ◽  
Nasal Tumor ◽  
Retrobulbar Space ◽  
Polymerase Chain ◽  
The Right

An eleven-year-old, female goat was presented for evaluation of breathing difficulties and epistaxis. Radiographs and computed tomographic (CT) examination of the head revealed the presence of a space-occupying lesion involving the right nasal passage and invading the cranial vault and retrobulbar space. Histologic examination and detection of viral genome from the nasal mass led to the diagnosis of nasal transitional carcinoma with concomitant infection with Enzootic Nasal Tumor Virus (ENTV-2). In this case report, the presence of a nasal transitional carcinoma is described in a goat; a very rare tumor which, to the authors’ knowledge, has not been previously reported in goats. Reverse transcription polymerase chain reaction (RT-PCR) detected the genome of ENTV-2 within the neoplastic tissue, suggesting an infectious etiology.

scholarly journals Prolongation of Survival in Metastatic Melanoma After Active Specific Immunotherapy With a New Polyvalent Melanoma Vaccine

1992 ◽  
Vol 216 (4) ◽  
pp. 463-482 ◽  
Author(s):  
DONALD L. MORTON ◽  
LELAND J. FOSHAG ◽  
DAVE S.B. HOON ◽  
J. ANNE NIZZE ◽  
LESLIE A. WANEK ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Specific Immunotherapy ◽  
Melanoma Vaccine ◽  
Active Specific Immunotherapy

Renal Cell Carcinoma With Intravascular Lymphomatosis

2001 ◽  
Vol 125 (9) ◽  
pp. 1239-1241
Author(s):  
Beverly Y. Wang ◽  
James A. Strauchen ◽  
David Rabinowitz ◽  
Steven M. Tillem ◽  
Pamela D. Unger
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Subcutaneous Tissue ◽  
B Cell Lymphoma ◽  
Left Breast ◽  
Computed Tomographic ◽  
Intravascular Lymphomatosis ◽  
First Case ◽  
The Right

Abstract We report the case of a 77-year-old white woman who presented with a left breast mass, lethargy, and weight loss. Pelvic computed tomographic scan revealed a 9.5-cm mass in the right kidney. Surgical pathology demonstrated a diffuse large B-cell lymphoma of the subcutaneous tissue of the breast and renal cell carcinoma with concurrent extensive intravascular lymphomatosis. Systemic dissemination of malignant lymphoma to a concurrent visceral primary neoplasm is rare. To the best of our knowledge, this is the first case illustrating a renal cell carcinoma collision with intravascular lymphomatosis.

Bronchialarterienembolisation bei Hämoptysen: Das Nutzen-Risiko-Verhältnis sorgfältig abwägen

2020 ◽  
Vol 8 (3) ◽  
pp. 144-145
Author(s):  
Simon-Dominik Herkenrath
Keyword(s):  
Lung Transplantation ◽  
Bronchial Artery ◽  
Computed Tomographic Angiography ◽  
Diaphragmatic Paralysis ◽  
Massive Hemoptysis ◽  
Low Grade ◽  
Thoracic Pain ◽  
Computed Tomographic ◽  
First Case ◽  
The Right

Background: Massive hemoptysis is a serious complication in Cystic Fibrosis (CF), occurring commonly in older patients. Bronchial artery embolization (BAE) can be performed to stop the bleeding. BAE is generally safe and effective, but can sometimes lead to serious complications. We report the first case of temporary unilateral diaphragmatic paralysis associated to lung consolidation following BAE in a pediatric CF female patient. This complication worsened the lung function of the patient who underwent lung transplantation after 9 months. Case presentation: A 14 years old female CF patient followed by the CF center of Florence presented low-grade fever, cough increase and recurrent episodes of major hemorrhages such as to carry out a BAE. Within 24 h the patient started to complain of severe thoracic pain in the right hemithorax, increased dyspnea and fever. A computed tomographic angiography and a dynamic fluoroscopic evaluation revealed the right diaphragmatic paralysis, not present before the procedure. After 4 days the clinical condition and radiological imaging had improved with restored mobility of the right hemidiaphragm. Nine months later, she required mechanical ventilation, and subsequently the initiation of extracorporeal membrane oxygenation (ECMO) for a pulmonary exacerbation with septic shock. Lung transplantation in ECMO was performed with success. Conclusion: Clinicians should be aware of the possibility of phrenic nerve injury with BAE in pediatric CF patients.

