Long-term impact of chemotherapy on early stage ovarian cancer patients

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 5024-5024 ◽  
Author(s):  
U. A. Matulonis ◽  
A. Kornblith ◽  
H. Lee ◽  
J. Bryan ◽  
C. Gibson ◽  
...  
Keyword(s):  
Social Support ◽  
Ovarian Cancer ◽  
Cancer Survivors ◽  
Unmet Needs ◽  
Early Stage ◽  
Fear Of Recurrence ◽  
Socioeconomic Impact ◽  
Abdominal Symptoms ◽  
Early Stage Ovarian Cancer

5024 Background: Quality of life (QOL) assessments in early stage (stage I and II) ovarian cancer survivors (CS) are limited and have to date not focused on CS who have received adjuvant platinum- and taxane-based chemotherapy (CT). Methods: 55 early stage ovarian patients (pts) were identified from patient logs from the Dana-Farber Cancer Institute and Massachusetts General Hospital. 54 pts. received CT. QOL and long-term medical sequelae were measured in pts who were > 3 years from diagnosis and had no evidence of recurrent cancer. Pts were interviewed by phone, and the following surveys were administered: EORTC QLQ-C30 (EORTC) and QLQ-OV28 (OV-28), MHI-17, CALGB sexual functioning, GOG Neuropathy, FACT Fatigue, Beck’s Hopelessness, Fear of Recurrence (FOR), Dyadic Adjustment Scale (DAS), PCL-C post-traumatic stress disorder (PTSD), Unmet Needs, FACT-Spirituality (FACT-Sp), complementary therapy use, and MOS Social Support (MOS). Results: 55 pts were interviewed (mean age 58 yrs, range 34 to 77 yrs). Mean time between diagnosis and interview was 5.6 yrs. CS reported significantly higher MHI-17 scores than the population norm, and higher MHI-17 scores were associated with better overall QOL (EORTC, r = 0.57, p < 0.0001), increased social support (MOS, r = 0.54, p < 0.0001), and better marital relationships (DAS, r = 0.42, p < 0.001). Sexual problems (1.57 out of 6) and unmet needs (1.5 out of 14) were minimal. FOR was correlated with lowered overall QOL (EORTC, r = −0.63, p < 0.0001), increased abdominal symptoms (OV-28 abdominal scale, r = 0.48, p < 0.0002), increased hopelessness (Beck’s, r = 0.46, p < 0.0005), and increased spirituality (FACT-Sp, r = −0.57, p < 0.0001). CS were using 5.4 complementary therapies for QOL purposes and 5.8 for cancer treatment. Minimal negative socioeconomic impact was observed in CS (0.16 out of 4). However, 12.5% of pts had scores indicative of a diagnosis of PTSD. Conclusions: Long-term QOL follow-up of early stage ovarian cancer survivors demonstrated minimal long-term symptoms, excellent mental health, minimal unmet needs, and minimal socioeconomic impact. No significant financial relationships to disclose.

Long-term adjustment of early-stage ovarian cancer survivors

2008 ◽  
Vol 18 (6) ◽  
pp. 1183-1193 ◽  
Author(s):  
U. A. Matulonis ◽  
A. Kornblith ◽  
H. Lee ◽  
J. Bryan ◽  
C. Gibson ◽  
...  
Keyword(s):  
Mental Health ◽  
Social Support ◽  
Ovarian Cancer ◽  
Cancer Survivors ◽  
Unmet Needs ◽  
Early Stage ◽  
Complementary Therapy ◽  
Fear Of Cancer Recurrence ◽  
Event Scale ◽  
Early Stage Ovarian Cancer

The objectives of this study were to describe the quality of life (QOL), consequences of treatment, complementary therapy use, and factors correlating with psychologic state in 58 survivors of early-stage ovarian cancer since little is known about the QOL of early-stage ovarian cancer survivors. Survivors were interviewed using standardized measures to assess physical, psychologic, social, and sexual functioning; impact of cancer on socioeconomic status; and complementary therapy use. Survivors reported good physical QOL scores and few unmet needs. However, menopausal symptoms and negative impact on sexuality were reported. Less than 10% of survivors reported either an interest in sex or were sexually active. Psychologic assessment yielded a subset of 26% of patients with scores suggestive of posttraumatic stress disorder (PTSD) and 40% of survivors scored below the norm on the Mental Health Inventory-17 Survey. One third of patients required treatment for family/personal problems and took antianxiety medications. About 56% of survivors reported fear of cancer recurrence and 59% reported anxiety when their CA125 is tested. Better mental health was significantly related to less fatigue (Functional Assessment of Cancer Therapy [FACT]—fatigue, r= 0.61, P< 0.0001), less pain (European Organisation for Research and Treatment of Cancer [EORTC], r= −0.54, P< 0.0001), fewer stressful life events (Life Event Scale, r= −0.44, P> 0.001), and greater social support (MOS Social Support Survey, r= 0.41, P< 0.01). Early-stage ovarian cancer survivors had few physical complaints and unmet needs, but psychologic distress was evident in a subset of survivors; the majority of survivors reported sexual dysfunction. These results indicate the need for intervention and improved distress screening in the early-stage ovarian cancer population.

