Meta-analysis of effects of zoledronic acid (ZOL) on survival in metastatic bone disease (MBD): Survival in patients with high bone turnover

At denosumab discontinuation, an antiresorptive agent is prescribed to reduce the high bone turnover, the rapid bone loss, and the risk of spontaneous vertebral fractures. We report the case of a woman treated with aromatase inhibitors and denosumab for 5 years. Raloxifene was then prescribed to prevent the rebound effect. Raloxifene was ineffective to reduce the high bone turnover and to avoid spontaneous clinical vertebral fractures. We believe that among the antiresorptive treatments, the most powerful bisphosphonates should be favored, and their administration adapted according to the serial follow-up of bone markers.

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High bone turnover status as a risk factor in symptomatic hypocalcemia following denosumab treatment in a male patient with osteoporosis

Clinical Interventions in Aging ◽

10.2147/cia.s180614 ◽

2018 ◽

Vol Volume 13 ◽

pp. 1929-1934 ◽

Cited By ~ 3

Author(s):

Koji Ishikawa ◽

Takashi Nagai ◽

Koki Tsuchiya ◽

Yusuke Oshita ◽

Takuma Kuroda ◽

...

Keyword(s):

Risk Factor ◽

Bone Turnover ◽

Male Patient ◽

High Bone Turnover ◽

Symptomatic Hypocalcemia ◽

High Bone ◽

Denosumab Treatment

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High bone turnover in fibromyalgia

Calcified Tissue International ◽

10.1007/bf02563822 ◽

1990 ◽

Vol 46 (5) ◽

pp. 314-317 ◽

Cited By ~ 9

Author(s):

Thierry Appelboom ◽

André Schoutens

Keyword(s):

Bone Turnover ◽

High Bone Turnover ◽

High Bone

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High bone turnover in Muslim women with vitamin D deficiency

The Medical Journal of Australia ◽

10.5694/j.1326-5377.2002.tb04699.x ◽

2002 ◽

Vol 177 (3) ◽

pp. 139-141 ◽

Cited By ~ 32

Author(s):

Terrence H Diamond ◽

Sherel Levy ◽

Angelina Smith ◽

Peter Day

Keyword(s):

Vitamin D ◽

Bone Turnover ◽

Vitamin D Deficiency ◽

Muslim Women ◽

High Bone Turnover ◽

High Bone

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Prediction of fracture risk and prophylactic intervention in metastatic bone disease: a systematic review

Romanian Journal of Orthopaedic Surgery and Traumatology ◽

10.2478/rojost-2018-0010 ◽

2018 ◽

Vol 1 (1) ◽

pp. 44-49

Author(s):

Bogdan Ştefan Creţu ◽

Călin Dragosloveanu ◽

Dragoş Cotor ◽

Şerban Dragosloveanu ◽

Cristian Ioan Stoica

Keyword(s):

Fracture Risk ◽

Bone Disease ◽

Meta Analysis ◽

Metastatic Bone Disease ◽

Bone Lesions ◽

Pathological Fractures ◽

Element Analysis ◽

Actual Knowledge ◽

Number Of Patients

AbstractPathological fractures occur in an area of bone where either the quantity or quality of bone is modified and the main cause of bone metastases that weaken the structure and will lead to fractures are in high proportion given by visceral tumors or primary hematopoietic tumors like myeloma.This paper’s objective was to review the actual knowledge in the treatment of fractures secondary to metastases. Spinal lesions were not discussed in this paper.Literature search was performed using MEDLINE and Web of Science to find literature relevant to fracture risk and prophylactic intervention in metastatic bone disease. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline was used for this review. As results, we identified 30 papers that were suitable for this review. Most of them concluded that it is difficult to assess the amount of bone involvement on radiographs alone. Using the actual guidelines for prophylactic fixation may result in an under treatment or overtreatment of patients with metastatic bone disease. Their ability to determine which metastatic bone lesions will fracture is altered mainly because of the small number of patients included in the studies. The prediction factors for fracture risk are still to be evaluated. CT, FDG-PET or CT scan-based finite element analysis may be useful tools for the identification of impending pathological fractures requiring prophylactic stabilization.

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