Cerebellar Malignant Fibrous Histiocytoma: Case Report and Literature Review

Neurosurgery ◽  
2004 ◽  
Vol 54 (3) ◽  
pp. 745-752 ◽  
Author(s):  
Abderrahmane Hamlat ◽  
Mahmoudreza Adn ◽  
Sylvie Caulet-Maugendre ◽  
Yvon Guegan
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Clinical Presentation ◽  
Treatment Approach ◽  
Fibrous Histiocytoma ◽  
Cerebellar Hemisphere ◽  
Cerebellar Syndrome ◽  
Computed Tomographic ◽  
First Case ◽  
The Central Nervous System ◽  
The Right

Abstract OBJECTIVE AND IMPORTANCE Malignant fibrous histiocytoma in the central nervous system is uncommon. Fewer than 70 cases have been documented and, to the best of our knowledge, this is the first case arising from the cerebellum. CLINICAL PRESENTATION A 44-year-old woman presented with headaches, vomiting, and dizziness. A neurological examination revealed right cerebellar syndrome. Brain computed tomographic scans revealed an isodense tumor in the right cerebellar hemisphere. The breast ultrasonographic, bone scintigraphic, and thoracoabdominal computed tomographic findings were normal. INTERVENTION The patient was surgically treated. The tumor recurred 1.5 months later, demonstrating hemorrhagic characteristics on brain computed tomographic scans. The patient underwent a second operation, followed by radiotherapy. CONCLUSION Malignant fibrous histiocytoma is still a controversial entity, and the lack of specific criteria means that it must be diagnosed via the process of elimination. With currently available therapy, our review can provide only a very poor prognosis. The median survival time was 27 months. In attempts to develop better therapeutic strategies, total excision and radiotherapy seem to represent the best treatment approach.

Unusual Clinical and Imaging Presentation of Chronic Subdural Hematoma

2017 ◽  
Vol 14 (02/03) ◽  
pp. 149-151
Author(s):  
Partha Ghosh ◽  
Kaushik Roy ◽  
Suniti Saha
Keyword(s):  
Subdural Hematoma ◽  
Chronic Subdural Hematoma ◽  
Subdural Collection ◽  
Computed Tomographic ◽  
Mode Of Presentation ◽  
First Case ◽  
Large Head ◽  
History Of ◽  
Operative Findings ◽  
The Right

AbstractVarious clinical and radiologic presentations of chronic subdural hematoma (SDH) are reported in the literature. Therefore, sometimes the presentation of a patient with chronic SDH often creates confusion regarding decision making. Here, the authors present three cases of chronic SDH, in which the clinical presentation, radiology, and operative findings were unusual. In the first case, the patient presented with acute extradural hematoma like clinical as well as radiologic presentation but intraoperatively found to have chronic calcified SDH, whereas another case with history of bilateral ventriculoperitoneal (VP) shunting at childhood presented with large head with discharging sinus at the forehead. Radiologic and operative findings were very much unusual. Intraoperatively, the bilateral subdural collection was found to have fungus-like projections with subdural space communicating with the forehead sinus. In another case, a 10-year-old girl with history of VP shunting at age of 6 months presented with left hemiparesis of subacute onset. Computed tomographic (CT) scan revealed biconvex lesion at the right parietal region intraoperatively. The authors found the shell-like lesion with inner and outer membrane calcified, within which the subdural collection was present. In these three cases, they observed the very unusual mode of presentation of chronic SDH, and in the literature such mode of presentation and operative findings of such type are very rare.

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