Long-term morbidity of adjuvant whole abdominal radiotherapy (WART) or chemotherapy for early stage ovarian cancer

2009 ◽  
Vol 45 (7) ◽  
pp. 1193-1200 ◽  
Author(s):  
M.J.A. Engelen ◽  
B.J. Snel ◽  
M. Schaapveld ◽  
E. Pras ◽  
E.G.E. de Vries ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Abdominal Radiotherapy ◽  
Early Stage Ovarian Cancer

Ten‐year follow‐up study of long‐term outcomes after conservative surgery for early‐stage ovarian cancer

2020 ◽  
Vol 150 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Giorgio Bogani ◽  
Antonino Ditto ◽  
Ciro Pinelli ◽  
Salvatore Lopez ◽  
Valentina Chiappa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Conservative Surgery ◽  
Long Term Outcomes ◽  
Follow Up Study ◽  
Early Stage Ovarian Cancer

Long-term safety of fertility sparing surgery in early stage ovarian cancer: Comparison to standard radical surgical procedures

2015 ◽  
Vol 138 (1) ◽  
pp. 78-82 ◽  
Author(s):  
Antonino Ditto ◽  
Fabio Martinelli ◽  
Giorgio Bogani ◽  
Domenica Lorusso ◽  
Marialuisa Carcangiu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Surgical Procedures ◽  
Early Stage ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Early Stage Ovarian Cancer

scholarly journals Work Ability Among Long-term Breast Cancer Survivors – Exploring the Role of Social Support in a Nation-wide Study

2022 ◽  
Author(s):  
kathrine vandraas ◽  
Ragnhild Sørum Falk ◽  
Synne Bøhn ◽  
Cecilie Kiserud ◽  
Hanne Lie ◽  
...  
Keyword(s):  
Social Support ◽  
Cancer Survivors ◽  
Work Ability ◽  
Breast Cancer Survivors ◽  
Protective Factor ◽  
Early Stage ◽  
Work Ability Index ◽  
Collegial Support ◽  
High Social Support

Abstract work ability (WA) is scarce. We aimed to identify factors, including social support, associated with excellent WA in a nation-wide population of long-term BCS. MethodsAll long-term BCSs (20-65 years) diagnosed with early-stage BC in 2011 or 2012 were identified by the Norwegian Cancer Registry in 2019 and invited to participate in a survey (n=2803). WA was assessed using the Work Ability Index. Factors associated with excellent WA were identified using univariate and multivariate logistic regression analyses, adjusted for sociodemographic-, health- and cancer related variables. ResultsThe final sample consisted of 926 BCSs with a mean age of 56 years at survey. WA was reduced from 8.9 (SD 2.3) at diagnosis to 6.3 (SD 3.1) eight years later. One in three BCSs reported poor WA, and seven out of ten reported that their physical WA was reduced due to cancer. Survivors with excellent WA reported high social support from supervisors and colleagues compared to BCSs with low WA. Additionally, cognitive impairment and fatigue were negatively associated with WA. ConclusionWA remains a significant challenge in long-term BC survivorship, with a substantial proportion of BCSs reporting poor WA eight years after diagnosis. Collegial support appears to be a protective factor for sustained WA, whilst survivors struggling with fatigue and cognitive impairments may represent a particularly vulnerable group for discontinued employment. Increased attention to WA in follow-up care is warranted.

Fear of recurrence in long-term cancer survivors—Do cancer type, sex, time since diagnosis, and social support matter?

2016 ◽  
Vol 35 (12) ◽  
pp. 1329-1333 ◽  
Author(s):  
Lena Koch-Gallenkamp ◽  
Heike Bertram ◽  
Andrea Eberle ◽  
Bernd Holleczek ◽  
Sieglinde Schmid-Höpfner ◽  
...  
Keyword(s):  
Social Support ◽  
Cancer Survivors ◽  
Fear Of Recurrence ◽  
Cancer Type ◽  
Time Since Diagnosis

Laparoscopic and Open Abdominal Staging for Early-Stage Ovarian Cancer: Our Experience, Systematic Review, and Meta-analysis of Comparative Studies

2014 ◽  
Vol 24 (7) ◽  
pp. 1241-1249 ◽  
Author(s):  
Giorgio Bogani ◽  
Antonella Cromi ◽  
Maurizio Serati ◽  
Edoardo Di Naro ◽  
Jvan Casarin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Open Surgery ◽  
Early Stage ◽  
Meta Analysis ◽  
Rank Test ◽  
Survival Outcomes ◽  
Log Rank Test ◽  
Early Stage Ovarian Cancer

ObjectivesThe aim of this study was to analyze perioperative and long-term survival outcomes after either laparoscopic or open abdominal staging for apparent early-stage ovarian cancer.MethodsData of consecutive women with early-stage ovarian cancer undergoing comprehensive laparoscopic staging between 2003 and 2010 were matched with a historical cohort of patients undergoing open surgery. Five-year survival outcomes were analyzed using the Kaplan-Meier method. In addition, a systematic review of the literature and meta-analysis of comparative studies was performedResultsA total of 35 women undergoing staging via laparoscopy were compared with a cohort of 32 patients undergoing open surgery. Baseline characteristics were similar between groups. Spillage occurred in 6 and 4 patients in laparoscopic and open group, respectively (P = 0.59). Patients undergoing laparoscopy experienced longer operative time (P < 0.001), shorter hospital stay (P = 0.03), and lower postoperative complication rate (3% vs 28%; P = 0.005) than patients undergoing staging via open surgery. The median (range) follow-up period was 64 (37–106) and 100 (61–278) months for case and control, respectively (P < 0.001). Five-year disease-free survival (P = 0.12, log-rank test) and overall survival (P = 0.26, log-rank test) were not influenced by surgical approach. Pooled analyses of the literature results corroborate our results suggesting an improvement of perioperative results in the laparoscopic group in comparison with the open abdominal one. In comparison with open surgery, laparoscopy did not influenced spillage (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.35–1.73) and upstaging rate (OR, 0.7; 95% CI, 0.38–1.27). No between-group differences in survival were observed (OR, 0.5; 95% CI, 0.21–1.21).ConclusionsLaparoscopy upholds open surgery in long-term oncologic control, reducing morbidity.

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