Relevance of peritoneal lavage cytology before and after gastrectomy in CY1 and R1 surgery for primary advanced gastric cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 4198-4198
Author(s):  
O. Kobayashi ◽  
A. Tsuburaya ◽  
T. Yoshikawa ◽  
T. Osaragi ◽  
H. Murakami ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Peritoneal Lavage ◽  
Peritoneal Lavage Cytology ◽  
Before And After ◽  
Lavage Cytology

The impact of pre-operative chemotherapy in patients with peritoneal lavage cytology positive or localized peritoneum metastasis for gastric cancer: A multicenter retrospective study.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 95-95 ◽  
Author(s):  
Rie Makuuchi ◽  
Toshifumi Yamaguchi ◽  
Atsuo Takashima ◽  
Kengo Nagashima ◽  
Tatsuya Yamada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Lavage ◽  
Group Status ◽  
Peritoneal Lavage Cytology ◽  
Cancer Group ◽  
Japanese Classification ◽  
Before And After ◽  
Lavage Cytology ◽  
N3 Lymph Node ◽  
The Impact

95 Background: Peritoneal lavage cytology of positive and localized peritoneum metastasis of gastric cancer (GC) are defined as CY1 and P1 in the 14th edition of the Japanese Classification of GC. Patients (pts) with CY1 and/or P1 have poor prognosis after removing all macroscopically visible disease by standard gastrectomy followed by S1. The aim of this study was to investigate the efficacy of pre-operative chemotherapy (Pre-Cx) in patients with CY1 and/or P1. Methods: We retrospectively reviewed the GC pts who were diagnosed to have CY1 and/or P1 at 34 institutions participating in the Stomach Cancer Group of Japan Clinical Oncology Group between 2007 and 2012. Inclusion criteria were: no distant metastasis other than CY1 or P1, no prior treatment for GC. The subjects were divided to two groups according to treatment strategy with/without Pre-Cx before surgery. In the Pre-Cx group, status of CY and P was diagnosed by laparoscopy before and after Pre-Cx, and indication of surgical resection was decided by each physician. Results: A total of 824 pts were collected from 34 institutions. Of the 713 eligible pts, 150 pts received Pre-Cx (Pre-Cx group) and 563 pts underwent surgery followed by Cx (Post-Cx group). Proportions of P0CY1/P1CY0/P1CY1 were 69/12/19% and 69/17/14% in the Pre- and Post-Cx. Cx regimen for Pre-Cx were S1 plus cisplatin/ docetaxel and cisplatin plus S1/others (n=90/37/23). In the Pre-Cx, 57 (38%) pts who achieved P0CY0 after Pre-Cx showed better survival than the remaining 92 pts (overall survival (OS), 31.0 vs. 19.9 months (M), HR=1.99, 95% CI 1.32-2.93, p=0.001). OS was 24.8 and 24.0 M in the Pre- and Post-Cx (HR 1.07; 95% CI 0.87-1.32, p=0.502). In multivariate analysis, P1CY1, over 65 years old and clinical N3 lymph node metastasis were identified as the independent prognostic factor for OS (p<0.05). Conclusions: Although Pre-Cx showed favorable survival in case of achieving P0 and CY0, Pre-Cx did not show a survival benefit for GC pts with CY1 and /or P1.

scholarly journals Intraoperative peritoneal lavage cytology offers prognostic significance for gastric cancer patients with curative resection

2017 ◽  
Vol 108 (5) ◽  
pp. 978-986 ◽  
Author(s):  
Eiji Higaki ◽  
Shinya Yanagi ◽  
Naoto Gotohda ◽  
Takahiro Kinoshita ◽  
Takeshi Kuwata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Curative Resection ◽  
Peritoneal Lavage ◽  
Prognostic Significance ◽  
Peritoneal Lavage Cytology ◽  
Lavage Cytology ◽  
Gastric Cancer Patients

Survival and prognosticators of gastric cancer patients with only positive peritoneal lavage cytology.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 16-16
Author(s):  
Kazuki Kano ◽  
Tsutomu Sato ◽  
Yukio Maezawa ◽  
Kenki Segami ◽  
Tetsushi Nakajima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Proportional Hazards Model ◽  
Peritoneal Lavage ◽  
Multivariate Analyses ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Peritoneal Cytology ◽  
Peritoneal Lavage Cytology ◽  
Lavage Cytology

16 Background: Treatment strategies for only positive peritoneal lavage cytology findings have not yet been established. The objective of this retrospective study was to clarify the survival and prognosticators in these patients. Methods: Overall survival (OS) rates were examined in 39 patients with gastric cancer who underwent a curative resection and had positive peritoneal cytology in the absence of overt peritoneal metastases between January 2000 and June 2015. Univariate and multivariate analyses were performed to identify risk factors using a Cox proportional hazards model. Results: A total of 39 patients were evaluated. The median overall survival was significantly longer in the 34 patients who received chemotherapy after surgery than that in the 5 who did not (19.1 vs 5.9 months, p < 0.01). Among the patients who received chemotherapy after surgery, univariate and multivariate analyses showed that pN3b was an independent significant prognosticator (hazard ratio of 4.169 with 95% CI: 1.108-15.684, p = 0.035). The median OS was 15.8 months when the patients diagnosed with N3b was 33.1 months when the patients diagnosed with N3a or lower. Conclusions: The prognosis of gastric carcinoma with positive peritoneal lavage cytology without peritoneal metastasis is still poor and need more aggressive treatment. The lymph node metastasis was a significant prognosticator in these patients.

When Is Curative Gastrectomy Justified for Gastric Cancer with Positive Peritoneal Lavage Cytology but Negative Macroscopic Peritoneal Implant?

2005 ◽  
Vol 29 (9) ◽  
pp. 1131-1134 ◽  
Author(s):  
Isao Miyashiro ◽  
Ko Takachi ◽  
Yuichiro Doki ◽  
Osamu Ishikawa ◽  
Hiroaki Ohigashi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Lavage ◽  
Curative Gastrectomy ◽  
Peritoneal Lavage Cytology ◽  
Peritoneal Implant ◽  
Lavage Cytology

scholarly journals Prognostic significance of peritoneal lavage cytology in gastric cancer in Singapore

2005 ◽  
Vol 8 (4) ◽  
pp. 228-237 ◽  
Author(s):  
Esther W.L. Chuwa ◽  
Lay-Wai Khin ◽  
Weng-Hoong Chan ◽  
Hock-Soo Ong ◽  
Wai-Keong Wong
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Lavage ◽  
Prognostic Significance ◽  
Peritoneal Lavage Cytology ◽  
Lavage Cytology

scholarly journals Prognostic significance of peritoneal lavage cytology in staging gastric cancer: systematic review and meta-analysis

2017 ◽  
Vol 21 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Sara Jamel ◽  
Sheraz R. Markar ◽  
George Malietzis ◽  
Amish Acharya ◽  
Thanos Athanasiou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Peritoneal Lavage ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Peritoneal Lavage Cytology ◽  
Lavage Cytology
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